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All Journal Majalah Kedokteran Bandung Jurnal Kedokteran Health Notions Manuju : Malahayati Nursing Journal Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) SCRIPTA SCORE Scientific Medical Journal Cardiovascular and Cardiometabolic Journal (CCJ) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Cerdika: Jurnal Ilmiah Indonesia Journal of Indonesia Vascular Access Jurnal Widya Medika Folia Medica Indonesiana
Soebroto, Heroe
Department Of Cardiothoracic And Vascular Surgery, Faculty Of Medicine Universitas Airlangga, Dr Soetomo General Academic Hospital, Surabaya Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Lung Cancer: A Literature Review Yan Efrata Sembiring; Wiwin Is Effendi; Jeffrey Jeswant Dillon; Heroe Soebroto; Dhihintia Jiwangga Suta Winarno; Puruhito Puruhito; I Gusti Agung Made Adnyanya Putra; Abed Nego Okthara Sebayang; Sri Pramesthi Wisnu Bowo Negoro
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.246-251

Abstract

Lung cancer is a cancer whose onset starts in the lungs where there is an abnormal cell growth that is very fast and uncontrolled. The abnormal cell growth is triggered by deoxyribonucleic acid (DNA) damage, including deletions in the DNA section, inactivation of tumor suppressor genes, activation of proto-oncogenes to oncogenes, the absence of apoptosis, and the activity of the telomerase enzyme. Lung cancer is initiated by oncogeneous activity and inactivation of tumor suppressor genes. Oncogenes are genes that help cells grow and divide and are believed to cause a person to develop lung cancer. In general, lung cancer is divided into two types, namely non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). World Health Organization (WHO) classifies lung cancer based on histopathology into 4 major cell types, namely SCLC, NSCLC which includes adenocarcinoma, squamous cell carcinoma (SCC), and large cell carcinoma (LCC). The difference between the two is that SCLC has a higher aggressiveness than NSCLC. Cancer treatment is based on the type, size, location and stage of the cancer, as well as the patient's overall condition.
Changes in Nutritional Status of Children Under Five with Acyanotic Congenital Heart Disease Left to Right Shunt Type After Defect Closure by Catheterization Marsa Hendra Utomo; Taufiq Hidayat; Heroe Soebroto
Cardiovascular and Cardiometabolic Journal (CCJ) Vol. 5 No. 1 (2024): Cardiovascular and Cardiometabolic Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ccj.v5i1.2024.11-22

Abstract

Highlights: 1. The nutritional status of children with CVD after therapy is interesting to discuss especially because children antibody varies. 2. Changes in their nutrition intake after the surgery would help for future treatments with related disease and same operation. - Background: One of the impacts that occur in patients with congenital heart disease (CHD) is malnutrition. Malnutrition will affect the growth of the child. Closure therapy with catheterization can improve nutritional status after a few months. This study aims to determine the nutritional status of toddlers with simple left to right shunt-type acyanotic CHD before and after closure therapy with catheterization. Material and Methods: This study is an analytical observational study with a retrospective cohort method using medical record data involving pediatric patients less than 5 years old with simple left to right shunt-type acyanotic CHD who received closure by catheterization at Dr. Soetomo General Hospital from January 2020 to December 2020. Results: From 10 samples, the characteristics of the most samples were women (90%), age group 2-5 years (60%), and PDA abnormalities (50%). In addition, nutritional status after closure by catheterization improved. Conclusion: There was an improvement in nutritional status (W/H) after defect closure with catheterization in patients aged less than 5 years with simple left to right shunt type acyanotic CHD within several months.
THE HDL LEVEL IN DIABETIC FOOT ULCER PATIENTS WITH AND WITHOUT AMPUTATION AT DR. SEOTOMO GENERAL ACADEMIC HOSPITAL SURABAYA Ahmed Eliaan Shaker Abuajwa; Hermina Novida; Heroe Soebroto; Yan Efrata Sembiring
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.30-37

