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Nusantara Medical Science Journal
Published by Universitas Hasanuddin
ISSN : 24609757     EISSN : 25977288     DOI : -
Core Subject : Science,
Materials Science & Nanotechnology Neuroscience
Nusantara Medical Science Journal (NMSJ) is an open access, peer-reviewed journal published by Faculty of Medicine, Hasanuddin University twice a year in June and December. NMSJ encompasses all basic and molecular aspects of medical sciences, with an emphasis on the molecular studies of biomedical problems and molecular mechanisms. Subjects suitable for publication include, but are not limited to the following fields of Cardiovascular; Allergy and immunology; Cancer and stem cells; Endocrinology; Gastroenterology; Tropical and Infectious Disease; and Internal medicine.
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Articles 119 Documents
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Histopathological Difference of Inflammatory Cells Infiltration into Fetal Membranes of PROM and Non-PROM SUDIARTA, KETUT EDY; FABIOLLA, FABIOLLA; HERDIYANTINI, MITA
Nusantara Medical Science Journal Vol. 10 No. 1 (2025): Volume 10 Issue 1, January - June 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i1.36072

Abstract

Introduction: Premature rupture of membranes (PROM) remains one of several causes of premature birth that increases both maternal mortality ratio and neonatal mortality rate. Inflammation of fetal membranes leads to release of inflammatory mediators and resulting in weakness of fetal membranes, particularly the amniotic membrane. The amniotic membrane in PROM has a focal weakness, which differs from the membrane in non-premature rupture of membrane (non-PROM) that has a generalized weakness. This research aimed to determine histopathological difference of inflammatory cells infiltration into fetal membranes of PROM and non-PROM.   Methods:  Quantitative observation was applied to this research. Cross-sectional design was used for analyzing data. Primary data was collected from the delivery room and operating theater of Emergency Department in dr. Ramelan Central Naval Hospital (RSPAL dr. Ramelan) Surabaya. Data collection started from August to November 2019 using total population sampling technique. Results: A total of 40 samples histopathologically examined showed that 11 out of 20 (55%) fetal membranes in PROM had polymorphonuclear (PMN) cells infiltration and 9 (45%) did not have PMN cells infiltration, 1 out of 20 (5%) fetal membranes in non-PROM had PMN cells infiltration and 19 (95%) did not have PMN cells infiltration. The prevalence ratio (PR) of PROM based upon the presence of PMN cells infiltration into fetal membranes was 2.85 (PR>1). The significance level of Chi-square test was 0.001 (ρ>0.05). Conclusions: The difference of inflammatory cells infiltration into fetal membranes of PROM and non-PROM was statistically significant.
Thyroglossal Duct Cyst: Clinical Insights from a Case Report Christeven, Robert; Hartungi, Florean
Nusantara Medical Science Journal Vol. 10 No. 1 (2025): Volume 10 Issue 1, January - June 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i1.48026

Abstract

Introduction and importance: A thyroglossal duct cyst (TGDC) is the most common congenital mass found in the neck region. TGDC originates from the thyroglossal duct and persists along the descending groove of the thyroid gland, from the foramen caecum to the superior thyroid gland in front of the trachea. Presentation of case: A 46-year-old man presented with a slowly enlarging lump at the anterior midline of the neck, first noticed about 10 years earlier. On examination, a well-defined, round, cystic mass measuring 3.5 × 3.3 cm was found superior to the thyroid cartilage. The mass moved with tongue protrusion and swallowing and was mobile, painless, and non-tender. These findings were consistent with a thyroglossal duct cyst. Discussion: Thyroglossal duct cyst (TGDC) is a congenital midline neck mass resulting from the persistence of the thyroglossal duct during thyroid descent. Diagnosis is based on clinical features and imaging, with the Sistrunk procedure serving as the gold standard treatment to prevent recurrence. The patient underwent successful surgical excision without complications, and histopathology confirmed the diagnosis. Conclusions: The Sistrunk's Procedure surgery was conducted successfully with no postoperative complication in this case.
Evaluation of Systemic Immune-Inflammation Index for Predicting Mortality in Sepsis Patients Haizah Nurdin; Salam, Syamsul Hilal; Tanra, Andi Husni; Palinrungi, Ari Santri; Sulkifli Mangga Barani, A.M. Irsyad; Faisal Muchtar
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.44770

