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All Journal Majalah Kedokteran Bandung Jurnal Kedokteran Health Notions Manuju : Malahayati Nursing Journal Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) SCRIPTA SCORE Scientific Medical Journal Cardiovascular and Cardiometabolic Journal (CCJ) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Cerdika: Jurnal Ilmiah Indonesia Jurnal Widya Medika
Soebroto, Heroe
Department Of Cardiothoracic And Vascular Surgery, Faculty Of Medicine Universitas Airlangga, Dr Soetomo General Academic Hospital, Surabaya Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Lung Cancer: A Literature Review Yan Efrata Sembiring; Wiwin Is Effendi; Jeffrey Jeswant Dillon; Heroe Soebroto; Dhihintia Jiwangga Suta Winarno; Puruhito Puruhito; I Gusti Agung Made Adnyanya Putra; Abed Nego Okthara Sebayang; Sri Pramesthi Wisnu Bowo Negoro
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.246-251

Abstract

Lung cancer is a cancer whose onset starts in the lungs where there is an abnormal cell growth that is very fast and uncontrolled. The abnormal cell growth is triggered by deoxyribonucleic acid (DNA) damage, including deletions in the DNA section, inactivation of tumor suppressor genes, activation of proto-oncogenes to oncogenes, the absence of apoptosis, and the activity of the telomerase enzyme. Lung cancer is initiated by oncogeneous activity and inactivation of tumor suppressor genes. Oncogenes are genes that help cells grow and divide and are believed to cause a person to develop lung cancer. In general, lung cancer is divided into two types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). World Health Organization (WHO) classifies lung cancer based on histopathology into 4 major cell types, namely SCLC, NSCLC which includes adenocarcinoma, squamous cell carcinoma (SCC), and large cell carcinoma (LCC). The difference between the two is that SCLC has a higher aggressiveness than NSCLC. Cancer treatment is based on the type, size, location and stage of the cancer, as well as the patient's overall condition.
Changes in Nutritional Status of Children Under Five with Acyanotic Congenital Heart Disease Left to Right Shunt Type After Defect Closure by Catheterization Marsa Hendra Utomo; Taufiq Hidayat; Heroe Soebroto
Cardiovascular and Cardiometabolic Journal (CCJ) Vol. 5 No. 1 (2024): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v5i1.2024.11-22

Abstract

Highlights: 1. The nutritional status of children with CVD after therapy is interesting to discuss especially because children antibody varies. 2. Changes in their nutrition intake after the surgery would help for future treatments with related disease and same operation. - Background: One of the impacts that occur in patients with congenital heart disease (CHD) is malnutrition. Malnutrition will affect the growth of the child. Closure therapy with catheterization can improve nutritional status after a few months. This study aims to determine the nutritional status of toddlers with simple left to right shunt-type acyanotic CHD before and after closure therapy with catheterization. Material and Methods: This study is an analytical observational study with a retrospective cohort method using medical record data involving pediatric patients less than 5 years old with simple left to right shunt-type acyanotic CHD who received closure by catheterization at Dr. Soetomo General Hospital from January 2020 to December 2020. Results: From 10 samples, the characteristics of the most samples were women (90%), age group 2-5 years (60%), and PDA abnormalities (50%). In addition, nutritional status after closure by catheterization improved. Conclusion: There was an improvement in nutritional status (W/H) after defect closure with catheterization in patients aged less than 5 years with simple left to right shunt type acyanotic CHD within several months.
THE HDL LEVEL IN DIABETIC FOOT ULCER PATIENTS WITH AND WITHOUT AMPUTATION AT DR. SEOTOMO GENERAL ACADEMIC HOSPITAL SURABAYA Ahmed Eliaan Shaker Abuajwa; Hermina Novida; Heroe Soebroto; Yan Efrata Sembiring
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.30-37

