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Innal Saitis
Universitas Pendidikan Muhammadiyah Sorong
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Pengaruh Perbedaan Metode Ekstraksi Terhadap Kadar Total Flavonoid dan Alkaloid Bonggol Buah Merah (Pandanus conoideus L.) Innal Saitis; A.M. Muslihin; Lukman Hardia; Angga Bayu Budiyanto; Irwandi Irwandi; Marzella Dea Rossardy; Wahyuni Watora; Justitia Cahyani Fadli; Wiwit Ayu Fitrianti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1666

Abstract

Background: Red fruit (Pandanus conoideus L.) is an endemic plant of Papua that has been traditionally used to treat various diseases. Its biological activities are associated with the presence of secondary metabolites, particularly flavonoids and alkaloids. Objective: This study aimed to identify the secondary metabolites and evaluate the effect of different extraction methods on the total flavonoid and alkaloid contents of ethanolic extracts of red fruit (Pandanus conoideus L.) stem core. Methods: Extraction was performed using three different methods, namely maceration, Soxhlet extraction, and reflux extraction with ethanol as the solvent. Secondary metabolites were identified qualitatively, while total flavonoid and alkaloid contents were determined spectrophotometrically. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids, steroids, and tannins in the ethanolic extract of red fruit stem core. The total flavonoid contents obtained by maceration, Soxhlet extraction, and reflux extraction were 218.966 mgQE/g (21.89%), 104.023 mgQE/g (10.40%), and 247.701 mgQE/g (24.77%), respectively. The total alkaloid contents obtained by maceration, Soxhlet extraction, and reflux extraction were 145.770 mgAE/g (14.58%), 65.767 mgAE/g (6.58%), and 76.433 mgAE/g (7.64%), respectively. Conclusion: The extraction method affected the total flavonoid and alkaloid contents obtained from the sample. Reflux extraction produced the highest total flavonoid content (247.701 mgQE/g), whereas maceration produced the highest total alkaloid content (145.770 mgAE/g). Therefore, reflux was the most effective method for flavonoid extraction, while maceration was the most effective method for alkaloid extraction from the stem core of red fruit (Pandanus conoideus L.).
Potensi Antipiretik Ekstrak Etanol Daun Sampare (Glochidion sp.) pada Mencit Zubaidah Zubaidah; Lukman Hardia; Innal Saitis
Jurnal Ners Vol. 10 No. 4 (2026): OKTOBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i4.62888

Abstract

Fever is a physiological response of the body that can be treated using antipyretic agents, both synthetic and natural ingredients. Sampare leaves (Glochidion sp.) have empirically demonstrated potential pharmacological activities, including as antipyretics, but the evidence for these activities still needs to be scientifically studied. This study aims to determine the antipyretic activity of the extract of Glochidion sp. in mice based on the difference in antipyretic response between treatment groups at several measurement times. The study was conducted using mice divided into positive control, negative control, and Glochidion sp. extract groups with doses of 100, 200, and 400 mg/kg BW. Antipyretic response measurements were performed at the 30th, 60th, 90th, and 120th minutes. Analysis of differences between groups was carried out using a post hoc LSD test with a significance level of p < 0.05. The results showed that the entire dose of the extract differed significantly compared to the negative control at the entire time of measurement with p < 0.001. In positive controls, significant differences were found at multiple doses and became more consistent at the 90th and 120th minutes. Based on these results, extract of Glochidion sp. showed potential as an antipyretic agent in mice, with a response that became more pronounced as the observation time increased.
Co-Authors A. M. Muslihin Angga Bayu Budiyanto Irwandi Irwandi Justitia Cahyani Fadli Lukman Hardia Marzella Dea Rossardy Wahyuni Watora Wiwit Ayu Fitrianti Zubaidah Zubaidah