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Soilia Fertilita
Fakultas Kedokteran Universitas Sriwijaya Palembang
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The Cytotoxic Activity of Annona muricata Linn Leaves Ethanolic Extract (AMEE) on T47D Breast Cancer Cell Line Soilia Fertilita; Willy Sandhika; Desak Gede Agung Suprabawati
Medical Laboratory Technology Journal Vol. 6 No. 1 (2020): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1113.168 KB) | DOI: 10.31964/mltj.v6i1.291

Abstract

Breast cancer is the most common cancer in women throughout the world, with new cases and deaths which continue to increase. Soursop leaves (Annona muricata L) have been used extensively in traditional medicine, including cancer. Acetogenin, alkaloids, and phenols contained in soursop leaves are known to have anti-cancer effects. Among them, acetogenin has the most dominant role and reported to have a cytotoxic effect on various cancer cell lines. This study aims to determine the cytotoxic activity of soursop leaf ethanol extract on T47D breast cancer cell line. Measurement of cytotoxic activity was carried out by the MTT method, and the viability percentage of T47D cells was calculated based on the absorbance values in the treatment, cell control, and media control groups of each replicate. The correlation between extract concentration and viability percentage of the T47D cell line was outlined in the regression equation to obtain the IC50 value. IC50 values of 109.91 ± 3.04 with R values 0.975 and R2 0.9508 obtained. R values close to 1 indicated a strong correlation between extract concentration and the percentage of living T47D cells. Meanwhile, the amount of R2 suggested that the level of AMEE had a 95.08% influence on the rate of cell viability, and the other 4.92% influenced by factors other than the AMEE dose. These results indicated that the ethanol extract of soursop leaves has a cytotoxic effect and has the potential to inhibit T47D cell proliferation in vitro.
The Standardization of Ethanolic Extract of Tahongai Leaves (Kleinhovia hospita L.) Indah Solihah; Mardiyanto Mardiyanto; Soilia Fertilita; Herlina Herlina; Oktia Charmila
Science and Technology Indonesia Vol. 3 No. 1 (2018): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.941 KB) | DOI: 10.26554/sti.2018.3.1.14-18

Abstract

Extract is basic material for herbal drug. The formulation of herbal drugs requires consistent of biological activity, a consistent chemical profile, or simply a quality assurance programs that can be achieved by standardizing extracts. The leaves of tahongai (Kleinhovia hospita L.) have been traditionally used in Komering tribes as phytotherapy to cure the inflammation related diseases including cancer, furuncles, polyps and tonsillitis. The aim at this study was to standardize the quality of tahongai leaves ethanolic extract by determining the specific and non specific parameters of ethanolic extract of Tahongai leaves (Kleinhovia hospita L.). The Preliminary phytochemical analysis revealed presence of alkaloids, flavonoids, saponins, tanins, and steroids in extract. The result of specific parameters extracts showed that the organoleptic properties of ethanolic extract of tahongai leaves were thick, brownish black in color, has characteristic odor, astringent with slightly bitter taste, the water and ethanol soluble extractive content were 19.263% ± 0.95 and 18.30% ± 0.51 respectively. The non specific parameters of tahongai leave ethanolic extract showed the density of extract was 1.413 g/mL ± 0.04, the water content value of 21.16% ± 0.55, total ash content 15.64% ± 0.75, acid insoluble ash content 8.282% ± 0.28, Pb contamination content 3,67 ppm, Cd contamination content <0,0043 ppm, total bacteria contamination 90.5 x 101 colony/g, and the total mold and yeast contamination of 1 x 101 colony/g.
Maintaining Healthy Skin During COVID-19 Pandemic Venny Larasati; Soilia Fertilita
Conferences of Medical Sciences Dies Natalis Vol. 2 No. 1 (2020): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.86 KB)

