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All Journal Media Ilmu Kesehatan Journal of Community Development Medical and Health Journal Riwayat: Educational Journal of History and Humanities
Dini Aulia Cahya
Fakultas Kedokteran Universitas Negeri Surabaya
Humanities Computer Science & IT Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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High-Fat Diet Impact on T Cell Polarization in First Degree relative (FDR) Subject with Type 2 Diabetes Mellitus Dini Aulia Cahya; Heri Wibowo; Alida Rosita Harahap
MEDIA ILMU KESEHATAN Vol 11 No 2 (2022): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v11i2.681

Abstract

Background: The prevalence of high-fat diet consumption that triggered obesity is increasing in last 2 decades. Type 2 diabetes mellitus is associated by the increasing number of inflammation marker, Acute phase protein in blood serum. In type 2 diabetes mellitus, combination of lifestyle and genetic factors is the most influential factors. Due to that fact, person with First Degree Relative ( FDR) in type 2 diabetes mellitus has the higher risk to develop into type 2 diabetes mellitus. T cell is one of leucocyte that has a significance role in adaptive immune response.T cell polarization will show the profile of adaptive immune response in chronic inflammation Objective: This study is purposed to analyse how T cell polarized in First Degree Relative (FDR) subject in risk of type 2 diabetes mellitus with high fat diet treatment.Methods: 30 Non-FDR subjects and 30 FDR subjects who included in parameter inclusion were treated with 250 mL whipping cream per day in 5 days. Pre and post treatment blood collection were tested for blood profile and flowcytometry intraseluler staining.Results: BMI is significantly increasing in Non-FDR subject meanwhile Cholesterol and HDL are significantly increasing in FDR subject. There are no significant changes in T cell subset including Th1, Th2, Th17 and Treg.Conclusion: Short term high fat diet treatment in 5 days increased some metabolic profiles on both group but there are no significantly different changes in T cell polarization.
Molecular Mechanisms and Clinical Effects of Medicinal Plants in Modulating Oxidative Stress: A Systematic Review from Athletic Performance to Vital Organ Protection Isma Nur Azzizah; Endah Wati Zahroh; Arifiana Wungu Kartika Dewi; Dini Aulia Cahya
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19721

Abstract

Oxidative stress constitutes a major pathophysiological mechanism in conditions ranging from exercise-induced muscle fatigue to chronic organ damage including diabetic nephropathy and ischemic stroke. Medicinal plants offer therapeutic potential through bioactive compounds that modulate cellular defense pathways. This systematic review evaluated the molecular mechanisms and clinical efficacy of medicinal plants (Kaempferia galanga, Nigella sativa, Panax ginseng, and other herbal formulations) in managing oxidative stress across diverse health contexts. A comprehensive literature search was conducted using reputable databases. Studies measuring oxidative stress biomarkers (MDA, SOD) and cellular signaling pathways (Nrf2, NF-κB, PI3K/AKT) were included. Results showed that N. sativa and K. galanga supplementation in athletes significantly reduced MDA levels and inflammatory cytokines (IL-6), accelerating post-exercise recovery. Bioactive compounds including Ginsenoside Ro and Kaempferide demonstrated organ-protective effects through Nrf2/HO-1 activation, autophagy promotion, and mitochondrial protection in ocular and renal tissues. These findings indicate that medicinal plants exert cytoprotective effects by activating endogenous antioxidant systems. The therapeutic spectrum spanning athletic performance enhancement to chronic organ protection underscores the translational potential of herbal interventions as promising antioxidant agents.
Edukasi Interaktif untuk Meningkatkan Literasi Kesehatan Reproduksi Remaja Dini Aulia Cahya; Endang Sri Wahjuni; Hafshah Yasmina Abidah; Devi Purnamasari Sasongko; Yenny Meilany Sugianto; Anggie Sasmita Kharisma Putri; Abqariyatuzzahra Munasib
Journal of Community Development Vol. 6 No. 2 (2025): Desember
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v6i2.1844

