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STUDI FITOKIMIA DAN ANALISIS GUGUS FUNGSI ESKTRAK DAUN SIRIH MERAH, DAUN SIRIH BUAH DAN DAUN SIRIH CINA ASAL SORONG PAPUA BARAT DAYA Mahmud Sulthon Khoiruzaman; Wahyuni Watora
JURNAL ETNOFARMASI Vol. 3 No. 02 (2025): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v3i02.4067

Indonesia has many plants that have medicinal properties, which are used to cure diseases. Medicinal plants native to Indonesia have quite promising potential, one of which is red betel leaf (Piper crocatum Ruiz) which contains phytochemical compounds including flavonoid compounds. Flavonoid compounds in betel leaves (Peperomia pellucida L.), fruit betel leaves (Piper betle L.) and Chinese betel leaves (Peperomia pellucida L.) herbal plants belonging to the Piperaceae family, have the ability to act as growth antibiotics against bacteria that cause acne, herbal plants included. The functional group (CO) of alcohol, ether, carboxylic acid, ester is of strong intensity with a frequency area of around 1050 - 1300. – 1360 and medium intensity with a frequency area of 3300 – 3500.. Functional group (CC) of strong intensity alkanes with a frequency area ranging between 1340 – 1470 and 2850 – 2970.. Alkene functional group (C= C) intensity varies with the frequency area around between 1610 – 1680..And the functional groups detected are the (C=O) aldehyde group, ketone, alcohol, ether, carboxylic acid, ester with a frequency area ranging between 1690 – 1760.

Efficacy of Akway (Drymis sp.) Bark Extract in Restoring Hemoglobin Levels: A Preclinical Study in a Sodium Nitrite-Induced Anemia Mice Model Lukman Hardia; Fabanyo, Syahrul H.; Budiyanto, Angga Bayu; Muslihin, A. M.; Rossardy, Marzella Dea; Irwandi, Irwandi; Watora, Wahyuni
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44062

The high prevalence of anemia prompted us to explore the potential of local herbs in Papua, Indonesia, which is known for its rich natural resources. In this study, we aim to conduct preclinical tests on anemia model test animals to validate the effectiveness of akway bark extract (ABE) as the basis for the development of effective and safe herbal antianemia drugs in the future. This study employs a quantitative analytical approach, utilizing an experimental design with a pre-posttest with a control group design. The research sample used 20 mice test animals, divided into 5 groups consisting of 4 animals each, namely: the control group (positive and negative), and the intervention group using ABE doses of 10, 30, and 50mg/kg. This study was approved by the Health Research Ethics Committee of STIFAR Makassar (Number: 299/EC.1.1.B/III/KEPK/2024). Data analysis showed that a 14-day intervention using ABE was able to increase Hb levels (D% = 52.00±27.13 [ABE dose 10mg/kg]; 49.72±7.86 [ABE dose 50mg/kg] and 42.82±12.75 [ABE dose 30mg/kg]) significantly (p<0.05) when compared with the negative control (D% = 4.54±5.14), but when compared with the positive control (D% = 52.57±10.85) the average increase in Hb levels was not significant (p>0.05). In conclusion, our study showed that mice of the anemia model, intervened using ABE at doses of 10, 30, and 50mg/kg once daily for 14 days, experienced increased Hb levels.

Studi Etnofarmasi dan Skrining Fitokimia Kulit Batang Nelambo Suon (Rubiceae) Sebagai Antimalaria Suku Tehit Papua Wahyuni Watora; Ratih Arum Astuti; Marzella Dea Rossardy
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.54145