Abstract

The Covid-19 pandemic has brought several changes to people's routine habits. Educating the public about the importance of washing and disinfecting hands as often as possible and the use of personal protective equipment such as masks, googles or face shields to avoid disease transmission and sunbathing habits to get the benefits of sunlight for health and the immune system has an impact on behavior changes on the community. These new habits can bring a negative effect to the skin. The use of disinfectants and personal protective equipment can cause allergic dermatitis, contact dermatitis, skin maceration, secondary fungal infection and acne. Sunbathing can cause changes in skin pigmentation, the appearance of black spots, the skin looks dull and rough and accelerates the appearance of premature wrinkles on the skin. Proper skin care routine during this pandemic situation is essential to maintain skin healthy and avoid skin problems due to the use of disinfectants or PPE. The use of emollients, moisturizers and barrier creams can prevent skin problems to happen. Skin moisturizers can be used regularly after hand washing and before using personal protective equipment. When it comes to maintaining healthy skin during pandemic, skin care routine consists of facial cleansers, toners, moisturizers, serums, morning creams and night creams are also recommended to keep the skin healthy and slow the appearance of premature aging signs on the skin. This activity aims to provide a better understanding to people especially worker how to prevent skin problems and how to maintain healthy skin during pandemic.
EDUCATIONAL VIDEO RELATED TO COVID-19 AND VACCINATION FOR THE COMMUNITY Zen Hafy; Venny Larasati; Soilia Fertilita; Dwi Handayani
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.932 KB)

Abstract

One of the efforts being promoted by WHO to prevent Covid-19 is vaccination. Vaccination aims to prevent the symptoms of a disease caused by pathogenic infection. In some cases, vaccination does not prevent infection but can limit the consequences of the infection. Some of the obstacles encountered in the community include the lack of public knowledge about vaccination, a lot of negative news that develops in the community about vaccination, and the availability of vaccines for the community is still limited. Efforts to educate the public have been carried out to increase public awareness about the benefits of vaccination, either through direct counseling by agencies engaged in the health sector or through social media. Such efforts need to be carried out massively and continuously so that education can reach all levels of society. This community service activity program is carried out by producing educational videos that will target all population levels to provide information about Covid-19 management and clarifications on some most common incorrect information or even myths about Covid-19 vaccination and give the public in Indonesia a chance to learn the facts about the Covid-19 vaccine.
HUBUNGAN KEBIASAAN OLAHRAGA DENGAN KADAR ANTIBODI IMMUNOGLOBULIN G SETELAH VAKSINASI COVID 19 Veny Larasati; Rohan Sabloak; Riana Sari Puspita Rasyid; Eka Febri Zulissetiana; Susilawati Susilawati; Soilia Fertilita
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I1.19620

Abstract

Kebiasaan olahraga identik dengan konsep FITT (Frequency, Intensity, Type, Time) untuk menentukan efektifitas dari olahraga yang dilakukan. Sistem imun tubuh responsif terhadap kebiasaan berolahraga sehingga mampu meningkatkan respon imun terhadap antigen penyusun yang terdapat di dalam vaksin. Tujuan dari penelitian ini yaitu mengetahui hubungan antara kebiasaan olahraga dengan respon imun pasca vaksinasi COVID-19 di Kota Palembang. Penelitian ini menggunakan pendekatan cross sectional terhadap individu yang mendapatkan inactivated vaccine COVID-19 dosis kedua, dengan pengambilan sampel secara consecutive sampling dengan 78 sampel. Data pada penelitian diambil dengan wawancara mengenai kebiasaan olahraga 1 bulan sebelum vaksinasi, serta dilakukan pengambilan sampel darah vena sebanyak 5 cc pada ±28-30 hari setelah vaksinasi kedua. Darah diproses menjadi serum untuk pemeriksaan kadar IgG anti s1 RBD SARS-CoV-2 menggunakan kit produksi Abbott dengan metode CMIA. Analisis data pada penelitian ini menggunakan uji Pearson’s Chi-squared atau uji Fisher’s Exact dan/atau uji penggabungan sel sebagai alternatif. Pada penelitian ini distribusi frekuensi sampel dominan pada usia dewasa muda (56,4%), jenis kelamin perempuan (52,6%) dan kadar IgG rendah (52,6%). Interval kadar IgG pada sampel adalah 42,1 – 12971,3 AU/mL, dengan rata-rata kadar IgG 1494,95 AU/mL dan median 794,35 AU/mL. Sebaran data dominan pada kelompok dengan kebiasaan olahraga (64,1%), frekuensi olahraga kurang ideal (33,3%), jenis olahraga aerobik (59%), intensitas olahraga ringan (46,2%), dan durasi olahraga sangat lama (20,5%). Tidak diperoleh hubungan yang signifikan antara kebiasaan olahraga olahraga (frekuensi, jenis, intensitas dan durasi olahraga) dengan respon imun pasca vaksinasi (P value > 0,05). Kata kunci: Kebiasaan olahraga, latihan fisik, frekuensi, jenis, intensitas, durasi, Respon Imun, COVID-19, IgG, dan vaksin inaktif.
KARAKTERISTIK EKSPRESI CD163 PADA TUMOR GANAS OVARIUM Soilia Fertilita; Riana Sari Puspita Rasyid; Raissa Nurwany; Wresnindyatsih Wresnindyatsih; Shafa Larasaty; Antania Phelia Zen
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I3.19107/19168

