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INDONESIA
Nusantara Medical Science Journal
Published by Universitas Hasanuddin
ISSN : 24609757     EISSN : 25977288     DOI : -
Core Subject : Science,
Nusantara Medical Science Journal (NMSJ) is an open access, peer-reviewed journal published by Faculty of Medicine, Hasanuddin University twice a year in June and December. NMSJ encompasses all basic and molecular aspects of medical sciences, with an emphasis on the molecular studies of biomedical problems and molecular mechanisms. Subjects suitable for publication include, but are not limited to the following fields of Cardiovascular; Allergy and immunology; Cancer and stem cells; Endocrinology; Gastroenterology; Tropical and Infectious Disease; and Internal medicine.
Arjuna Subject : -
Articles 112 Documents
Significance of HBsAg Expression in Placental Tissue with Serum Positivity in Hepatitis B Virus-infected Mother Kalatiku, Jane Magdalena; J Nelwan, Berti; Zainuddin, Andi Alfian; Kaelan, Cahyono; Achmad, Djumadi; Masadah, Rina
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.20242

Abstract

Introduction:  Hepatitis B virus infection in fetal and newborn may result from the intrauterine vertical transmission. The purpose of our study is to determine the association between HBsAg expression in the placental and HBsAg serum in pregnant women. Methods: Total 67 placental tissues and serum were obtained from HBV-infected mothers. This study was conducted in various hospitals in Makassar, Indonesia from December 2017 until August 2018. Maternal serum and placental tissues were tested by ELISA and Immunohistochemistry staining. Results: 67 samples from placental tissues and serum were categorized into two different levels of serum titer and staining positivity. Twenty nine samples (43.3%) were categorized in low titer of HBsAg positive serum and 38 samples (56.7%) in high titer of  HBsAg positive serum. From the total of 67 placental samples, 43 (64.2%) samples had positive expression of HBsAg immunohistochemistry staining and 24 (34.8%) samples had negative expressions. Conclusions: There was a significant correlation between the expressions of HBsAg in the placental tissues and serum titers of HBV-infected mothers that is important in predicting the risk of transplacental transmission. The results of this study can be used as guidelines for the prevention and therapeutic approach of mother-to-child HBV infection.
Effect of Probiotics as Therapeutical and Preventive Modality for Atopic Dermatitis; Lessons from Clinical Trials SUCIANGTO, WILLIAM; NASRUM, NADA INDIRA RAMADHANI
Nusantara Medical Science Journal Volume 9 Issue 1, January - June 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.20734

Abstract

Introduction:   Atopic dermatitis is a chronic relapsing inflammatory skin disease that can significantly impact patients' quality of life. Current therapy for atopic dermatitis is corticosteroids, calcineurin inhibitors, and immunosuppressants, but the recurrence of this disease is still reported, and their long-term use is vicious due to their immunosuppressive side effects; the need to discover a new modality that can be used as a therapeutical and preventive modality for atopic dermatitis. Probiotics have been well known for decades due to their various biological activities, including anti-inflammatory and immune-regulatory activity, that have many potential benefits for some skin diseases, including atopic dermatitis. Method:     The method consisted of analyzing and evaluating relevant journal literature published within the past ten years. Result: Several clinical trials have proven the effectiveness of various species of Lactobacilli in improving clinical outcomes for children with atopic dermatitis.  Clinical improvement of atopic dermatitis in children can be achieved not only through the administration of a single probiotic but also by combining different probiotic species. Conclusions:  Based on those studies, probiotics are the potential therapeutical and preventive modality for atopic dermatitis and its primary possible mechanism.
Therapeutic Exergaming and Its Feasibility in Developing Countries Setting: Review Article Mubarak, Husnul; Andi Amirah Shaleha Junaed
Nusantara Medical Science Journal Volume 9 Issue 1, January - June 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.23626