Abstrak Malaria masih menjadi permasalahan kesehatan di wilayah Papua, sehingga pemanfaatan tumbuhan obat tradisional tetap menjadi pilihan utama masyarakat pedalaman. Penelitian ini bertujuan untuk mendeskripsikan pemanfaatan tradisional tumbuhan Nelambo suon oleh masyarakat Suku Tehit di Distrik Teminabuan, Kabupaten Sorong Selatan, serta mengidentifikasi kandungan metabolit sekundernya melalui skrining fitokimia. Penelitian dilakukan melalui wawancara mendalam kepada informan lokal untuk memperoleh data pengetahuan, pengalaman, cara penggunaan, dan keyakinan terhadap efektivitas tanaman tersebut, serta uji fitokimia secara kualitatif terhadap ekstrak kulit batang. Hasil penelitian menunjukkan bahwa kulit batang Nelambo suon secara turun-temurun digunakan sebagai obat antimalaria, dengan cara direbus dan airnya diminum dua kali sehari hingga gejala berkurang. Analisis responden menunjukkan bahwa tingkat pengetahuan dan pengalaman tertinggi terdapat pada kelompok berpendidikan rendah (SD dan SMP), menandakan bahwa pengetahuan tradisional lebih dipengaruhi oleh pewarisan budaya dibandingkan pendidikan formal. Hasil skrining fitokimia menunjukkan adanya kandungan alkaloid, flavonoid, dan tanin, sedangkan saponin tidak terdeteksi. Senyawa-senyawa ini diketahui memiliki aktivitas antiplasmodium, antioksidan, serta antiinflamasi, sehingga mendukung potensi Nelambo suon sebagai kandidat obat tradisional antimalaria berbasis kearifan lokal. Kata Kunci: Etnofarmasi, Nelambo suon, antimalaria, skrining fitokimia. Abstract Malaria remains a major health problem in papua, making traditional medicinal plants an essential therapeutic option for remote communities. this study aims to describe the traditional use of nelambo suon by the tehit community in teminabuan district, south sorong regency, and to identify its secondary metabolites through phytochemical screening. data on traditional knowledge, experience, usage methods, and beliefs were collected through in-depth interviews with local informants, while qualitative phytochemical tests were performed on the stem bark extract. the results show that nelambo suon has been traditionally used for generations as an antimalarial remedy, prepared by boiling the stem bark and consuming the decoction twice daily until symptoms reduce. respondent analysis revealed that the highest levels of traditional knowledge and experience were found among those with lower formal education (elementary and junior high school), indicating that cultural transmission plays a greater role than formal schooling. phytochemical screening confirmed the presence of alkaloids, flavonoids, and tannins, while saponins were absent. these compounds possess antiplasmodial, antioxidant, and anti-inflammatory activities, supporting the potential of nelambo suon as a traditional antimalarial agent grounded in local wisdom. Keywords: ethnopharmacy, Nelambo suon, antimalarial, phytochemical screening.

Evaluasi Kelengkapan Administrasi dan Farmasetik Resep di Apotek Kimia Farma A. Yani Kota Sorong Ernifan Ernifan; Lukman Hardia; Wahyuni Watora
Jurnal Ners Vol. 10 No. 2 (2026): APRIL 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i2.56679

Abstrak Kelengkapan administrasi dan farmasetik pada resep merupakan tahapan penting dalam pelayanan kefarmasian untuk menjamin keselamatan pasien serta meminimalkan risiko medication error. Seiring dengan meningkatnya jumlah apotek di Indonesia, tuntutan terhadap mutu pelayanan kefarmasian juga semakin tinggi, khususnya dalam proses skrining resep. Penelitian ini bertujuan untuk mengevaluasi tingkat kelengkapan administrasi dan farmasetik resep di Apotek Kimia Farma A. Yani Kota Sorong pada periode Januari–Desember 2024. Sampel penelitian terdiri atas 370 lembar resep untuk evaluasi aspek administrasi dan 689 item obat untuk evaluasi aspek farmasetik. Analisis data dilakukan secara deskriptif dengan menghitung persentase kelengkapan masing-masing komponen yang diteliti. Hasil penelitian menunjukkan bahwa seluruh resep (100%) mencantumkan nama pasien, jenis kelamin (52,7%), umur (46,2%), berat badan pasien (11,1%), dan alamat pasien (9,7%). Pada aspek identitas dokter, sebanyak 97,5% resep mencantumkan nama dokter dan 100% mencantumkan alamat praktik, sedangkan nomor Surat Izin Praktik (SIP) hanya tercantum pada 11,1% resep dan nomor telepon dokter pada 4,6% resep. Tanggal penulisan resep ditemukan pada 97,8% resep. Dari aspek farmasetik, sebanyak 73,9% resep memenuhi kriteria kelengkapan. Seluruh item obat (100%) mencantumkan jumlah obat yang diresepkan, dan 97% mencantumkan aturan pakai. Namun demikian, hanya 59,9% item obat yang mencantumkan bentuk sediaan dan 38,8% yang mencantumkan kekuatan sediaan. Temuan ini menunjukkan bahwa meskipun beberapa komponen telah terpenuhi dengan baik, masih terdapat kekurangan pada aspek administrasi dan farmasetik tertentu yang berpotensi meningkatkan risiko kesalahan pengobatan. Oleh karena itu, diperlukan upaya peningkatan kepatuhan terhadap standar penulisan resep guna meningkatkan mutu pelayanan kefarmasian. Kata kunci: aspek administrasi, aspek farmasetik, kelengkapan resep, medication error, pelayanan kefarmasian.