Abstract

Immune checkpoint blcokade therapy yang menjadi kandidat terapi kanker menjanjikan, menunjukkan rata-rata respon yang rendah pada kanker ovarium. Hal ini disebakan karena heterogenesitas lingkungan mikronya. Makrofag merupakan sel imun yang ditemukan di lingkungan mikro tumor ganas ovarium, salah satu subtipenya adalah M2 yang merupakan fraksi infiltrasi terbesar di lingkungan mikro tumor kanker ovarium, bersifat protumor dan mengekspresikan CD163. Mengetahui karakteristik ekspresi CD163 pada berbagai subtipe tumor ganas ovarium dengan karakter klinis berbeda dapat membantu dalam menentukan prognosis dan target terapi pada tumor ganas ovarium. Sampel penelitian adalah 60 blok parafin jaringan tumor ganas ovarium. Blok parafin diproses untuk membuat preparat jaringan, pewarnaan hematoksilin eosin dan imunohistokimia. Penghitungan sel yang mengekspresikan CD163 dilakukan di area stroma dan intratumoral pada 10 lapang pandang besar untuk setiap sampel. Hasil positif pada pewarnaan imunohistokimia diperoleh jika sitoplasma terwarnai coklat. Data karakteristik jaringan dan klinis pasien diperoleh dari rekam medis dan hasil pembacaan dokter spesialis patologi anatomi. Hasil penelitian ditemukan ekspresi CD163 area stroma relatif lebih tinggi jika dibandingkan area intra tumoral kecuali pada subtipe LGSC dan terdapat hubungan yang bermakna antara ekspresi CD163 pada stroma dengan stadium tumor ganas ovarium. 
C-Reactive Protein as The Predictor of Mortality for COVID-19 Patients in Indonesia Astari Rahayu Afifah; Phey Liana; Soilia Fertilita; Nelda Aprilia Salim; Verdiansah Verdiansah; Fadhilatul Hilda; Chris Alberto Amin; Tungki Pratama Umar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1997

Abstract

Coronavirus Disease 2019 (COVID-19) confirmed cases and deaths continue to rise. When a virus infects the body, the immune system tries to eliminate the virus. C-Reactive Protein (CRP) is a substance produced in the body in response to infection and inflammation. The study aimed to determine the role of CRP in predicting COVID-19 patients’ mortality. From the 1st of March to the 31st of August 2020, data on patients confirmed with COVID-19 were collected from medical records. The correlation between CRP levels and patient mortality was determined using a Chi-Square test. A Receiver Operator Curve (ROC) analysis was used to determine the best CRP cut-off point, and a survival analysis was used to assess the patient outcome. This study included a total of 210 eligible patients. Survivors and non-survivors were divided into two groups of patients (159 patients and 51 patients, respectively). The CRP cut-off was 54 mg/L, with an AUC of 0.817 (p<0.001). C-reactive protein levels were related to COVID-19 patient mortality (p=0.000). According to the survival analysis, patients with CRP levels > 54 mg/L had a lower chance of 30-day survival (p=0.0001). This study presented that CRP levels can be used to predict mortality in COVID-19 patients.
Edukasi Kondisi Sindrom Metabolik dan Upaya Pencegahannya Dengan Tepung Ubi Jalar Ungu di Desa Ulak Kerbau Baru Indah Solihah; Shaum Shiyan; Rianasari Puspita Rasyid; Soilia Fertilita
Jurnal Pengabdian Pada Masyarakat Vol 8 No 3 (2023): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v8i3.460

