cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Aryadi Arsyad
Contact Email
aryadi.arsyad@gmail.com
Phone
-
Journal Mail Official
aryadi.arsyad@gmail.com
Editorial Address
-
Location
Kota makassar,
Sulawesi selatan
INDONESIA
Nusantara Medical Science Journal
Published by Universitas Hasanuddin
ISSN : 24609757     EISSN : 25977288     DOI : -
Core Subject : Science,
Materials Science & Nanotechnology Neuroscience
Nusantara Medical Science Journal (NMSJ) is an open access, peer-reviewed journal published by Faculty of Medicine, Hasanuddin University twice a year in June and December. NMSJ encompasses all basic and molecular aspects of medical sciences, with an emphasis on the molecular studies of biomedical problems and molecular mechanisms. Subjects suitable for publication include, but are not limited to the following fields of Cardiovascular; Allergy and immunology; Cancer and stem cells; Endocrinology; Gastroenterology; Tropical and Infectious Disease; and Internal medicine.
Arjuna Subject : -
Articles 112 Documents
 8   9   10   11   12 
Geospatial analysis of type B and C hepatitis in South Sulawesi Rachmawarni Bachtiar, Rini; Andi Alfian Zainuddin; Rahmawati Minhajat1; Sri Jayanti
Nusantara Medical Science Journal Volume 9 Issue 1, January - June 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.34204

Abstract

Introduction: Hepatitis C and B are two infectious diseases that increase distribution and high mortality and morbidity. Conditions that exacerbate the economic burden of these two viral hepatitis infections are complications of cirrhosis and gastrointestinal bleeding. This study sought to assess the risk levels of hepatitis C and B across various districts and cities in South Sulawesi. It involved identifying spatial clusters of affected individuals through an analytical model, employing Generalized Poisson Regression to evaluate the potential impacts of these viral infections. Methods:  The natural break method is a quantifiable technique for identifying value clusters indicative of data distribution and for detecting geographical illness clusters, using Global Moran’s I statistics. This research utilizes data from health insurance members diagnosed with hepatitis C and B between January 2020 and December 2022, including 24 districts and cities in South Sulawesi Province. Results:  According to the results of the Local Morans I analysis, there is no significant clustered hepatitis C and B in all districts and cities in South Sulawesi from 2020 until 2022. Conclusions: In South Sulawesi, the incidence of hepatitis C and B cases reported to National Social Health Insurance Administration Body (BPJS Kesehatan) appeared to manifest randomly or sporadically.
The Dermatofibrosarcoma Protuberans In A 13-Year-Old: A Rare Case Of Soft Tissue Sarcoma Of The Skin : A Rare Case Of Soft Tissue Sarcoma Of The Skin ., Windy Rhomadani Putra; Iskandar, Fery; Dumaria Ketty
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.34471

Abstract

Introduction and importance: Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma that primarily affects middle-aged adults but can also occur in children. Despite its low metastatic potential, DFSP displays aggressive local behavior and a high rate of local recurrence. Diagnosis in children can be delayed due to confusion with other skin conditions. This case report aims to discuss the case management of dermatofibrosarcoma protuberans in a 13 year old female. Presentation of case: A 13-year-old female patient presented with a progressively enlarging lump on the left eyelid, initially resembling small brown spots that coalesced over 7 months. Intermittent bleeding and pain were reported. Physical examination revealed a dark brown mass in the left frontotemporal region, with solid, non-fragile characteristics. Clinical diagnosis suggested a suspicious malignant skin tumor, confirmed as basal cell carcinoma. Treatment involved wide excision and flap reconstruction. Post-operative care included infusion, antibiotic injection, and pain management. The patient's prognosis was favorable, though functional impairment was possible. Follow-up revealed histopathological findings of pigmented dermatofibrosarcoma protuberans. Discussion: DFSP is a rare but significant malignancy that poses diagnostic challenges due to its varied clinical presentations and histopathological features. While primarily affecting young to middle-aged individuals, it can also manifest in pediatric populations. Diagnosis typically involves histopathological assessment, confirming characteristic spindle cell proliferation with CD34 expression. Surgical excision remains the cornerstone of treatment, complemented by adjuvant therapies like imatinib mesylate or radiation in select cases. Regular surveillance, comprising frequent evaluations in the initial post-excision period followed by yearly monitoring, is imperative for detecting any recurrence or metastasis promptly. Conclusions: The structured approach in DFSP ensures optimal patient management and outcomes. Surgical management with Wide local excision (WLE) or Mohs micrographic surgery (MMS) is the gold standard in the treatment of DFSP.
Potential of Cat’s Whisker (Orthosiphon stamineus B) As Antidiabetic in Traditional Medicine of The Dayak Tribe in West Kalimantan : A Literature Review Hartono Putra, Galih Abisatya; Andayani, Sari; Qisthi, Dianelita Asyifa; Aurelion, Candra; Mochammad, Taufiq; Zakiah, Mistika; Assegaf, Syarifah Nurul Yanti Rizki Syahab
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.37072