Abstract

Highlights1. Diabetes mellitus is a category of metabolic disease characterized by uncontrolled hyperglycemia.2. This study revealed no statistically significant differences in total cholesterol, TG, LDL, HDL, or LDL/HDL ratio between amputated and non-amputated DFU patients. AbstractBackground: Diabetic foot ulcers (DFU) are microvascular and macrovascular consequences of diabetes and are associated with neuropathy, vascular disease, and immunosuppression. Increased blood glucose levels may result in the glycosylation of proteins in the nerve cells of the foot, leading to ischemia and cellular disturbances that can damage muscular, sensory, and autonomic neurons. Objective: To compare the lipid profiles of amputated and non-amputated DFU patients. Material and Method: This was a cross-sectional, analytic, retrospective research using total sample approach to analyze the medical records of all diabetes patients admitted to Dr. Soetomo General Academic Hospital between February 2018 and December 2020, with or without amputation. Result: The average age of DFU patients at Dr. Soetomo General Academic Hospital was 55.6 9.4 years, and the majority of patients were female (57%). Diabetic foot ulcers were most prevalent in the age group ≥50 years old (74%), amputated DFU patients had larger mean total cholesterol, TG, LDL, and HDL than non-amputated DFU patients, although the difference was not statistically significant. While the mean LDL/HDL ratio was greater in non-amputated DFU patients, the difference was statistically insignificant. The HDL level was low in 84% of amputated DFU patients, whereas in non-amputated DFU patients it was 81%. Conclusion: This research showed no significant variation in total cholesterol, TG, LDL, HDL, or the LDL/HDL ratio between amputated and non-amputated DFU patients. Most DFU patients with and without amputations had low HDL values.
Profile of Primary Arteriovenous Fistula Failure in End-Stage Renal Disease Patients on Hemodialysis at Dr. Soetomo General Academic Hospital, Surabaya Reviano, Moses Orvin; Sembiring, Yan Efrata; Widodo, Widodo; Soebroto, Heroe
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 1 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I12025.43-49

Abstract

Highlights: Arteriovenous fistula is preferred for dialysis vascular access. Twenty-eight (4.8%) cases had primary arteriovenous fistula failure.   Abstract Introduction: Primary arteriovenous fistula failure in Indonesia is still relatively high, and end-stage renal disease patients are prioritized to have arteriovenous fistula as their main vascular access for hemodialysis. This study aimed to determine the primary arteriovenous fistula failure profile in end-stage renal disease patients on hemodialysis at Dr. Soetomo General Academic Hospital, Surabaya. Methods: This was a descriptive retrospective study. The population was primary arteriovenous fistula failure patients. A total sampling method was used from the medical records of Dr. Soetomo General Academic Hospital, Surabaya, from January 2021 until January 2023. The research variables were gender, age, diabetes mellitus (DM) history, hypertension (HTN) history, duration of catheter double-lumen (CDL) usage before arteriovenous fistula placement, incidence of early thrombosis, and incidence of maturation failure. Data was analyzed with Microsoft Excel 2018. Results: There were 28 primary arteriovenous fistula failure cases from 580 surgical procedures performed in the research period (4.8%). The dominant results were: 15 female patients (54%), 25 non-elderly patients (89%), 16 non-DM patients (57%), 14 patients in both HTN and non-HTN (50%), 20 prolonged CDL patients (71%), followed by 7 patients that did not use CDL (25%), 28 maturation failure patients (100%), and 18 non-early thrombosis patients (64%). Conclusion: Female gender, duration of CDL usage, and maturation failure were the more prominent characteristics in this research profile. Meanwhile, the less prominent characteristics were old age, DM history, HTN history, and early thrombosis.
Predictive Factors of Amputation for Post-Bypass Surgery on Vascular Trauma Patients Kusworo, Afila Reza; Soebroto, Heroe; Suroto, Heri
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3107