Abstract

Highlights1. Diabetes mellitus is a category of metabolic disease characterized by uncontrolled hyperglycemia.2. This study revealed no statistically significant differences in total cholesterol, TG, LDL, HDL, or LDL/HDL ratio between amputated and non-amputated DFU patients. AbstractBackground: Diabetic foot ulcers (DFU) are microvascular and macrovascular consequences of diabetes and are associated with neuropathy, vascular disease, and immunosuppression. Increased blood glucose levels may result in the glycosylation of proteins in the nerve cells of the foot, leading to ischemia and cellular disturbances that can damage muscular, sensory, and autonomic neurons. Objective: To compare the lipid profiles of amputated and non-amputated DFU patients. Material and Method: This was a cross-sectional, analytic, retrospective research using total sample approach to analyze the medical records of all diabetes patients admitted to Dr. Soetomo General Academic Hospital between February 2018 and December 2020, with or without amputation. Result: The average age of DFU patients at Dr. Soetomo General Academic Hospital was 55.6 9.4 years, and the majority of patients were female (57%). Diabetic foot ulcers were most prevalent in the age group ≥50 years old (74%), amputated DFU patients had larger mean total cholesterol, TG, LDL, and HDL than non-amputated DFU patients, although the difference was not statistically significant. While the mean LDL/HDL ratio was greater in non-amputated DFU patients, the difference was statistically insignificant. The HDL level was low in 84% of amputated DFU patients, whereas in non-amputated DFU patients it was 81%. Conclusion: This research showed no significant variation in total cholesterol, TG, LDL, HDL, or the LDL/HDL ratio between amputated and non-amputated DFU patients. Most DFU patients with and without amputations had low HDL values.
Profile of Primary Arteriovenous Fistula Failure in End-Stage Renal Disease Patients on Hemodialysis at Dr. Soetomo General Academic Hospital, Surabaya Reviano, Moses Orvin; Sembiring, Yan Efrata; Widodo, Widodo; Soebroto, Heroe
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 1 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I12025.43-49

Abstract

Highlights: Arteriovenous fistula is preferred for dialysis vascular access. Twenty-eight (4.8%) cases had primary arteriovenous fistula failure.   Abstract Introduction: Primary arteriovenous fistula failure in Indonesia is still relatively high, and end-stage renal disease patients are prioritized to have arteriovenous fistula as their main vascular access for hemodialysis. This study aimed to determine the primary arteriovenous fistula failure profile in end-stage renal disease patients on hemodialysis at Dr. Soetomo General Academic Hospital, Surabaya. Methods: This was a descriptive retrospective study. The population was primary arteriovenous fistula failure patients. A total sampling method was used from the medical records of Dr. Soetomo General Academic Hospital, Surabaya, from January 2021 until January 2023. The research variables were gender, age, diabetes mellitus (DM) history, hypertension (HTN) history, duration of catheter double-lumen (CDL) usage before arteriovenous fistula placement, incidence of early thrombosis, and incidence of maturation failure. Data was analyzed with Microsoft Excel 2018. Results: There were 28 primary arteriovenous fistula failure cases from 580 surgical procedures performed in the research period (4.8%). The dominant results were: 15 female patients (54%), 25 non-elderly patients (89%), 16 non-DM patients (57%), 14 patients in both HTN and non-HTN (50%), 20 prolonged CDL patients (71%), followed by 7 patients that did not use CDL (25%), 28 maturation failure patients (100%), and 18 non-early thrombosis patients (64%). Conclusion: Female gender, duration of CDL usage, and maturation failure were the more prominent characteristics in this research profile. Meanwhile, the less prominent characteristics were old age, DM history, HTN history, and early thrombosis.
Predictive Factors of Amputation for Post-Bypass Surgery on Vascular Trauma Patients Kusworo, Afila Reza; Soebroto, Heroe; Suroto, Heri
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3107

