Garuda - Garba Rujukan Digital

Correlation Between Warfarin Levels in the Blood and the Value of Normal INR in Fibrillation Atrium Inpatients Suryoputri, Masita Wulandari; Endriastuti, Nialiana Endah; Ilma, Dewi Latifatul; Azzahra, Alfita
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 2
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.89898

Background: Warfarin is an anticoagulant inhibitor of vitamin K that is effective in preventing systemic embolization in atrial fibrillation patients. Warfarin has a narrow therapeutic index, so it requires monitoring of rates to prevent the occurrence of toxic effects and to ensure the passage of INR values.Objectives: The study aims to find out the correlation between warfarin levels and normal INR values.Methods: Observational research method with the collection of retrospective data on the medical records of patients treated with atrial fibrillation at Prof. Dr. Margono Soekarjo Hospital, Purwokerto, in January 2019–December 2021. Warfarin levels were calculated pharmacokinetically using the steady-state concentration (Css) and plasma concentration (Cp) formulas. Data analysis is carried out using the Spearman test to determine the correlation between warfarin levels and normal INR values.Results: The number of patients with normal INR values was less than the number of patients with abnormal INR values, namely 21 patients and 48 patients. The Spearman test results show a p-value of 0.31 (p>0.05), showing that the correlation between warfarin levels in the blood and the corresponding INR value is not significant (p> 0.05), and the R value in the Spearman test is 0.122, showing that the direction of the correlation is positive with very weak correlation strength.Conclusion: The correlation between warfarin levels in the blood and the appropriate INR value is not significant (p>0.05), where the R value in the Spearman test shows R=0.122, meaning the direction of the correlation is positive with a very weak correlation strength.

Comparison of unfractionated heparin and fondaparinux in relation to the incidence of recurrent myocardial infarction Suryoputri, Masita Wulandari; Astuti, Dwi Aprilia; Endriastuti, Nialiana Endah; Ilma, Dewi Latifatul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1680

Acute Myocardial Infarction (AMI) is a cardiovascular condition that involves necrosis of the heart muscle because of a decrease in blood supply to the heart caused by an obstruction of the coronary arteries. The prevalence of cardiac disease is 1.5% including AMI, and ranked 4th above all provinces in Indonesia. Anticoagulants are administered for the management of AMI treatment. Anticoagulants are treatments utilized to prevent thrombosis and reduce ischemic injury, preventing hemorrhage from developing in the heart's arteries and veins. Unfractionated heparin (UFH) and fondaparinux are both anticoagulants, that are utilized frequently in the treatment of AMI-EST patients. In decreasing the production of thrombin and preventing coagulation, unfractionated heparin, and fondaparinux can avoid death and recurrent myocardial infarction. The research was conducted as an observational study with retrospective data collection from medical records of inpatients diagnosed with acute transmural myocardial infarction of the anterior wall at Prof. Dr. Margono Soekarjo Purwokerto from January 2019 to December 2021. The chi-square test was used to examine the association between the type of anticoagulant therapy (unfractionated heparin or fondaparinux) and the incidence of recurrent myocardial infarction. The statistical analysis showed a significant association between the type of anticoagulant therapy and the incidence of recurrent myocardial infarction (p < 0.05). A higher proportion of patients treated with fondaparinux did not experience recurrent myocardial infarction compared to those treated with unfractionated heparin, suggesting that fondaparinux may be more effective in preventing recurrence.

Perbedaan Heparin dengan Fondafarinux terhadap Efektivitas dan Kejadian Yang Tidak Diinginkan pada Pasien Infark Miokard Akut Suryoputri, Masita Wulandari; Ilma, Dewi Latifatul; Endriastuti, Nialiana Endah; Astuti, Dwi Aprilia
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1680

Acute Myocardial Infarction (AMI) is a cardiovascular condition that involves necrosis of the heart muscle because of a decrease in blood supply to the heart caused by an obstruction of the coronary arteries. The prevalence of cardiac disease is 1.5% including AMI, and ranked 4th above all provinces in Indonesia. Anticoagulants are administered for the management of AMI treatment. Anticoagulants are treatments utilized to prevent thrombosis and reduce ischemic injury, preventing hemorrhage from developing in the heart's arteries and veins. Unfractionated heparin (UFH) and fondaparinux are both anticoagulants, that are utilized frequently in the treatment of AMI-EST patients. In decreasing the production of thrombin and preventing coagulation, unfractionated heparin, and fondaparinux can avoid death and recurrent myocardial infarction. The research was conducted as an observational study with retrospective data collection from medical records of inpatients diagnosed with acute transmural myocardial infarction of the anterior wall at Prof. Dr. Margono Soekarjo Purwokerto from January 2019 to December 2021. The chi-square test was used to examine the association between the type of anticoagulant therapy (unfractionated heparin or fondaparinux) and the incidence of recurrent myocardial infarction. The statistical analysis showed a significant association between the type of anticoagulant therapy and the incidence of recurrent myocardial infarction (p < 0.05). A higher proportion of patients treated with fondaparinux did not experience recurrent myocardial infarction compared to those treated with unfractionated heparin, suggesting that fondaparinux may be more effective in preventing recurrence.

Potential Antibiotic-Drug Interactions: Analysis of Pediatric Patient Prescriptions at Omnia Farma Pharmacy Purwokerto Utami, Esti Dyah; Maharani, Farah Ayu; Ekowati, Heny; Suryoputri, Masita Wulandari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 16, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.101427

Background: The use of drugs in pediatric patients requires special attention because pediatrics have physiological and anatomical differences with adults. Children are more susceptible to infectious diseases and often get antibiotic therapy and other symptomatic drugs to support recovery, thus increasing the potential for drug interactions.Objectives: The study aimed to analyze the incidence of potential antibiotic drug interactions prescribed to pediatric patients at Omnia Farma Pharmacy Purwokerto. Methods: This observational study was conducted retrospectively by collecting prescription data of pediatric patients aged 0-18 years at Omnia Farma Pharmacy Purwokerto from January to December 2023 using a simple random sampling method. Data were analyzed descriptively using the standard of the Lexicomp Interaction Checker database and other scientific literature. Results: There were 286 patient prescriptions that met the inclusion criteria. The majority of patients were male, aged 1-5 years, with the most prescribed antibiotic being amoxicillin (73.13%). The study only found potential drug interactions in 12 antibiotic prescriptions (4.20%), of which 50% were interactions between azithromycin and salbutamol. Most of the potential antibiotic-drug interactions found were of minor severity (91.67%), with pharmacodynamic interaction mechanisms (83.33%).Conclusion: The antibiotic prescriptions given to pediatric patients at Omnia Farma Pharmacy were quite good in terms of the minimal number of potential drug interactions found. Special attention to the therapy of pediatric patients through the collaboration of doctors and pharmacists is important to help patients get optimal therapy.

Title

Found 14 Documents
Search

Abstract

Abstract

Abstract

Abstract

Title Search

Found 14 Documents Search

Abstract

Abstract

Abstract

Abstract

Title

Found 14 Documents
Search