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All Journal JURNAL FARMASIMED (JFM) Jurnal Ilmiah Farmako Bahari Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Pharmaceutical and Sciences. Usadha Journal of Pharmacy ASSYIFA: Jurnal Ilmu Kesehatan
Adit Andriyannto
Sekolah Tinggi Farmasi Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary

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FORMULATION AND STABILITY EVALUATION OF TRANSFEROSOMAL GEL CONTAINING PHOSPHATIDYLCHOLINE AS A VESICLE-FORMING COMPONENT AND TWEEN 80 AS A SURFACRANT Yola Desnera Putri; Linda Suci Ramdianti; Deby Tristiyanti; Adit Andriyannto
Usadha Journal of Pharmacy Vol. 5 No. 2 (2026): Mei
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v5i2.1014

Abstract

Gel transfersom merupakan sediaan semipadat yang mengandung vesikel transfersom dengan kemampuan meningkatkan penetrasi ke dalam kulit sehingga berpotensi digunakan sebagai sistem penghantaran transdermal. Penelitian ini bertujuan untuk merancang dan mengevaluasi stabilitas basis gel transfersom menggunakan fosfatidilkolin sebagai komponen pembentuk vesikel dan Tween 80 sebagai surfaktan untuk meningkatkan elastisitas vesikel. Penelitian ini difokuskan pada formulasi basis gel transfersom tanpa penambahan zat aktif, sehingga evaluasi dilakukan terhadap karakteristik fisik dan stabilitas sediaan. Karakterisasi awal meliputi uji organoleptik, pengukuran pH, viskositas, daya sebar, daya lekat, serta analisis ukuran partikel menggunakan Particle Size Analyzer (PSA). Seluruh parameter evaluasi dilakukan pada penyimpanan suhu 25 °C dan 40 °C selama 4 minggu. Selain itu, uji stabilitas dipercepat dilakukan hingga minggu ke-12 menggunakan climatic chamber pada suhu 40 °C ± 2 °C dan kelembapan relatif 75% ± 5%, dengan parameter yang diamati meliputi organoleptik, pH, dan ukuran partikel. Hasil pengamatan menunjukkan bahwa selama penyimpanan tidak terjadi perubahan warna, bentuk, maupun bau sediaan. Nilai pH berada pada rentang 6–7 dan masih sesuai dengan persyaratan Standar Nasional Indonesia (SNI). Ukuran partikel rata-rata dan indeks polidispersitas pada minggu ke-4 masing-masing sebesar 229,4 nm dan 0,687, kemudian menurun pada minggu ke-12 menjadi 172,2 nm dan 0,476. Tidak ditemukan adanya aglomerasi selama penyimpanan, yang menunjukkan kestabilan fisik sediaan yang baik. Secara keseluruhan, formulasi basis gel transfersom yang dihasilkan memenuhi persyaratan mutu fisik dan stabilitas, sehingga berpotensi untuk dikembangkan lebih lanjut sebagai sistem pembawa transdermal dengan penambahan zat aktif pada penelitian selanjutnya.
The Effect of Variation in Polyvinylpyrrolidone (PVP) Concentration as a Binder in The Formulation of Curcumin Isolate Lozenges Yola Desnera Putri; Annisa Putri Dewantara; Yeyet Cahyati Sumirtapura; Adit Andriyannto
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/tqs16n98

Abstract

Background: The pharmaceutical industry continues to develop user-friendly dosage forms to improve patient compliance, especially for individuals who have difficulty swallowing conventional tablets. Lozenges are an alternative oral dosage form that does not require water and allows drug absorption through the oral mucosa, making them more practical and convenient. In lozenge formulation, polyvinylpyrrolidone (PVP) as a binder plays an important role in determining physical characteristics such as hardness, friability, and disintegration time. Objective: This study aimed to evaluate the effect of varying PVP concentrations on the physical characteristics of curcumin isolate lozenges and to determine the optimal formulation. Methods: An experimental method using wet granulation was applied with PVP concentrations of 1%; 2%; 3%; 4% and 5%. Evaluations included granule properties (moisture content, flow rate, angle of repose, compressibility index) and tablet properties (organoleptic characteristics, weight and size uniformity, hardness, friability, and disintegration time). Results: Increasing PVP concentration influenced tablet characteristics, particularly hardness, friability, and disintegration time. All formulations met the physical quality requirements for lozenges. The formulation containing 3% PVP showed the most balanced characteristics compared to others. Conclusion: PVP concentration affects the physical properties of curcumin lozenges, with 3% identified as the optimal concentration, indicating its potential as a practical alternative oral dosage form.
Formulation and Stability Evaluation of Sunscreen Cream: Utilization of Methyl Cinnamate Isolate from Alpinia galanga L. Rhizome as a Photoprotective Agent Yola Desnera Putri; Alidya Canticha Sari; Deby Tristiyanti; Adit Andriyannto
Jurnal Ilmiah Farmako Bahari Vol 17 No 2 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i2.43620