Abstract

Introduction: Diabetes mellitus or better known as diabetes is a disease characterized by the body's inability to produce insulin or the inability to use insulin (insulin resistance). The high prevalence of diabetes sufferers in Indonesia requires attention and treatment, especially through medication. One of Indonesia's advantages compared to other countries is the biodiversity and cultural diversity sector in Indonesia, namely medicinal plants. The cat's whisker plant (Orthosiphon stamineus B) can be an alternative treatment for treating complications of diabetes mellitus. Cat's whisker leaves contain orthosiphon glucose, saponins, essential oils, flavonoids, polyphenols, potassium salts and myoinositol, several substances contained in this plant have the potential to lower blood sugar levels. Methods: This writing is a literature review by collecting literature from English and Indonesian language articles from 2014-2024, most of which are research articles. Results: The search using the keywords, resulting in a final total of 5 articles to be included in the literature review. Conclusion:  This research reveals that cat's whiskers (Orthosiphon stamineus B) show potential as an effective antidiabetic agent. Treatment with Orthosiphon stamineus B extract significantly reduced blood glucose levels, increased insulin secretion, and increased ghrelin and GLP-1 levels, all of which contribute to glucose regulation
Twin Reversed Arterial Perfusion Sequence (TRAPS): A Case Report Astari, Prilly; Efendi Lukas
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.42368

Abstract

Introduction and importance: Acardiac twins are a complication of monozygotic twin pregnancies. Twin Reversed Arterial Perfusion Sequence (TRAPS) is reported to occur in approximately 1% of monochorionic twin pregnancies and 1 in 35,000 pregnancies. The objective is to provide a brief description of acardiac twins. Presentation of case: A 25-year-old multigravida, 35/36 weeks of twin pregnancy. On ultrasound examination of acardiac twins, no heart structure, head bones, and sternum were found, and the shape of the fetus was unclear. Vaginal delivery was carried out; the first live female baby was born, followed by the acardiac baby. The acardiac baby is seen to have imperfect development of the head and upper extremities, Spina bifida, deformity of the lower extremities, Phocomelia of the lower limb, and Split foot. After 9 days, the baby's condition improved, and she was allowed to go home. Discussion: TRAPS's etiology and pathophysiological mechanisms are still poorly understood. Ultrasound findings show an absent or non-functioning heart in one twin, malformation with cystic hygroma, and generalized edema. The first baby (donor twin) was born prematurely, weighing 2200 grams, and there were no signs of heart failure, while the second baby (acardiac) was born weighing 1050 grams. Current therapy for acardiac twins aims to prevent congestive heart failure in the donor twin and stop blood flow to the acardiac twin. Conclusions: Early diagnosis of abnormalities in monochorionic pregnancy using ultrasound in the first trimester plays a role in assessing the prognosis for the viability of the pregnancy.
Perioperative Pediatric Transfusion Strategy Ahmad Nur Islam; Elizeus Hanindito; Muhammad Ramli Ahmad; Maman Surya Permana; Hanna Aulia Namirah
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.42398

