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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Cytotoxic Activity Test Of Ethanolic Extract Of Berenuk Fruit (Crescentia Cujete L.) On Artemia Salina Leach Shrimp Larva Using Brine Shrimp Lethality Test (BSLT) Method Dona Suzana; Isnani Handayanti
Biomedical Journal of Indonesia Vol. 9 No. 1 (2023): Vol 9, No 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i1.123

Abstract

Introduction. Cancer is one of the leading causes of human death in the world. One of the therapies given to cancer patients is chemotherapy which has cytotoxic effects. One of the plants that have the same effect is the berenuk or calabash (Crescentia cujete L.) plant, from the family of Bignoniaceae, which grows wild and is often referred to as a poisonous plant. However, some people traditionally use this plant as a medicinal plant such as for antifungal, anthelmintic, analgesic, and anti-inflammatory. This plant contains naphthoquinones as one of the cytotoxic chemical compounds and another metabolite secondary such as alkaloids, flavonoids, saponins, tannins, terpenoids, and anthraquinones. Methods. The BSLT (Brine Shrimp Lethality Test) method was used for this study. The powder of berenuk fruit flesh was extracted using ethanol. The obtained solvent was evaporated using a rotary evaporator to obtain a thick extract. The extract was tested on A. salina larva that has been prepared and the value of mortality was observed. Results. The result of the cytotoxic activity test of ethanolic extract of berenuk fruit on A. salina larva had the LC50 value of 529.386 ppm which is categorized as toxic. Conclusion. Extract ethanolic of berenuk fruit on A. salina had cytotoxic activity.
Genetics Of Hearing Loss: Focusing On Gene Therapy Ziske Maritska; Fitri Az-Zahrah; Amalia Salsabilla; Rahmat Afif; Setiadi Winata; Robby Pardiansyah; Ayu Purnama Sari
Biomedical Journal of Indonesia Vol. 8 No. 3 (2022): Vol 8, No 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v8i3.124

Abstract

Genetic is one of the most common causes of hearing loss with more than a hundred genes related to hearing loss have been identified. A genetic diagnosis can assist clinicians to keep away from unimportant and expensive clinical examinations, put up prognostic information, and assist in constructing medical therapy for patients. The development of gene therapy to improve hereditary hearing loss continues to grow these days, showing promising results. This literature review aims to review the genetic aspects of hearing loss, focusing on the gene therapy.
Relationship Between The Location Of Benign Vocal Cord Lesion And The Degree Of Voice Handicap Index-30 Lisa Apri Yanti; Irfannuddin Irfannuddin; Nilam Kusuma Anggraeni
Biomedical Journal of Indonesia Vol. 9 No. 1 (2023): Vol 9, No 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v9i1.134

Abstract

Introduction. Voice disorder or dysphonia is a condition that includes all changes in a person’s voice including tone, intensity, phonation, and others caused by laryngeal disorders. Each sound production disorder can be evaluated through the VHI-30 questionnaire. Therefore, data are needed regarding the relationship of the extent of the lesion location site to the degree of VHI-30 produced in dysphonic patients with benign vocal cord lesions. Methods. Observational research using cross sectional design. Data collection using medical record data on 30 dysphonic patients with benign vocal cord lesions who underwent surgery in the ENT department in RSMH in January 2019 to June 2022. Results. Out of the 30 patients with benign vocal cord lesions, age of 31-45 and 46-60 age groups were most found 11(36,7%) Female gender was found 16(53,3%) and the non-professional voice user category was found the highest 28 (93,3%). The 1–6-month onset group was the highest 12(40,0%). The most common location of benign vocal cord lesions was in 1/3 anterior 8(26,7%), and the most common type of benign lesion was vocal cord nodules 13(43,3%). Severe degree VHI-30 were most found 18(60,0%). The area of bilateral locations along the vocal cords had a significant relationship, with p-value of 0,040 (p<0,05), to the degree of VHI-30 when compared to the unilateral location of the anterior 2/3 of the vocal cords. Conclusion. The benign lesions’ position of bilateral along the vocal cord has a significant relationship to the severe degree of VHI-30
Stem Cell Therapy in Esophageal Disorders Puspa Zuleika; Legiran Legiran
Biomedical Journal of Indonesia Vol. 8 No. 3 (2022): Vol 8, No 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v8i3.135

Abstract

Disorders of the esophagus could include various conditions such as inflammation, stricture or esophageal-phase dysphagia. Management of these disorders is rapidly developing, which includes conservative, surgical and modern techniques such as the use of stem cells. Stem cells are characterized as cells which have not differentiated, able to multiply and differentiate into multiple organ cells, and has the ability of self-renewal which is vital in disease management. Mesenchymal stem cells or MSCs are mature stem cells with multidirectional differentiation and also has the ability of self -renewal. It includes adipose MSCs (AMSCs), bone marrow MSCs (BMSCs), umbilical cord MSCs (UC-MSCs) and gingival MSCs. Based on the characteristics of stem cells as well as the anatomy and physiology of the esophagus, stem cells may have a role in the management of esophageal disorders.
Reflux Symptom Index And Reflux Finding Score Correlation With Quality Of Life Of Laryngopharyngeal Reflux Patients Lisa Apri Yanti; Rama Mandela; Erial Bahar
Biomedical Journal of Indonesia Vol. 8 No. 3 (2022): Vol 8, No 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v8i3.139

