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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Rasyid, Riana Sari Puspita
Universitas Sriwijaya
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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THE EXPRESSION OF NFATC1 IS MORE PREDOMINANT IN TRIPLE NEGATIVE BREAST CARCINOMA PATIENTS Riana Sari Puspita Rasyid; Krisna Murti; Zen Hafy
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 1 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I1.14137

Abstract

Breast carcinoma is the most common malignancy among women in developed and developing countries. Invasive breast carcinomas are classified into 4 subtypes i.e. luminal A and B, human epidermal growth factor receptor 2 (HER2)-enriched and triple negative, the latter has the worst prognosis. Nuclear factor of activated T cell (NFATc)1 is an important transcription factor in malignant transformation and progression. Therefore, NFATc1 expression may determine prognosis of breast carcinoma. This study aimed to determine the roles of NFATc1 inbreast carcinoma progression. Materials and Methods  Fifty-two paraffin blocks were selected and prepared to assess NFATc1 expression by immunohistochemistry. These data were taken from medical records: i.e. molecular classification, patient age, tumor size, lymphovascular invasion and grade of tumor were recorded. Results: Positive NFATc1 expression was observed in 4 samples i.e. in the nuclei of luminal A (1 out of 12; 8.8%), luminal B (1 out of 15; 6.7%), and triple negative (2 out of 12; 16.7%), but no NFATc1 expression was detected in HER2-enriched samples. Clinicopathologically, more of these patients were in the fifth decade (38.5%), with larger tumor size (?2 cm; 90%), lymphovascular invasion positive (80.8%), and high degree (3; 59.6%). Conclusion: NFATc1 expression is more predominant in triple negative breast carcinoma.
Gambaran Histologi Ketebalan Jaringan Granulasi Pada Tikus Wistar Jantan dengan Luka Bakar Setelah Pemberian Ekstrak Kayu Manis (Cinnamomun burmanii) Riana Sari Puspita Rasyid; Iche Andriyani Liberty; Subandrate Subandrate
JURNAL KEDOKTERAN DAN KESEHATAN Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V7I1.7609

Abstract

Luka bakar merupakan salah satu cedera yang sering terjadi di masyarakat dan menjadi masalah global di masyarakat. Penyembuhan luka adalah suatu bentuk proses usaha untuk memperbaiki kerusakan yang terjadi pada kulit. Pembentukan jaringan granulasi adalah tahap yang penting dalam fase proliferasi dan penyembuhan luka.Saat ini, selain menggunakan obat modern seperti antibiotika silver sulfadiazine 1%, penelitian untuk pengobatan luka bakar menggunakan bahan-bahan herbal mulai banyak dilakukan oleh para peneliti. Salah satu bahan herbal yang digunakan untuk mengobati luka adalah Kayu Manis (Cinnamomun Burmanii).Hasil penelitian ini diharapkan dapat menjadi inovasi baru pemanfaatan kayu manis sebagai penyembuh luka dan dapat dikembangkan sebagai terapi komplementer yang efektif dan efisien. Tujuan penelitian ini untuk mengetahui efektifitas penggunaan Silver Sulfadiazine 1%  Dibandingkan Kayu Manis (Cinnamomun Burmanii)pada Proses Pembentukan Jaringan Granulasi Tikus Wistar dengan Luka Bakar Derajat II.Penelitian ini merupakan studi eksperimentalmenggunakan rancangan penelitian post test only control group designyangdilaksanakan pada bulan September-November 2018 di Laboratorium Teknik Kimia Universitas Sriwijaya, di Animal HouseFakultas Kedokteran Unsri dan Laboratorium Patologi RSUP dr.Mohammad Hoesin Palembang. Sampel yang digunakan adalahtikus putih sebanyak 30 sampeldibagi menjadi 5 kelompok perlakuan yaitu I (kontrol negatif), II (diberikan salep ekstrak kayu manisdosis 10%), III (dosis 20%), IV (dosis 40%) dan V (kelompok kontrol positif diberikanSilver Sulfadiazine 1%). Data dianalisisdengan menggunakan program STATA 15 yaitu dengan uji homogenitas, uji OneWay Anovadan dilanjutkan uji post hoc multiple comparisons. 
Antibacterial Activity of Cinnamon Extract (Cinnamomum burmannii) against Staphylococcus aureus and Escherichia coli In Vitro Nita Parisa; Rahma Nur Islami; Ella Amalia; Mariana Mariana; Riana Sari Puspita Rasyid
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 2 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i2.85

