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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Mechanical Bowel Obstruction Caused by Incarcerated Left Amyand’s Hernia with Acute Appendicitis in Children Muhammad Zaki Abdul Hafiz; Jon Efendi; Budi Pratama Arnofyan
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.299

Abstract

Amyand’s hernia is rare condition defined as the inclusion of the appendix in an ingunal hernia sac, It is an uncommon and rare condition estimated to be found in approximately 1 % of hernia. However, in just 0.08 %, the condition is complicated by an acute appendicitis. It may present as a tender inguinal or inguinoscrotal swelling. In patients presenting amyand’s hernia with mechanical bowel obstruction, signs of acute appendicitis may not be initially recognized. This was the case while our patient was in surgery, as signs suggestive of acute appendicitis were discovered and the patient received appendectomy and herniotomy. Presently, We report a case of Amyand’s hernia in a 9-month-old male, who presented as a left-sided congenital hernia with distended abdominal and pain in the left groin. He underwent appendectomy and herniotomy, which revealed that the hernia sac containing elongated inflamed appendix appeared with some adhesions to sac, lying in the inguinal canal.
Effect of Artemisia vulgaris Extract on P53 Expression and Caspase-8 Expression (Study on Adenocarcinoma Mammae C3H Mice Given AdriamycinCyclophosphamide Chemotherapy Regimen) Jonathan Sugiharto; Hardian; Selamat Budijitno
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.300

Abstract

Background : The incidence of breast cancer worldwide is still high. Surgery remains the top choice with other modalities of chemotherapy. radiation.and immunotherapy such as Artemisia vulgaris (AV). Purpose : The study was aimed to demonstrate that administration of AV extract increased the levels of p53 and Caspase-8 in adenocarcinoma mammae. M ethods : This study used "Post test only control group design" on 24 females C3H mice that were randomly selected and divided into four groups : group K (control). P1 (chemotherapy). P2 (extract). and P3 (combination). Adenocarcinoma mammae comes from the inoculation of donor mice. Chemotherapy of Adriamycin 0.18 mg and Cyclophosphamide 1.8 mg were given in 2 cycles. AV 13 mg (0.2 ml) was given once daily orally. P53 and Caspase-8 levels were evaluated by imunohistochemical staining. Results : Mean of p53 and Caspase-8 levels were found in groups K. P1. P2. P3 were 22.06+1.73. 37.16+1.20. 24.60+1.08. 39.78+1.19 dan 17.16+1.28. 26.20+1.11. 24.60+1.08. 39.78+1.19. The statistical analysis showed that there were significant differences in the levels of p53 between groups of K vs P1. P3 (p=0.001). K vs P2 (p=0.048). P1 vs P2 (p=0.001). P1 vs P3 (p=0.039). P2 vs P3 (p=0.001). and in Caspase-8 between groups of K vs P1. P3 (p=0.001). K vs P2 (p=0.048). P1 vs P2 (p=0.001). P1 vs P3 (p=0.039). P2 vs P3 (p=0.001). Correlation analysis between p53 and Caspase-8 showed significant correlation (p=0.047 dan r=0.883). Conclusion : Artemisia vulgaris can improve the effectivity of AdriamycinCyclophosphamide chemotherapy on C3H mice with adenocarcinoma mammae in terms of elevated levels of P53 and Caspase-8.
Efficacy of Cyombopogon Citratus Extract Against Enterococcus Faecalis Tassya Nitulo Permatasari Lahagu; Hyunh Diem An; Cindy Denhara Wijaya; Mellisa Sim
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.301

Abstract

Endodontic treatment refers to the act of removing infected pulp tissue and forming and reforming the root canals to prevent bacteria from entering the root canals. Microbial infection in the root canal or in the periapical area is a factor that can le ad to failure of root canal treatments. Endodontic treatment failure can be caused the bacteria Enterococcus faecalis. The irrigation agent commonly used is sodium hypochlorite. Sodium hypochlorite in large concentrations can be toxic to tissues. Lemongrass plant (Cymbopogon citratus) is a natural ingredient that can be used as an antibacterial agent. The aims of study to determine the comparison of the antibacterial effectiveness of lemongrass plant extracts (Cyombopogon citratus (DC). Staph) concentrations of 25%, 50%, 75%, 100% with 2.5% sodium hypochlorite in inhibiting the growth of the bacterium Enterococcus faecalis. Lemongrass plant extracts Cyombopogon citratus (DC). Staph) made by maceration method and converted into 25%, 50%, 75%, and 100%. The bacterial test method used the agar diffusion test (Kirby-Bauer test) to see the effectiveness of antibacterialsThe result of the one way ANOVA statistical test resulted in significance value of p=0,001 (p<0,05) so that means there was differences in the ave rage diameter of inhibitory lemongrass plant extracts (Cyombopogon citratus (DC). Staph) concentrations of 25%, 50%, 75%, 100% with 2.5% sodium hypochlorite in inhibiting the growth of the bacterium the results are 13.68 ± 1.34 mm, 16.08 ± 0.87 mm, 16.33 ± 0.35 mm, 17.78 ± 0.93 mm and 7.83 ± 0.44 mm and reinforced by the posthoc Tukey HSD test. The conclusion from the study that there is a difference between the antibacterial effectiveness of lemongrass plant extract (Cyombopogon citratus (DC). Staph) concentrations of 25%, 50%, 75% and 100% with 2.5% sodium hypochlorite in inhibiting the growth of the bacterium Enterococcus faecalis.
The Antibacterial Effectiveness of Red Ginger (Zingiber Officinale Roscoe) Essential Oil in Inhibiting The Growth of Staphylococcus Aureus and Streptococcus Mutans Shavilla Lukita; Winda Khosasi; Chandra Susanto; Florenly
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.305