Abstract

n Indonesia, most vascular trauma is linked to traffic collisions. According to the Statistics Indonesia (Badan Pusat Statistik, BPS), there were 116,411 accidents in 2019. Limb salvages become important in  vascular trauma, which is performed through, among others, vascular bypass surgery. However, secondary amputation still occurs after vascular bypass. This study aimed to determine the predictors of secondary amputation after vascular bypass due to vascular trauma. This study used descriptive analysis of medical records and univariate analysis. Medical records of patients with vascular trauma underwent vascular bypass in Dr Soetomo Regional Hospital, Indonesia, from January 2018 to December 2020 were collected. Independent variables were age, MESS, time interval between the incident of trauma to the first incision of bypass surgery, penetrating and blunt injury, injured arterial segment, multiple injuries, and obesity. The dependent variable was secondary amputation. Fisher Exact Test was used to analyze the correlation between dependent and independent variables. Results showed a significant difference between patients with a MESS score of >7 and those with a MESS score of  ≤7 (p=0.044), where more patients with a MESS score of >7 experienced secondary amputation. Other variables showed no significant difference (p>0.05). This study concluded that MESS could be used as a predictor of secondary amputation in vascular trauma after vascular bypass. Further studies using multivariate analysis and a larger sample need to be conducted to get further insights on this phenomenon.
COMPLETE REPAIR OF TETRALOGY OF FALLOT (TOF) ON BEATING HEART SURGERY WITHOUT AORTIC CROSS CLAMPING : REPORT OF A CASE Gerardo AK Laksono; Heroe Soebroto; Paul L Tahalele
JURNAL WIDYA MEDIKA Vol. 7 No. 2 (2021): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i2.3516

Abstract

Introduction: Reperfusion injury is a well-known phenomenon that occurred in cardioplegic techniques with cardiopulmonary bypass. Therefore great effort is made to prevent reperfusion injury. Beating Heart Continuous Coronary Perfusion (BHCCP) surgery is one of the alternative techniques to improve an ischemic reperfusion injury in open-heart surgery, either in pediatric or in adult. This technique can be done in complete repair of tetralogy of Fallot (TOF). Purpose: To report our first experience in doing complete repair of TOF using beating heart technique without aortic cross-clamping Case Report: A five-year-old boy came on to ER on January 6th, 2012, with a history of cyanotic since birth. His echocardiography and catheterization concluded a tetralogy of Fallot with a McGoon ratio of 1.95 (the diameter of RPA and LPA were 9.14 mm and 8.79 mm, respectively). A complete repair of TOF was done using beating heart surgery without aortic cross-clamping technique. One month post-surgery evaluation, there weren't any neurological or motor disorders. Echocardiography results showed no residual pulmonary stenosis, but 0.2 mm residual VSD was found. Conclusion: This heart rate technique is an alternative method of myocardial protection in cardiac surgery. In several cardiac centres globally, this technique is relatively safe and can be used during surgery, especially in the total correction of TOF.
Implementation of Enhanced Recovery After Surgery (ERAS) Protocols in Pediatric Cardiac Surgery: A Comprehensive Review Nugroho, Edwin Rasendriya; Heroe Soebroto; Ketut Alit Utamayasa
SCRIPTA SCORE Scientific Medical Journal Vol. 7 No. 2 (2026): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v7i2.23099

