Biomedical Journal of Indonesia
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
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392 Documents
<![CDATA[Correlations Between Mandibular Third Molars to Inferior Alveolar Nerve Locations in Vietnamese Population ]]>
<![CDATA[Pham Ngoc Anh Thu]]>;
<![CDATA[Tran Nhut Thao Trang]]>;
<![CDATA[Florenly]]>;
<![CDATA[Novelya]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i2.382
<![CDATA[One of the probable complications in mandibular third molar extraction is the damage to the inferior alveolar nerve (IAN). Calculating the distance between IAN and third mandibular can decrease the complication risk. In this study, cone beam computed tomography (CBCT) scans were used to evaluate several factors related to the positional relationship between mandibular third molar and IAN in the Vietnamese population. One-hundred-seventy-eight CBCT scans were collected from dental clinics at Ho Chi Minh City, from 1st January 2018 to 28th February 2021. Only 100 scans were included in this study, 55 scans of female and 45 scans of male patients. The age of the patients ranged from 19 to 59 years old. From this study, the most common location of IAN relative to the roots of the mandibular third molar was on the apical side (60.5%), followed by the buccal side (21.5%), the lingual side (16%), and the least common located between the roots (2%). Overall, the mean distance between mandibular third molar roots to IAN was 3.19 ±1.85mm. There was a significant correlation between the left and right sides of the IAN location, indicating symmetry. Moreover, there is no association was found between gender and the location of IAN.]]>
<![CDATA[Effectivity of Jatropha multifida L. Leaves Extract as Antibacterial on Streptococcus mutans using In Vitro Testing Methods ]]>
<![CDATA[Listyaning Kartiko Kinasih]]>;
<![CDATA[Idamawati Nabahan]]>;
<![CDATA[Suci Erawati]]>;
<![CDATA[Rouli Natasia M. Simanjuntak]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i2.384
<![CDATA[Intoduction : Health is the condition of the entire body and body parts of an individual who is free from disease both physically, mentally and socially, thus enabling the individual to be able to carry out daily activities more productively. However, many people neglect their own health, especially in the field of dental and oral health. Caries is one of the most common oral and dental problems. The prevalence of dental caries in Indonesia is high, namely 88.8%. Dental caries is caused by Streptococcus mutans bacteria which plays a role in the conversion of sucrose to lactic acid. Infection due to Streptococcus mutans bacteria can be treated by taking antibiotics. Apart from drugs, antibiotics can also be obtained from natural ingredients, one of which is the tintir castor plant (Jatropha multifida Linn) or commonly known as the betadine. Objective: To see the effect of the antibacterial content of tintir leaves against Streptococcus mutans bacteria and to determine the differences in the antibacterial effect of betadine leaf extract (Jatropha multifida L.) from a concentration of 25%, 50%, 75%, and 100% against Streptococcus mutans. M ethods: The type of research used in this study was a laboratory experimental study with a post-test-only control group design as the research design and to test the sensitivity of bacteria using the paper disc diffusion test. Data analysis using One -Way ANOVA. Result: The results of this study indicate the effect of tintir castor leaf extract (Jatropha multifida L.) in inhibiting the growth of Streptococcus mutans bacteria.]]>
<![CDATA[The Effect of Pure Garlic (Allium Sativum L.) Juice on The Color Stability of Heat Polymerized Acrylic Resin Denture Base ]]>
<![CDATA[Herlin Nadya Tumara]]>;
<![CDATA[Mourent Miftahullaila]]>;
<![CDATA[Sopan Sinamo]]>;
<![CDATA[Yohana Aprilia Singgih]]>;
<![CDATA[Silvia Giovani]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i2.385
<![CDATA[Intoduction : PMMA or acrylic resin is a necessary material in dentistry for denture bases, one of which is often used is heat cured acrylic resin or heat polymerized acrylic resin. Garlic juice is a denture cleaner to inhibit bacteria and is also an extrinsic factor that causes discoloration. Purpose: To determine the duration of immersion in pure garlic juice which can cause discoloration of the acrylic resin. M ethods: laboratory experiments with posttest only control group design research. Results: The mean ± SD change in color of hot polymerized acrylic resin after immersing in garlic juice for 2, 4, 6, 8 hours was 0.67 ± 0.22; 0.91 ± 0.31; 1.22 ± 0.32; and 1.56 ± 0.25. Conclusion: There is an effect of soaking time with garlic juice on the base of denture acrylic resin on discoloration.]]>
<![CDATA[Hepatitis Lupus in Systemic Lupus Erythematosus in Male Patients ]]>
<![CDATA[Andikha Putra]]>;
<![CDATA[Raveinal]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i2.517