Abstract

Gaya hidup kurang gerak dikombinasikan dengan asupan kalori yang berlebihan menghasilkan penyimpanan energi ekstra sebagai lemak. Prevalensi sindrom metabolik diperkirakan akan berkembang secara substansial dalam skala global. Pasien dengan sindrom metabolik memiliki resiko terkena stroke 3-4x lebih besar. Sebanyak 34% penduduk di Ulak Kerbau Baru memperoleh penghasilan dari pertanian dan perkebunan. Ubi jalar ungu mengandung jauh lebih banyak antosianin daripada ubi jalar kuning dan putih. Antosianin dapat menjaga kesehatan dan menurunkan bahaya penyakit degeneratif, aktivitas antikanker, kapasitas antioksidan, aktivitas antiulcer, dan gangguan kardiovaskular. Pemahaman masyarakat tentang manfaat ubi ungu bagi kesehatan masih terbatas. Program pengabdian masyarakat dengan sistem perkuliahan desa dapat menjadi sarana peningkatan pemahaman masyarakat. Kegiatan pengabdian dilakukan dengan metode penyuluhan dan demo pembuatan produk pangan sehat yang berbahan dasar tepung ubi jalar ungu. Peningkatan persentase jawaban dari pre-test (33,913%) ke post-test (87,273%) menunjukkan bahwa informasi diterima dengan baik oleh masyarakat desa Ulak Kerbau Baru. Hasil penilaian organoleptik masyarakat dimana mayoritas responden menilai suka dan sangat suka pada produk olahan tepung ubi jalar ungu dengan parameter rasa, aroma, tekstur, warna, dan bentuk. A sedentary lifestyle combined with an excessive caloric intake results in the storage of extra energy as fat. The prevalence of metabolic syndrome is predicted to expand substantially on a global scale. Patients with metabolic syndrome have a 3-4 times increased risk of having a stroke. The majority of residents in Ulak Kerbau Baru derive their income from agriculture and plantations. Purple sweet potatoes contain far more anthocyanins than their orange and white counterparts. Anthocyanins can preserve health and lower the danger of degenerative diseases, anticancer activity, antioxidant capacity, antiulcer activity, and cardiovascular disorders. The public's understanding of the health benefits of purple sweet potato remains limited. Through this community service program and the village lecture plan, it is anticipated that public awareness of metabolic syndrome disease will rise. Using lecture approaches that are integrated with electives courses in Traditional Medicine, knowledge is enhanced. The increase in the percentage of accurate responses from the pre-test (33,913%) to the post-test (87,273%) indicates that the information is well received by the general population. The results of the organoleptic assessment of the community, in which the majority of respondents rated the parameters of taste, scent, texture, colour, and shape of the product as like or liking very much, indicate that people prefer the processed items that are produced.
STATUS ANEMIA TIDAK BERHUBUNGAN DENGAN SUBTIPE DIFFUSE LARGE B-CELL LYMPHOMA Angga Febriyanto; Krisna Murti; Soilia Fertilita
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 3 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I3.22336