Phytochemical Screening and Antioxidant Activity Test of Ethanol Extract of Nelambosuon (Rubiaceae) Leaves Using the DPPH Method Natalia Aksamina Sagisolo; Ratih Arum Astuti; Wahyuni Watora; A.M. Muslihin
Jurnal EduHealth Vol. 17 No. 02 (2026): Jurnal EduHealt, April - June
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Indonesia is recognized as one of the world’s megabiodiversity countries, possessing a vast diversity of medicinal plants that have long been utilized in traditional medicine. Nelambo suon (Rubiaceae) is an indigenous plant traditionally used by the Tehit Imian tribe in South Sorong, Southwest Papua, for treating wounds, skin infections, and inflammatory conditions. However, scientific information regarding its phytochemical profile and antioxidant activity remains limited. This study aimed to evaluate the phytochemical constituents and antioxidant activity of the ethanol extract of Nelambo suon leaves using the DPPH method. Fresh, undamaged green leaves were dried at room temperature without direct sunlight and extracted by maceration using 96% ethanol. Phytochemical screening was performed to identify major secondary metabolites, while antioxidant activity was assessed using the DPPH free radical scavenging assay and expressed as IC₅₀ values. The phytochemical screening revealed the presence of flavonoids and tannins in the ethanol extract, whereas alkaloids, saponins, steroids, and terpenoids were not detected. The antioxidant assay demonstrated a concentration-dependent increase in radical scavenging activity. The ethanol extract of Nelambo suon leaves exhibited an IC₅₀ value of 83.7 µg/mL, indicating strong antioxidant activity. These findings suggest that Nelambo suon leaves are a promising source of natural antioxidants, likely attributed to their flavonoid and tannin contents. This study provides preliminary scientific evidence supporting the traditional use of Nelambo suon and highlights its potential for further development as a natural antioxidant agent in pharmaceutical and herbal product applications.

Efektivitas Kulit Buah Naga Merah (Hylocereus Polyrhizus) sebagai Antikolesterol Lukman Hardia; Rizqi Fadil Nadila; Wahyuni Watora
Jurnal Sains & Kesehatan Vol 5 No 1 (2026): Jurnal Sains dan Kesehatan
Publisher : Politeknik Baubau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57151/jsika.v5i1.1698

Hypercholesterolemia is a condition where blood cholesterol levels exceed normal limits, becoming a risk factor for coronary heart disease. The skin of the red dragon fruit (Hylocereus polyrhizus) contains flavonoids, betayanin, and dietary fiber that have the potential to lower cholesterol levels. This study aims to determine the effectiveness and optimal dose of red dragon fruit peel extract as a cholesterol lowering in white rats of the Wistar strain (Rattus novergicus) induced by high cholesterol feed. This study used the pretest and post-test with control group design method, with 25 mice divided into 5 groups: negative control, positive control (simvastatin 10mg) and treatment groups with extract doses of 15, 30, and 60 mg/kg BB. The results showed that red dragon fruit peel extract had the effectiveness of hypercholesterolemia with a dose of 60mg/kgBB providing the most optimal reducing effect. Conclusion: Ethanol extract of red dragon fruit peel can significantly lower cholesterol levels in rats with hypercholesterolemia.