Abstract

n Indonesia, most vascular trauma is linked to traffic collisions. According to the Statistics Indonesia (Badan Pusat Statistik, BPS), there were 116,411 accidents in 2019. Limb salvages become important in  vascular trauma, which is performed through, among others, vascular bypass surgery. However, secondary amputation still occurs after vascular bypass. This study aimed to determine the predictors of secondary amputation after vascular bypass due to vascular trauma. This study used descriptive analysis of medical records and univariate analysis. Medical records of patients with vascular trauma underwent vascular bypass in Dr Soetomo Regional Hospital, Indonesia, from January 2018 to December 2020 were collected. Independent variables were age, MESS, time interval between the incident of trauma to the first incision of bypass surgery, penetrating and blunt injury, injured arterial segment, multiple injuries, and obesity. The dependent variable was secondary amputation. Fisher Exact Test was used to analyze the correlation between dependent and independent variables. Results showed a significant difference between patients with a MESS score of >7 and those with a MESS score of  ≤7 (p=0.044), where more patients with a MESS score of >7 experienced secondary amputation. Other variables showed no significant difference (p>0.05). This study concluded that MESS could be used as a predictor of secondary amputation in vascular trauma after vascular bypass. Further studies using multivariate analysis and a larger sample need to be conducted to get further insights on this phenomenon.
COMPLETE REPAIR OF TETRALOGY OF FALLOT (TOF) ON BEATING HEART SURGERY WITHOUT AORTIC CROSS CLAMPING : REPORT OF A CASE Gerardo AK Laksono; Heroe Soebroto; Paul L Tahalele
JURNAL WIDYA MEDIKA Vol. 7 No. 2 (2021): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v7i2.3516

Abstract

Introduction: Reperfusion injury is a well-known phenomenon that occurred in cardioplegic techniques with cardiopulmonary bypass. Therefore great effort is made to prevent reperfusion injury. Beating Heart Continuous Coronary Perfusion (BHCCP) surgery is one of the alternative techniques to improve an ischemic reperfusion injury in open-heart surgery, either in pediatric or in adult. This technique can be done in complete repair of tetralogy of Fallot (TOF). Purpose: To report our first experience in doing complete repair of TOF using beating heart technique without aortic cross-clamping Case Report: A five-year-old boy came on to ER on January 6th, 2012, with a history of cyanotic since birth. His echocardiography and catheterization concluded a tetralogy of Fallot with a McGoon ratio of 1.95 (the diameter of RPA and LPA were 9.14 mm and 8.79 mm, respectively). A complete repair of TOF was done using beating heart surgery without aortic cross-clamping technique. One month post-surgery evaluation, there weren't any neurological or motor disorders. Echocardiography results showed no residual pulmonary stenosis, but 0.2 mm residual VSD was found. Conclusion: This heart rate technique is an alternative method of myocardial protection in cardiac surgery. In several cardiac centres globally, this technique is relatively safe and can be used during surgery, especially in the total correction of TOF.
Clinical outcomes of splenorenal shunts in esophageal varices patients: a literature review Putra, I Gusti Agung Made Adnyana; Hakim, Arief Rakhman; Soebroto, Heroe; Sembiring, Yan Efrata; Limanto, Danang Himawan; Rizki, Mohamad; Puruhito
Journal of Indonesia Vascular Access Vol. 4 No. 1 (2024): (Available online : June 2024)
Publisher : Indonesian Vascular Access Association (IVAA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jinava.v4i1.40