Abstract

Introduction: This study aims to measure the accuracy of Systemic Immune-Inflammation Index (SII) in predicting 28-day mortality in sepsis patients in intensive care unit. Methods:   This study was conducted as a retrospective cohort study. The study was conducted in the intensive care unit of Dr. Wahidin Sudirohusodo General Hospital. The study subjects consisted of all sepsis patients admitted to the intensive care unit during the period January 2023 to December 2023 who met the inclusion criteria. Results:  Total sample is 147 participants. Systemic Immune-Inflammation Index (SII) showed a significant difference in predicting sepsis mortality. SII has an AUC value of 0.763 with a sensitivity of 69.6% and a specificity of 71.1% at a cut-off of 2003.395. Conclusions: Systemic Immune-Inflammation Index (SII) scores are associated with increased mortality in sepsis patients in the intensive care unit of Dr. Wahidin Sudirohusodo Hospital. The SII can be a prediction tool in clinical practice in predicting mortality of sepsis patients.  
Twists and Turns in The Fibrinolytic Therapy of Infero-Posterior ST Elevation Myocardial Infarction and Right Ventricular Infarction Patient with Cardiogenic Shock: A Case Report Afandy, Jonathan Edbert; Taslim
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.45901

Abstract

Introduction: Fibrinolytic therapy is preferred for ST-segment elevation myocardial infarction (STEMI) when the timeframe for percutaneous coronary intervention (PCI) cannot be achieved. Although effective, fibrinolytics are also associated with several adverse effects in addition to the complications of STEMI itself. Case: A 45-year-old active smoker man presented with chest pain, dyspnea, and diaphoresis for the past hour. Electrocardiography revealed infero-posterior STEMI with right ventricular infarction. Echocardiography demonstrated akinetic inferior, infero-septal, and posterior walls with an estimated right atrial pressure of 15 mmHg. Management: Therapy consisted of aspirin, clopidogrel, furosemide, and streptokinase infusion. Within five minutes of initiating streptokinase, the patient developed sudden hypotension that required norepinephrine, dobutamine, and dopamine. At approximately halfway of the streptokinase infusion, he developed accelerated idioventricular rhythm which progressed to pulseless ventricular tachycardia lasting for one minute.  Before defibrillation was performed, his rhythm reverted to sinus, after which a bolus of amiodarone was administered. Given his instability, streptokinase was discontinued after approximately 70 percent of the total dose had been delivered. Outcome: The patient was transferred to the intensive care unit with stable hemodynamic, resolved chest pain, and more than 50 percent ST-segment resolution on ECG. Heparin, atorvastatin, maintenance amiodarone, and furosemide were added to his regimen. He continued to improve clinically and was discharged without complication. Conclusion: This case shows that fibrinolysis remains essential when PCI is unavailable, but streptokinase can cause hemodynamic and arrhythmic complications, highlighting the need for close monitoring and rapid intervention in resource-limited settings.
The Correlation between Plasma IL-17 Levels, Lymphocyte Counts, and Neutrophil Counts with the Colonisation of Candida sp. in Tuberculosis Patients with a Treatment History Yunivita, Vycke; Anastasia, Mutiara; Warma Dewi, Intan Mauli; Murad, Chrysanti
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.46139