Abstract

Introduction: In the modern healthcare system, blood transfusion is an essential treatment that plays a significant role in the clinical improvement of adult and pediatric patients. Given the physiological and hematological differences between children and adults, careful planning and an individualized approach are essential to maximize its effectiveness and avoid serious side effects. Method:  A thorough review of the literature was performed, utilizing PubMed, Embase, and the Cochrane Library, to gather evidence on pediatric perioperative transfusion practices. The search encompassed studies published between 2013 and 2024, employing a combination of terms and free-text keywords, as well as Boolean operators, to refine the results. Conclusion: Intraoperative blood loss in pediatric patients requires special attention with an approach that includes pre to postoperative management. This approach must be adapted to the anatomical and physiological differences of children compared to adults. Research, development of universal transfusion strategies, and education and training for medical personnel are essential to improve blood management and prevention of complications.      
Surgical Treatment Of Pendred Syndrome With Thyroid Nodule: A Case Report Ferianto, Djonny; Syamsu, Salman Ardi; Sapan, Vannes Caesar Palebangan; Indra; Sampepajung, Elridho; Pieter Jr, John
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.42770

Abstract

Introduction and importance: Pendred syndrome (PS) is a genetic disease inherited in an autosomal recessive pattern. In PS patients, the ability of thyroid gland to accumulate iodide in the follicle lumen is disrupted, causing insufficient thyroid hormone synthesis and goiter to occur as compensation. However, this symptom does not often appear, as goiter is only detected in 30–75% of PS patients. Presentation of case: A 33-year-old Buginese man complained of a painless mass in the neck. In the past 3 months, the mass has shown rapid growth, followed by symptoms of agitation, irritability, and hyperhidrosis. The patient was previously diagnosed with nodular goiter and was taking Levothyroxine. Furthermore, there was a history of the same disease in the patient’s grandmother and younger sibling. Physical examination showed grade III goiter (WHO criteria) with hard consistency and no palpable nodules. Laboratory tests showed routine blood tests, kidney and liver function in normal limits, 1.14 ng/dL FT4, free triiodothyronine level of 6.07 pg/dL, and 2,401 mIU/L TSH level. Chest X-ray results showed tracheal narrowing at the level of the superior thoracic aperture. Similarly, thyroid USG showed that the size of the right lobe was enlarged and anechoic. CT (Computerized Tomography) scan of the cervix showed diffuse enlargement in each lobe and the patient was diagnosed with PS. Right isthmolobectomy and thyroid biopsy were carried out and pathological anatomical examination results showed thyroid follicular nodular disease with cystic degeneration. After surgery, thyroxine hormone replacement therapy was continued. Discussion: Surgical intervention strategies may be employed to inhibit the advancement of disease and mitigate thyroid enlargement, consequently decreasing the likelihood of obstruction and malignancy. Conclusions: In cases of PS with large thyroid nodules pressing on the trachea, isthmolobectomy was carried out to obtain good results and no recurrence.
The Immunoreactivity of recombinant protein MPT63 Mycobacterium tuberculosis as serodiagnostic tuberculosis Fidhatami, Ian Imanuel; R Agus; M N Massi
Nusantara Medical Science Journal Volume 9 Issue 2, July - December 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.42583

