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MNJ (Malang Neurology Journal)
Published by Universitas Brawijaya
ISSN : 24076724     EISSN : 24425001     DOI : -
Core Subject : Science,
Neuroscience
Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.
Arjuna Subject : -
Articles 297 Documents
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CEREBRAL VENOUS SINUS THROMBOSIS WITH GOOD RESPONSE TO HEPARINIZATION THERAPY: TWO CASE REPORT AND DIAGNOSTIC ALGORITHM Indah, Carolin Tiara Lestari; Tini, Kumara; Susilawathi, Ni Made; Wijayanti, Ida Ayu Sri; Mahadewi, Ni Putu Ayu Putri; Pramaswari, Anak Ayu Agung; Mahaalit Aribawa, I Gusti Ngurah; Dewi, Putu Utami; Krisnawardhani Kumbara, Cokorda Istri Yuliandari
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.17

Abstract

Cerebral venous sinus thrombosis (CVST) is an uncommon condition of cerebral venous sinus thrombosis with a varied clinical presentation that can be diagnostically challenging. Intravenous heparin is the optimal immediate anticoagulant according to the European Academy of Neurology (EAN) guideline 2017. This report aims to describe highly suspicious CVST clinical features and suggest a diagnostic algorithm based on two cases of CVST found in our center. The first case is a 52-year-old man who presented with serial seizures preceded by subacute headache and diparesis. Non-contrast head CT (NCCT) showed multifocal haemorrhages and cord signs. The second case is a 19-year-old woman who presented with slowly decreased consciousness, headache, and a history of upper respiratory infection. Diffuse cerebral edema was revealed in NCCT. Both of these patients had thrombosis in superior sagittal sinus, right transverse, and sigmoid sinus. Heparinization was conducted and continued with rivaroxaban with a good response. CVST is rare case and often unrecognized; since it has serious complications, early diagnosis and treatment improve prognosis and survival.
THE SAFETY AND OUTCOME OF ACUTE ISCHAEMIC STROKE PATIENTS WITH COVID-19 TREATED WITH INTRAVENOUS RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR: A SYSTEMATIC REVIEW Machin, Abdulloh; Setjaputra, Vina Lidya; Susianto, Steven Christian; Husni, Nadya; Sugondo, Alexander Tikara
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.12

Abstract

Background: Strokes associated with SARS-CoV-2 may be linked to increased mortality rates. The utilization of intravenous thrombolysis is anticipated to enhance the clinical results in such patients. Moreover, emerging evidence underscores the importance of evaluating the safety and effectiveness of intravenous thrombolysis in individuals suffering from Acute Ischaemic Stroke along with COVID-19. Objective: To assess the safety and effectiveness of intravenous thrombolysis in Acute Ischaemic Stroke patients with COVID-19. Methods: A systematic literature search (Pubmed, Elsevier, and Cochrane database) with keywords (((intravenous thrombolysis) AND (acute ischemic stroke)) AND (covid-19)) AND (outcome))). We selected research studies for evaluation based on specific inclusion and eligibility criteria. Two independent reviewers then proceeded to extract and analyze various data points, including the name of the first author, the year of publication, the study's design, the National Institute of Health Stroke Scale (NIHSS) scores at admission and post-treatment, hospitalization-related mortality, and the occurrence of hemorrhagic transformation. Results: Three studies (n=153 patients) were included, mostly men with advanced age with the most common comorbidity being hypertension. Median of NIHSS Score of subjects on admission is 11, 12, and 13, with interquartile range from 3 to 20 (minor to severe stroke). The mRS at discharge and 1 month after admission is: 0–2 pts in 57 patients, ≥2 in 43 patient. Hemorrhagic transformation involved 3.23% of patients from total samples, death within hospitalization and 1-month mortality were in 23 patients (15%). In numerous studies, there was inadequate data available to determine the precise reason for mortality. Conclusion: Following IV-rTPA therapy, our COVID-19 infection subjects' mRS scores ranged from mild to moderate disability. Fifteen percents of all subjects died, and 3.23% of subjects experienced hemorrhagic transformation. However, majority of our subjects have high median NIHSS scores at admission, advanced age, complicated with baseline risk factors as high blood pressure, diabetes, and hyperlipidemia.
THYMOMA REMISSION WITH STEROID THERAPY IN MYASTHENIA GRAVES WITH GIANT THYMOMA Şimşek, Fatma
MNJ (Malang Neurology Journal) Vol. 10 No. 1 (2024): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.01.17

