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All Journal Indonesian Journal of Pharmaceutical and Clinical Research Malahayati International Journal of Nursing and Health Science
Lie, Sukirman
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Moringa leaf tea as an antihyperglycemic alternative of type 2 diabetes mellitus in the elderly Prasetya, Fika Indah; Haryanti, Eka; Lie, Sukirman; Sulastri, Afianti; Sumartini, Sri; Astuti, Novia Dwi; Jubaedah, Ade; Anggraeni, Surti; Sasmito, Priyo
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 1 (2025): Volume 8 Number 1
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i1.834

Abstract

Background: Type 2 diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to insulin resistance or decreased insulin secretion. Herbal complementary therapies are increasingly in demand as an alternative to managing blood sugar levels. However, studies of its effectiveness as a single therapy in the elderly have not been widely researched. Purpose: To evaluate the effectiveness of moringa leaf tea as an antihyperglycemic alternative in elderly patients with type 2 diabetes mellitus. Method: A case report study conducted on one participant to evaluate the effect of moringa leaf tea on fasting blood sugar levels in elderly people with type 2 Diabetes Mellitus (DM). This approach was chosen to document individual responses to herbal interventions in actual clinical conditions and provide an in-depth picture of changes in blood sugar levels after intervention. The patient in this study was a 61-year-old woman who had been diagnosed with type 2 DM for one year and was not taking antihyperglycemic drugs. The participant had a history of non-compliance with pharmacological therapy due to previously felt side effects. Results: Before the intervention, the patient reported experiencing typical symptoms of hyperglycemia, such as frequent thirst, increased urination frequency especially at night, and fatigue that interfered with daily activities. Blood sugar levels were measured before the intervention, and were found to be 256 mg/dL, indicating hyperglycemia. After consuming moringa leaf tea 3 times a day for three consecutive days, blood sugar levels decreased and on the 3rd day it was 220 mg/dL. In addition, the patient also reported improvements in clinical symptoms, such as reduced thirst, increased urination frequency especially at night, and increased energy. Conclusion: Consumption of Moringa leaf tea can lower blood sugar levels in elderly people with type 2 diabetes mellitus without antidiabetic drugs. In addition, improvements in clinical symptoms such as reduced thirst, urination frequency, and increased energy were also observed. Suggestion: Further studies are needed with larger samples and longer intervention periods to evaluate its long-term efficacy and safety. In addition, this study can explore more deeply the molecular mechanisms associated with the antihyperglycemic effects of Moringa leaves and its potential in natural therapy-based diabetes management strategies.
Sepsis protocol adherence and emergency department overcrowding: An observational study Arifani, Nisa; Mulyati, Leli; Sasmito, Priyo; Sujana, Treesia; Gayatri, Sri Wahyuni; Astuti, Novia Dwi; Librianty, Nurfanida; Lie, Sukirman; Deviana, Elina; Ihsan , Farly
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 2 (2025): Volume 8 Number 2
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i2.870

Abstract

Background: Emergency Department (ED) overcrowding is a persistent global challenge that affects the quality and timeliness of patient care, particularly for sepsis management. Despite established guidelines such as the hour-1 sepsis bundle and national sepsis guideline, adherence remains inconsistent. Purpose: To analyze the relationship between sepsis protocol compliance and emergency unit crowding. Method: A retrospective observational cohort study was conducted, analyzing adult sepsis and septic shock patients triaged as Priority 1. Data on patient demographics, sepsis severity scores, ED occupancy rates, and adherence to sepsis protocols using the Hour-1 sepsis bundle and the National Sepsis Guideline were collected. Statistical analysis was performed using Fisher’s Exact Test to examine associations between ED overcrowding and compliance with sepsis protocols, with a significance threshold of p<0.05. Results: This study included 38 cases with a mean age of 56.6 years and the majority (52.6%) of patients were female. Most cases were diagnosed with septic shock (55.3%) and the average occupancy rate of the emergency department was 80.8%. Serum lactate measurements were performed in 68.4% of cases, blood culture sampling in 21.1%, and broad-spectrum antibiotics were given in 94.7%. Full compliance with both sepsis protocols was only 5.3%. Compliance with fluid resuscitation was high at 97.4%, while compliance with blood culture sampling was low at 5.3% and 7.9%. No significant association was found between protocol compliance and ED crowding (p > 0.05). Conclusion: There was no significant correlation between ED crowding and adherence to sepsis protocols. Strategic and clinical policy interventions are needed to improve adherence to sepsis management guidelines. Suggestion: Future research should investigate additional barriers to sepsis care, such as financial constraints, physician decision-making processes, and variations in adherence across healthcare settings to develop more comprehensive strategies to improve sepsis outcomes worldwide.
Nephroprotective Effect of Ethanolic Extract of Balakka (Phyllanthus emblica L.) on Rats Induced Ethylene Glycol and Ammonium Chloride Girsang, Ermi; Halima, Piyanto; Nasution, Ali Napiah; Lister, I nyoman Ehrich; Lie, Sukirman
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (814.27 KB)

Abstract

The kidneys are a pair of symmetrical organs that function to filter the blood and are located in the retroperitoneal region on the posterior wall of the abdomen. The kidneys are drained about 25% of cardiac output. Kidney damage due to the accumulation of kidney stones can be caused by ethylene glycol substances to form calcium oxalate crystals (CaC2O4). This crystal is common in urine specimens even in healthy animals. Crystal formation can be accelerated by the administration of ammonium chloride. This study aims to determine the nephroprotective effects of balakka ethanol extract to reduce creatinine and urea levels in rats induced by ethylene glycol and ammonium chloride. The results showed that the balakka ethanol extract with a dose variation of 50 mg/kg body weight, 100 mg/kg body weight, and 150 mg/kg body weight had nephroprotective activity in rats that had been induced by ethylene glycol and ammonium chloride. Where the induction group had the largest serum creatinine mean of 1.43 mg/dl. The EEB treatment group dose of 50 mg / kgBB had a serum creatinine value of 1.01 mg / dl. The EEB treatment group dose of 100 mg / kgBB had a serum value of 0.91 mg / dl. The balakka ethanol extract treatment group dose of 150 mg / kgBB had a serum value of 0.73 mg / dl. The induction group had the largest serum urea serum of 76.56 mg/dl. EEB treatment group dose of 50 mg / kgBB had serum urea value of 63.36 mg / dl. The EEB treatment group dose of 100 mg / kgBB had a serum urea value of 49.73 mg / dl. The balakka ethanol extract treatment group dose of 150 mg / kgBB had a serum urea value of 49.90 mg / dl. Key Word : ureum, creatine, kidney.
Co-Authors Afianti Sulastri, Afianti Anggraeni, Surti Arifani, Nisa Deviana, Elina Gayatri, Sri Wahyuni Girsang, Ermi Halima, Piyanto Haryanti, Eka Ihsan , Farly Jubaedah, Ade Librianty, Nurfanida Lister, I Nyoman Ehrich Mulyati, Leli Nasution, Ali Napiah NOVIA DWI ASTUTI Prasetya, Fika Indah Sasmito, Priyo Sri Sumartini Treesia Sujana