Abstract

Introduction: Mycobacterium tuberculosis protein-63 (MPT63) is an extracellular protein encoded by the Rv1926c gene with a size of 16 kDa. MPT63 can specifically induce macrophage activation, stimulate cytokine production (TNF-α and IL-6), and stimulate Th1 cells. The immunogenic properties of MPT63 can be concluded from the presence of a high density of T cell epitopes in the N-terminal immunodominant. This research aims to emphasize and determine the antibody response from the administration of the MPT63 antigen as a candidate in active TB serodiagnostic testing. Methods:  This type of research is quantitative and is a diagnostic study. Serum samples were taken from Hasanuddin University Hospital stored biological material with 10 for healthy serum and 36 for sick serum. The determination of optical density values ​​is based on the results of the ELISA reader.  The determination of optical density values ​​is based on the results of the ELISA reader. Sensitivity and specificity were tested using the Mc Nemar formula and then they calculated the sensitivity and specificity values ​​manually. Results:  Based on the interpretation of the ELISA test from the MPT63 antigen, the antibody reaction response was obtained for a sensitivity of 50% and a specificity of 58.33%. Conclusions: Antibody responses to an antigen that is used indicate that all samples successfully respond well to the serum antigen in the serum of healthy and active tuberculosis but have a sensitivity that is still lacking.
Challenges in Managing Myocardial Stunning Following Cardiac Arrest in a Very High-Risk NSTE-ACS Patient: A Case Report Afandy, Jonathan Edbert; Taslim
Nusantara Medical Science Journal Vol. 10 No. 1 (2025): Volume 10 Issue 1, January - June 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i1.44050

Abstract

Introduction: Myocardial stunning is a reversible myocardial dysfunction that can occur due to various conditions, including focal ischemia—such as acute coronary syndrome (ACS)—and global ischemia, such as cardiac arrest. The proposed mechanisms include oxygen free radical damage during early reperfusion and altered calcium inflow leading to transient myofilament desensitization. Case Presentation: A 61-year-old woman with a history of uncontrolled hypertension and obesity presented with sudden loss of consciousness lasting one hour, preceded by chest pain and dyspnea. She experienced cardiac arrest and achieved return of spontaneous circulation (ROSC) after 10 minutes of cardiopulmonary resuscitation. Initial echocardiography showed a left ventricular ejection fraction (LVEF) of 32.9% and global hypokinesia. She was diagnosed with very high-risk non-ST-elevation ACS (NSTE-ACS), with suspected left main coronary artery obstruction or three-vessel disease. Her clinical course was complicated by acute pulmonary edema, respiratory failure, and cardiogenic shock. Management included intubation, dual antiplatelet therapy, anticoagulation, statin therapy, and inotropic support with dopamine and dobutamine. Her hemodynamic status improved within 18 hours, and she was extubated. On the third day post-arrest, follow-up echocardiography revealed a restored LVEF of 69.5% with normal wall motion. The patient was discharged after 9 days and continued to do well on outpatient follow-up for at least 6 months. Conclusions: Myocardial stunning should be considered in post-cardiac arrest and ACS patients with transient ventricular dysfunction. Early supportive care and close monitoring are essential, particularly in settings lacking advanced cardiac interventions.
Strategies for Managing Preoperative Anxiety in Children: A Comprehensive Approach Riswandi, Riswandi; Santoso, Kohar Hari; Andriyanto, Lucky
Nusantara Medical Science Journal Vol. 10 No. 1 (2025): Volume 10 Issue 1, January - June 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i1.44560

Abstract

Introduction: Preoperative anxiety is prevalent among pediatric patients and may adversely affect anesthetic induction, postoperative recovery, and long-term psychological outcomes. It arises from developmental vulnerability, lack of understanding, and exposure to unfamiliar environments. Method: This narrative review synthesizes evidence from studies retrieved via PubMed, ScienceDirect, and EBSCO, using keywords related to preoperative anxiety, pediatric patients, and management strategies. The review explores both risk factors and intervention modalities. Results: The database search using predefined keywords yielded a total of 193 articles. After screening and eligibility assessment, 22 articles met the inclusion criteria and were included in this literature review. Conclusions: A comprehensive, individualized approach combining both pharmacological and non-pharmacological strategies is essential to effectively manage preoperative anxiety in children. Early identification of risk factors and tailored interventions can significantly enhance perioperative experiences and outcomes.
Non-involuting congenital hemangioma have angioproliferative features of both congenital vascular malformations and of vascular tumors- insights from apoptosis, autophagy and senescence Utami, Amalia Mulia; Cinkara, Gonca; Pertiwi, Kartika Ratna; Lokhorst, Max M.; de Boer , Onno J.; van der Horst , Chantal MAM; Meijer-Jorna , Lorine B.; van der Wal, Allard C.
Nusantara Medical Science Journal Vol. 10 No. 1 (2025): Volume 10 Issue 1, January - June 2025
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v10i1.44711