Abstract

Introduction: Games have an important role from a social point of view in human and cultural development.  Exergaming is a form of digital gaming that combines video games and physical activity that uses a motion tracking device to record gestures and complete gameplay on a screen.  Therapeutic exergaming has the potential to facilitate improved balance, including reducing center of pressure (CoP) variability, home-based exercise for older adults, and exercise for people with balance disorders. Method: for this literature review we searched journals taken from search engines such as google, google scholar, Pubmed, and PubMed Central,  published from the inception of the respective databases to June 2022.  The keywords therapeutic exergaming, exergaming, video game, physical therapy, consoled game, virtual reality were used in writing this literature. The literature search and journal reading were limited to sources which was free and written in English. We addressed several aspects of exergaming such as the device sensor feedback, its application to augment therapy and to manage diseases, and its implementation in developing countries. Conclusions: The benefits of exergaming have been widely studied and are known to have many positive effects on health, such as improving cognitive function, increasing physical activity, exercising balance, and improving vascular function. Exergaming has become an alternative therapy in Huntington's disease, Parkinson's disease, and as a means of gait rehabilitation in geriatric patients. Exergaming also has the potential to reduce the risk of obesity in children.
Intussusception And Obstructive Ileus Et Causa Caecal Tumor In Children Y. Kusumo Adi Arji Atmanto; Mutmainnah; Ibrahim Abd. Samad
Nusantara Medical Science Journal Volume 9 Issue 1, January - June 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.24766

Abstract

Introduction and importance: Intussusception/invagination is a condition where the intestine is folded and infiltrates into other parts of the intestine, which can cause obstructive ileus. One of the causes of intussusception in children is a tumor or colorectal malignancy. Treatment should be started as soon as possible concurrently with fluid resuscitation management. Presentation of cases: A 9-month-old female patient complained of flatulence, inability to defecate, and often color vomiting since 4 days ago. The examination result of 3 three-position abdominal photos is a high obstruction ileus. Exploratory laparotomy, loop modification ileostomy, and to-side anastomosis of the ascending colon and ileum were performed. Histopathological examination of the caecum tissue is non-specific inflammation and lymph nodes with sinus histiocytosis. Discussion: 9 months old is a risk factor for intussusception. The patient's condition is acute. Icteric sclerae or jaundice may occur with gastrointestinal lymphoma tumor types. Histopathological examination shows the process of histiocytosis in the lymph nodes and the activation of adaptive immune cells.   Conclusions: Intussusception is the most common cause of obstructive ileus in children. One of the causes of intussusception in children is a tumor that requires operative management.  
Carbohydrate Over Nutrition Harmfull to both Obese Pregnant Mice and Fetus Idris, Irfan; Paharu, Kabah; Satriana, Satriana; Tadjuddin Chalid, Maisuri; Wardihan Sinrang, Andi
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.25339

Abstract

Background : Obesity in pregnancy due to carbohydrate over nutrition is still rarely reported and the incidence of obesity in pregnancy in the developing countries begin to increase. The aims of this study is to observe the detrimental effect of obesity in both mother and developing fetus of mice which fed by high carbohydrate diet. Methods : Female mice were divided to four groups. Group 1 (obese group) were fed with high carbohydrate (HC) diet and group 2 (control group) with standard diet for 12 weeks. All mice will be mated until pregnant and terminated for collecting blood with cardiac puncture every trimester. Another mice (7 mice from obese group and 7 mice from control group) will follow until 3rd trimester than terminated to collecting lipid profile of blood and examined the fetal’s anthrophometric. Lipid and blood glucose were examined by chemichal photometric and glucometer kit, while anthrophometric’s variables measured by weight scale and meter scale. Results : Blood glucose, total cholesterol, HDL and LDL are similar between obesity group and normal weight group every trimester, while only blood TG increased in obesity group particularly in first and second trimester of pregnancy. The detrimental effect also found in the developing fetus of obesity group which have significance higher of bodyweight, body lengths, head circumference, and waist circumference. Conclusions: Obesity in pregnancy due to carbohydrate over nutrition could have detrimental effect to both mother and developing fetus.
Nutritional Therapy in High Output Enterocutaneus Fistula with Ileum Adhesion Grade III-IV : A Case Report January, Rima; Agussalim Bukhari; Nurbaya Syam; Nurpudji Astuti Taslim; Suryani As’ad; Haerani Rasyid; A. Yasmin Syauki
Nusantara Medical Science Journal Volume 9 Issue 1, January - June 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.26614