Abstract

The thymoma is an uncommon neoplasm. It is detected incidentally in some patients. Myasthenia gravis (MG) is an autoimmune disease and closely related to thymoma. Between 10% and 20% of patients with MG have thymoma and 30%–50% of patients with thymoma have MG. Thymectomy is part of the treatment for MG patients. However, the patient must be stabilized before thymectomy. We present a 26-year-old male case with giant thymoma. In the initial evaluation of the patient, a giant-sized thymoma was observed, which was thought to cause vascular invasion.  Interestingly, the introduction of corticosteroid therapy for MG symptom management resulted in unexpected significant remission of giant thymoma. After steroid treatment, thymectomy was performed. This case demonstrated that steroid therapy was effective and well tolerated for the treatment of both thymoma and MG. Therefore, steroid therapy should be continued for a while for thymoma remission before surgery in MG patients with giant thymoma. Treatment is arranged according to the clinical findings of the patient. Each patient's response to treatment and duration of treatment may differ from each other.   After thymectomy, long-term follow-up is required for the possibility of thymoma becoming malignant.
EVALUATION OF VITAMIN B12 LEVELS WITH NEUROPATHIC PAIN IN HEMODIALYSIS PATIENTS: A SINGLE CENTER OBSERVATIONAL STUDY Sri Wijayanti, Ida Ayu; Tresna Erawan, I Gusti Ngurah Agung; Mulyantari, Ni Kadek; Tertia, Clarissa; Widyadharma, I Putu Eka
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.03

Abstract

Background: Uremic syndrome in chronic kidney disease (CKD), particularly in hemodialysis (HD) patients, is a growing global health problem. The majority of patients with this condition experience one or more neurological disorders, such as neuropathic pain. One of the adjuvant therapies in the treatment of neuropathic pain is vitamin B12, which is important for the regeneration and myelination of peripheral nerves and also plays an important role in the restoration of functional nerves. Objective: The aim of this research is to evaluate the role of vitamin B12 in the relief of pain symptoms Method: This research was conducted at General Hospital in Bali use a case-control design and consecutive sampling. This was carried use 21 patients with CKD on regular hemodialysis with neuropathic pain, while 22 patients without neuropathic pain were used as the control group. All patients were tested for serum vitamin B12 levels. Neuropathic pain was assessed using the DN4. Results: The data values of total vitamin B12 levels in blood serum were obtained within a range of 81.72 pmol/L to 2337.5 pmol/L, and a median value of 1306.25 pmol/L. A cut-off value of 1509.375 pmol/L was obtained with 76.2% sensitivity and 59.1% specificity. Furthermore, an odd ratio between low serum vitamin B12 and the incidence of neuropathic pain was also obtained, namely OR= 3.611 (95% CI= 1.012-12.9; p=0.044). Conclusion: It was found that low serum vitamin B12 in CKD patients on hemodialysis increased the risk of experiencing neuropathic pain by 3.611 times compared to those with normal serum vitamin B12.
COGNITIVE FUNCTION ASPECTS IN HIV-ASSOCIATED CEREBRAL TOXOPLASMOSIS: A CASE REPORT Lasta Arshinta; Anak Agung Ayu Putri Laksmidewi; Ni Wayan Nurlina Ekasari; Dian Kusumastuti Anggraeni Putri; Gede Suputra; Bagus Ngurah Mahasena Putera Awatara
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.18

Abstract

HIV-associated cerebral toxoplasmosis may lead to cognitive function impairment through accumulation of β-amyloid plaques and Tau protein which cause damage, inflammatory and oxidative processes in the brain. A 40-year-old, Balinese, right-handed female patient, came with chief complaint of three times of seizure before admission. After the seizures stopped, the patient was fully conscious again. Since the last 2 months, the patient seemed more confused and spoke a little slower. The patient also often repeated a story about something and forgot that she had already told it. The patient has a known history of HIV infection in the past 3 months before admission, she had taken anti-retroviral agents but she stopped them by herself since last 1 month. Anti-Toxoplasma IgG antibody showed reactive results and CD-4 of 62 cells/µL. The results of the overall cognitive function examination found mild cognitive impairment with activities that required mild assistance. HIV-associated neurocognitive disorders (HAND) are still a challenge to study, and the importance of improving patient cognitive function to maintain or increase aspects of independence and quality of life is a target in the care of HIV patients, especially patients with HIV-associated cerebral toxoplasmosis infection.
THE EFFECT OF DRY NEEDLING THERAPY ON MYOFASCIAL PAIN SYNDROME Pratiwi, Ni Made Dwita; Sutama, I Komang Reno; Widyadharma, I Putu Eka
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.04

