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All Journal Jurnal Keperawatan Priority Indonesian Journal of Global Health research Indonesian Journal of Global Health Research
Fathia Meirina
Universitas Sumatera Utara
Dentistry Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Factors Influencing Tuberculosis Infection in Children with Close Contact of Adult Pulmonary Tuberculosis Patients Fadhliani Putri Mayasri; Wisman Dalimunthe; Pertin Sianturi; Rina Amelia; Rini Savitri Daulay; Fathia Meirina
Jurnal Keperawatan Priority Vol. 8 No. 2 (2025)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v8i2.6647

Abstract

This research aims to determine the factors that influence tuberculosis infection in children with close contact with adult pulmonary tuberculosis sufferers. This research is an analytical observational study with a consecutive sampling method at the Glugur Darat Health Center in November 2024 until January 2025. Bivariate analysis using chi-square to determine whether there is a relationship between the independent and dependent variables. The type of test used is the Fisher Exact and Kruskal Wallis Test. There is no multivariate test because there are no significant variables in the bivariate test. In total, in 42 samples there were 10 children with positive Mantoux tests. Of the 23 female children there were 7 (30.4%) with positive results and of the 19 male children there were 3 (15.8%) positive results. Of the 39 children with a history of BCG immunization, there were 10 (25.6%) with tuberculosis infection. Of the 37 children with parents whose income was <UMR, 10 children (27%) had tuberculosis infection. 37 children whose parents had junior high school education, 9 people (24.3%) had tuberculosis infection. 10 children aged 1-5 years and 6-10 years, there were 2 (20%) each with tuberculosis infection. 26 children aged 11-18 years, there were 6 people (27.3%) with tuberculosis infection. There was no significant relationship between age, gender, immunization status, nutritional status, parental income and parental education level in this research.
Association Between Glycaemic Control and Cardiac Function in Children with Diabetes Mellitus M Ridho; Siska Mayasari Lubis; Putri Amelia; Juliandi Harahap; Rita Evalina; Fathia Meirina
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.7020

Abstract

The prevalence of Diabetes Mellitus (DM) among children and adolescents has been progressively increasing, with Type 1 DM constituting the majority of cases. Cardiovascular disease (CVD) is a major long-term complication, yet early cardiac involvement remains poorly understood in this population. This study aimed to assess the association between glycaemic control and cardiac function in paediatric patients with DM. A cross-sectional observational study was conducted involving 30 children with type 1 or type 2 DM at H. Adam Malik General Hospital, Medan. Glycaemic control was assessed using HbA1c levels. Cardiac function was evaluated using electrocardiography (ECG) and echocardiographic parameters, including ejection fraction (EF), fractional shortening (FS), tricuspid annular plane systolic excursion (TAPSE), and E/A ratio. Data were analysed using Chi-Square and Mann-Withney Test. Most subjects (90%) had poor glycaemic control (HbA1c ≥7%). Cardiac dysfunction (reduced EF <55%) was identified in 16.7% of patients. However, no statistically significant associations were found between cardiac function and HbA1c, duration of diagnosis, blood pressure, or body mass index (BMI) (p>0.05). There was no significant relationship was found between glycaemic control and cardiac function, highlighting the need for more sensitive diagnostic tools and long-term follow-up to detect subclinical cardiovascular complications.
Correlation between Procalcitonin Values and Pneumonia Severity in Pediatric Patients Yogi Zulkifli; Rini Savitri Daulay; Fera Wahyuni; Ranti Permatasari; Hendri Wijaya; Fathia Meirina
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.237

Abstract

Pneumonia remains one of the leading causes of morbidity and mortality among children, particularly in developing countries. Rapid assessment of disease severity is essential for appropriate clinical management. Procalcitonin (PCT) is recognized as a biomarker of systemic bacterial infection; however, its role in determining the severity of pediatric pneumonia is still debated. This study aimed to analyze the correlation between procalcitonin levels and pneumonia severity in pediatric patient. This was an observational analytic study with a retrospective cross-sectional design using consecutive sampling. Data were collected from medical records of 102 pediatric patients aged 1 month to 18 years who were diagnosed with pneumonia throughout 2024. PCT levels were compared between children with severe pneumonia and those with severe pneumonia accompanied by danger signs. Statistical analysis included the Mann-Whitney test to assess differences in PCT values and ROC curve analysis to determine the optimal cut-off, sensitivity, specificity, and accuracy. The majority of patients (71.6%) presented with severe pneumonia with danger signs. PCT levels differed significantly between groups (p < 0.001). ROC analysis identified an optimal cut-off value of ≥1.06 µg/L, yielding a sensitivity of 82.2%, specificity of 79.3%, positive predictive value of 90.9%, negative predictive value of 63.9%, and overall accuracy of 81.37% (AUC = 0.874). There is a significant association between procalcitonin levels and the severity of pneumonia in children. Procalcitonin may serve as a valuable early biomarker for assessing disease severity and guiding clinical decision-making in pediatric pneumonia, particularly in healthcare settings in North Sumatra.
NLR (Neutrophil-To-Lymphocyte Ratio), MLR (Monocyte-To-Lymphocyte Ratio) and NMLR (Neutrophil-Monocyte-To-Lymphocyte Ratio) as Biomarkers for Establishing the Diagnosis of Tuberculosis in Children Nindy Putri Ferisa; Wisman Dalimunthe; Winra Pratita; Juliandi Harahap; Mahrani Lubis; Fathia Meirina
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.476

