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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Majalah Obat Tradisional Acta Pharmaciae Indonesia : Acta Pharm Indo JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmu Kefarmasian Indonesia JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat)
Suryoputri, Masita Wulandari
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Engineering Health Professions Medicine & Pharmacology Public Health Other

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Comparison of unfractionated heparin and fondaparinux in relation to the incidence of recurrent myocardial infarction Suryoputri, Masita Wulandari; Astuti, Dwi Aprilia; Endriastuti, Nialiana Endah; Ilma, Dewi Latifatul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 2 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i2.1680

Abstract

Acute Myocardial Infarction (AMI) is a cardiovascular condition that involves necrosis of the heart muscle because of a decrease in blood supply to the heart caused by an obstruction of the coronary arteries. The prevalence of cardiac disease is 1.5% including AMI, and ranked 4th above all provinces in Indonesia. Anticoagulants are administered for the management of AMI treatment. Anticoagulants are treatments utilized to prevent thrombosis and reduce ischemic injury, preventing hemorrhage from developing in the heart's arteries and veins. Unfractionated heparin (UFH) and fondaparinux are both anticoagulants, that are utilized frequently in the treatment of AMI-EST patients. In decreasing the production of thrombin and preventing coagulation, unfractionated heparin, and fondaparinux can avoid death and recurrent myocardial infarction. The research was conducted as an observational study with retrospective data collection from medical records of inpatients diagnosed with acute transmural myocardial infarction of the anterior wall at Prof. Dr. Margono Soekarjo Purwokerto from January 2019 to December 2021. The chi-square test was used to examine the association between the type of anticoagulant therapy (unfractionated heparin or fondaparinux) and the incidence of recurrent myocardial infarction. The statistical analysis showed a significant association between the type of anticoagulant therapy and the incidence of recurrent myocardial infarction (p < 0.05). A higher proportion of patients treated with fondaparinux did not experience recurrent myocardial infarction compared to those treated with unfractionated heparin, suggesting that fondaparinux may be more effective in preventing recurrence.
Potential Antibiotic-Drug Interactions: Analysis of Pediatric Patient Prescriptions at Omnia Farma Pharmacy Purwokerto Utami, Esti Dyah; Maharani, Farah Ayu; Ekowati, Heny; Suryoputri, Masita Wulandari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 16, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.101427

Abstract

Background: The use of drugs in pediatric patients requires special attention because pediatrics have physiological and anatomical differences with adults. Children are more susceptible to infectious diseases and often get antibiotic therapy and other symptomatic drugs to support recovery, thus increasing the potential for drug interactions.Objectives: The study aimed to analyze the incidence of potential antibiotic drug interactions prescribed to pediatric patients at Omnia Farma Pharmacy Purwokerto. Methods: This observational study was conducted retrospectively by collecting prescription data of pediatric patients aged 0-18 years at Omnia Farma Pharmacy Purwokerto from January to December 2023 using a simple random sampling method. Data were analyzed descriptively using the standard of the Lexicomp Interaction Checker database and other scientific literature. Results: There were 286 patient prescriptions that met the inclusion criteria. The majority of patients were male, aged 1-5 years, with the most prescribed antibiotic being amoxicillin (73.13%). The study only found potential drug interactions in 12 antibiotic prescriptions (4.20%), of which 50% were interactions between azithromycin and salbutamol. Most of the potential antibiotic-drug interactions found were of minor severity (91.67%), with pharmacodynamic interaction mechanisms (83.33%).Conclusion: The antibiotic prescriptions given to pediatric patients at Omnia Farma Pharmacy were quite good in terms of the minimal number of potential drug interactions found. Special attention to the therapy of pediatric patients through the collaboration of doctors and pharmacists is important to help patients get optimal therapy.
Analysis of Virgin Coconut Oil (VCO) Purity Using UV-Vis Spectrophotometry Combined with PCA and HCA Chemometrics Wijaya, Triyadi Hendra; Rehana, Rehana; Arisma, Divaa' Rizqi; Endriastuti, Nialiana Endah; Suryoputri, Masita Wulandari
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.63230

Abstract

VCO is a vegetable oil with many health and cosmetic benefits, but it is relatively more expensive than other vegetable oils, making it vulnerable to adulteration. UV-Vis spectrophotometry, combined with chemometric techniques, was used to distinguish VCO from other oils. Soybean oil (SO) and sunflower oil (SFO) are the main adulterants of VCO. This study aimed to evaluate the ability of UV-Vis spectrophotometry combined with chemometrics to differentiate VCO from SO and SFO. Samples were measured for absorbance at wavelengths from 200 to 400 nm. The UV-Vis spectral data were further analyzed using chemometric methods, PCA, and HCA, to classify the samples. The PCA model successfully differentiated VCO, SO, and SFO in RStudio 4.4.2, with variance explained by PC1 (81.3%) and PC2 (17.1%). VCO samples are clearly separated from other samples, while SO and SFO appear close to each other due to their similar physicochemical properties. Mixed oil samples were grouped by composition. HCA analysis also showed a grouping pattern consistent with PCA results. Therefore, UV-Vis spectrophotometry, combined with chemometric techniques, can effectively distinguish VCO from SO and SFO.
Co-Authors Arisma, Divaa' Rizqi Astuti, Dwi Aprilia Azzahra, Alfita Dewi Latifatul Ilma Endriastuti, Nialiana Endah Esti Dyah Utami Hanif Nasiatul Baroroh Heny Ekowati Laksmi Maharani Maharani, Farah Ayu Mahardika, Elisa Nadzif, Faradina Qorina Purgiantari, Purgiantari Putri, Atika Rehana, Rehana Sunarto, Ade Martinus Triyadi Hendra Wijaya Tunggul Adi Purwonugroho Warsinah Warsinah