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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Factors Related to Anx iety Events in Parkinson's Patients in Dr. M Djamil Padang Yoga Setia Kurniawan; Yuliarni Syafrita; Restu Susanti
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.282

Abstract

Introduction : Anxiety is one of the most non-motorized symptoms in patients with Parkinson's which greatly affects the quality of life, but in clinical practice it is often neglected. Anxiety in patients with Parkinson's can accelerate motor deterioration / disability and also increase mortality. M ethods: This cross-sectional study was conducted at the Neurology polyclinic Dr. M Djamil Padang from July to December 2020 in patients who had been diagnosed with Parkinson's Disease (PD) by excluding secondary Parkinson's and a history of stroke. Anxiety was measured using the Hamilton Anxiety Rating Scale (HARS). The research subjects were 60 people. Univariate analysis to present baseline characteristics and bivariate tests assessed factors associated with anxiety and the relationship between variables. A p value <0.05 was considered statistically significant. Results: Most of the subjects were male (55%) with a mean age of 58.05 ± 9.7 years and disease duration of 6.35 ± 5.29 years. By examining the Hamilton Anxiety Rating Scale (HARS), it was obtained 38.3% of Parkinson's sufferers with anxiety. There is a significant relationship between marital status, duration of illness and degree of disease with the incidence of anxiety (p <0.05) and there is no significant relationship between age and sex with the incidence of anxiety in patients with Parkinson's. Conclusion: There is a significant relationship between marital status, duration of illness and degree of disease with the incidence of anxiety in patients with Parkinson's and there is no relationship between age and sex with the incidence of anxiety in patients with Parkinson's.
Characteristics and Patterns of Deep Neck Infection in Dr. Mohammad Hoesin General Hospital Palembang 2020 Lisa Apri Yanti
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.283

Abstract

Intoduction: Deep neck infection is the accumulation of pus in the potential space and facial area in the deep neck. The incidence of deep neck space infections is 1/100.000 in adults and 2/100.000 in children. Risk factors such as age, oral hygiene, and comorbidities such as DM are predisposed factors in deep neck infection. Effective pus collection of specimens is essential, to obtain the organisms and determine the effective antibiotics. Purpose: The aim of this study was to describe the characteristics and bacterial patterns of abscess in Dr. Mohammad Hoesin General Hospital Palembang. Methods: This study was conducted retrospectively using medical records of patients who diagnosed deep neck infection in Dr. Mohammad Hoesin General Hospital Palembang during January to December 2020 who took pus collection and been checked in microbiology laboratory. Data recorded include gender, age, site, onset, risk factors, comorbidities, bacteria culture, antibiotic sensitivity, and complications. Results: Of the 36 patients, 23 (63.8%) were males, followed by 13 (36.1%) were female, and the age of 31-45 years old group were found in 13 subjects (36.1%). The onset was mostly found at 0-1 week as many as 19 subjects (52.7%). The highest complaints of dysphagia and odynophagia were found in 22 cases (26,2%), odontogenic factors were found in 35 cases (97,2%). Abscess location in multiple space were found in 17 cases (47,2%), while in single space there were 19 cases (52.7%), where the most location was in submandibular space in 7 cases. Diabetes was the most comorbid factors found in 6 subjects (50%). The most bacterial were Klebsiella pneumoniae in 4 cases (11.1%) and sensitive antibiotics including ciprofloxacin, meropenem, and tigecycline, in 6 cases (20%) respectively. And the most complication was mediastinitis in 6 cases (75%). Conclusion: Klebsiella pneumoniae is the most common found in deep neck infection with sensitive antibiotics including ciprofloxacin, meropenem, and tigecycline.
Anatomy and Physiology of Animal Model Rats in Biomedical Research Rachmat Hidayat; Patricia Wulandari
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.287

Abstract

A distinguishing feature of rodents, including rats, is the absence of canines and the presence of prominent incisors. Rats are monophydontic, meaning they grow one set of teeth in their lifetime. The enamel of the rodent incisor contains iron, which gives it its yellow-orange color. Rats are mammals and as such, possess many similarities with other mammals. Only the peculiarities of the rat’s anatomy are addressed. Male rats reach puberty at 40 - 60 days of age. Descent of the testes usually occurs between days 30 - 60. Sperm counts vary by strain. The male rat has an os penis. Male rats have the following accessory sexual organs: ampulla, seminal vesicles, prostate, bulbourethral glands, coagulating glands, and preputial glands. The coagulating gland and prostatic and vesicular secretions are responsible for the copulation plug, a firm plug deposited in the vagina of the female after copulation. (This plug, when found outside the female rat, is capsuleshaped and approximately 5 mm long.) The male rat has no nipples. The adult male rat has a prominent scrotum and a longer anogenital distance than the female rat.
Epigenetic Regulation of Breast Cancer Stem Cells Elvira Yunita
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.289