Abstract

Red ginger extract has a category strong antibacterial effect on Staphylococcus aureus and Streptococcus mutans. Red ginger essential oil has the potential for stronger inhibition. This study aims to compare the antibacterial effectiveness of red ginger essential oil against Staphylococcus aureus and Streptococcus mutans. The design of this study was a laboratory experimental design with a factorial completely randomized design. The red ginger used in this study was proven to be a species of Zingiber officinale Roscoe. The production of essential oils in this study uses the steam distillation method. The content of secondary metabolites in red ginger was tested quantitatively by the GC-MS method. Determination of antibacterial activity using the disc diffusion method. The data were processed using the SPSS 21.0 program. The normality of data distribution was tested with the Shapiro-Wilk test, followed by one-way ANOVA, Levene's test, and the Tukey HSD Post Hoc Test. The results of the antibacterial test of red ginger essential oil against Staphylococcus aureus (21.21mm ± 0.315) and Streptoococcus mutans (23.43mm ± 0.189) prove d that the inhibition power of the category was very strong at a concentration of 75%.
Neuropsychiatric Aspects of Congenital Heart Disease: A Review of Current Literatures Herick Alvenus Willim; Kartini RIta Sari; Nurfadella; Nurlia Desyanti
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.312

Abstract

Congenital heart disease (CHD) is a structural abnormality in the heart or major intrathoracic blood vessel that is present at birth. Advances in modern medical science and technology have contributed to an increase in life expectancy and population of CHD patients. Survivors of CHD may not only experience complex medical problems due to sequelae or complications of the underlying CHD but may also experience neuropsychiatric disorders. This review article aims to provide an understanding of the neuropsychiatric aspects of CHD, including clini cal manifestations, risk factors and mechanisms, detection, and management of neuropsychiatric disorders in CHD. This review showed that CHD patients are prone to behavioral disorders, neurodevelopmental disorders, and mental health disorders such as anxie ty, depression, and post-traumatic stress disorder which can cause a decrease in quality of life. The risk factors and mechanisms of neuropsychiatric disorders in CHD are complex and multifactorial. Early detection and referral of neuropsychiatric disorders are important. Management requires a multidisciplinary team approach.
Comparison of Inhibition Zones Between Butterfly Pea Flower (Clitoria ternatea) and Lemongrass (Cymbopogon citrarus) Against Streptococcus mutans and Staphylococcus aureus Steven Martin Haditio; Zulfan Muttaqin; Lina Hadi
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.313

Abstract

This study aims to determine the comparison of the inhibition zone between the extract of butterfly pea flower and lemongrass, against the bacteria streptococcus mutans and staphylococcus aureus. The samples that will be used in this research are streptococcus mutans and staphylococcus aureus bacteria. Data analysis used normality test and statistical test was performed using ANOVA analysis test and post hoc test. The results showed that there was no difference in the inhibition zone of butterfly pea flower extract against streptococcus mutans bacteria and lemongrass extract against streptococcus mutans. There was diffe rence in the inhibition zone between butterfly pea flower extract against staphylococcus aureus bacteria and lemongrass extract against staphylococcus aureus bacteria. Butterfly pea flower extract has a good inhibition zone in staphylococcus aureus bacteri a. Lemongrass extract has the same inhibition zone against both types of bacteria
Covid-19 Infection in Elderly with Comorbids Edo Yudistira; Roza Mulyana
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.376

Abstract

The senior population has a higher risk of contracting Covid-19 and is at risk of developing more severe disease. This is due to physiological changes in old age, which causes a decrease in immune function accompanied by an increase in comorbid disorders such as diabetes, hypertension, heart disease, lung disease, and dementia. WHO reports that the mortality rate for Covid-19 patients in the elderly above 80 years in China is around 21.9%, Italy is about 89% at the age above 70 years, and the United States is 85% at the age of 65 years and over. Delirium syndrome often appears as the primary complaint or infrequently; it occurs on the first day the patient is treated and shows fluctuating symptoms. Symptoms of delirium, such as disorientation, difficulty concentrating, and inattention, often occur in the elderly and are associated with a poor prognosis. Management of geriatric patients with covid 19 must be carried out thoroughly and completely, especially in geriatric patients with comorbidities. Management includes primary diseases, namely Covid-19 infection, delirium, nutritional therapy, blood sugar, family education for patient assistance, maintaining the patient's body and environment cleanliness, oral hygiene, and, last but not least, moral support from the family for the patient. With complete management, elderly patients with various comorbid can survive the Covid-19 infection.
The Effectiveness of The Combination of Nanoparticles from Carica papaya L. Leaf and Chitosan 1% Against Fibroblasts in The Tooth Socket of Wistar Rats. Mellisa Sim; Helen Theresia Nauli; Dang Phuong Khanh; Novelya; Felice Florencia Nicoline
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.378