<![CDATA[Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease characterized by autoantibodies against the cell nucleus and involves many organ systems in the body with unknown etiologies and various clinical manifestations, disease course and prognosis. SLE can be found at all ages, generally appearing at age 9-58 years with a peak at age 28 years. It is more common in women with a ratio of women to men 15: 1 to 22: 1. The highest incidence and prevalence of SLE was found in North America 23.2 / 100.000 population / year and 241 / 100.0000 population. In Indonesia, there has been an increase in visits to SLE patients from 17.9-27.2% in 2015 to 30.3-58% in 2017. One of the manifestations of SLE is hepatitis lupus, which is inflammation of the liver tissue. Lupus hepatitis can occur in 20-50% of patients with SLE. It was reported that a 20-year-old man presented with complaints of pain in the joints of the right and left hands which increased since 1 week. The patient also complained of reddish patches on the face, hair loss and mouth sores. Physical examination revealed anemic eye conjunctiva, malar rash, oral ulcer. During the joint examination, there was tenderness in bilateral MCP and PIP. The abdominal examination revealed hepatomegaly. Investigations revealed anemia, thrombocytopenia, increased liver function. Abdominal ultrasound revealed hepatomegaly. ANA profile examination was positive for anti RNP, anti -sm, and anti -ribosomal protein antibodies. The patient was diagnosed with Systemic Lupus Erythematosus with lupus hepatitis according to the ACR (American College of Rheumatology) criteria in which the patient had 6 criteria. The patient was given therapy with 2x125 mg of intravenous methyl prednisolone for 3 days and hydroxychloroquine 1x200 mg orally and other symptomatic drugs.]]>
<![CDATA[Severe Anemia in Non Suicide Self Injury as a Complication of Major Depression Disorder ]]>
<![CDATA[Tris Mardi]]>;
<![CDATA[Arina Widya Murni]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i2.516
<![CDATA[Non suicide self injury (NSSI) is a rare case in adults. Non suicide self injury is an act of hurting himself such as cutting, burning, punching without intending to commit suicide. NSSI itself is a complication of major depression that is not treated properly from the onset of symptoms. Severe depression that lasts for a long time, can aggravate illnesses such as the appearance of symptoms of psychosis and have an impact on various complications such as NSSI and somatic complications that can reduce the patient's health condition. Reported a case of a 22 year old woman with severe anemia due to chronic bleeding. It is known that chronic bleeding in the patient is the result of habitual cutting, in which the patient slashes her left forearm. Cutting habitualis is part of the action of NSSI where the management must be holistic and sustainable, the management of patients consists of psychotherapy as starting from dialectical behavior therapy is a form of cognitive therapy that can help a person adapt to activities that can pass through distress. Psychodynamic therapy is to help someone form new habits that previously could cause pleasure to the patient. Psychotherapy accompanied by psychopharmaceuticals can accelerate improvement in patient.]]>
<![CDATA[The Hepatoprotective Effects of Basil Leaf (Ocimum sanctum L.) Extract on Paracetamol Induced Liver Damage in Male Rat ]]>
<![CDATA[Ronaldo Panggabean]]>;
<![CDATA[Nofita]]>;
<![CDATA[Ade Maria Ulfa]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i2.518
<![CDATA[Basil leaf have antioxidants such as flavonoids, so it is thought to have a hepatoprotective effect. This study aims to investigate the effect of basil leaf extract on SGOT and SGPT levels in male rats induced by paracetamol. Basil leaf extract was carried out by the percolation method using ethyl acetate solvent, Some 20 male sprague dawley rats were randomly divided into 5 groups. Basil leaf extract (400 mg/kgBB and 600 mg/kgBB) and sylimarin (100 mg/kgBB) were carried out every day for 28 days, paracetamol was induced 24 hours after giving the last day of basil leaf extract. The parameters measured were SGOT and SGPT level to assess the effect of basil leaf extract on liver damage caused by paracetamol. The results showed that basil leaf extract (400 mg/kgBB dan 600 mg/kgBB) showed that the activities of SGOT and SGPT levels were statistically significant (p<0,05) to negative control. Basil leaf extract shows the effect of hepatoprotector on liver induced by paracetamol, however the effect given was not able to equate with positive control.]]>
<![CDATA[Antiviral Therapy in Corona Virus Disease-19 (Covid-19) ]]>
<![CDATA[Laisa Azka]]>;
<![CDATA[Irvan Medison]]>;
<![CDATA[Dessy Mizarti]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i2.520
<![CDATA[Coronavirus disease 2019 (COVID-19) is a disease caused by a new coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously known as 2019-nCoV), which was first identified in Wuhan City, Hubei Province, PRC. The total number of COVID-19 cases worldwide has reached 102 million cases with 54 million cases recovered and 2.3 million cases dead. Handling for this pandemic is still being carried out. In Indonesia, the antiviral drugs used are those that meet the Emergency Use Authorization (EUA) requirements, and are included in the COVID-19 management guidelines issued by the Ministry of Health. Antiviral options used are Oseltamivir, Favifirapir, Remdesivir. Until now, the use of antivirus is still being researched regarding the effectiveness and security of the antivirus used. Oseltamivir is used as an antiviral for COVID-19 with a mild clinical course, Favifirapir is used for mild to moderate clinical cases of COVID-19. For the use of remdesivir in COVID-19 patients with severe and critis clinical conditions.]]>
<![CDATA[Characteristics of Calvaria Depression Fractures Patients in Dr. Kariadi General Hospital, Semarang ]]>
<![CDATA[Tan Hengky]]>;
<![CDATA[Setya Budi Azhar]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i2.524