Abstract

Breast cancer arises as a result of abnormal breast cells forming at an uncontrolled rate. Death in this case of breast cancer is due to the ability of cancer cells to adapt so that it can have an effect on metastasis and recurrence of cancer that was previously thought to have been resolved. The results showed, there is a stem cell population in breast cancer cases which will cause breast cancer to become increasingly difficult to treat. Such cells are known as breast cancer stem cells. Breast cancer cells have the ability to differentiate and contribute greatly to the breast cancer program, as well as to resistance to therapy. Therefore, epigenetic regulation of breast cancer cells is important to study in order to overcome cancer so that it can overcome progression and resistance to cancer therapy being carried out.Epigenetic regulation that has been known in cancer cases includes DNA methylation, histone acetylation, histone methylation and epigenetic regulation by miRNA. DNA methylation is the addition of a methyl group to the nitrogen base of DNA cytosine which will force the DNA transcription process. Acetylation of the addition of an acetyl group at the end of the histone causes reduced chromatin condensation so that it will activate the transcription process. Methylation histones will also suppress transcription so that genes cannot be expressed. In addition, there is also a small RNA molecule known as miRNA which can bind to the transcribed mRNA. This binding will cause the mRNA to degrade or inhibit its translation.
Effect of Non-Coding Region RNA Gene XIST (X-Inactive Specific Transcript) on Human Breast Cancer Liya Agustin Umar
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.290

Abstract

X chromosome is a sex chromosome found in both women and me n. The inactivation of the X chromosome is linked to a non-coding region of RNA known as the XIST gene (X-inactive specific transcript). This gene is located in the X inactivation center (XIC X-inactive center). The XIST gene is a region that belongs to the RNA group, non-coding transcripts (NCT), also known as microRNA. Breast cancer (Breast Cancer) is a type of cancer that commonly affects women, but men can develop breast cancer, but the chances are small, about 1 in 1000. Breast cancer is a cancerous neoplasm that is malignant, and occurs in the mammary gland. The presence of a specific XIST gene on the X chromosome and the prevalence of breast cancer, which is mostly in women, raises the idea that there is an influence of this gene on breast cancer (breast cancer) in the epigenetic process. The XIST gene related to microRNA has an opportunity to be looked at because certain microRNAs have a greater or lesser level (concentration) in cancer cells than normal cells. This is a new opportunity to continue to be developed as a consideration for a new treatment method involving gene therapy.
Comparison of Widal Test Using Serum and Plasma Samples Debie Rizqoh; Roina Sitanggang
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.291

Abstract

The widal test is a test for diagnostic of thyfoid fever serology. Widal test aims to detect the presence of antibodies against Salmonella antigen, by measuring the degree of agglutination of antibody titer to antigen O and H in sample. In this research Widal test was performed using serumand plasma samples. This study aims to determine whether there is a difference in the value of titer on the Widal test between serum samples and plasma EDTA samples. This type of research is an experimental study. Samples were taken from patient suspected of thyfoid fever of 10 sample in the Laboratory of SM Raja Amplas in 2018. The result of comparative titer Widal test using serum and plasma samples obtained results 30% of the 10 samples examined there are differences in the value of Widal titer but does not affect the final diagnosis of typhoid fever. The value of the Widal test titer using plasma is lower than the value of Widal Titer with the serum samples. The use of plasma samples to determine the Widal titer is particularity susceptible to mingling with the erythrocytes due to the presence of anticoagulant particles but does not affect the result of the Widal test. EDTA anticoagulants do not damage the antibodies contained in the serum, this can be seen in the results of the study, there were no differences in each sample examined, so the difference in results obtained due to other factors, namely the error of researchers in the Widal test. The Widal test using serum samples can gives results according to the actual circumstances because serum is not contaminated by EDTA anticoagulants.
Effectiveness of Artemisia Vulgaris as Supplementation Against Chemotherapy of Mammae Adenocarcinoma to Reduce Ex pression of NF -κB and CD 34 (Study in C3H Mice Given Chemotherapy Adriamycin - Cyclophosphamide) Bayu Teguh Saputro; Selamat Budijitno
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.292