Abstract

AbstrakDiffuse large B-cell lymphoma (DLBCL) merupakan neoplasma sel-B sedang atau besar yang pola pertumbuhanya secara difus dengan inti besar. Sekitar 30-40 % kasus limfoma merupakan DLBCL. Berdasarkan fiturmolekuler dan cell of origin (COO), DLBCL dibagi menjadi subtipegerminal center B-cell (GCB) dan activated B-cell (ABC) / non-germinal center B-cell (non-GCB). Anemia menjadi salah satu kondisi klinis yang seringmenyertai limfoma. Anemia pada limfoma dikaitkan dengan prognostik yang lebihburuk. Tujuan penelitian ini untuk mengetahui hubungan subtipe molekular DLBCL dengan anemia. Penelitian ini adalah jenis penelitian cross-sectional, dengan sampel adalah semua pasien yang terdiagnosis DLBCL di RSUP Dr. Mohammad Hoesin Palembang tahun 2017-2021 sesuai kriteria yang ditentukan. Data Hb yang diambil adalah hasil pemeriksaan Hb paling awal pasien sebelum dilakukan biopsi. Dari 93 sampel, kasus DLBCL tinggi pada kelompokusia<60 tahun (64,5%), jenis kelaminlaki-laki (58,1%), lokasi ekstranodal (72%), varian sentroblastik (75,3%), dan subtipe non-GCB (75,3%). Anemia terjadi pada 76,3% kasus. Derajat mild (69%) memiliki proporsi yang paling tinggi. Tidak terdapat hubungan yang signifikan antara subtipe molekular DLBCL baik dengan status anemia (p= 0,97) maupun dengan derajat anemia (p= 0,97). Berdasarkan hasil penelitian, tidak terdapat hubungan yang bermakna subtipe molekular DLBCL dengan status anemia dan derajat anemia.Kata Kunci: DLBCL, SubtipeMolekular, GCB, Non-GCB, Anemia.
Association Between Patient Characteristics and Histopathological Features of Lung Cancer At RSUP Dr. Mohammad Hoesin Palembang Isnani Nur I; Susilawati Susilawati; Soilia Fertilita
Biomedical Journal of Indonesia Vol. 9 No. 2 (2023): Vol 9, No 2, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i2.149

Abstract

Introduction. Lung cancer is the uncontrolled growth of malignant cells by the body in lung tissue and is caused by genetic mutations and changes in protein synthesis in normal cells. Histopathological features of lung cancer include squamous cell carcinoma, adenocarcinoma, small cell carcinoma, and other types. Early detection, as well as prevention, needs to be done in high-risk communities with the aim of reducing the number of events. This study aims to determine the relationship between sociodemographic factors and histopathological features of lung cancer. Methods. This study is an analytic observational study with a cross-sectional design. The research sample is in the form of secondary data from the Department of Anatomical Pathology and Medical Record Installation for 2019-2021. The research was conducted at Dr. Mohammad Hoesin Palembang. The sampling technique was carried out by total sampling. Results. Most of the respondents were in the age group >45 years (84.1%), male (78.3%), had no history of smoking (60.9%), the predominant main complaint was shortness of breath (63, 8%), the most common histopathological picture is adenocarcinoma. There was no significant relationship between age (p=0.998), gender (p=0.736), smoking history (p=0.572) and histopathological features of lung cancer patients. Conclusion. There was no significant relationship between age, sex and smoking status on the histopathological features of lung cancer.
Co-Authors Angga Febriyanto Antania Phelia Zen Antania Phelia Zen Astari Rahayu Afifah Chris Alberto Amin Dwi Handayani Eka Febri Zulissetiana Fadhilatul Hilda Herlina Herlina Indah Solihah Isnani Nur I Krisna Murti Larasati, Veny Mardiyanto Mardiyanto Muhammad Farhan Nelda Aprilia Salim Oktia Charmila Phey Liana Raissa Nurwany Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Rianasari Puspita Rasyid Rohan Sabloak Shafa Larasaty Shaum Shiyan Suprabawati, Desak Gede Agung Susilawati Susilawati Susilawati Susilawati Tri Suciati Tungki Pratama Umar Venny Larasati Venny Larasati Verdiansah Verdiansah Willy Sandhika Wresnindyatsih Wresnindyatsih Zen Hafy