Abstract

Background: Enhanced Recovery After Surgery (ERAS) represents an evidence-based, multidisciplinary approach that optimizes perioperative care, reduces surgical stress, and accelerates postoperative recovery. While ERAS protocols have been widely implemented in adult cardiac surgery, their adaptation to pediatric congenital heart disease (CHD) remains emerging and underexplored. Pediatric populations pose unique challenges due to differences in physiology, surgical complexity, and developmental status. Objectives: This review aims to provide a comprehensive overview of ERAS implementation in pediatric cardiac surgery, focusing on its key components, outcomes, and research gaps to guide future practice and investigation. Methods: A narrative literature review was conducted using PubMed and Google Scholar, targeting publications from 2010 to 2025. The search utilized the keywords “Enhanced Recovery After Surgery,” “ERAS,” “Pediatric Cardiac Surgery,” and “Congenital Heart Disease.” Relevant randomized controlled trials, cohort studies, reviews, and clinical guidelines were critically analyzed to identify core ERAS elements, perioperative strategies, and reported outcomes. Discussion: The reviewed evidence supports that ERAS protocols in pediatric cardiac surgery are feasible and associated with reduced mechanical ventilation duration, ICU stay, and hospital length of stay, without increasing complications or readmissions. However, most available studies are observational, highlighting the scarcity of randomized controlled trials specifically addressing pediatric CHD. Conclusion: ERAS offers a promising framework to enhance recovery and safety in pediatric cardiac surgery. Standardized, multicenter trials are required to establish evidence-based pediatric ERAS models and determine their long-term impact on recovery and quality of life. Keyword: cardiac surgery, congenital heart disease, ERAS, pediatric, recovery Latar Belakang: Enhanced Recovery After Surgery (ERAS) merupakan pendekatan multidisiplin berbasis bukti yang bertujuan mengoptimalkan perawatan perioperatif, mengurangi stres pembedahan, dan mempercepat pemulihan pascaoperasi. Meskipun protokol ERAS telah banyak diterapkan pada pembedahan jantung dewasa, adaptasinya pada kasus Congenital Heart Disease (CHD) pediatrik masih tergolong baru dan belum banyak diteliti. Populasi pediatrik memiliki tantangan tersendiri karena perbedaan fisiologi, kompleksitas pembedahan, serta status perkembangan. Tujuan: Tinjauan ini bertujuan untuk memberikan gambaran komprehensif mengenai penerapan ERAS pada pembedahan jantung pediatrik, dengan menyoroti komponen utama, luaran klinis, serta kesenjangan penelitian untuk panduan praktik dan penelitian selanjutnya. Metode: Tinjauan literatur naratif dilakukan dengan menggunakan basis data PubMed dan Google Scholar untuk publikasi tahun 2010 hingga 2025. Pencarian dilakukan dengan kata kunci “Enhanced Recovery After Surgery,” “ERAS,” “Pediatric Cardiac Surgery,” dan “Congenital Heart Disease.” Artikel yang relevan, termasuk randomized controlled trials, studi kohort, tinjauan pustaka, dan pedoman klinis dianalisis secara kritis untuk mengidentifikasi elemen utama ERAS, strategi perioperatif, serta luaran yang dilaporkan. Pembahasan: Bukti yang ditinjau menunjukkan bahwa penerapan protokol ERAS pada pembedahan jantung pediatrik bersifat layak dan berhubungan dengan penurunan durasi ventilasi mekanik, lama perawatan di ICU, serta lama rawat inap, tanpa meningkatkan komplikasi maupun angka readmisi. Namun, sebagian besar studi yang tersedia bersifat observasional, menyoroti keterbatasan uji acak terkontrol yang secara khusus meneliti CHD pediatrik. Kesimpulan: ERAS menawarkan kerangka kerja yang menjanjikan untuk meningkatkan pemulihan dan keamanan pada pembedahan jantung pediatrik. Diperlukan uji multicenter terstandar untuk membangun model ERAS berbasis bukti pada populasi pediatrik serta menilai dampak jangka panjangnya terhadap pemulihan dan kualitas hidup. Keyword: bedah jantung, ERAS, pediatrik, pemulihan, penyakit jantung bawaan
Co-Authors Abed Nego Okthara Sebayang Agus Subagjo Ahmed Eliaan Shaker Abuajwa Ansyori, Maz Isa Arief Rakhman Hakim Arifoel Hajat Chronica Elsa Retta Lumban Tobing Danang Himawan Limanto Dharmadjati, Budi Baktijasa Dhihintia Jiwangga Suta Winarno Dhihintia Jiwangga Suta Winarno Erdyanto Akbar Fhahira Rizkhika Admadiani Gerardo AK Laksono Hartono Kahar, Hartono Heri Suroto Hermina Novida, Hermina Hildegardis Dyna Dumilah I Gusti Agung Made Adnyanya Putra I Gusti Agung Made Adnyanya Putra2 Ito Puruhito Jeffrey Jeswant Dillon Jeffrey Jeswant Dillon Juliana Juliana Ketut Alit Utamayasa Ketut Putu Yasa Kusworo, Afila Reza Mahrus A Rahman, Mahrus A Marsa Hendra Utomo Mochamad Wildan Nugroho, Edwin Rasendriya Paul L Tahalele Puruhito Puruhito Putranto, J.Nugroho Eko Reido Dafa Annafis Reviano, Moses Orvin Salsabila Fabianca Alsaid Sembiring, Yan Efrata Setiawan, Philia Sony Wibisono Sri Pramesthi Wisnu Bowo Negoro Sri Pramesthi Wisnu Bowo Negoro Taufiq Hidayat Taufiq Hidayat Widodo Widodo Wiwin Is Effendi