Abstract

Backgrounds: Non-Involuting Congenital Hemangiomas (NICH) are benign vascular lesions distinguished by the proliferation of micro-vessels. Currently, the underlying pathophysiology and connection with congenital vascular malformations remain uncertain. This study aims to explore age-related discrepancies in NICH and compare them with malformations by examining histological characteristics and assessing markers for cell death, maturation and proliferation. The goal is to ascertain whether NICH should be classified as vascular tumors or vascular malformations, in order to properly classify them within the wide spectrum of vascular anomalies. Methods: Paraffin blocks of 36 clinically documented cases of NICH (n=12) and congenital vascular malformations (n=24) were immunostained using antibodies against cell-death (C-Caspase-3) and cell-cycle related proteins (Ki67, p62, LC3B, p21, p27), and immunodouble stained with smooth muscle actin antibody for identifying immunolocalization with vessel walls. Three independent observers conducted semi-quantitative scoring of stained samples. Statistical analysis was employed to compare differences between NICH in two age groups (young and old), and congenital vascular malformations. Results: Clinical history in combination with histology and Ki67 categorized the lesions into four groups: NICH younger ages (n=7), NICH old ages (n=5), non-proliferative vascular malformations (n=12), and proliferative vascular malformations (n=12). C-Caspase-3 and LC3B showed significantly higher expression in the younger age group of NICH (p<0.05) and proliferative AVM (p<0.05). The senescence marker p21 was elevated only in proliferative AVM, while p27 exhibited higher expression in both NICH and proliferative AVM compared to non-proliferative vascular malformations. Conclusions: This study revealed distinct expression patterns of cell cycle related proteins in different types of benign vascular anomalies and within the same type across different age groups. NICH, despite sharing certain clinical characteristics (onset in utero, no tendency to regress) with congenital vascular malformations, displayed a persistent vasoproliferative behavior and different patterns of apoptosis, autophagy and senescence. These findings may endorse the view that NICH should not be classified as congenital vascular malformations. However, NICH revealed similarities with AVM subtypes harbouring a vasoproliferative component. Therefore, it could be argued whether proliferative components of AVM are really part of the developmental disorder itself , or could represent a (reactive) epiphenomenon.

Page 11 of 12 | Total Record : 112

 8   9   10   11   12 

Filter by Year

2016 2025


Reset
Filter By Issues
All Issue Vol. 10 No. 1 (2025): Volume 10 Issue 1, January - June 2025 Volume 9 Issue 2, July - December 2024 Volume 9 Issue 1, January - June 2024 Volume 8 Issue 2, July - December 2023 Volume 8 Issue 1, January - June 2023 Volume 7 Issue 2, July - December 2022 Volume 7 Issue 1, January - June 2022 Volume 6 Issue 2, July - December 2021 Volume 6 Issue 1, January - June 2021 Volume 5 No. 2 Juli - Desember 2020 Volume 5 No. 1 Januari - Juni 2020 Volume 4 No. 2 Juli - Desember 2019 Volume 4 No. 1 Januari - Juni 2019 Volume 3 No. 2 Juli - Desember 2018 Volume 3 No. 1 Januari - Juni 2018 Volume 2 No. 1 Januari - Juni 2017 Volume 1 No. 4 Oktober - Desember 2016 Volume 1 No. 3 Juli - September 2016 Volume 1 No. 2 April - Juni 2016 Volume I No. 1 Januari-Maret 2016 More Issue