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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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The Relations Between Breast Cancer and Hormonal Contraception Acceptor At RSUP Dr. Mohammad Hoesin Palembang in 2021 Nur Nabila Sabrina; Heriyadi Manan; Hadrians Kesuma Putra
Biomedical Journal of Indonesia Vol. 9 No. 2 (2023): Vol 9, No 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i2.157

Abstract

Introduction. Breast cancer is a non-communicable disease that has become a health problem in the world. One of the risk factors for breast cancer is hormonal factors that can be obtained from the use of hormonal contraception. This study describes the relationship between the incidence of breast cancer and the use of hormonal contraception at RSUP Dr. Mohammad Hoesin Palembang in 2021. Method. This is an observational analytic study with a case-control design. The data used are secondary data and primary data. The sample are women with breast cancer and benign breast tumors at RSUP Dr. Mohammad Hoesin Palembang in 2021who met the inclusion criteria. Results. There was a significant relationship between the use of hormonal contraceptives (p = 0.003), duration of the use of hormonal contraceptives>5 years (p = 0.004), the type of injectable hormonal contraceptive (p = 0.001), the type of hormonal pills (p = 0.018) and a family history (p = 0.001). Meanwhile, there was no significant relationship between the type of hormonal contraceptive implant (p = 0.724), parity (p = 1.000), and age at menarche (p = 0.129),with the incidence of breast cancer. Conclusion. There is a significant relationship between the use of hormonal contraception, duration of use of hormonal contraception >5 years, type of injectable hormonal contraceptive use, type of use of hormonal contraceptive pills, and family history of breast cancer with breast cancer incidence.
Percentage Of Body Fat Related With Functional Capacity In Young Adults Delia Ainnaya; Mustika Anggiane Putri
Biomedical Journal of Indonesia Vol. 9 No. 1 (2023): Vol 9, No 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i1.159

Abstract

Introduction. The percentage of body fat is a component of body composition in addition to bone mass, muscle mass, and body water content related to obesity. Diseases caused by an increase in body fat will have an impact on decreasing the body's functional capacity, disability, and death. Maximum Oxygen Volume (VO2 max) refers to the maximum amount of oxygen that humans can use during physical activity. It is usually used to test aerobic endurance or cardiovascular fitness so that VO2 max can describe a person's functional capacity. Percentage of body fat can affect VO2 max. Based on data from the Sports Development Index (SDI) in Indonesia, 43.9% of young adults have a poor VO2 max. This study aims to determine whether or not there is a relationship between body fat percentage and functional capacity in young adults. Methods. The study used a cross-sectional method and was followed by 92 respondents throughout October and November 2022. Bioelectrical Impedance Analysis (BIA) is used to measure body fat percentage. The 6-minute Walk Test is used to measure VO2 max. Results. The results of the study showed that the bivariate analysis of the Fisher's Exact test obtained a significant relationship between body fat percentage (measured by BIA) and body functional capacity (VO2 max) (p=0.028).   Conclusion. There was a significant relationship between body fat percentage through BIA measurements and functional capacity in young adults.
Correlation Between Hemoglobin Level And Functional Capacity In Young Adult Population Fiona Rista Utami; Patwa Amani
Biomedical Journal of Indonesia Vol. 9 No. 1 (2023): Vol 9, No 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i1.160

Abstract

Introduction. Functional capacity defines as an individual's ability to do activities of daily living and is assessed by VO2 max as a basic indicator of physical fitness. The more sufficient hemoglobin levels, the more oxygen can be transported, so the body will be more optimal to produce energy. This study aimed to determine the relationship between hemoglobin levels and the functional capacity of the body in young adults. Methods This was an analytic observational study with a cross-sectional approach. A total 34 healthy young adults who met the inclusion and exclusion criteria were recruited as subjects in this study. Functional capacity was assessed by six minutes walking test, and hemoglobin level was measured using the strip test method. Data analysis was performed using the Spearman correlation test in SPSS version 25 with a significance level of p <0.05. Results. The average value of hemoglobin levels in respondents was 16.0 mg/dl. The mean functional capacity based on the predicted VO2 max is 20.3 kg/m2 and 530m based on the distance. Spearman's test results showed that there was a significant correlation between hemoglobin levels and predicted VO2 max (p=0.001).   Conclusion. Our study concluded a significant correlation between hemoglobin level and functional capacity assessed by predicted VO2 max. Therefore, hemoglobin level should be considered as a factor in enhancing functional capacity.
Long-Term Growth and Development Monitoring Of Children With Rhesus Hemolytic Disease of The Newborn Nia Nurul Aziza; Dita Setiati; Patwa Amani
Biomedical Journal of Indonesia Vol. 9 No. 2 (2023): Vol 9, No 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i2.162