Abstract

Background: One of the nonpharmacological management that can currently be used to treat Myofascial Pain Syndrome  (MPS) is dry needling (DN). Dry needling is a pain intervention technique by inserting a solid needle into the skin to stimulate myofascial trigger points (TrPs). In a previous study conducted at Central Hospital in Bali, DN was shown to reduce pain and oral analgetic usage in patients with upper trapezius muscle MTrPs, but the effect of DN on overall life quality (such as sleep quality and depression) is still lacking. Objective: This research was conducted to find out whether there was an improvement in pain scale, depression and quality of sleep of health employees in Sanglah Hospital who experienced myofascial pain syndrome after dry needling therapy. Methods: an observational experimental design, which compares the difference of the Numerical Pain rating score, Pittsburg Sleep Quality Index, and Hamilton Depression Scale before and after DN. The study used a consecutive sampling method to reach the designated sample size. Results: A total of 53 samples followed the entire series of studies. The mean difference between NPRS before DN and after DN showed a significant result of p= 0.00 (<0.05), but in the aspect of PSQI and HDS no statistical difference. Conclusion: There is a trend of improvement in the quality of life after DN from pain scale, mood condition and sleep quality. However, this research still cannot show a link between DN therapy with depressive disorders and sleep quality.
EVALUATION OF DEPRESSION FREQUENCY AND ITS EFFECT ON PROGNOSIS IN PATIENTS TREATED FOR ACUTE ISCHEMIC STROKE Kalyoncu Aslan, Işıl; Akpinar, Ahmet; Salt, Irmak
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.02

Abstract

Background: Stroke is one of the most important causes of mortality and morbidity in the world. Although mortality and morbidity rates decrease with mechanical thrombectomy and intravenous thrombolytic treatments in suitable patients, post-stroke depression may develop in these patients. Poststroke depression occurs in approximately 30% of patients with stroke and is associated with poor prognosis and quality of life. Objective: Depression is a common complication that leads to dysfunction even years after a stroke. In this study, we aimed to evaluate the frequency of depression, determine the risk factors, the relationship between the infarct localization and stroke severity in patients who underwent acute ischemic stroke treatment (intravenous tissue plasminogen activator (IV-tPA) and/or endovascular mechanical thrombectomy (MT)). Methods: In this prospective study, 230 patients older than 18 years of age who were hospitalized with the diagnosis of acute ischemic stroke between 2021-2022 and treated for acute ischemic stroke were evaluated. Patient characteristics such as age, gender, education level, stroke risk factors, infarct localization were noted in the first month follow up outpatient clinic as well as their Modified Rankin Score (MRS), National Health Institutes Stroke Scale (NIHSS) and Beck Depression Scale (BDI). Results: There was a statistically significant difference in age groups compared to BDI values (x2=10.215, p=0.037). A statistically significant difference was found between BDI levels and MRS (x2=21.177, p<0.001) and BDI score and NIHSS (x2=28.074, p<0.001). There was a statistically significant difference between education levels and MRS values (x2=17.147, p=0.002) and NIHSS scores(x2=14.715, p=0.005). Conclusion: Whereas disability can lead to depression, depression is one of the leading causes of disability. Despite the benefit of acute stroke treatments, they are ineffective in preventing post-stroke depression and subsequent disability. Therefore identification, and prevention of risk factors and early treatment of depression are necessary to effectively prevent morbidity.
DOES THE COMBINATION OF ROSMARINUS OFFICINALIS AND CENTELLA ASIATICA NANOEMULSIONS AFFECT BDNF EXPRESSION IN THE GESTATIONAL DIABETES MELLITUS MODEL IN ZEBRAFISH LARVAE Khotimah, Husnul; Lamadi, Sutini; Amelia, Rizki; Arista, Devi Maya; Prastiwi, Fajar Dwi; Raras, Tri Yudani Mardining
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.08

