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All Journal MEDISAINS Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Aisyah : Jurnal Ilmu Kesehatan Buletin Kedokteran dan Kesehatan Prima Nutriture Journal
Lister, I Nyoman Ehrich
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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Effectiveness Analysis of Antidiabetic Property from Dragon Fruit Peel Methanol Extract in Alloxan-Induced Diabetic Rats Sumartin, Sonia Apriani; Lister, I Nyoman Ehrich; Fachrial, Edy
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.57-62

Abstract

Diabetes is a health burden in various countries, one of these countries, is also Indonesia. Dragon fruit peel is an alternative diabetes therapy that has been widely studied. Therefore, this study aimed to investigate an antidiabetic effect of dragon fruit peel methanol extract on alloxan-induced diabetic male Wistar rats. This experimental study used twenty-five male Wistar rats induced by alloxan injection. After 48 hours, all rats were grouped into five different groups, including control (0.5% SCMC), standard (Metformin), Dragon Fruit Peel Methanol Extract-1 (500 mg/kg BW), 2 (750 mg/kg BW), and 3 (1,000 mg/kg BW). These treatments were given for two weeks. After that, all rats were dissected to obtain the pancreas. The results showed that dragon fruit peel methanol extract significantly decreased blood glucose levels after the 7th and 14th days (P value <0.05). In addition, pancreatic histology showed a decrease in the extract dose followed by a smaller size of the pancreatic Langerhans islet. The lowest dose of the extract showed a similar size of pancreatic Langerhans islet to the control group with an atrophic pancreatic Langerhans islet. Therefore, it can be concluded that dragon fruit peel extract can significantly decrease blood glucose levels and improve the structure of pancreatic Langerhans islet at higher doses.
Analgesic and Antipyretic Activity of Sweet Orange Peel Methanol Extract Silalahi, Elsa Debora; Lister, I Nyoman Ehrich; Fachrial, Edy
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.577-584

Abstract

An analgesic-antipyretic drug widely used is paracetamol, which has various health benefits and several adverse effects. Therefore, various natural products have been extensively studied as alternative analgesic-antipyretics, one of which is sweet orange peel. This study aimed to investigate sweet orange peel's analgesic and antipyretic activity by in vivo methods. This experimental study evaluated the analgesic and antipyretic effects of sweet orange peel extract extracted by the maceration method. The analgesic effect was evaluated by tail immersion (Maximum Possible Analgesia) and acetic acid-induced writhing method (total abdominal writhing). Meanwhile, the antipyretic effect was evaluated by the brewer yeast-induced hyperpyrexia (body temperature) method. This study showed that sweet orange peel methanol extract significantly increased the maximum possible analgesia value (132.79%) and reduced the number of abdominal writhing (44.05%) at the highest dose of 750 mg/kg BW. It indicated analgesic activity from sweet orange peels. Meanwhile, the antipyretic effect of sweet orange peel methanol extract was observed from 1-4 hours after administration, and the highest percentage inhibition of body temperature 4 hours after administration was found in a moderate dose, that was 5.98% (P value: 0.042). Therefore, it can be concluded that sweet orange peel methanol extract has analgesic and antipyretic effects with an optimal dose range of 500-750 mg/kg BW.
In vivo study of cardioprotective effect of bay leaf (Syzygium polyanthum) extract Ikhtiari, Refi; Sari, Laura Kartika; Nasution, Ali Napiah; Ginting, Chrismis Novalinda; Handoko, Erwin; Lister, I Nyoman Ehrich
MEDISAINS Vol 20, No 1 (2022)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v20i1.12502

Abstract

Background: The excessive use of chemotherapy drugs such as doxorubicin might induce cardiovascular diseases. Heart-specific biomarker enzymes such as LDH and BNP indicated the early signs of cardiotoxicity. However, there is no report on the effect of bay leaf on LDH and BNP nor its bioactive compounds and histopathology analysis.Objective: This study aims to determine the cardioprotective effect of Ethanol Extract of Bay Leaf (EEBL) based on phytochemical analysis, LDH and BNP levels, and cardiac histology of rats administered with doxorubicin.Methods: About 24 Wistar rats were divided into six groups treated with 100 mg/kg BW, 300 mg/kg BW, and 500 mg/kg BW of EEBL with CMC-Na 0.5 %, vitamin E, and doxorubicin. Preconditioning was 14 days, followed by 21 days of intraperitoneal administration. LDH and BNP parameters were measured on days 1st, 7th, 14th, and 20th. Histology analysis was conducted on day 21st.Results: Dark green EEBL showed sufficient physical quality and properties for practical application in pharmacy. EEBL has significantly affected LDH, BNP, and cardio recovery dose-dependent. The most effective doses were observed at 500 mg/kg BW, and its performance is not statistically different from those of the commercial vitamin E. The histopathological images revealed significant improvements in interstitial edema, wavy fibers, hemorrhage, intracellular vacuole, and inflammatory cell infiltration. Here we report six bioactive compounds obtained from EEBL have cardioprotective effects; Neophytadiene, squalane, phytol, methyl palmitate, stigmasterol, and  9,12-Octadecanoic acid methyl ester.Conclusion: This study has shown the promising potential of bay leaf extract as a cardioprotector with sufficient quality pharmacological standards.
Comparison of Interleukin-1b-511 C/T Polymorphism in Schizophrenia of Batak and Minangkabau Ethnicities in Pematang Siantar Wijaya, Raysha Awlia; Fachrial, Edy; Lister, I Nyoman Ehrich; Ariatama, Bayu
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.601-608