Abstract

Rhesus hemolytic disease of the newborn (RHDN) occurs due to alloimmunization of maternal red blood cells.  Complications of RHDN in infants can lead to hyperbilirubinemia, kernicterus, and anemia. In Indonesia, RHDN prevention has not been a common activity so it is very important for pediatricians to recognize early signs of an infant with severe anemia and severe hyperbilirubinemia, to prevent long-term mortality and morbidity. A case with longitudinal observation of long-term growth and development of a child with a history of RHDN has been reported. Throughout the monitoring carried out, the child did not experience serious problems in the medical field but showed disorders or developmental delays that did not improve over time with various therapeutic efforts. Based on a serial monitoring and treatment data that has been carried out on the child, we assumed there has been permanent brain damage caused by hyperbilirubinemia conditions accompanied by co-morbid sepsis. Brain damage is characterized by low DQ values from the beginning, progressive head circumference leads to microcephaly conditions and the presence of brain defects in the form of arachnoid cysts. The management of child development disorders with RHDN to date has not shown encouraging results. Therefore, experts have shifted their focus towards preventive measures, such as intra-uterine fetal transfusion, which has been shown to significantly decrease the occurrence of RHDN-related child development disorders over the past decade.
Potassium Competitive Acid Blockers: A New Paradigm For The Management of Stomach Acid Disorders Gerie Amarendra; Wawan Kurniawan; Mizanul Adli
Biomedical Journal of Indonesia Vol. 9 No. 2 (2023): Vol 9, No 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i2.164

Abstract

Proton pump inhibitors (PPIs) are the main therapy for stomach acid disorders to date. The disadvantage of PPI is the difficulty of controlling symptoms at night, such as tightness, chest pain, and coughing cough. Potassium competitive acid blockers (P-CAB) are a new class in the management of stomach acid disorders. Potassium competitive acid blockers work by a different mechanism, which binds non-covalently to H+/K+-ATPase. This mechanism results in a faster, stronger, and long-lasting suppression effect of gastric acid production. Besides being able to cure gastric complaints at night, P-CAB increases the success of Helicobacter pylori eradication. The safety of the use of this P_CAB drug, according to research is quite mild and acceptable. Currently, examples of P-CAB groups on the market are vonoprazan and tegoprazan. This narrative review is intended to provide further insight into this potassium competitive acid blocker (P-CAB) class of drugs.
Clinical Symptoms of Carpal Tunnel Syndrome and Its Correlation With Vitamin D Level Andira Larasari; Rima Anindita; Andini Aswar; Yudhisman Imran
Biomedical Journal of Indonesia Vol. 9 No. 2 (2023): Vol 9, No 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i2.165

Abstract

Carpal tunnel syndrome (CTS) is a common entrapment neuropathy of the peripheral nerves in the upper extremities that is often found in workers. Nerve conduction disorders occur due to compression of the carpal tunnel, resulting in motor and sensory symptoms in the hands and wrists. This causes clinical symptoms and characteristic neurophysiological examinations. Vitamin D is an intrinsic factor that causes CTS which is now widely studied and is expected to play a role in the choice of CTS management. Vitamin D is important for maintaining health and has been found to have neuroprotective function. Several studies have proven the association between vitamin D deficiency and the incidence of CTS. Supplementation can improve clinical symptoms and neurophysiological features of mild to moderate CTS patients.
Demographic, Clinical, and Tumor Profile Of Meningioma In Mohammad Hoesin Hospital Palembang, Indonesia Dya Anggraeni; Yunni Diansari; Zen Hafy
Biomedical Journal of Indonesia Vol. 8 No. 1 (2022): Vol 8, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i1.122

Abstract

Introduction. Meningioma was the most frequently reported primary intracranial tumor. There had been a few reports about meningioma profile in Indonesia. The objective of this study is to identify the profile of meningioma based on demographic, clinical, and tumor characteristics. Methods. This is a cross-sectional study using secondary data from medical records. There were 67 meningioma patients based on histopathological examination at Mohammad Hoesin Hospital  from January to December 2018. Various data were recorded, including demografic profile,  history of hormonal contraceptive use, neurologic symptoms, and tumor characteristic. Results. During 2018, the incidence of meningioma was 68,3% of all primary CNS tumors. Meningioma was mostly found in the age group 35-44 years (44.8%). Most of the patients was female (92.5%) and 29 patients (46.8%) had a history of hormonal contraceptive use. Headache showed the highest rate of clinical manifestation in meningioma patient (34.3%). Based on the location, convexity meningioma was the most frequently found (65.7%). Of the 67 meningioma patients, only 26 datas were obtained regarding a history of radiation exposure and all without a history of radiation. There was only one patient (1.5%) with a family history of malignancy (breast tumor). Based on histopathological examination, 60 patients (89.6%) reported as WHO grade I, mostly the meningothelial subtype (40%). The outcome was generally good in most patients (88.1%). Conclusion. In our institution, meningioma is the most commonly found primary brain tumor. Headache was the most common clinical manifestation and these tumors were mostly located in convexity of the brain, with the majority being WHO grade I and meningothelial subtype.
Neuropsychiatric Aspects of Long Covid Bintang Arroyantri Prananjaya; Muhammad Yusuf Wijahaska; Chris Alberto Amin; Carissa Delania; Ziske Maritska; Nita Parisa; Mohammad Hilal Atthariq Ramadhan
Biomedical Journal of Indonesia Vol. 8 No. 1 (2022): Vol 8, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i1.125