Abstract

Methyl cinnamate isolate is an aromatic ester compound with a conjugated chromophore system capable of absorbing UV-B radiation, making it a promising candidate for sunscreen formulations. This study aimed to determine the optimum concentration of methyl cinnamate isolate based on its sun protection factor (SPF) and to develop a sunscreen cream with satisfactory physical stability. Methyl cinnamate isolate solutions were prepared at concentrations of 1000, 2000, 3000, 4000, and 5000 ppm and screened for SPF activity. The concentration yielding the highest SPF value was incorporated into cream formulations containing different stearic acid concentrations as an emulsifier (F1: 8% w/w and F2: 10% w/w). The resulting formulations were assessed for SPF, physical characteristics during 28 days of storage at room temperature, microbiological quality, and methyl cinnamate content under accelerated stability conditions (40 ± 2°C and 75 ± 5% RH). The isolate at 5000 ppm (0.5%) exhibited the highest SPF value of 33.49, corresponding to the ultra-protection category. Both formulations maintained acceptable physical characteristics throughout the storage period. At day 28, SPF values were 13.87 for F1 and 17.02 for F2, with F2 remaining within the ultra-protection category. After three months of accelerated stability testing, methyl cinnamate content was 47.62% in F1 and 68.32% in F2. Microbiological evaluation also revealed contamination based on total plate count and yeast–mold count analyses. These findings indicate that methyl cinnamate isolate has potential as a sunscreen active ingredient; however, further formulation optimization and preservative incorporation are required to improve chemical stability and microbiological quality.
PENINGKATAN KELARUTAN EKSTRAK ETANOL DAUN SIRIH MERAH (PIPER CROCATUM RUIZ & PAV.) MELALUI KOMPLEKSASI DENGAN β-SIKLODEKSTRIN Yola Desnera Putri; Princesa Elnovita Tierra; Sohadi Warya; Adit Andriyannto
ASSYIFA : Jurnal Ilmu Kesehatan Vol. 4 No. 2 (2026)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/ajk.v4i2.232