Abstract

Introduction and importance: Enterocutaneus fistula (ECF) is an uncommon connection between the gastrointestinal tract and the skin. Loss of intestinal fluid in ECF patients results in an imbalance of electrolytes. The objectives of nutritional therapy were to fulfill nutrient needs, maintain fluid balance, & promote ECF closure.  Presentation of case:    A 22-year-old male, was diagnosed with post-adhesiolysis and end colostomy surgery. His oral intake was reduced for one month, and he experienced weight loss. We detected a loss of subcutaneous fat and fistula in the right abdomen region and wasted time on physical examination. Abnormal laboratory findings were leucocytosis, thrombocytosis, imbalance electrolyte, and hypoalbuminemia.  Discussion: Nutritional assessment was based on mid-upper arm circumference. Nutritional treatment was provided with a calorie target of 2300 kcal and protein 2g/kg ideal body weight (IBW)/day. On the seventh day of treatment, the patient went through relaparotomy due to high output ECF (2000 ml/d) and ileum adhesion grade 3-4. Following surgery, the patient was on parenteral nutrition for eighteen days. Due to high ECF output, protein intake was increased by 2g/kg IBW/day, and fluid intake was adjusted based on fistula output. The patient received a combination of polymeric formula and whey protein by oral intake and micronutrient supplementation at twice the usual dosage. By the 27th day of treatment, ECF output had decreased to 0 ml/d, and laboratory results showed improvement. Conclusions:   Adequate nutrition, fluid, and electrolyte balance through optimal nutritional therapy can improve laboratory values and reduce ECF output in ECF patients
Rabies: Diagnostic, Treatment, and Prevention Bintang, Andi Kurnia; Basri, Muhammad Iqbal; Lotisna, Mimi; Carrey, Michael
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.27671

Abstract

Rabies is a neurological disease with fatal impacts because it has a high mortality rate. Animals, primarily dogs, mediate the spread of rabies. Clinical findings of rabies are divided into two categories: classic rabies (furious type) and paralytic type. Furious rabies has many cardinal features, such as fluctuating consciousness, aerophobia or hydrophobia, inspiratory spasm, and autonomic dysfunction. Ascending paralysis with a lower motor neuron lesion is the initial sign of paralytic rabies. The rabies virus invades and lives in neurons. It is virulent. Besides clinical findings, the diagnostic approach can involve radiology, microbiology, and histopathology. There are not only symptomatic treatments for rabies patients but also vaccines, immunoglobulin, and antivirals to decrease the progressivity of the disease. Vaccination programs and animal control have become essential in reducing rabies cases in Indonesia.
Relationship Between Position and Work Duration with Suspect Carpal Tunnel Syndrome in Maxim Online motorcycle taxi at Makassar -, Marfuah Nawawi; Putri, Melda; Mustari, Yery
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.32049