Abstract

Introduction:  Tuberculosis (TB) patients with a history of ATT therapy are associated with changes in IL-17 levels, lymphocyte counts, and neutrophil counts. Increased IL-17 levels, lymphocyte counts and neutrophil counts indicate colonisation of Candida sp. fungus. Changes in the immune response in TB patients with Candida sp. colonisation may cause complications of TB that affect the treatment success rate. Methods:  This research was designed for observational analytical study with a cross-sectional design. 59 subjects are divided into 3 groups, consisting of 21 TB-positive people with Candida sp. colonisation, 21 TB-positive people without Candida sp. colonisation, and 17 TB-negative people with Candida sp. colonisation. Plasma IL-17 levels are examined using the ELISA test, while the lymphocyte and neutrophil counts are seen from previous study examinations (AFFECT). Results:   The plasma IL-17 levels in the TB-positive group with Candida sp. colonisation were 24.05 pg/ml (IQR 21.77-30.50). The plasma IL-17 levels in the TB-positive group without Candida sp colonisation were 23.08 pg/ml (IQR 19.11-32.46). The plasma IL-17 levels in the TB-negative group with Candida sp. colonisation is 20.72 pg/ml (IQR 18.51-22.84) pg/ml, (p=0.046). However, there are no statistically significant difference was observed in lymphocyte and neutrophil counts (p=0.078). Conclusions:  The differences in IL-17 levels that occur in the TB group with Candida sp colonisation may serve as an immunological signal suggesting the need for fungal assessment if the TB patients do not improve their treatment outcome after undergoing ATT for over 6 months.
Maternal Obesity, Metabolic Syndrome, and Long-Term Effects on Offspring: A Developmental Origins of Health and Disease (DOHaD) Perspective Tsaqifah, Nabila Aulia; Hanifah, Rifdah; Husna, Firda Asma'ul; Hidayati, Mailani Dwi; Widyawati , Dwi; Putri, Ghea Farmaning Thias; Al Shadrina, Ainina
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.47907

Abstract

Introduction: The global prevalence of obesity among women of reproductive age has increased markedly over the past two decades, reaching 24% in high-income and 16% in low- and middle-income countries. This trend contributes to adverse maternal and neonatal outcomes, including a 2–4-fold higher risk of gestational diabetes, a threefold increase in preeclampsia, and up to a 50% higher caesarean delivery rate. Maternal metabolic disorders also have long-term consequences for offspring metabolic and cardiovascular health. Objective: To synthesize current biological and epidemiological evidence linking maternal metabolic status to offspring health within the Developmental Origins of Health and Disease (DOHaD) framework. Methods: A comprehensive search was conducted in PubMed, Scopus, and Web of Science from January 2015 to September 2025 using keywords related to maternal obesity, metabolic syndrome, DOHaD, offspring health, and epigenetics. Included studies comprised human and animal research with follow-up beyond two years, while case reports, editorials, and studies without long-term outcomes were excluded. Findings: From 22 eligible studies, consistent evidence indicates that maternal obesity and metabolic syndrome affect offspring through placental dysfunction, systemic inflammation, and epigenetic reprogramming. Offspring of obese mothers show a 1.5–2.8-fold increased risk of obesity and insulin resistance during adolescence and adulthood. Epigenome-wide analyses reveal altered methylation of genes regulating lipid metabolism (LEP, IGF2) and inflammatory pathways, supporting the DOHaD hypothesis. Conclusion: Maternal metabolic health critically shapes offspring developmental and metabolic outcomes. Preconception and antenatal interventions targeting metabolic optimization provide key opportunities to prevent intergenerational transmission of metabolic risk and promote healthier future generations.
Clinicopathological Profile and Disease-Free Survival in Stage I-II Endometrial Cancer at Cipto Mangunkusumo Hospital Muhammad Rizkinov Jumsa; Nuryanto, Kartiwa Hadi; Tricia Dewi Anggraeni; Tantri Hellyanti
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.48383

Abstract

Introduction: This study aimed to describe the clinicopathological profile and evaluate the disease-free survival (DFS) of patients with FIGO 2009 stage I–II endometrioid endometrial cancer, and to determine the prognostic value of key factors, emphasizing lymphovascular space invasion (LVSI) and tumor grade. Methods: A retrospective cohort of 111 patients treated between January 2017 and December 2022 was analyzed. Variables included age, menopausal status, BMI, depth of myometrial invasion, LVSI, and tumor grade. Survival was estimated using the Kaplan–Meier method; associations were assessed with Fisher’s exact test, and independent prognostic factors were identified using multivariate Cox regression analysis Results: The median follow-up for the 111 patients was 32 months. Most were stage IB (42.4%), aged 45–60 years (46.8%), postmenopausal (73%), and obese (63%). Stage-specific DFS rates were: Stage IA – 94.6% (1-year), 87.8% (2-year), 87.8% (3-year); Stage IB – 93.6% (1-year), 91.0% (2-year), 91.0% (3-year); Stage II – 92.6% (1-year), 88.9% (2-year), 88.9% (3-year). LVSI positivity (15.3%) and high tumor grade emerged as the strongest prognostic factors. Multivariate analysis confirmed LVSI as an independent predictor across all stages, with hazard ratios ranging from 3.85 in stage IA to 4.25 in stage IB and 12.5 in stage II (p<0.05). In stage II, LVSI-positive patients showed a 57.1% 3-year DFS versus 100% in LVSI-negative patients. Conclusions: LVSI and tumor grade are independent, interrelated prognostic markers in early-stage endometrial carcinoma. Their integration into risk stratification refines adjuvant therapy guidance. Implementation requires standardized pathological reporting and efficient referral systems to improve long-term surveillance adherence.
Le Fort Fractures: A Narrative Review of Diagnosis and Management Madani, Amanda Refa; I Gede Sutawan
Nusantara Medical Science Journal Vol. 10 No. 1 (2025): Volume 10 Issue 1, January - June 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i1.48840