Abstract

Abstract Infectious disease is one of the most common diseases in the world. Staphylococcus aureus and Escherichia coli are two common causes of infection and are resistant to many antibiotics, so the new agents are needed to overcome antibiotic resistance. Cinnamon is often used as a preservative because it has antibacterial activity. Cinnamomum burmannii is kind of native cinnamon from Indonesia. The antimicrobial active compounds cinnamaldehyde and eugenol are the main reasons for its antibacterial activity. This study observed the efficacy of the cinnamon extract (Cinnamomum burmannii) as antibacterial against Staphylococcus aureus and Escherichia coli. An experimental study, in vitro using Post-test Only Control Group Designed, has been done in Microbiology and Biotechnology Laboratory of Medical Faculty of Sriwijaya University. Cinnamon was extracted, then tested for its antibacterial activity using well diffusion and serial dilution to determine diameter of inhibition zone and minimum bactericidal concentration. Phytochemical tests were also conducted to determine the antibacterial compounds of cinnamon extract. Ethanol extract of cinnamon was able to inhibit the growth of Staphylococcus aureus with MBC 5% and inihibitory zone 6,84±0,68 mm and Escherichia coli with MBC 10% and inhibitory zone 5,69±0,69 mm. Cinnamon extract which has the greatest effectiveness is concentration of 40% with inhibition zone 15,69±0,80 mm (Staphylococcus aureus) and 9,63±0,59 mm (Escherichia coli). This ability is due to the antibacterial compounds as evidenced by positive results in various phytochemical tests. Cinnamon extract is effective as antibacterial against Staphylococcus aureus and Escherichia coli in vitro. Keywords: efficacy, antibacterial, Cinnamomum burmannii, Staphylococcus aureus, Escherichia coli
Antibacterial Activity of Cinnamon Extract (Cinnamomum burmannii) against Staphylococcus aureus and Escherichia coli In Vitro Nita Parisa; Rahma Nur Islami; Ella Amalia; Mariana Mariana; Riana Sari Puspita Rasyid
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 3 No. 2 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v3i2.85

Abstract

Abstract Infectious disease is one of the most common diseases in the world. Staphylococcus aureus and Escherichia coli are two common causes of infection and are resistant to many antibiotics, so the new agents are needed to overcome antibiotic resistance. Cinnamon is often used as a preservative because it has antibacterial activity. Cinnamomum burmannii is kind of native cinnamon from Indonesia. The antimicrobial active compounds cinnamaldehyde and eugenol are the main reasons for its antibacterial activity. This study observed the efficacy of the cinnamon extract (Cinnamomum burmannii) as antibacterial against Staphylococcus aureus and Escherichia coli. An experimental study, in vitro using Post-test Only Control Group Designed, has been done in Microbiology and Biotechnology Laboratory of Medical Faculty of Sriwijaya University. Cinnamon was extracted, then tested for its antibacterial activity using well diffusion and serial dilution to determine diameter of inhibition zone and minimum bactericidal concentration. Phytochemical tests were also conducted to determine the antibacterial compounds of cinnamon extract. Ethanol extract of cinnamon was able to inhibit the growth of Staphylococcus aureus with MBC 5% and inihibitory zone 6,84±0,68 mm and Escherichia coli with MBC 10% and inhibitory zone 5,69±0,69 mm. Cinnamon extract which has the greatest effectiveness is concentration of 40% with inhibition zone 15,69±0,80 mm (Staphylococcus aureus) and 9,63±0,59 mm (Escherichia coli). This ability is due to the antibacterial compounds as evidenced by positive results in various phytochemical tests. Cinnamon extract is effective as antibacterial against Staphylococcus aureus and Escherichia coli in vitro. Keywords: efficacy, antibacterial, Cinnamomum burmannii, Staphylococcus aureus, Escherichia coli
KARAKTERISTIK EKSPRESI CD163 PADA TUMOR GANAS OVARIUM Soilia Fertilita; Riana Sari Puspita Rasyid; Raissa Nurwany; Wresnindyatsih Wresnindyatsih; Shafa Larasaty; Antania Phelia Zen
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I3.19107/19168

Abstract

Immune checkpoint blcokade therapy yang menjadi kandidat terapi kanker menjanjikan, menunjukkan rata-rata respon yang rendah pada kanker ovarium. Hal ini disebakan karena heterogenesitas lingkungan mikronya. Makrofag merupakan sel imun yang ditemukan di lingkungan mikro tumor ganas ovarium, salah satu subtipenya adalah M2 yang merupakan fraksi infiltrasi terbesar di lingkungan mikro tumor kanker ovarium, bersifat protumor dan mengekspresikan CD163. Mengetahui karakteristik ekspresi CD163 pada berbagai subtipe tumor ganas ovarium dengan karakter klinis berbeda dapat membantu dalam menentukan prognosis dan target terapi pada tumor ganas ovarium. Sampel penelitian adalah 60 blok parafin jaringan tumor ganas ovarium. Blok parafin diproses untuk membuat preparat jaringan, pewarnaan hematoksilin eosin dan imunohistokimia. Penghitungan sel yang mengekspresikan CD163 dilakukan di area stroma dan intratumoral pada 10 lapang pandang besar untuk setiap sampel. Hasil positif pada pewarnaan imunohistokimia diperoleh jika sitoplasma terwarnai coklat. Data karakteristik jaringan dan klinis pasien diperoleh dari rekam medis dan hasil pembacaan dokter spesialis patologi anatomi. Hasil penelitian ditemukan ekspresi CD163 area stroma relatif lebih tinggi jika dibandingkan area intra tumoral kecuali pada subtipe LGSC dan terdapat hubungan yang bermakna antara ekspresi CD163 pada stroma dengan stadium tumor ganas ovarium. 
Co-Authors ., Mariana Ali Djamhuri Antania Phelia Zen Ardesy Melizah Kurniati Ella Amalia, Ella Iche Andriyani Liberty, Iche Andriyani Krisna Murti Martadiansyah, Abarham Nita Parisa Oswari, Liniyanti D Rahma Nur Islami Raissa Nurwany Shafa Larasaty Soilia Fertilita Subandrate Syarif Husin Trisa, Yusdela Wardatu, Aggra Wresnindyatsih Wresnindyatsih Zen Hafy