Abstract

Introduction: Online motorcycle taxi is a service that is currently widely used in goods delivery services and other forms of services. There are several things that are not considered by online motorcycle taxi drivers when driving, namely the driving position that is not good and correct. The more consumer demand for online motorcycle taxi applications, the higher the working hours of online motorcycle taxi drivers which leads to increased complaints of pain in the body. This study aims to determine the relationship between position and duration of work with complaints of suspected carpal tunnel syndrome in maxim motorcycle taxi drivers in Makassar City. Methods: The sampling technique in this study was purposive sampling through a cross sectional approach. Respondents in this study were riders aged 17 years and over as many as 373 riders who met the exclusion and inclusion criteria. Work position was measured using REBA, Work Duration was measured using a work duration questionnaire, while Suspect carpal tunnel syndrome complaints were measured using Phalen's Test. Results: The Kolmogorov Smirnov normality test shows a significance value (p) of 0.000, meaning that the data is not normally distributed (p <0.05). Then the correlation test between the two variables using the Spearman's rho test (p), namely the work position with complaints of suspected carpal tunnel syndrome obtained results (p=0.025; r=0.116 *) which means there is a significant relationship between the two variables and for the duration of work with complaints of suspected carpal tunnel syndrome obtained results (p=0.448; r=0.39) which means there is no relationship between the two variables. Conclusions: The distribution of maxim online motorcycle taxi drivers' work positions in the city of Makassar is dominated by respondents who experience the high risk category and category of work duration are more than 8 hours/day. There is a significant relationship between work position and complaints of suspected carpal tunnel syndrome on maxim online motorbike taxis in the city of Makassar. There is no significant relationship between work duration and complaints suspect carpal tunnel syndrome on maxim online motorcycle taxi in Makassar city.
A Rare Case of Aplastic Anemia in Toxic Typhoid Fever NOVITA, MUTIARA PUTRI NOVITA; Zaimatuddunia, Irma
Nusantara Medical Science Journal Volume 9 Issue 1, January - June 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.32595

Abstract

Introduction and importance: Typhoid fever is one of the representative febrile diseases in the tropics, with unhygienic environmental conditions and poor public health systems. Pancytopenia from hemophagocytic lymphohistiocytosis is a rare complication of typhoid fever, which may be fatal if untreated. Presentation of case: A 20-year-old woman presented to our tertiary care center with high-grade fever, body pain, and slurring of speech. Investigations showed pancytopenia, TUBEX IgM Salmonella test positive, lymphadenopathy, and peripheral blood smear showed aplastic anemia after ruling out other possibilities and diagnostics. The patient responded to culture-sensitive antibiotics, steroids, and supportive care. Discussion: Pancytopenia in typhoid fever patients is linked to the mechanism of HLH (Hemophagocytic lymphohistiocytosis). Conclusion: It is essential to diagnose and treat toxic typhoid fever with an appropriate antibiotic to prevent complications.
The Cure Rate of COVID-19 Patients with Comorbid Hypertension Giri, Made Widiantara; I Made Subhawa Harsa
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.33144

Abstract

Introduction: Coronavirus Disease 2019 (COVID-19) is an outbreak that has resulted in a global pandemic. In 2020, 185 countries were affected, and more than 3,000,000 cases have been reported worldwide, with more than 210,000 deaths. COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2), an RNA virus that can cause respiratory system disorders. Hypertension, commonly called high blood pressure, is a health problem that often occurs in the community because its prevalence is relatively high throughout the world. Approximately 7.5 million deaths, or 12.8% of all annual deaths in the world, are caused by hypertension. Generally, the presence of comorbid hypertension in COVID-19 can worsen the patient's condition. Methods:  This literature review study aims to determine the recovery rate of COVID-19 patients with comorbid hypertension. Journals in this literature review used three databases, including Google Scholar, PubMed, and Science Direct, using the keywords COVID-19 with Hypertension and COVID-19 with Hypertension. The literature search was adjusted based on the inclusion and exclusion criteria. Results: The search results obtained 25 journals consisting of 4 national journals and 21 international journals. The results showed that the average recovery rate for COVID-19 patients with comorbid hypertension was 75.40%. Factors influencing the recovery rate of COVID-19 patients with comorbid hypertension include ACE-2, ACEI/ARBs, age, male, and cytokines. Conclusions:  It can be concluded that the presence of comorbid hypertension affects the recovery rate of COVID-19 patients.

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