Abstract

Background: Pancreatic β-cells compensate for the increased insulin demand due to increasing glucose levels during pregnancy or in gestational diabetes mellitus (GDM). The enzyme that regulates the rate of gluconeogenesis production is PEPCK. Circulatory and metabolic disturbances in the brain caused by hyperglycemia could affect brain-derived neurotrophic factor (BDNF) expression as an agent for neurodevelopment. Objective:  The purpose of this work is to ascertain the impact of combining nanoemulsions of Rosmarinus officinalis and Centella asiatica on the expression of BDNF and PEPCK. Methods: This study was a true experimental laboratory using zebrafish larvae. The larvae were exposed to 3% glucose and a combination of nanoemulsion extracts. The study sample of zebrafish larvae at 72 hpf (hour post fertilization) was divided into control, glucose, treatment 1, 2, and 3, with the combination of Rosmarinus officinalis and Centella asiatica nanoemulsions at 2.5 μg/ml, 5 μg/ml, and 10 μg/ml, respectively. PEPCK and BDNF expression were measured by the real-time PCR method. Results: The expression of PEPCK increased significantly in the glucose group (3.05 ± 0.27). The combination of Rosmarinus officinalis and Centella asiatica nanoemulsions significantly decreased PEPCK (p-value 0,001 < 0.05). The BDNF level did not significantly differ (p-value 0.253 >0.05) among groups, but the highest level (1.06 ± 0.60) was gained in the T2 group, which received an embryonic medium (EM), 3% glucose, and the combination of Rosmarinus officinalis and Centella asiatica nanoemulsions at 5μg/ml. Conclusion: The combination of Rosmarinus officinalis and Centella asiatica nanoemulsions significantly reduces PEPCK expression but does not affect BDNF expression.
EFFECT OF BALINESE FLUTE INSTRUMENT FOR IMPROVING COGNITIVE FUNCTION IN ELDERLY Laksmidewi, Anak Agung Ayu Putri; Tertia, Clarissa; Indah, Carolin Tiara Lestari; Suherlim, Richard; Arshinta, Lasta; Mahadewi, Ni Putu Ayu Putri
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.05

Abstract

Background: Cognitive impairment is mostly affected the elderly population which reduces the quality of life for sufferers and their families. The last research showed that listening to Balinese flute instrument music increased cognitive function, especially in the memory domain. However, the study is still limited to small populations. Objective: to determine whether playing the Balinese flute with or without listening to the "Morning Happiness" song affects the cognitive function of elderly. Methods: This experimental study was conducted on healthy geriatric patients above 55 years old with controlled risk factors or no history of any chronic conditions which were divided into 2 groups. The "Morning Happiness" song will be played with Balinese flute instrument in both groups whereas the intervention will add to listen to similar songs. Results: 28 subjects in the intervention group and 20 subjects in the control group. Both groups were comprised of typical gender distribution with an average of 65.08±6.41 years old. Both the intervention and control groups had improved in MoCA-Ina (The Indonesian Version of Montreal Cognitive Assessment) scores, but the intervention group gained a better Z-score (-3.193, p-value 0.001) than the control group (-1.466, p-value 0.143) after procedural. The delayed recall domain also showed significant improvement in both groups with a Z-score of -3.241 (p-value 0.001) in control and -2.30 (p-value 0.026) in intervention group respectively. Interestingly, the attention domain is improved in the control group with a Z-score of -2.142 (p-value 0.032) rather than in intervention group. Conclusion: The overall MoCa-Ina score was significantly higher in interventional subjects than control, specifically in the delayed recall domain.
PHOTOBIOMODULATION ON MUSCLE STRENGTH AND FATIGUE IN MULTIPLE SCLEROSIS: SYSTEMATIC REVIEW Santos, Heber; Santos, Yasmim; Ribeiro, Bianca; Artioli, Dérrick; Buzanello, Márcia; Bertolini, Gladson Ricardo Flor
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.11

Abstract

Background: Photobiomodulation plays an important role in modulating the inflammatory process, accelerating tissue repair, which can be beneficial in cases such as multiple sclerosis. Objective: To carry out a literature review about effectiveness of photobiomodulation on muscle strength and fatigue in multiple sclerosis. Methods: The databases included were PubMed, Embase, Cochrane, Web of Science, Scopus and LILACS (Latin American and Caribbean Health Sciences Literature). Also the gray literature: Google Scholar, LIVIVO (ZB MED Search Portal for Life Sciences), Open Grey and Library of Thesis and Dissertations CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior). The risk of bias was assessed using the Cochrane tool, Rob 2, and the data was extracted and assessed by blinded reviewers. Results: Initially 7302 records were found, 7102 in the main databases and 200 in the gray literature.  After removing duplicates, 4217 studies were left for Phase 1 and 10 for Phase 2. Finally, 3 randomized clinical trials were included in this review. Conclusion: The studies included risk of bias in this review was predominantly low. PBM proved to be effective in improving muscle strength, but not fatigue. However, the number of human clinical trials is still too few for a more conclusive analysis.

Page 23 of 30 | Total Record : 297

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