Abstract

Le Fort fractures represent complex midfacial fracturestypically resulting from high-velocity trauma,characterized by the separation of the maxillary structurefrom the cranial base. This narrative review synthesizescontemporary literature regarding the etiopathogenesis,classification, diagnosis, and management of thesefractures. Diagnosis requires a comprehensive clinicalassessment supplemented by non-contrast computedtomography (CT) as the gold standard for delineatingfracture patterns and buttress involvement. The reviewdiscusses the clinical relevance of classical Le Fortclassifications alongside Wassmund and Marcianimodifications to guide surgical planning. Managementstrategies prioritize initial stabilization according toAdvanced Trauma Life Support (ATLS) principles,particularly airway control, followed by definitive surgicalintervention. Open reduction and internal fixation (ORIF)remains the primary surgical modality, focusing on therestoration of vertical and horizontal buttresses,occlusion, and orbital integrity. Postoperative care iscritical for preventing complications such as infection,malunion, and ocular dysfunction. Ultimately, successfulmanagement necessitates a multidisciplinary approachcombining precise imaging and rigid fixation to restorefacial aesthetics and function while minimizing long-termmorbidity.
Mandibular Metastasis as a Rare Presentation of Follicular Variant Papillary Thyroid Carcinoma: A Case Series Hamdani, William; Patabang, Erwin A.; Haryasena , Haryasena; Ferianto, Djonny; Pieter Jr., John; Salman Ardi Syamsu
Nusantara Medical Science Journal Vol. 10 No. 2 (2025): Volume 10 Issue 2, July - December 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i2.48914

Abstract

Introduction: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. The follicular variant of papillary thyroid carcinoma (FV-PTC) represents a distinct histologic subtype that tends to spread hematogenously to distant organs, including bone. Mandibular metastasis from FV-PTC is exceedingly rare and may pose a diagnostic challenge, particularly when it precedes recognition of the primary thyroid lesion. Presentation of case:   We report two Asian female patients presenting with mandibular masses. The first patient had a history of total thyroidectomy for papillary thyroid carcinoma (follicular variant) ten years earlier. Imaging revealed an extensive osteolytic lesion of the right mandible. Histopathology of an incisional biopsy confirmed metastatic PTC, and the patient underwent right hemimandibulectomy with immediate reconstruction using a titanium plate. The second patient presented with a large, painful left mandibular mass without any history or clinical evidence of thyroid disease. Imaging showed a destructive lytic lesion of the left mandible, while neck ultrasonography revealed no thyroid enlargement. Biopsy suggested FV-PTC of thyroid origin. The patient underwent left hemimandibulectomy with titanium plate reconstruction. Final histopathology in both cases confirmed FV-PTC metastasis to the mandible. Conclusion: Mandibular metastasis from FV-PTC is a rare manifestation that may occur as late recurrence after thyroidectomy or as the first indication of an occult thyroid carcinoma. Comprehensive diagnostic workup and appropriate surgical reconstruction are crucial to achieve local disease control and preserve function. Clinicians should consider metastatic thyroid carcinoma in the differential diagnosis of lytic mandibular lesions, even in the absence of a palpable thyroid

Page 12 of 12 | Total Record : 119

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