Pengaruh Konsentrasi Ekstrak Etanol Metimun (Cucumis sativus L.) Terhadap Konsentrasi Antioksidan dalam Sediaan Masker Gel Peel Off Gilda Fransiska; Wahyuni Watora; Lukman Hardia
Jurnal Sains & Kesehatan Vol 4 No 2 (2025): Jurnal Sains dan Kesehatan
Publisher : Politeknik Baubau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57151/jsika.v4i2.1590

Salah satu tanaman yang berpotensi sebagai sumber antioksidan alami adalah mentimun (Cucumis sativus L.). Kandungan air yang tinggi serta keberadaan vitamin C dan flavonoid di dalam mentimun berperan dalam aktivitas antioksidan dengan mekanisme menghambat, menangkap, maupun memutus reaksi radikal bebas yang bersifat sangat reaktif dan dapat memicu terbentuknya radikal bebas baru. Berdasarkan hasil uji fitokimia, ekstrak mentimun diketahui mengandung beberapa senyawa metabolit sekunder, seperti alkaloid, flavonoid dan saponin. Pemanfaatan bahan tersebut sebagai sediaan kosmetik berbentuk masker gel peel off dinilai sangat tepat. Jenis masker ini memiliki keunggulan dari segi kepraktisan karena setelah mengering dapat dilepaskan langsung dari permukaan kulit tanpa harus dibilas terlebih dahulu. Penelitian ini bertujuan untuk menganalisis pengaruh perbedaan konsentrasi ekstrak etanol mentimun (Cucumis sativus L.) yang diformulasikan dalam masker gel peel off terhadap aktivitas antioksidan yang dihasilkan. Metode yang digunakan adalah metode DPPH (2,2-diphenyl-1-picrylhydrazil atau 1,1-diphenyl-2-picrylhydrazil). Sediaan masker gel peel off diformulasikan dengan variasi konsentrasi ekstrak, yaitu 0,5% pada formula I, 1% pada formula II, dan 1,5% pada formula III. Nilai IC₅₀ yang diperoleh dari pengujian masker gel peel off pada F1 dengan konsentrasi ekstrak 0,5% menunjukkan hasil bernilai negatif sehingga IC₅₀ tidak dapat ditentukan, sedangkan ekstrak 1% (F2) memiliki nilai IC₅₀ sebesar 230,7 ppm dan ekstrak 1,5% (F3) sebesar 79,29 ppm, yang menunjukan peningkatan aktivitas antioksidan seiring dengan meningkatnya konsentrasi ekstrak dalam sediaan masker.

STUDI FITOKIMIA DAN ANALISIS GUGUS FUNGSI ESKTRAK DAUN SIRIH MERAH, DAUN SIRIH BUAH DAN DAUN SIRIH CINA ASAL SORONG PAPUA BARAT DAYA Mahmud Sulthon Khoiruzaman; Wahyuni Watora
JURNAL ETNOFARMASI Vol. 3 No. 02 (2025): JURNAL ETNOFARMASI
Publisher : Universitas Pendidikan Muhammadiyah Sorong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36232/jurnalfarmasiunimuda.v3i02.4067

Indonesia has many plants that have medicinal properties, which are used to cure diseases. Medicinal plants native to Indonesia have quite promising potential, one of which is red betel leaf (Piper crocatum Ruiz) which contains phytochemical compounds including flavonoid compounds. Flavonoid compounds in betel leaves (Peperomia pellucida L.), fruit betel leaves (Piper betle L.) and Chinese betel leaves (Peperomia pellucida L.) herbal plants belonging to the Piperaceae family, have the ability to act as growth antibiotics against bacteria that cause acne, herbal plants included. The functional group (CO) of alcohol, ether, carboxylic acid, ester is of strong intensity with a frequency area of around 1050 - 1300. – 1360 and medium intensity with a frequency area of 3300 – 3500.. Functional group (CC) of strong intensity alkanes with a frequency area ranging between 1340 – 1470 and 2850 – 2970.. Alkene functional group (C= C) intensity varies with the frequency area around between 1610 – 1680..And the functional groups detected are the (C=O) aldehyde group, ketone, alcohol, ether, carboxylic acid, ester with a frequency area ranging between 1690 – 1760.