Abstract

Introduction. Laryngopharyngeal reflux (LPR) usually occurs due to the effects of reflux on the gloves and vocal cords. Symptoms range from more common symptoms such as hoarseness,  globus sensations, and a feeling of getting stuck in the throat to less common symptoms such as heartburn and regurgitation. Symptoms common to LPR are not specific and may be related to other diseases. In other words, it is difficult to diagnose LPR based solely on symptoms. Belafsky et al in 2001 and 2002 developed the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS) to assist in the diagnosis of LPR. Health-related quality of life Health-Related Quality of Life (HRQOL) in LPR patients have a negative impact on psychological status, social functioning, and quality of life. Symptoms of reflux appear to be a major contributor to the decline in quality of life. LPR patients have a significant impact on the mental component of their HRQO. Methods. Descriptive research with a correlation test design, conducted at RSUP Dr. Mohammad Hoesin Palembang on 22 samples of LPR patients who were treated at ENTKL polyclinics, IGD, or consulted from other departments in July-August 2022. Results. The majority of the study were women (81.85%) with dominant in the age group of 31-45 years (45.5%) with an average age of 42.23±11.88 years and a range of 19-66 years. There is a strong correlation between RSI and RFS with quality of life (r = 0.615; p = 0.016, r = 0.635; p = 0.028, respectively). Conclusion. RSI and RFS are significantly related to the quality of life of the sample so the treatment is recommended to also focus on the LPR only but also the mental health aspects.
The Characteristics of Deviated Nasal Septum Patients and Computed Tomography Findings at Dr. Mohammad Hoesin General Hospital Palembang Ermalinda Kurnia; Fiona Widyasari; Puspa Zuleika; Ahmad Hifni; M Ricky Al Hafiz Sazili
Biomedical Journal of Indonesia Vol. 9 No. 1 (2023): Vol 9, No 1, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i1.142

Abstract

Introduction. The deviated nasal septum is found in 80% of people in the world either with or without specific symptoms. Mladina has divided the classification of deviation of the septum nasi into seven parts based on the findings of the deviation to facilitate the determination of diagnosis, therapy, and which type often appears. This study aims to determine the characteristics of patients with a deviated nasal septum at Dr. Mohammad Hoesin General Hospital Palembang from January to December 2021.   Methods. Data was obtained from medical records of patients with a deviated nasal septum at Dr. Mohammad Hoesin General Hospital Palembang from January to December 2021. Results. The majority of patients were in the age range of 16-25 years (37.8%) and male gender (64.9%). The most common etiology was congenital (86.5%). Clinical manifestation mainly is nasal obstruction (94.6%), and the most common secondary diagnoses found are concha hypertrophy (54%) and allergic rhinitis (16.2%). The most common pathological condition was narrowed cavum nasal (91.9%). The majority of patients had type III deviation (51.4%). All patients were treated with septoplasty (100%). Conclusion.  Most patients are predominantly male aged between 16-25 years. Congenital factors primarily caused this condition, leading to complaints of nasal obstruction. Secondary diagnoses included concha hypertrophy and allergic rhinitis. Physical examinations often revealed a narrowed nasal cavity. Most patients exhibited type III septal deviation and all patients were treated with septoplasty
Comparison Of Handicap Inventory Tinnitus Scores Before and After Intra Tympanic Steroid Injection In Tinnitus Patients Amir Hamzah; Erial Bahar; Ahmad Hifni; Abla Ghanie
Biomedical Journal of Indonesia Vol. 8 No. 3 (2022): Vol 8, No 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v8i3.148

Abstract

Introduction. Tinnitus is a symptom in the form of a conscious perception of sound that is not produced by a sound source outside the body. Patients with tinnitus often have complaints of quality of life, with some situations of extreme anxiety, depression, and life changes. The Tinnitus Handicap Inventory (THI) is a valid questionnaire to be associated with patients associated with tinnitus. The Tinnitus Research Initiative (TRI), an international academic organization founded in 2006, recommends the use of THI for the evaluation of tinnitus defects and therapeutic effects. Therefore, a THI assessment is needed at RSUP Dr. Mohammad Hoesin Palembang as a result of therapy. Methods. This research using a design that aims to determine the comparison of THI scores before and after intratympanic injection of corticosteroids in 18 samples at RSUP Dr. Mohammad Hoesin Palembang. Results. The average age of the sample was 57 (23-66) years and the number of men and women were the same, namely 9 (50%) samples. Most of the samples had problems in unilateral ears by 14 (77,8%) samples. The average THI before intratympanic steroid injection was 37 (12-72) and after injection was 20 (4-80). Wilcoxon test results showed significant changes between before and after intratympanic steroid injection. Conclusion. There was a significant improvement in THI scores after intratympanic steroid injection.
Association Between Patient Characteristics and Histopathological Features of Lung Cancer At RSUP Dr. Mohammad Hoesin Palembang Isnani Nur I; Susilawati Susilawati; Soilia Fertilita
Biomedical Journal of Indonesia Vol. 9 No. 2 (2023): Vol 9, No 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i2.149