Abstract

Long COVID is a term used for persistent symptoms after being infected with COVID-19 with an estimated point of onset ranging from 3-12 weeks after infection. The risk factors for the occurrence of Long COVID are influenced by age, gender, comorbidity, ethnicity, and the severity of the acute phase. It is known that central, peripheral, and psychological factors play an important role in chronic fatigue, which is one of the most common symptoms of Long COVID. The most common neuropsychiatric clinical manifestations in Long COVID are sleep disturbances, fatigue, depression, anxiety disorders, decreased cognitive function or decreased concentration, and post-traumatic stress disorder. Therapeutic management for Long COVID cases involves various aspects, such as physical rehabilitation, management of pre-existing co-morbidities, mental health support management, and social services.
The Association Between Clinical Characteristics and Histopathology of Nasopharyngeal Carcinoma At Dr. Mohammad Hoesin General Hospital, In 2019-2020 Argo Fauzan; Susilawati Susilawati; Veny Larasati
Biomedical Journal of Indonesia Vol. 8 No. 1 (2022): Vol 8, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i1.133

Abstract

Introduction. Nasopharyngeal carcinoma is a cancer originating from the nasopharyngeal epithelium. Clinical characteristics such as age, gender, and risk factors are believed to influence the incidence of this cancer. Patients suffering from nasopharyngeal cancer may have certain clinical symptoms and provide certain histopathological features. Methods. The method used in this research were analytic observational with a cross sectional design using secondary data in the form of medical records from the Department of Anatomical Pathology section and the Central Medical Record section of RSUP Dr. Mohammad Hoesin Palembang as the research subject. Samples obtained 64 samples, then managed using the SPSS application. Results. The highest age group was 35-55 years old, which amounted to 44 people (68.8%). According to gender, the most common were males with 53 people (82,8%). According to clinical symptom, the most common were non-epistaxis with 33 people (51.6%). According to risk factors, the most were smokers with 36 people (56.3%).  According to histopathology, the most common features were differentiated non-keratinized squamous cell carcinoma with 40 people (62,5%). From the statistical test, it resulted that p > 0,05 for all variables (age, gender, clinical symptoms, and risk factors) that associated with histopathology of nasopharyngeal carcinoma. Conclusion. There was no significant association found between clinical characteristics and histopathology of nasopharyngeal carcinoma.
Comparison of Oropharyngeal Microbial Pattern Based on Nasogastric Tube (NGT) Use in Dr. Mohammad Hoesin Hospital Puspa Zuleika; Riezki Indrina Pratiwi; Erial Bahar
Biomedical Journal of Indonesia Vol. 8 No. 1 (2022): Vol 8, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i1.137

Abstract

Introduction. A Nasogastric Tube (NGT) is a flexible tube inserted into the stomach through the nose (nares) to preserve nutritional support. The use of NGT is claimed to increase the risk of pathogenic bacteria colonization due to stagnation, ultimately worsening the patient's outcome. Proper identification of bacterial patterns is required as colonization grows to avoid further complications. This study aims to compare oropharyngeal microorganism patterns in patients with NGT to those without NGT at Dr. Mohammad Hoesin Palembang. Methods. A cross-sectional observational study was used. From September 2022 to October 2022, data were collected using primary data from interviews (research questionnaires) and oropharyngeal swab results (bacterial culture) in 42 patients undergoing treatment at Dr. RSUP. Mohammad Hoesin Palembang's ENT department. Results. Positive colonization was found in all patients with NGT (100%) and 90.47% in the group without NGT. P. aeruginosa was the most common pathogen in the NGT group (47.62%). The use of NGT, body weight, height, and body mass index were significant risk factors in the incidence of P. aeruginosa colonization (p=0,012). Conclusion. There is a significant difference in P. aeruginosa colonization between NGT and non-NGT users. NGT use is the most important driving factors of colonization development. However, these findings were not found in colonization in general or specific bacteria categories.

Page 33 of 40 | Total Record : 392

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