Abstract

Red betel leaves (Piper crocatum Ruiz & Pav.) are rich in secondary metabolites, particularly flavonoids, which exhibit pharmacological potential such as antioxidant and antidiabetic properties. However, the low solubility of the extract poses a major challenge in drug formulation development. This study was designed to enhance the solubility of ethanol extract from red betel leaves by forming inclusion complexes with β-cyclodextrin using the kneading method, and further developing it into instant-dissolving granules. Extraction was performed via maceration technique with 70% ethanol as the solvent. Complexes were prepared by kneading at ratios of 1:1, 1:2, and 1:3 (extract:β-cyclodextrin). The resulting complexes were tested for solubility and formulated into granules through wet granulation. The extraction yielded 10.92% render. Kneading complex formation successfully increased solubility to 16.092% (F1), 27.844% (F2), and 36.302% (F3). Evaluation of the granules' physical properties showed parameters meeting standard requirements. The study concludes that β-cyclodextrin incorporation via kneading is effective in improving the solubility of red betel leaf extract and producing granules with optimal physical characteristics.
Pemanfaatan Isolat Katekin dari Gambir (Uncaria Gambir Roxb.) pada Essence Sheet Mask: Kajian Stabilitas, Antioksidan dan Cemaran Mikroba Sediaan Yola Desnera Putri; Retty Azka Djumar Danawiria; Hesti Riasari; Adit Andriyannto
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 2 (2026): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Isolat katekin dari gambir (Uncaria gambir Roxb.) merupakan golongan polifenol yang memiliki aktivitas antioksidan tinggi melalui kemampuan menetralisir radikal bebas ROS. Dalam upaya memanfaatkan bioaktivitasnya, isolat katekin diformulasikan sebagai essence sheet mask yang mendukung penetrasi transdermal optimal untuk mengatasi penuaan dini, hiperpigmentasi, dan stres oksidatif jaringan kulit. Penelitian ini bertujuan mengembangkan dan mengkarakterisasi essence sheet mask berbasis katekin untuk aplikasi topikal inovatif, meliputi aktivitas antioksidan metode DPPH, stabilitas sediaan, cemaran mikroba (ALT dan AKK), serta penetapan kadar isolat katekin dalam sediaan essense sheet mask. Sediaan dibuat dalam dua formula, (F1, F2; rasio basis 2:1). Hasil uji DPPH menunjukkan nilai IC₅₀ asam askorbat sebesar 3,879 ppm dan isolat katekin 3,010 ppm. Setelah diformulasikan, aktivitas antioksidan isolat katekin menurun menjadi 64,066 ppm (F1) dan 50,565 ppm (F2), yang menunjukkan pengaruh matriks sediaan terhadap aktivitas bioaktif. Uji cemaran mikroba menunjukkan nilai ALT dan AKK berada di bawah batas maksimum (<10³), serta tidak terdeteksi Staphylococcus aureus dan Pseudomonas aeruginosa. Formulasi F1 dengan xanthan gum 0,2% menunjukkan stabilitas fisik yang optimal dan nilai IC₅₀ sebesar 96,049 ppm setelah penyimpanan 28 hari, serta kemampuan mempertahankan kadar zat aktif lebih baik dibandingkan F2. Dengan demikian, sediaan ini memenuhi standar stabilitas fisik dan mikrobiologis yang berpotensi sebagai alternatif antioksidan topikal.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Buah Murbei Hitam (Morus nigra L.) sebagai Antijerawat Yola Desnera Putri; Susi Sulastri; Deby Tristiyanti; Adit Andriyannto
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1471

Abstract

Acne is one of the most common skin disorders affecting various age groups, particularly adolescents, and is caused by inflammation of the pilosebaceous follicles associated with bacterial proliferation. The primary bacteria involved in acne pathogenesis are Propionibacterium acnes (P. acnes) and Staphylococcus epidermidis (S. epidermidis). This study aimed to formulate an anti-acne gel containing ethanol extract of black mulberry (Morus nigra L.) fruit and to evaluate its antibacterial activity. The black mulberry fruit was extracted by maceration using 96% ethanol. The resulting extract was formulated into a Carbopol 940-based gel at three different concentrations: 1.25% (F1), 2.5% (F2), and 5% (F3). The formulated gels were evaluated for organoleptic properties, homogeneity, pH, viscosity, spreadability, antibacterial activity using the agar well diffusion method, and skin irritation using the Draize method. The results showed that the ethanol extract of black mulberry fruit exhibited antibacterial activity against P. acnes and S. epidermidis, with inhibition zone diameters of 12.0 ± 0.90 mm and 12.8 ± 0.59 mm, respectively, at a concentration of 1.25%, indicating strong antibacterial activity. After formulation into a gel, the highest antibacterial activity was observed in Formula 3 (F3) after 28 days of storage, with inhibition zone diameters of 15.1 ± 0.06 mm against P. acnes and 15.3 ± 0.10 mm against S. epidermidis. All formulations met the required physical evaluation parameters and showed no signs of irritation in a preliminary Draize irritation test during the observation period. Therefore, the ethanol extract of black mulberry fruit has the potential to be developed as a topical anti-acne gel with antibacterial activity against P. acnes and S. epidermidis.
Co-Authors Alidya Canticha Sari Annisa Putri Dewantara Deby Tristiyanti Hesti Riasari Linda Suci Ramdianti Princesa Elnovita Tierra Retty Azka Djumar Danawiria Sohadi Warya Susi Sulastri Yeyet Cahyati Sumirtapura Yola Desnera Putri