Abstract

This research is an overview of a comparative study on the Interleukin-1β-511 C/T polymorphism in individuals with schizophrenia of Batak and Minangkabau ethnicities in Pematang Siantar, Indonesia. The study aims to investigate genetic differences among these ethnic groups to better understand susceptibility to schizophrenia, which is influenced by multiple factors including genetics. The research uses a comparative categorical analytic approach with a cross-sectional method and involves DNA isolation and polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) examinations. Based on the results,  significant demographic differences between the Batak and Minangkabau ethnic groups, particularly in gender distribution, age, onset of illness, duration of illness, and PANSS scores. Notably, it finds a significant difference in the occurrence of the C allele and the T allele between the two ethnic groups, with the C allele being more prevalent in the Minangkabau group and the T allele more so in the Batak group. This suggests that the IL-1β -511 C/T polymorphism may play a differential role in the susceptibility to schizophrenia among these ethnicities, indicating a potential for ethnic-specific risk factors or protective elements.
Sociodemographic and knowledge profile of patients with type 2 diabetes mellitus at Royal Prima General Hospital Naibaho, Iren Theresia Melati Br; Lister, I Nyoman Ehrich; Girsang, Ermi
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7178

Abstract

This study utilized a descriptive design with a cross-sectional approach, conducted from April to May 2024 at Royal Prima General Hospital, Medan. A total sampling technique was employed, including all 64 registered T2DM patients. Sociodemographic and knowledge data were collected via questionnaire and analyzed using univariate analysis to generate frequency distributions and percentages. The findings revealed that the majority of respondents were aged ≥45 years (62.5%), male (53.13%), had a low education level (≤9 years of schooling) (53.13%), and were unemployed (51.56%). Nevertheless, a majority of patients (62.5%) possessed a good level of knowledge regarding their disease. The profile of T2DM patients is consistent with that of a socioeconomically high-risk population. The high level of knowledge observed in the majority of patients may not guarantee optimal disease management due to potential structural and economic barriers. Therefore, intervention strategies for T2DM must be multifaceted, moving beyond education to address socioeconomic obstacles that impede the translation of knowledge into effective self-care behaviors.
Screening dan Identifikasi Molekuler Probiotik dari Dadih sebagai Inhibitor Alpha-Glukosidase Marbun, Togi Rut Marlita; Naidu, Ramawathy; Lister, I Nyoman Ehrich; Fachrial, Edy
NUTRITURE JOURNAL Vol. 4 No. 1 (2025): Nutriture Journal
Publisher : Politeknik Kesehatan Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/nj.v4i1.5268