Abstract

The disease known as esophageal varices is usually caused by portal hypertension. Portal hypertension is most commonly caused by extrahepatic portal vein thrombosis and other conditions, such as cardiac problems or hepatic cirrhosis. Clinical manifestations of esophageal varices can include melena, haematemesis, and gastrointestinal bleeding. Effective venous pressure reduction is achieved via the distal splenorenal shunt. We acquired the literature for our review from PubMed and Google Scholar. The search was done in English using terms that indicated a connection between improvements in bone grafting methods and the restoration of alveolar clefts. To expand the search results, we also looked through the papers cited in the literature. Almost all of the five gathered articles demonstrated that the distal splenorenal shunt (DSRS) is a beneficial surgical treatment that effectively avoids postoperative PH issues. Finally, DSRS is presented as a surgical long-term treatment for variceal esophageal reflux disease and portal hypertension. Because DSRS selectively decompresses the venous collaterals around the stomach and lower esophagus, it is a safe and effective therapy choice for decreasing bleeding over nonselective shunting surgeries as a selective shunt.
Correlation Between Intraoperative Blood Vessel Diameter and Technical Success Rate of AV Shunt Surgery in Dr. Soetomo Hospital Surabaya Saphira, Diva; Soebroto, Heroe; Thaha, Mochammad; Hakim, Arief Rakhman; Widipriyatama, Gabriel Rio
Journal of Indonesia Vascular Access Vol. 3 No. 2 (2023): (Available online: 1 December 2023)
Publisher : Indonesian Vascular Access Association (IVAA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jinava.v3i2.45

Abstract

Introduction: An arteriovenous (AV) shunt is an anastomosis between vein and artery made in a surgical procedure as vascular access for patients with end-stage renal disease that are projected to undergo hemodialysis. Unfortunately, AV shunt failure remains a significant clinical problem for hemodialysis patients. In general, the cause of most early AV shunt failure is still unknown, but the quality of the blood vessels is suspected as a factor. This study aimed to determine the correlation between blood vessel diameter and the success of AV shunt surgery. Methods: This study is a cross sectional study that uses a descriptive-analytic design. The samples were obtained from the patient’s medical records with the total sampling technique of all patients who have undergone AV shunt surgery from January 2019 – December 2020 at Dr. Soetomo General Hospital which matches the inclusion and exclusion criteria. Results: Patients’ blood vessel diameter measurement is divided into four categories which are <2 mm, 2 - <4 mm, 4 - <6 mm, and ≥6 mm. From a total of 62 patients, the highest successful surgery rate is carried out in patients with a vein diameter of 2 - <4 mm (77.59%) and artery diameter of 2 - <4 mm (63.79%). The results of the Chi-Square analysis found no significant correlation between vein diameter (p=0.769) or artery diameter (p=0.922) and the success of AV shunt surgery at Dr. Soetomo Hospital, Surabaya 2019-2020. Conclusions: In conclusion, this study did not find a correlation between the intraoperative blood vessel diameter and the technical success of AV shunt surgery.
Faktor Risiko Pasien Acute Limb Ischemia Admadiani, Fhahira Rizkhika; Ekoputranto, J Nugroho; Soebroto, Heroe; Subagjo, Agus
Cerdika: Jurnal Ilmiah Indonesia Vol. 2 No. 4 (2022): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v2i4.376