Abstract

Nanoparticles size can make easier for drugs to enter and react quickly to the body. In this study, nanoparticles Carica papaya L. leaf were used and combined with chitosan 1%. The aim of this study was to measure the effectiveness of the combination of nanoparticles from Carica papaya L. leaf and chitosan 1% against fibroblasts in the tooth socket of Wistar rats. Carica papaya L. leaf extract was made by maceration method and converted into a concentration of 25%, 50%, 75% and 100%, then made into nanoparticles using the nanoemulsion method. Chitosan 1% was made using Na-TPP solvent using the ionic gelation method with a ratio of 2:1 and after that it was mixed with nanoparticles of Carica papaya L. leaf then made into a gel preparation. The ANOVA statistical test shows a significant number of p <0.05, so it can be ignored that the increase in the number of fibroblast cells produced by the nano gel extract is 25%, 50%, 75% and 100%, its 138, 173, 177.4 and 328. Thus, the combination of 100% Carica papaya L. leaf nanoparticle extract and 1% nanocitosan was the most effective in increasing fibroblast cells on Wistar rat tooth socket.
Effectiveness of Tamarillo Skin Extract (Solanum betaceum Cav.) with Sealer Combination in Inhibiting Growth of Enterococcus faecalis Siregar E.Y.; Novelya; Susanto C.
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.380

Abstract

Introduction : Caries is a growth medium for pathogenic micro-organisms an inflammatory process can occur which can cause damage to the tooth pulp. Enterococcus faecalis one of the Gram-positive facultative anaerobes which causes failure after endodontic treatment. In the field of dentistry, herbal ingredients can be used as alternative medicinal ingredients because the ingredients is tamarillo skin which contains flavonoids, terpenoids, saponins and phenol compounds. In addition to herbal alternatives, endodontic filling also uses ingredients that have antibacterial potential that can kill and prevent reproduction in the root canals, one of which is the zinc oxide eugenol sealer which is usually applied together with gutta percha. Research objective: to determine the effectiveness of the extract of tamarillo (Solanum betaccum Cav.) skin sealer combination in inhibiting the growth of Enterococcus faecalis. M ethod: The research was conducted in an experimental laboratory post test only control group design. Results : a sealer made from zinc oxide-eugenol had the largest diameter compared to the combination group of 100%, 75%, 50%, 25% tamarillo skin extract with sealer, and aquadest. Based on the One Way Anova test, there was a significant difference in the mean diameter of the inhibition zone (p <0.05) and the Post Hoc LSD analysis test showed that the sealer was the best group to kill the Enterococcus faecalis bacteria. Conclusion : sealers have a good effect on inhibiting Enterococcus faecalis bacteria as a cause of failure in endodontic treatment.
Activity of Averrhoa Bilimbi L Leaf Extract as Denture Cleaner Towards The Number of Colonies of Candida Albicans in Heat Cured Resin with a 30 Minutes Period Idamawati; Rouli Natasia; Molek; Listyaning Kartiko Kinasih
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.381

Abstract

Denture stomatitis is a chronic inflammatory condition of the oral mucosa that generally occurs in users of removable dentures. The cause is multifactorial but is often associated with the presence of Candida albicans. The mucosa which is covered by the denture base also reduces the function of saliva which functions as a cleanser for the oral cavity and results in food waste accumulating and microorganisms such as Candida albicans can increase in number. Candida albicans is a normal flora of the oral cavity which is an opportunistic pathogen. The starfruit plant (Averrhoa billimbi l) is a natural ingredient that can be used as an antifungal agent. The aim was to determine the ratio of the effectiveness of starfruit leaf extract (Averrhoa billimbi) between the concentrations of 12.5%, 25%, 50%, 100%, control + (Clorhexidine) and control - (Aquadest) in reducing the number of Candida albicans colonies. The test method used the dilution method, the colony count of Candida albicans using a spectrophotometer. The results of the one way ANOVA statistical test resulted in a significance value of p = 0.000 (p <0.05) which means that there is a difference in the average concentration of Candida albicans between the extract concentrations of 12.5%, 25%, 50%, 100%, control + and control. -namely 6.78 ± 0.35, 6.27 ± 0.21, 4.89 ± 0.29, 1.01 ± 0.18, 0.59 ± 0.19 and 9.13 ± 2.28 in inhibiting growth Candida albicans and this was confirmed by the Tukey HSD posthoc test. The conclusion of this study is that there is a difference between the antifungal effectiveness of starfruit leaf extract (Averrhoa billimbi) concentrations of 12.5%, 25%, 50% and 100% in inhibiting the growth of Candida albicans colonies.

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