Abstract

Intoduction: Breast cancer is a significant healthcare problem worldwide. Surgery remains the treatment of choice combined with other modalities such as chemotherapy, radiation, and immunotherapy such as Artemisia vulgaris (AV). Selective cytotoxicity of AV is intended as a supplementation to AdriamycinCyclophosphamide, improving the response rate of chemotherapy in adenocarcinoma mammae. M ethod: This study used a "Post-test only control group design" on 24 females C3H mice that were randomly selected and divided into four groups: group K (control), P1 (chemotherapy), P2 (extract), and P3 (combination). Adenocarcinoma mammae come from the inoculation of donor mice. Chemotherapy of Adriamycin 60 mg / m2 and Cyclophosphamide 600 mg / m2 were given in two cycles. AV 13 mg (0.2 ml) was given once daily orally. NF-κB expression and CD34 were evaluated using imunohistochemical staining. Result: The expression of NFκB and microvascular density of CD 34 were obtained in groups of K, P1, P2, P3 Statistical analysis showed significant decrease in the expression of NF-κB between groups K and P1, P2, P3. Correlation analysis between NF-κB expression with CD 34 was found to have significant correlation (p = 0,039 and r = 0,897). Conclusion: Artemisia vulgaris can reduce angiogenesis by decreasing NF-κB expression and the microvascular density CD34 of adenocarcinoma mammae of C3H mice treated with Adriamycin-Cyclophosphamide chemotherapy and can improve the effectivity.
Comparison of the Effectiveness of 5 Iu Oxytocin Bolus and 20 Iu Infusion on Uterine Contraction and Hemodynamic Response in Caesarean Section Aidyl Fitrisyah; Rose Mafiana; Agustina Br. Haloho; Theodorus
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.293

Abstract

Uterine atonic can result in postpartum hemorrhage, gravid hysterectomy and maternal mortality. Oxytocin is the most commonly used agent for the prevention and treatment of atonic uterine during cesarean section. However, the provision of rapid and increasing the dose may result in hemodynamic instability, cardiovascular collapse, and death. This study aimed to compare the effectiveness of oxytocin bolus 5 IU and oxytocin infusion 20 IU to contractions of the uterus and the hemodynamic response in cesarean section with spinal anesthesia.An experimental study, Randomized Controlled Trial (RCT) was conducted in the operating room Mohammad Hoesin Hospital Palembang from July to August 2016. It was obtained a 44 pregnant at term women who will do a cesarean section that meet the inclusion and exclusion criteria. The frequency and distribution of data are described in tables and comparisons between the two groups were analyzed using SPSS.Of the 44 pregnant women at term, 22 women in the group of oxytocin bolus 5 IU and 22 women in the group of oxytocin infusion 20 IU. By statistical analysis, there was no significant hemodynamic changes after bolus administration of oxytocin 5 IU or oxytocin infusion 20 IU (p> 0.05) and there were no significant hemodynamic differences between oxytocin bolus 5 IU and infusion of 20 IU oxytocin (p> 0.05). In addition, there are significant changes in uterine contractions after bolus administration of oxytocin 5 IU or oxytocin infusion 20 IU (p< 0.05) and there were significant differences in uterine contraction in the 3rd minute (p = 0.006), 6th minute ( p = 0.010) and 9th minute (p = 0.008) between oxytocin bolus 5 IU and infusion of oxytocin 20 IU.It can be concluded that there is no significant hemodynamic changes after administration of oxytocin 5 IU bolus and oxytocin infusion 20 IU and there are differences in uterine contractions significantly in the 3rd minute, 6th minute and 9th minute between oxytocin bolus 5 IU and oxytocin infusion 20 IU.
Glandula Tiroid Problem: Literature Review Muhammad Zaki Abdul Hafiz; Daan Khambri
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.295

Abstract

Thyroid cancer is the most common endocrine system neoplas m . Based on the "Pathologycal Based Registration" in Indonesia, thyroi d cancer is a cancer with the highest incidence in the ninth rank. According to statistics from the National Cancer Institute (NCI), the incidence of thyroid cancer in men is about 2.5 per 100.000 population and women around 6.7 per 100.000 populati on. Thyroi d cancer can affect all age groups and the frequency increases afte r the age of 50 years. Only about 5% can affect the age of 15-20 years. NCI also states that this thyroid cancer can affect 16.000 people pe r year. Diagnosis is important to improve the quality of life for sufferers. Clinical diagnosis is the basis for determining furthe r management, so that knowledge and skills are needed in determining the diagnosis. The first treatment for a cancer is the best chance for the patient to achieve optimal cure rates, as is the case for thyroid cancer.
Giant Lipoma of The Breast: Special Clinical Finding Muhammad Zaki Abdul Hafiz; Daan Khambri; Anandia Putriyuni
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.296

Abstract

Lipomas are the most common benign tumors of mesenchymal origin. Lipoma of breast is somewhat difficult to diagnose clinically because of fatty consistency of breast. Giant lipoma is the mass of lipoma that exceeds at least 10 cm in one dimension or weighs a minimum of 1000 gr.Only very few case reports giant lipoma of the breast available in literature because rarity in size and location. Due to the fatty composition of the breast, difficulties in diagnosis, threatment, and reconstruction are often encountered.Presently, we have reported a case of this rare entity in 49 years old female with giant tumor of the left breast that most of its mass, causing breast asymmetry and feel heavy. The operative finding: looks like lipoma between pectoralis major muscle and pectoralis minor muscle with a diameter of 31 cm and weighs 3.1 kg. After excision the tumor we need to mammoplasty.Pathology anatomy examination showed a lipoma.

Page 29 of 40 | Total Record : 392

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