Analisis Pemakaian BMHP pada Pasien Persalinan Normal, Operasi Caesar Umum, Dan BPJS di RSUD Sorong Levina Virginia; Lukman Hardia; Wahyuni Watora
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 5 (2025): Oktober 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i5.6395

Disposable Medical Materials play an important role in maternity services and their use is influenced by the type of delivery and the patient's payment method. This study aims to analyze the influence of both on the use of disposable medical materials in the Emergency Department Pharmacy and the Medical Depot of Dr. J.P. Wanane Regional General Hospital, Sorong Regency, and to comparing the use of disposable medical materials between caesarean section patients of the social security administration and general normal delivery. This quantitative cross-sectional study used a total sampling of 108 delivery patients from January 2025 to June 2025. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests (α=5%). The Kruskal-Wallis test results showed a significant difference in the use of medical consumables between patient groups based on the combination of delivery type and payment method (p = 0.011). Caesarean section patients from the Social Security Administration used the most medical consumables, while patients with normal delivery used the least. Mann-Whitney analysis confirmed that the use of medical consumables was higher among Caesarean section patients from the Social Security Administration compared to normal delivery (p = 0.007). Thus, the type of delivery and payment method had a significant influence, with the highest use of medical consumables among Caesarean section patients from the Social Security Administration. It was concluded that the type of delivery and payment method had a significant effect, with the highest use of disposable medical materials in the social security administration caesarean section patients.

ANALISIS VITAMIN C EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI GUMMY CANDY Letia Veronica Utami; Wahyuni Watora; Ratih Arum Astuti
Jurnal Kesehatan Tambusai Vol. 7 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i2.56894

Vitamin C merupakan vitamin yang larut dalam air dan mudah teroksidasi oleh oksigen di udara sehingga kestabilannya relatif rendah. Vitamin C tidak dapat disintesis oleh tubuh manusia sehingga pemenuhannya harus diperoleh dari asupan makanan, terutama buah-buahan. Salah satu buah yang mengandung vitamin C adalah buah naga merah (Hylocereus polyrhizus). Selain daging buahnya, kulit buah naga merah juga diketahui mengandung vitamin C sehingga berpotensi dimanfaatkan sebagai sumber alternatif vitamin C. Penelitian ini bertujuan untuk mengetahui kandungan vitamin C pada kulit buah naga merah serta pemanfaatannya dalam bentuk sediaan gummy candy. Penelitian ini menggunakan metode uji kualitatif perubahan warna dengan larutan kalium permanganat (KMnO₄) untuk mengidentifikasi adanya vitamin C. Ekstrak kulit buah naga merah diperoleh melalui proses maserasi menggunakan pelarut etanol 70%. Ekstrak kemudian diformulasikan dalam bentuk sediaan gummy candy dengan tiga variasi konsentrasi, yaitu Formula I (5 gram), Formula II (10 gram), dan Formula III (15 gram). Evaluasi sediaan meliputi uji organoleptik, pengukuran pH, uji keseragaman bobot, serta uji stabilitas. Hasil pengujian menunjukkan bahwa ketiga formula memberikan hasil positif mengandung vitamin C yang ditandai dengan perubahan warna larutan menjadi cokelat setelah penambahan KMnO₄. Evaluasi fisik menunjukkan bahwa seluruh formula memiliki karakteristik organoleptik yang baik, nilai pH yang sesuai, serta keseragaman bobot yang memenuhi standar mutu sediaan. Ekstrak kulit buah naga merah hasil maserasi dengan etanol 70% terbukti mengandung vitamin C berdasarkan uji kualitatif menggunakan KMnO₄. Namun, berdasarkan evaluasi standar mutu, sediaan gummy candy yang dihasilkan belum sepenuhnya memenuhi parameter mutu yang dipersyaratkan karena menunjukkan ketidakstabilan selama penyimpanan.

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