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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences KOVALEN: Jurnal Riset Kimia Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Pure and Applied Chemistry Jurnal Kartika Kimia Stannum : Jurnal Sains dan Terapan Kimia Jurnal Riset Sains dan Kimia Terapan CHEDS: Journal of Chemistry, Education, and Science Arfak Chem: Chemistry Education Journal BIO-CONS: Jurnal Biologi dan Konservasi Jurna Beta Kimia
Situmeang, Boima
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Energy Environmental Science Materials Science & Nanotechnology Social Sciences

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Phytochemical Composition, Antioxidant, and Antibacterial Potential of Tridax procumbens Plant Fraction from West Sumatera, Indonesia: Phytochemical Composition, Antioxidant, and Antibacterial Potential of Tridax procumbens Widyawati; Situmeang, Boima
Journal of Tropical Life Science Vol. 16 No. 01 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.01.10

Abstract

Research on the Gletang plant (Tridax procumbens) is still in its nascent stages and requires further development. The presence of secondary metabolites such as alkaloids, flavonoids, phenolics, terpenoids, and tannins is one of the reasons for the potential possessed by T. procumbens. Our previous study successfully demonstrated the antibacterial activity of leaf, flower, and stem extracts against oral pathogenic bacteria, specifically Streptococcus mutans and Enterococcus faecalis. This study introduces a bioactivity guided fractionation approach of Tridax procumbens, integrating phytochemical profiling, antioxidant, and antibacterial evaluations, coupled with LC-MS based compound identification to pinpoint the most active fraction. The fractionation of T. procumbens was carried out using column chromatography. Phytochemical screening tests, total phenolic and total flavonoid content analyses, antioxidant activity and antibacterial activity test were conducted for all fractions. The EATF was found to have the highest total flavonoid content (TFC) and total phenolic content (TPC), with mean values of 16.573 ± 0.04 mg QE/g and 10.993 ± 0.05 mg GAE/g, respectively. The highest antioxidant activity was also found in EATP with an IC50 of 5.839 ± 0.100 ppm. Antibacterial activity revealed that the EATP exhibited the best antibacterial activity against S. mutans and E. faecalis. The LC-MS analysis indicated the presence of octaverine, myristyl myristate, phenol, 2,2'-methylenebis(3,5,6-trichloro), and β-carotene in EATP. The findings provide a scientific basis for the development of plant based antibacterial agents targeting oral pathogens, while also supporting the advancement of evidence based phytopharmaceutical applications.
Co-Authors Afriyandi, Adfin Amin, Fauzan Anjulita, Ratna Asad, Hafidz Al Bilangi, Nurhayati Dewaldo, Dany Dzulhijar Eko Setiawan Fauji, Fajar Rizki Harianja, Lokky Sardomu Humesi, Lusi iin Farlina, iin Juliandoz Julianti Julianti, Julianti Lailatusholihah, Isna Mahardika, Micha Masyhuri, Aga Adi Mervina Rondonuwu Mohammad Rofik Usman Muhammad Akbar Musa, Weny J.A. Musa, Weny Junus Abdul Nani Yulianti Nasiro, Siti Ningrum, Sekar Ayu Ninik Triayu Susparini, Ninik Triayu Nurhayati Bialangi Pradana, Agrin Febrian Prastiwi, Dina Alva Puspita Sari Puspitasari Puspitasari Ramadhan, Muhammad Bagus Sagala, Iman Setyoko, Lintang Panji Sri Wijayanti Sriwijayanti Sriwijayanti, Sriwijayanti Suganda, Angga Susvira, Dian Wibowo, Arianto Widiyanto, Holisha Widyawati