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Ekspresi p16 dan CDK4 pada Berbagai Stadium T Karsinoma Laring Diana Purnamasari; Dyah Fauziah
Majalah Patologi Indonesia Vol 29 No 1 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (302.885 KB) | DOI: 10.55816/mpi.v29i1.404

Abstract

BackgroundDefect in cell cycle control affect cell proliferation and play an important role in pathogenesis of cancer. Recently, some proteins areknown to have an influence in cell cycle proliferation. P16 and CDK4 may have influenced in laryngeal carcinoma. CDK4, anoncogene, can form cyclin D1-CDK4 complex that inactivates pRb so that the cell cycle goes from G1 phase to S phase. P16, atumor suppressor protein, can prevent cyclin D1-CDK4 complex so that inhibit cell proliferation.MethodsThis research was an observational analysis study with paraffin block samples, consists of 3 samples of stage T1 and each 10samples of stage T2, T3 and T4 in Laboratory of Anatomical Pathology of RSUD dr. Soetomo that was collected from 2013-2015.Samples were stained with antibody of p16 and CDK4. P16 and CDK4 expression were assessed based on the percentage andintensity of tumor cells that were stained. The differences between variables were analyzed by Kruskal-Wallis. The correlationbetween variables was analyzed by Spearman correlation test.ResultsP16 expression of carcinoma larynx T1 (88.33±7.64), T2 (85.00±5.27), T3 (61.00±21.83), and T4 (62.00±25.30). Besides CDK4expression of carcinoma larynx T1 (43.33±15.28), T2 (47.00±14.18), T3 (75.00±8.50), and T4 (70.00±9.43). Statistic analysisshowed significant differences between p16 and CDK4 expression on each stade of carcinoma larynx (p=0.017 and p=0.000). Andthere were corelation between p16 and CDK4 expression on each stage of carcinoma larynx (p=0.000 and p=0.000).ConclusionThe lower p16 expression and the higher CDK4 expression showed the higher stage of carcinoma larynx.
The Influence Of Financial Innovation And Financial Ratio On The Financial Performance Of The Banking Sector Diana Purnamasari
Jurnal Perbankan Syariah Vol 4 No 1 (2024): JUNI
Publisher : Program Studi Perbankan Syariah, Fakultas Ekonomi dan Bisnis Islam, Institut Agama Islam Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51675/jib.v4i1.826

Abstract

Financial performance involves analyzing how well a company adheres to financial regulations and standards. This study investigates the impact of financial innovation and financial ratios on the performance of banking companies from 2009 to 2018. The research employs a descriptive approach with quantitative methods, utilizing secondary data. Purposive sampling is the chosen sampling method. Data analysis is conducted using panel regression analysis techniques, which include the Chow test, Hausman test, Lagrange multiplier test, classical assumption test, and partial regression test. The findings indicate that the NPL ratio has a significant negative effect on ROA, the LDR ratio has a significant positive effect on ROA, while the financial innovation variable and CAR had no effect on ROA
PENGUKURAN FINANCIAL DISTRESS MENGGUNAKAN METODE ALTMAN Z-SCORE DAN SPRINGATE S-SCORE PADA PERUSAHAAN FOOD AND BEVERAGE YANG TERDAFTAR DI BURSA EFEK INDONESIA Purnamasari, Diana; Siswoyo, Siswoyo; Wahyudin, Roviq
Brainy: Jurnal Riset Mahasiswa Vol 5 No 2 (2024): Jurnal Riset Ekonomi dan Bisnis Mahasiswa Edisi Desember 2024
Publisher : Fakultas Ekonomi dan Bisnis Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/brainy.v5i2.115

Abstract

Penelitian ini berorientasi untuk mengidentifikasi tingkat Financial Distress pada perusahaan subsektor makanan dan minuman yang terindeks di Bursa Efek Indonesia (BEI) dengan mengimplementasikan pendekatan Altman Z-Score dan Springate S-Score. Penelitian ini mengimplementasikan pendekatan deskriptif kuantitatif. Populasi penelitian mencakup 24 perusahaan subsektor makanan dan minuman yang terindeks di BEI sepanjang periode 2019–2022, menghasilkan total 44 data observasi sebagai sampel. Hasil analisis dengan pendekatan Altman Z-Score menampilkan jika dari total sampel, 14 perusahaan menempati situasi distress, 6 perusahaan menempati di grey area, dan 24 perusahaan tidak menghadapi Financial Distress. Sementara itu, analisis mengimplementasikan pendekatan Springate S-Score menampilkan 13 perusahaan menempati situasi distress, sementara 31 perusahaan tidak menghadapi Financial Distress.
Peran Permodalan dalam Meningkatkan Efisiensi Biaya melalui Pengaruh Suku Bunga dan Inflasi di Sektor Perbankan Diana Purnamasari; Muslim, Dzurotun Khanifah; Wardah Sukriya
Jurnal Perbankan Syariah Vol 5 No 1 (2025): JUNI
Publisher : Program Studi Perbankan Syariah, Fakultas Ekonomi dan Bisnis Islam, Institut Agama Islam Nahdlatul Ulama Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51675/jib.v5i1.1119