Abstract

Introduction. Lung cancer is the uncontrolled growth of malignant cells by the body in lung tissue and is caused by genetic mutations and changes in protein synthesis in normal cells. Histopathological features of lung cancer include squamous cell carcinoma, adenocarcinoma, small cell carcinoma, and other types. Early detection, as well as prevention, needs to be done in high-risk communities with the aim of reducing the number of events. This study aims to determine the relationship between sociodemographic factors and histopathological features of lung cancer. Methods. This study is an analytic observational study with a cross-sectional design. The research sample is in the form of secondary data from the Department of Anatomical Pathology and Medical Record Installation for 2019-2021. The research was conducted at Dr. Mohammad Hoesin Palembang. The sampling technique was carried out by total sampling. Results. Most of the respondents were in the age group >45 years (84.1%), male (78.3%), had no history of smoking (60.9%), the predominant main complaint was shortness of breath (63, 8%), the most common histopathological picture is adenocarcinoma. There was no significant relationship between age (p=0.998), gender (p=0.736), smoking history (p=0.572) and histopathological features of lung cancer patients. Conclusion. There was no significant relationship between age, sex and smoking status on the histopathological features of lung cancer.
Protein Intake in Medical Students, and Its Relationship to Gender and Physical Activity Dhanty Mukhsina; Ardesy Melizah Kurniati; Mutiara Budi Azhar; Liniyanti D. Oswari; Theodorus Theodorus; Syarinta Adenina
Biomedical Journal of Indonesia Vol. 8 No. 3 (2022): Vol 8, No 3, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v8i3.154

Abstract

Introduction. Protein is a physically and functionally complex macromolecule that has a role in the body. Medical students have been expected to have more knowledge about healthy lifestyles: healthy diet and physical activity. Previous studies have stated many factors affect protein intake. This research was conducted to find out about protein intake and its relationship to gender and physical activity of medical students in the Faculty of Medicine, Universitas Sriwijaya. Methods. This was an analytic observational study with a cross-sectional design. Data were collected using questionnaires, food records and food recall conducted from 8 September 2017 until 27 September 2017, against 279 respondents in the Faculty of Medicine, Universitas Sriwijaya. The data obtained were analyzed with the statistical test of Chi-square with SPSS Version 24. Results. Most of the respondents were female. In this study, the majority of respondents have low physical activity (49.8%). The mean protein intake of the respondents was low (81%). There was no significant relationship between gender and protein intake (p-value=0,135). There was no significant relationship between physical activity and protein intake (p-value=0.299). Conclusion. This study concluded that protein intake was not related to gender and physical activity of medical students
Quality of Life in Elderly with Stress Urinary Incontinence at Elderly Posyandu Dempo Health Center Palembang Namira Amalia; Amir Fauzi; Hadrians Kesuma Putra
Biomedical Journal of Indonesia Vol. 9 No. 2 (2023): Vol 9, No 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i2.156

Abstract

Introduction. Urinary incontinence is the loss of a person's ability to control urination. This condition is a common health problem that is often found in the elderly, especially in women. Stress urinary incontinence is one of the urinary incontinence that is often found due to increased intra-abdominal pressure. Urinary incontinence can have a negative effect on the quality of life of the elderly. This study aims to provide an overview of the quality of life in elderly women with stress urinary incontinence. Method. This study is observational descriptive research.  The data was obtained from interviews with elderly women at the Elderly Posyandu Dempo Health Center Palembang in the period October  – November 2022, who met the inclusion and exclusion criteria. Results. The samples in this study have more demographic characteristics of the elderly group at the age 60-69 years (70%), last education level in elementary school (47.5%), married (57.5%), and normal BMI (53.8%). This study found elderly women with a history of parity ≥ 2 (81.3%), and vaginal delivery (75%). It was found that elderly women with stress urinary incontinence had a moderate quality of life (82.5%) and moderate results in all domains of quality of life, namely physical health (46.3%), psychology (62.5%), social relations (53.7%), and the environment (62.5%). Conclusion. Elderly women with stress urinary incontinence at the Elderly Posyandu of the Dempo Palembang Health Center have a moderate quality of life and moderate impact on the domains of physical health, psychology, social relations, and the environment.

Page 32 of 40 | Total Record : 392

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