<![CDATA[Introduction. Head injury is one of trauma cases with high morbidity and mortality, with an incidence of 7.3 to 811 cases per 100.000 individuals per year and mortality ratio varying from 5.2 to 80.73 cases per 100.000 cases. Calvaria fractures that result from head injuries are often associated with risk of post-traumatic morbidity and mortality, where the incidence of post-trauma calvaria fractures is about 25% of all cases and around 10% of calvaria fractures are depressed calvaria fractures. This study was aimed to identify the characteristics of patients with depressed calvaria fractures at Dr. Kariadi General Hospital in 2020. Methods. This research is a descriptive study using secondary data from medical records. There were 30 patients with depressed calvaria fractures in January - December 2020 at Dr. Kariadi Hospital. The data is then presented in tabular form. Results. Depressed calvaria fractures in the period 2020 at Dr. Kariadi General Hospital was dominated by male (76.7%), mainly age 12-45 years old with a mean of 25.73 years old. The most common cause of depressed calvaria fractures is high velocity trauma. Minor head injury is the most common type of head injury. Depressed calvaria fractures of the frontal bone predominate in 80% of cases, with fracture depth > 1 tabula. Conclusion: There were no cases of posttraumatic infection. There were 16.7% of cases with neurological deficits at the time of discharge. There were 73.3% cases with other intracranial disorders associated with depressed calvaria fractures. Operative management is the main choice of management with most cases length of stay are 5-10 days.]]>
<![CDATA[Management of Jakarta Metropolitan Medical Center Hospital in Preventing Burnout in Nurses during the Covid-19 Pandemic ]]>
<![CDATA[Amelia Chintia]]>;
<![CDATA[Ede Surya Darmawan]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Vol 7, No 3, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i3.581
<![CDATA[Introduction: The COVID-19 pandemic has caused considerable losses to the health care system in Indonesia. The Indonesian Doctors Association (IDI) noted that as of October 3, 2020, 130 doctors, nine dentists, and 92 nurses died due to COVID-19. The problems that caused the death of health workers during the COVID-19 pandemics included the lack of PPE, inadequate patient screening in health facilities, and fatigue of medical personnel due to the increasing number of COVID-19 patients as long working hours and psychological pressure. Of course, this condition can disrupt the quality of life and work productivity in the health series. Therefore, the hospital needs to make various efforts to prevent burnout in health workers during the COVID-19 pandemic. Methods: This research was a descriptive method with quantitative and qualitative approaches. The researcher revealed the facts that occurred when the study was running and presented them as they were. The research respondents were nurses who were in the isolation room and ICU COVID-19 at MMC Hospital Jakarta. Researchers used the Maslach Bach Inventory (MBI) questionnaire instrument to 43 respondents via the Google form. Researchers also conducted interviews with the Head of Nursing and several COVID-19 nurses who had filled out questionnaires. Results: The majority of COVID-19 nurses at MMC Hospital had moderate burnout levels. MMC Hospital Jakarta has made various efforts to prevent burnout in nurses. Conclusion: Management of MMC Hospital in preventing burnout in nurses was good enough, but several points can be improved to make it better.]]>
<![CDATA[Granzyme-B Expression as a Predictor of Immune Surveillance (Correlation Study in Patient with Squamous Cell Carcinoma and Uterine Cervical Dysplasia) ]]>
<![CDATA[Ledisda Apriana]]>;
<![CDATA[Udadi Sadhana]]>;
<![CDATA[Ika Pawitra Miranti]]>;
<![CDATA[Awal Prasetyo]]>;
<![CDATA[Dik Puspasari]]>
<![CDATA[ Biomedical Journal of Indonesia Vol. 7 No. 3 (2021): Vol 7, No 3, 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran Universitas Sriwijaya ]]>
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DOI: 10.32539/bji.v7i3.585
<![CDATA[Background: The most common histologic type of cervical cancer is squamous cell carcinoma (SCC), with the risk of recurrence depending on immune surveillance with granzyme-B markers, and tumor infiltrating lymphocytes (TIL) is an immunological determinant associated with a better prognosis. Granzyme-B is produced by TIL. The study was aimed to prove the difference in expression of granzyme-B in SCC epithelial cells with cervical dysplasia precancerous lesions as a predictor of immune surveillance. Methods: Correlation analytic study with cross-sectional design on paraffin block patients with SCC and cervical epithelial dysplasia at the Anatomical Pathology Laboratory, RSUP Dr. Kariadi, Semarang, during 2018 and 2019, using granzyme-B immunohistochemistry assays, assessed TIL activation. Results: Most cases of cervical SCC were 40 years old, 50% were stage IIIB, 20% with the final condition died on observation 1 year after the initial diagnosis was made. The uterine cervical SCC group expressed granzyme-B with a mean score of 5.81±1.17 (p=0.001) and the dysplastic epithelial lesion group with a mean score of 6.83±0.95 (p=022), the Mann-Whitney test showed p value = 0.009, so that the test results are statistically significant. Conclusion: Expression of granzyme-B in dysplasia is higher than in uterine cervical SCC.]]>