Abstract

Banks are financial intermediary institutions, therefore in a country a bank is needed that can carry out its functions properly and operate optimally. This study aims to determine the effect of capital, interest rates and inflation on bank cost efficiency in banks going public in 2021-2024. The data used is secondary data obtained through the idx.co.id website. The data analysis method used is multiple linear regression. The results of this study indicate that simultaneously capital, interest rates, and inflation have a significant effect on cost efficiency, partially capital and interest rates have a negative and insignificant effect on cost efficiency, partially inflation has an insignificant effect on cost efficiency. The greater the capital owned by a bank, the greater the size of the bank. Large bank capital can be channeled to third parties in the form of financing, or other investments that provide profits for the bank. if the bank's profits are large, then the bank's cost efficiency will also increase.
Ekspresi p16 dan CDK4 pada Berbagai Stadium T Karsinoma Laring Diana Purnamasari; Dyah Fauziah
Majalah Patologi Indonesia Vol. 29 No. 1, Januari 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i1.404

Abstract

BackgroundDefect in cell cycle control affect cell proliferation and play an important role in pathogenesis of cancer. Recently, some proteins areknown to have an influence in cell cycle proliferation. P16 and CDK4 may have influenced in laryngeal carcinoma. CDK4, anoncogene, can form cyclin D1-CDK4 complex that inactivates pRb so that the cell cycle goes from G1 phase to S phase. P16, atumor suppressor protein, can prevent cyclin D1-CDK4 complex so that inhibit cell proliferation.MethodsThis research was an observational analysis study with paraffin block samples, consists of 3 samples of stage T1 and each 10samples of stage T2, T3 and T4 in Laboratory of Anatomical Pathology of RSUD dr. Soetomo that was collected from 2013-2015.Samples were stained with antibody of p16 and CDK4. P16 and CDK4 expression were assessed based on the percentage andintensity of tumor cells that were stained. The differences between variables were analyzed by Kruskal-Wallis. The correlationbetween variables was analyzed by Spearman correlation test.ResultsP16 expression of carcinoma larynx T1 (88.33±7.64), T2 (85.00±5.27), T3 (61.00±21.83), and T4 (62.00±25.30). Besides CDK4expression of carcinoma larynx T1 (43.33±15.28), T2 (47.00±14.18), T3 (75.00±8.50), and T4 (70.00±9.43). Statistic analysisshowed significant differences between p16 and CDK4 expression on each stade of carcinoma larynx (p=0.017 and p=0.000). Andthere were corelation between p16 and CDK4 expression on each stage of carcinoma larynx (p=0.000 and p=0.000).ConclusionThe lower p16 expression and the higher CDK4 expression showed the higher stage of carcinoma larynx.
Berbagi Santunan Yatim Piatu dan Dhuafa Arsyada Kecamatan Citeureup bersama GENRE Kabupaten Bogor dan STIE Kalpataru Bukhari Muslim; Diana Purnamasari; Angga Sukmana; Neny Hidayah Nur Imani
Aksi Kita: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 2 (2026): MARET-APRIL
Publisher : Indo Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/6ffqpk17

Abstract

Kegiatan pengabdian kepada masyarakat merupakan salah satu implementasi Tri Dharma Perguruan Tinggi yang bertujuan memberikan kontribusi nyata dalam meningkatkan kepedulian sosial dan kesejahteraan masyarakat. Salah satu bentuk kegiatan tersebut adalah pemberian santunan kepada anak yatim piatu dan kaum dhuafa yang secara ekonomi membutuhkan perhatian dari berbagai pihak. Kegiatan pengabdian ini dilaksanakan melalui program Berbagi Santunan Yatim Piatu dan Dhuafa Arsyada Kecamatan Citeureup bersama GENRE Kabupaten Bogor dan STIE Kalpataru yang dilaksanakan pada Minggu, 8 Maret 2026 di Kecamatan Citeureup, Kabupaten Bogor. Tujuan kegiatan ini adalah untuk membantu meringankan beban ekonomi anak yatim piatu dan kaum dhuafa, meningkatkan kepedulian sosial masyarakat, serta memperkuat kolaborasi antara perguruan tinggi, organisasi kepemudaan, dan masyarakat. Metode yang digunakan adalah pendekatan partisipatif melalui tahapan persiapan, pelaksanaan, dan evaluasi kegiatan. Tahap persiapan meliputi koordinasi dengan GENRE Kabupaten Bogor, pengumpulan donasi, dan pendataan penerima santunan. Tahap pelaksanaan mencakup pembukaan kegiatan, sambutan penyelenggara, penyerahan santunan, dan doa bersama, sedangkan tahap evaluasi dilakukan melalui dokumentasi dan penilaian partisipasi kegiatan. Hasil kegiatan menunjukkan bahwa santunan berhasil disalurkan kepada 40 anak yatim piatu dan dhuafa dengan keterlibatan 25 relawan dari mahasiswa STIE Kalpataru dan anggota GENRE Kabupaten Bogor. Kegiatan ini tidak hanya memberikan bantuan materi, tetapi juga meningkatkan kepedulian sosial generasi muda serta memperkuat solidaritas dan kolaborasi antara lembaga pendidikan, organisasi pemuda, dan masyarakat.
Development of a Smart Quality Assurance Framework Based on Forensic Audit 5.0 with Artificial Intelligence Support to Enhance Internal Quality Assurance Systems in Higher Education: Alignment with Permendiktisaintek No. 39 of 2025 Ali Mutaufiq; Mizwar Anwar; Diana Purnamasari; Vonny Novera; Eddy Purnairawan; Desti Kumala
Pasundan Social Science Development Vol. 6 No. 2 (2026): Pasundan Social Science Development (PASCIDEV)
Publisher : Doctoral Program of Social Science Pasundan University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56457/pascidev.v6i2.383