Abstract

Abstrak Latar Belakang: Saat ini, berbagai jenis obat antidiabetes tersedia di pasaran. Namun, penggunaan obat sintetis untuk pengobatan diabetes seringkali menimbulkan kendala, termasuk efek samping, resistensi terhadap terapi, dan biaya pengobatan yang tinggi. Inhibitor SGLT-2, Pioglitazone, Metformin, Sulfonilurea, inhibitor DPP4 (Gliptin), agonis GLP-1, Acarbose, dan berbagai obat lainnya umum digunakan dalam farmakoterapi diabetes. Selain obat antidiabetes oral konvensional, zat alami seperti Bakteri Asam Laktat (BAL) probiotik dapat menjadi terapi alternatif untuk diabetes. Beberapa jenis probiotik memiliki kemampuan untuk menghambat aktivitas enzim alfa-glukosidase di mikrovili usus yang menurunkan kadar glukosa darah. Tujuan: Penelitian ini bertujuan untuk menenemukan karakteristik yang cocok sebagai kandidat probiotik di dalam dadih dengan skrining dan mengidentifikasi molekuler probiotik dari dadih sebagai inhibitor alpha-glukosidase. Metode: Metode dalam penelitian ini menggunakan metode eksperimental. Hasil: Hasil penelitian menunjukkan bahwa isolat DDH 8 memiliki persentase pertumbuhan sebesar 48% dalam uji asam, yang menunjukkan pertumbuhan bakteri yang signifikan, dengan tingkat pertumbuhan hidup sebesar 46,595% dan toleransi garam empedu yang rendah. DDH 8 juga menunjukkan aktivitas antibakteri sedang, dengan diameter zona hambat rata-rata sebesar 10,5 mm terhadap E. coli. Berdasarkan identifikasi fenotipik dan molekuler menggunakan 16S rRNA, isolat DDH8 diidentifikasi sebagai Lactobacillus fermentum, yang memiliki karakteristik yang cocok sebagai kandidat probiotik. Simpulan: Isolat bakteri asam laktat (LAB), yang diidentifikasi sebagai Lactobacillus fermentum melalui identifikasi fenotipik dan molekuler berdasarkan gen 16S rRNA, menunjukkan dadih berpotensi sebagai probiotik. LAB dari dadih bersifat gram-positif, berwarna merah, dan berbentuk batang, serta hasil skrining menunjukkan bahwa isolat ini bersifat katalase-negatif dan homofermentatif. Kata Kunci: alpha-glukosidase; asam laktat; bakteri; dadih; probiotik
Sociodemographic and knowledge profile of patients with type 2 diabetes mellitus at Royal Prima General Hospital Naibaho, Iren Theresia Melati Br; Lister, I Nyoman Ehrich; Girsang, Ermi
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7178

Abstract

This study utilized a descriptive design with a cross-sectional approach, conducted from April to May 2024 at Royal Prima General Hospital, Medan. A total sampling technique was employed, including all 64 registered T2DM patients. Sociodemographic and knowledge data were collected via questionnaire and analyzed using univariate analysis to generate frequency distributions and percentages. The findings revealed that the majority of respondents were aged ≥45 years (62.5%), male (53.13%), had a low education level (≤9 years of schooling) (53.13%), and were unemployed (51.56%). Nevertheless, a majority of patients (62.5%) possessed a good level of knowledge regarding their disease. The profile of T2DM patients is consistent with that of a socioeconomically high-risk population. The high level of knowledge observed in the majority of patients may not guarantee optimal disease management due to potential structural and economic barriers. Therefore, intervention strategies for T2DM must be multifaceted, moving beyond education to address socioeconomic obstacles that impede the translation of knowledge into effective self-care behaviors.
Potential Ethyl Acetate Fraction of Mangkokan Leaf Extract (Nothopanax Scutellarium) in Hyperglycemic Rats: A Systematic Review Nasution, Sri Lestari Ramadhani; Ginting, Chrismis Novalinda; Lister, I Nyoman Ehrich
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (707.143 KB) | DOI: 10.30604/jika.v7i1.855

Abstract

Mangkokan leaves (Nothopanax scutellarium) contain various phytochemicals such as flavonoids and saponins, where these compounds have antioxidant activity that can improve oxidative stress in the body. Treatment of Diabetes Mellitus disease can be done with drugs and herbs, optimal blood glucose control alone cannot prevent complications. The available therapies for DM include insulin therapy and other hypoglycemic agents that can not be separated from various side effects and failure to significantly prevent complications, including the Mangkokan leaf herbal treatment (Nothopanax scutellarin) which has an antidiabetic effect. To systematically review the effect of the ethyl acetate fraction of the extract of the Mangkokan (Nothopanax scutellarium) leaf extract on blood sugar levels, malondialdehyde, insulin expression in pancreatic cells and pancreatic histopathology in hyperglycemic rats. A systematic search was carried out in the PubMed database, Medline, Web of Science, Scopus, EMBASE from 2017 to 2021. The reported results stated that Alloxan is a compound that has diabetogenic properties and is toxic especially to pancreatic beta cells and when administered to animals will cause the rat to be diabetic. Alloxan causes damage to pancreatic beta cells by activating reactive oxygen (ROS) which is initiated by the reduction reaction of alloxan.Daun mangkokan (Nothopanax scutellarium) mengandung berbagai fitokimia seperti flavonoid dan saponin, dimana senyawa tersebut memiliki aktivitas antioksidan yang dapat meningkatkan stres oksidatif dalam tubuh. Pengobatan penyakit Diabetes Mellitus dapat dilakukan dengan obat-obatan dan herbal, pengendalian glukosa darah yang optimal saja tidak dapat mencegah terjadinya komplikasi. Terapi yang tersedia untuk DM antara lain terapi insulin dan agen hipoglikemik lainnya yang tidak lepas dari berbagai efek samping dan kegagalan untuk mencegah komplikasi secara nyata, termasuk pengobatan herbal daun mangkokan (Nothopanax scutellarin) yang memiliki efek antidiabetik. Mengkaji secara sistematis pengaruh fraksi etil asetat ekstrak ekstrak daun mangkokan (Nothopanax scutellarium) terhadap kadar gula darah, malondialdehid, ekspresi insulin pada sel pankreas dan histopatologi pankreas pada tikus hiperglikemik. Penelusuran sistematis dilakukan di database PubMed, Medline, Web of Science, Scopus, EMBASE dari tahun 2017 hingga 2021. Hasil yang dilaporkan menyatakan bahwa Alloxan merupakan senyawa yang memiliki sifat diabetogenik dan bersifat toksik terutama terhadap sel beta pankreas dan bila diberikan pada hewan akan menyebabkan tikus menjadi diabetes. Aloksan menyebabkan kerusakan sel beta pankreas dengan mengaktifkan oksigen reaktif (ROS) yang diawali dengan reaksi reduksi aloksan.
Nephroprotective Effect of Ethanolic Extract of Balakka (Phyllanthus emblica L.) on Rats Induced Ethylene Glycol and Ammonium Chloride Girsang, Ermi; Halima, Piyanto; Nasution, Ali Napiah; Lister, I nyoman Ehrich; Lie, Sukirman
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (814.27 KB)