Abstract

Tuberculosis (TB) in children presents a major diagnostic challenge due to the paucibacillary nature of the infection and difficulties in sputum collection. As an alternative, blood cell ratios such as Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), and Neutrophil-Monocyte-to-Lymphocyte Ratio (NMLR) have been proposed as hematological biomarkers that can support the diagnosis of TB in children. This study aimed to evaluate the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of NLR, MLR, and NMLR in establishing the diagnosis of TB in children at RS Adam Malik. A retrospective observational study was conducted using data from the TB DOTS medical records of children aged 0–18 years during 2024. Hematologic parameters (neutrophils, monocytes, lymphocytes) and the ratios NLR, MLR, and NMLR were analyzed and compared with clinical and bacteriological TB diagnosis (TCM/BTA). Of the 219 children who met the inclusion criteria, NLR showed a sensitivity of 82.3%, specificity of 78.7%, PPV of 84.9%, NPV of 75.3%, and accuracy of 80.8%. MLR showed a sensitivity of 80.8%, specificity of 75.3%, PPV of 82.7%, NPV of 72.8%, and accuracy of 78.5%. NMLR showed a sensitivity of 76.9%, specificity of 66.3%, PPV of 76.9%, NPV of 66.3%, and accuracy of 72.6%. These ratios were significantly associated with TB diagnosis (p < 0.05). The most common clinical symptoms found in positive cases included persistent cough, prolonged fever, weight loss, and night sweats. NLR, MLR, and NMLR demonstrate good diagnostic value in supporting the diagnosis of TB in children. NLR showed the most optimal results, followed by MLR and NMLR. These hematological ratios can be used as quick, inexpensive, and easily accessible diagnostic aids, especially in facilities with limited bacteriological testing capabilities.
Comparison of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Pediatric Acute Lymphoblastic Leukemia Patients Before and After Induction Chemotherapy M. Arie Wibisono; Olga Rasiyanti Siregar; Fera Wahyuni; Juliandi Harahap; Bidasari Lubis; Fathia Meirina
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.552

Abstract

Acute Lymphoblastic Leukemia (ALL) is the most common hematologic malignancy in children. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple inflammatory biomarkers that may serve as prognostic and therapeutic response indicators. The aim of this research is to evaluate the differences in NLR and PLR before and after induction chemotherapy and to determine optimal cut-off values for predicting treatment response in pediatric ALL patients. An observational analytic study with a retrospective design was conducted on 48 pediatric ALL patients at Adam Malik General Hospital, Medan. Data were obtained from medical records between January 2023 and December 2024. Consecutive sampling was applied on this study. The Wilcoxon test was applied to assess differences in NLR and PLR, while ROC analysis was used to determine cut-off values, sensitivity, and specificity. Most patients were under 10 years of age (66.7%) and male (58.3%). Following induction chemotherapy, 87.5% achieved complete remission. Significant differences in NLR and PLR were observed before and after therapy (p<0,001). The optimal cut-off for NLR was 2.33 (sensitivity 45.2%, specificity 83.3%), while for PLR it was 219.98 (sensitivity 42.9%, specificity 83.3%). NLR and PLR significantly changed after induction chemotherapy in pediatric ALL patients. Despite limited sensitivity, both markers may serve as simple hematological tools for evaluating treatment response.
Pneumonia among Children with Congenital Heart Disease: Patterns by Shunt Type in A Tertiary Hospital in Indonesia Aris Bayu Retnaningsih Alisyah Maria; Putri Amelia; Fathia Meirina; Juliandi Harahap; Lily Irsa; Olga Rasiyanti Siregar
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1297

Abstract

Congenital Heart Disease (CHD) in children is frequently associated with lower respiratory tract infections, particularly pneumonia. Pneumonia risk in CHD is influenced by shunt type, defect size, nutritional status, yet local data regarding these associations remains limited. To determine the incidence of pneumonia in children with CHD and to analyze its association with shunt type and defect size. This retrospective cross-sectional study consecutively extracted demographic and clinical data—including CHD shunt type and defect size, nutritional status, and pneumonia diagnosis—from 134 echocardiography-confirmed medical records of hospitalized and outpatient pediatric CHD treated at Adam Malik General Hospital, Medan, from January 2022 to December 2024. Data associations were analyzed using Chi-square or Fisher’s exact tests, and prevalence ratios (PR) were calculated. Pneumonia occurred in 32.8% (44/134) of children with CHD. A higher proportion of pneumonia was observed in acyanotic CHD compared with cyanotic CHD (40.3% vs. 25.4%; PR 1.57; p = 0.066). Among acyanotic CHD, pneumonia was more frequent in children with large defects than in those with moderate to small defects (47.0% vs. 38.0%; PR 1.24; p = 0.511). Pneumonia is a frequent complication in children with CHD. Acyanotic CHD and larger defect size show a tendency toward increased pneumonia risk, although no statistically significant associations were identified.
Co-Authors Aris Bayu Retnaningsih Alisyah Maria Bidasari Lubis Fadhliani Putri Mayasri Fera Wahyuni Hendri Wijaya Juliandi Harahap Lily Irsa M Ridho M. Arie Wibisono Mahrani Lubis Nindy Putri Ferisa Olga Rasiyanti Siregar Pertin Sianturi Putri Amelia Putri Amelia Ranti Permatasari Rina Amelia Rini Savitri Daulay Rini Savitri Daulay Rita Evalina Siska Mayasari Lubis Winra Pratita Wisman Dalimunthe Yogi Zulkifli