Abstract

The promulgation of the Ministry of Higher Education, Science, and Technology Regulation (Permendiktisaintek) No. 39 of 2025 institutes a systemic transformation in the governance and quality assurance paradigms of Indonesian Higher Education Institutions (HEIs). By simplifying accreditation tiers into a streamlined categorical system, decentralizing curriculum design to accommodate flexible pathways such as the Recognition of Prior Learning (RPL), and mandating absolute data integration with the national Higher Education Database (PD Dikti), the regulatory framework demands an unprecedented level of institutional agility, accountability, and data veracity. However, empirical observations indicate that traditional Internal Quality Assurance Systems (SPMI) are structurally constrained by analog workflows, fragmented data architectures, and retroactive evaluation methodologies that fail to pre-emptively mitigate compliance deviations. This comprehensive research report proposes the conceptualization and implementation of a Smart Quality Assurance (SQA) Framework, fundamentally anchored in the principles of Forensic Audit 5.0 and augmented by Artificial Intelligence (AI). The proposed framework integrates real-time continuous auditing mechanisms, machine learning-driven anomaly detection utilizing Classification and Regression Tree (CART) algorithms, and blockchain-based immutable ledgers to transform the standard Penetapan, Pelaksanaan, Evaluasi, Pengendalian, dan Peningkatan (PPEPP) cycle into a proactive, predictive, and strategically aligned digital ecosystem. By leveraging real-time data analytics and Explainable AI (XAI) such as SHapley Additive exPlanations (SHAP), the SQA framework addresses inherent vulnerabilities in academic governance, demonstrating empirical potential to reduce processing latency by up to 73% while enhancing data accuracy by 89%. The findings conclusively suggest that adopting AI-driven forensic auditing not only guarantees rigid compliance with the National Standards for Higher Education (SN Dikti) but also provides a scalable, ethically governed pathway for institutions to achieve the coveted "Terakreditasi Unggul" (Excellent Accreditation) status, thereby fostering global academic competitiveness and sustainable institutional resilience.
Pendampingan Perhitungan Potensi Penerimaan Retribusi Pelayanan Persampahan di Kabupaten Bandung Eko Aristanto; Zaenal Aripin; Aspan Priana; Idris Idris; Vonny Novera; Diana Purnamasari; Wasinininingsih Wasinininingsih; Angga Sukmana
Jurnal Pengabdian Bersama Masyarakat Indonesia Vol. 4 No. 3 (2026): Juli : : Jurnal Pengabdian Bersama Masyarakat Indonesia
Publisher : CV. Aksara Global Akademia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59031/jpbmi.v4i3.995

Abstract

This community engagement program aimed to assess the revenue potential of municipal solid waste service charges based on the mapping of chargeable service users and the applicable service tariffs stipulated in Bandung Regency Regional Regulation No. 9 of 2023 on Regional Taxes and Regional Charges. The strategic partners involved in this program included the Bandung Regency Environmental Agency, the Regional Technical Implementation Unit (UPTD) for Solid Waste Collection and Transportation, Integrated Waste Processing Facilities (TPST), and the Regional Final Waste Processing Site (TPPAS). The technical assistance employed a participatory approach consisting of technical coordination meetings, and field surveys to collect data, validate findings, and formulate recommendations for optimizing municipal solid waste service charge revenue. The primary outcome of this community engagement program was the successful identification of 60,341 household chargeable units and 62,635 non-household chargeable units as the basis for estimating the revenue potential of municipal solid waste service charges in Bandung Regency. Based on the assessment, the estimated revenue potential reached IDR 13,873,338,846 under the pessimistic scenario, IDR 14,500,674,306 under the moderate scenario, and IDR 18,384,609,542 under the optimistic scenario.