Abstract

Literasi kesehatan reproduksi remaja merupakan komponen penting dalam pembangunan kesehatan masyarakat karena berkaitan langsung dengan kemampuan remaja memahami perubahan biologis, psikososial, serta mengambil keputusan yang aman dan bertanggung jawab. Namun demikian, di banyak lingkungan sekolah, topik kesehatan reproduksi masih dipengaruhi oleh mitos, norma tabu, serta keterbatasan akses terhadap informasi yang tervalidasi secara ilmiah. Kondisi ini berpotensi memperkuat miskonsepsi, ketimpangan pengetahuan berbasis gender, serta meningkatkan kerentanan remaja terhadap berbagai risiko kesehatan. Kegiatan Pengabdian kepada Masyarakat (PKM) ini bertujuan untuk meningkatkan literasi kesehatan reproduksi remaja melalui pendekatan edukasi yang holistik, ilmiah, dan interaktif, sekaligus mendukung pencapaian Sustainable Development Goals (SDGs), khususnya SDG 3 (Good Health and Well-being) dan SDG 5 (Gender Equality). Kegiatan PKM dilaksanakan pada tanggal 30 Oktober 2025 dengan sasaran 60 siswa sekolah menengah pertama. Intervensi dilakukan melalui sesi edukasi interaktif yang mencakup pemahaman dasar anatomi dan fisiologi sistem reproduksi, kesehatan pubertas dan menstruasi, penguatan konsep kesehatan reproduksi yang setara gender, serta pelurusan mitos kesehatan reproduksi berbasis bukti ilmiah. Evaluasi kegiatan menggunakan desain pra–pasca dengan pre-test dan post-test masing- masing terdiri atas 10 soal pilihan ganda yang mencakup domain materi sepadan. Hasil evaluasi dianalisis dan disajikan secara deskriptif menggunakan kategori tingkat pemahaman. Sebelum intervensi, tingkat pemahaman siswa secara umum berada pada kategori rendah–sedang, terutama pada isu-isu yang berkaitan dengan pubertas, menstruasi, dan persepsi peran gender dalam kesehatan reproduksi. Setelah kegiatan edukasi, terjadi pergeseran kecenderungan tingkat pemahaman menjadi sedang–tinggi, disertai peningkatan kemampuan siswa dalam membedakan mitos dan fakta kesehatan reproduksi serta meningkatnya sikap saling menghormati antara siswa laki-laki dan perempuan. Kegiatan PKM ini menunjukkan bahwa edukasi kesehatan reproduksi yang dirancang secara holistik dan interaktif tidak hanya berpotensi meningkatkan literasi kesehatan remaja, tetapi juga berkontribusi pada upaya pengurangan kesenjangan gender dalam akses pengetahuan kesehatan. Dengan demikian, program ini relevan sebagai strategi penguatan peran sekolah dalam mendukung pencapaian SDG 3 dan SDG 5 secara berkelanjutan.
Integrating Traditional Medicine into Mainstream Healthcare Systems: Challenges and Opportunities Dini Aulia Cahya; Riskha Dora Candra Dewi; Aninda Tanggono; Rachmad Hidayat
Riwayat: Educational Journal of History and Humanities Vol 8, No 2 (2025): April
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jr.v8i2.45054

Abstract

The integration of traditional medicine into mainstream healthcare systems presents both significant challenges and unique opportunities. This study employs a literature review methodology to examine the current landscape of traditional medicine practices and their potential role within conventional healthcare frameworks. By analyzing various studies, policy documents, and case reports, this paper identifies key barriers to integration, including regulatory issues, lack of standardization, and the prevailing skepticism among healthcare professionals. Additionally, it highlights the opportunities for enhanced patient care through a more holistic approach that combines the strengths of both traditional and modern medical practices. The findings suggest that successful integration requires collaborative efforts among stakeholders, including policymakers, healthcare providers, and traditional medicine practitioners. Furthermore, the study emphasizes the need for comprehensive training programs to educate healthcare professionals about traditional medicine and its benefits, as well as the establishment of regulatory frameworks to ensure safety and efficacy. This paper contributes to the growing discourse on healthcare integration by providing insights into the complexities of merging traditional and modern medical systems and offering recommendations for future research and policy development.
Co-Authors Abidah, Hafshah Yasmina Abqariyatuzzahra Munasib Alida Rosita Harahap Anggie Sasmita Kharisma Putri Aninda Tanggono Arifiana Wungu Kartika Dewi Azzizah, Isma Nur Devi Purnamasari Sasongko Endah Wati Zahroh Endang Sri Wahjuni Heri Wibowo Rachmad Hidayat Riskha Dora Candra Dewi Yenny Meilany Sugianto