Abstract

The kidneys are a pair of symmetrical organs that function to filter the blood and are located in the retroperitoneal region on the posterior wall of the abdomen. The kidneys are drained about 25% of cardiac output. Kidney damage due to the accumulation of kidney stones can be caused by ethylene glycol substances to form calcium oxalate crystals (CaC2O4). This crystal is common in urine specimens even in healthy animals. Crystal formation can be accelerated by the administration of ammonium chloride. This study aims to determine the nephroprotective effects of balakka ethanol extract to reduce creatinine and urea levels in rats induced by ethylene glycol and ammonium chloride. The results showed that the balakka ethanol extract with a dose variation of 50 mg/kg body weight, 100 mg/kg body weight, and 150 mg/kg body weight had nephroprotective activity in rats that had been induced by ethylene glycol and ammonium chloride. Where the induction group had the largest serum creatinine mean of 1.43 mg/dl. The EEB treatment group dose of 50 mg / kgBB had a serum creatinine value of 1.01 mg / dl. The EEB treatment group dose of 100 mg / kgBB had a serum value of 0.91 mg / dl. The balakka ethanol extract treatment group dose of 150 mg / kgBB had a serum value of 0.73 mg / dl. The induction group had the largest serum urea serum of 76.56 mg/dl. EEB treatment group dose of 50 mg / kgBB had serum urea value of 63.36 mg / dl. The EEB treatment group dose of 100 mg / kgBB had a serum urea value of 49.73 mg / dl. The balakka ethanol extract treatment group dose of 150 mg / kgBB had a serum urea value of 49.90 mg / dl. Key Word : ureum, creatine, kidney.
Antidiabetic and Liver Tissue Improvement Potency of Surf Redfish (Actinopyga mauritiana) in Alloxan-Induced Diabetic Mice Citra, Arma; Lister, I Nyoman Ehrich; Fachrial, Edy; Ginting, Sahna Ferdinand
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.5270

Abstract

Long-term hyperglycemia is associated with various organ damage. One of these damages is Non-Alcoholic Fatty Liver Disease (NAFLD). One of the potential natural products that may improve this impact is Surf Redfish. Hence this study aimed to investigate the antidiabetic and liver protection effects of Surf Redfish in some diabetic male Mice. This study was an experimental study that used 25 male mice grouped into control, standard, Surf Redfish Extract-I (100 mg/ kg BW), II (200 mg// kg BW), and III (400 mg/ kg BW). This study evaluated the blood glucose level (before and after induction, third, sixth, ninth, twelfth, and fifteenth days) and histology study of liver tissue. This study showed that the Surf Redfish ethanol extract significantly decreased blood glucose levels every day for fifteen days (P-Value < 0.05). This extract also showed a significant decrease in vacuolated degeneration after fifteen days of extract administration (P-Value). Hence, it can be concluded that the most effective dose of Surf Redfish extracts in this study was 400 mg/ kg BW to decrease blood glucose level and width of vacuolated degeneration after fifteen days of administration.
Co-Authors Ariatama, Bayu Berampu, Ira Manda Sari Citra, Arma Edy Fachrial Ginting, Chrismis Novalinda Ginting, Sahna Ferdinand Girsang, Ermi Halima, Piyanto Handoko, Erwin IKHTIARI, REFI Lie, Sukirman Marbun, Togi Rut Marlita Naibaho, Iren Theresia Melati Br Naidu, Ramawathy Nasution, Ali Napiah Nasution, Sri Lestari Ramadhani Sari, Laura Kartika Silalahi, Elsa Debora Sumartin, Sonia Apriani Wijaya, Raysha Awlia