Abstract

Acute Limb Ischemia (ALI) is a classification of peripheral arterial disease that causes decreased blood flow to the extremities, with onset within 2 weeks and characterized by 6 'P's, namely pallor, pain, perishing cold, pulseless, paralysis, and paresthesia. This can be identified through several risk factors, including: diabetes, smoking, gender, high blood pressure, age,hyperlipidemia, atrial fibrillation (AF) and diabetes. This study aims to identify risk factors in ALI patients. Hospital identification. Soetomo Surabaya Period January 2016 – March 2019. This study uses a total sampling technique. This study uses a descriptive cross sectional method with medical record instruments and direct interviews with patients. Twenty-five (25) patients were known to have ALI (14 males and 11 females), and the age of the patients ranged from 65 to 69 years (20%). The causes of risk included a history of smoking obtained from 10 subjects (40%), a history of hypertension in 7 subjects (28%), a history of stage 1 hypertension, a history of diabetes mellitus with the highest blood glucose test value > 126 mg/dl up to 10 people. . (62.5%), with a history of hyperlipidemia, with total cholesterol within normal limits of up to 4 (66.7%), LDL in the normal range of not more than 3 (60%), and HDL with 2 with low HDL values (40%). ), and the highest triglyceride levels were within the normal range. Electrocardiographic examination revealed 7 patients (28%) with atrial fibrillation. Most of the ALI patients in this study were aged between 65 and 69 years and were male. Most ALI patients in this study were 65-69 years old and males. The most common risk factors for ALI patients were hypertension, diabetes mellitus, and hypercholesterolemia.
Mortality Risk Factors in Tetralogy of Fallot Patients Undergoing Total Correction Juliana, Juliana; Sembiring, Yan Efrata; Rahman, Mahrus Abdur; Soebroto, Heroe
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A total correction is a preferred treatment for Tetralogy of Fallot patients in every part of the world. However, the mortality in developing countries was as high as 6.9% to 15.3%. This was a retrospective analytic study that analyzed pre and post-operative risk factors that affected mortality on TOF patients that were performed total correction in Indonesia. A total of 47 TOF patients that were performed total correction from January 2016 to September 2019 were enrolled in this study based on the inclusion criteria. Preoperative and post-operative data were obtained from medical records. In this research, the majority of mortality was found in male patients (39.3%), while the female's rate was lower (36.8%). Overall mortality was 38.3% and one operative death was found. The average age of patients was 84.12 months (12-210 months), whereas the average height (85.56 ± 36.17cm vs. 112.93 ± 21.73) and weight (17.22kg vs. 28.21kg) were lower for mortality patients. Some significant preoperative variables were identified as mortality risk factors such as: age below 60 months (p=0.047), smaller weight and height (p=0.008; p=0.002), abnormal hematocrit (p=0.002), and oxygen saturation below 75% (p=0.018). Significant post-operative risk factors included: temperature above 38.5⁰C (p=0.000), and ventilator time of more than 48 hours (p=0.033). In conclusion, the mortality of TOF patients undergoing a total correction in developing countries was quite high. It was associated with some risk factors, such as younger age, lower weight and height, low oxygen saturation, post-operative fever, and prolonged ventilator time.
Co-Authors Abed Nego Okthara Sebayang Admadiani, Fhahira Rizkhika Ahmed Eliaan Shaker Abuajwa Ansyori, Maz Isa Arief Rakhman Hakim Arifoel Hajat Chronica Elsa Retta Lumban Tobing Danang Himawan Limanto Dharmadjati, Budi Baktijasa Dhihintia Jiwangga Suta Winarno Dhihintia Jiwangga Suta Winarno Dillon, Jeffrey Jeswant Effendi, Wiwin Is Ekoputranto, J Nugroho Erdyanto Akbar Fhahira Rizkhika Admadiani Gerardo AK Laksono Hakim, Arief Rakhman Hartono Kahar, Hartono Heri Suroto Hermina Novida, Hermina Hildegardis Dyna Dumilah I Gusti Agung Made Adnyanya Putra I Gusti Agung Made Adnyanya Putra2 Ito Puruhito Jeffrey Jeswant Dillon Jeffrey Jeswant Dillon Juliana Juliana Juliana Juliana Ketut Alit Utamayasa Ketut Putu Yasa Ketut Putu Yasa Kusworo, Afila Reza Mahrus A Rahman, Mahrus A Marsa Hendra Utomo Mochamad Wildan MOCHAMMAD THAHA Negoro, Sri Pramesthi Wisnu Bowo Nugroho, Edwin Rasendriya Paul L Tahalele Puruhito Puruhito Puruhito Puruhito, Ito Putra, I Gusti Agung Made Adnyana Putra2, I Gusti Agung Made Adnyanya Putranto, J.Nugroho Eko Rahman, Mahrus Abdur Reido Dafa Annafis Reviano, Moses Orvin Rizki, Mohamad Salsabila Fabianca Alsaid Saphira, Diva Sembiring, Yan Efrata Setiawan, Philia Siregar, Ludwina Rouli Hilary Sony Wibisono Sri Pramesthi Wisnu Bowo Negoro Sri Pramesthi Wisnu Bowo Negoro Subagjo, Agus Taufiq Hidayat Taufiq Hidayat Taufiq Hidayat Widipriyatama, Gabriel Rio Widodo Widodo Winarno, Dhihintia Jiwangga Suta