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All Journal Jurnal Analis Kesehatan Jurnal Ilmu dan Teknologi Kesehatan SANITAS: Jurnal Teknologi dan Seni Kesehatan Jurnal Ilmiah Kesehatan Journal of Telenursing (JOTING) Anakes: Jurnal Ilmiah Analis Kesehatan Jurnal Fisioterapi dan Kesehatan Indonesia Jurnal Info Kesehatan
Widhyasih, Retno Martini
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Correlation of C-Reactive Protein (CRP) Levels with D-Dimer Levels in COVID-19 Patients Choirunisa, Churiyyah Eka; Widhyasih, Retno Martini; Fajrunni’mah, Rizana
jitek Vol 11 No 1 (2023): September 2023
Publisher : Poltekkes Kemenkes Jakarta III

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32668/jitek.v11i1.1317

Abstract

Coronavirus disease 2019 is caused by SARS-CoV-2 infection. COVID-19 causes increased levels of proinflammatory cytokines, so CRP and d-dimer levels in COVID-19 patients tend to increase. This study aimed to analyze the correlation between C-Reactive Protein (CRP) levels and D-dimer levels in COVID-19 patients. This research method is analytic observational by using cross-sectional secondary data. The population of this study were all COVID-19 inpatients at Budhi Asih Hospital, East Jakarta, with a sample of 338 patients and were taken by random sampling. The results of this study found that female and male COVID-19 patients had the same risk of being infected with female patients as much as 52,7% and male patients amounting to 47,3%. Most COVID-19 patients occurred at the age of ≥60 years, namely 32,2%. All patients, which is 100% patients had high CRP levels, with a mean of 76,06 mg/L. As for D-dimer levels, 47,9% of patients had normal D-dimer levels and 52,1% had high D-dimer levels with an average of 721,48 ng/mL. The results of the Spearman's correlation test obtained a p value = 0,000, so it can be seen that there is a correlation between C-Reactive Protein (CRP) levels and D-dimer levels in COVID-19 patients with a correlation strength of 0,300 (medium). An increase in CRP levels followed by an increase in D-dimer levels but evaluation of other laboratory examination parameters also needs to be considered.
Pengaruh Penambahan Saffron (Crocus sativus) Pada Yoghurt Terhadap Pertumbuhan Pseudomonas aeruginosa Widhyasih, Retno Martini; Suminar, Nunu; Lestari, Diah
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 8 No. 1 (2022): Anakes: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v8i1.800

Abstract

Saffron (Crocus sativus) merupakan tumbuhan yang dapat digunakan sebagai obat tradisional dan juga digunakan dalam produk olahan makanan. Bahan aktif saffron, seperti flavonoid, saponin, dan tanin, diketahui merupakan senyawa antibakteri. Saffron dapat digunakan dalam produk fermentasi seperti yoghurt yang berperan sebagai prebiotik untuk zat aktif yang terkandung dalam yoghurt, yaitu bakteri asam laktat (BAL). Bakteri patogen dapat menyebabkan beberapa penyakit, diantaranya Pseudomonas aeruginosa. Bakteri ini diketahui menyebabkan infeksi pneumonia nosokomial yang ditularkan melalui pernapasan. Penelitian ini bertujuan untuk mengetahui nilai zona hambat, volume hambat minimum dan pengaruh penambahan saffron yoghurt terhadap Pseudomonas aeruginosa. Penelitian ini dilakukan dengan menggunakan metode true experimen dengan desain post test only control group. Uji daya hambat dilakukan dengan metode difusi sumur dengan lima kelompok perlakuan yaitu 5 helai dan 10 helai saffron dalam yoghurt dengan volume 25 µl, 50 µl, 100 µl, 150 µl, dan 200 µl. Setiap perlakuan diulangi lima kali. Sebagai kontrol positif larutan ciprofloxacin 0,25% dan akuades sebagai kontrol negatif. Pengujian dilakukan di Laboratorium Bakteriologi Politeknik Kemenkes Jakarta III pada bulan Juni 2020. Data yang diperoleh dianalisis secara statistik dengan uji Kruskal-Wallis dan dilanjutkan dengan uji Mann-Whitney pada tingkat kepercayaan 95% dengan α = 0,05 (5%). Hasil statistik diperoleh nilai p <0,05 (p = 0,000). Maka dapat disimpulkan penambahan saffron pada yoghurt berpengaruh terhadap pertumbuhan bakteri Pseudomonas aeruginosa.Kata kunci: Crocus sativus, Pseudomonas aeruginosa, Saffron, Yoghurt.
Gambaran Kadar CEA dan CA 19-9 Sebagai Skrining Kanker Pankreas Di Rumah Sakit X Jakarta Utara Tahun 2021 Widhyasih, Retno Martini; Zuraida, Zuraida; Mukti, Septiana Widya; Permana, Atna; Fauziah, Prima Nanda; Nurdiani, Catu Umirestu
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 8 No. 2 (2022): Anakes: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v8i2.1201

Abstract

Kanker pankreas merupakan salah satu penyebab utama kematian yang disebabkan karena kanker. Pada umumnya, kanker pankreas dikaitkan dengan prognosis yang sangat buruk dikarenakan beberapa alasan, salah satunya karena didiagnosis pada stadium lanjut dan beberapa kasus tidak ada gejala. Dalam penegakan diagnosis kanker pankreas dapat digunakan kombinasi pemeriksaan pencitraan seperti USG/CT Scan dan pemeriksaan laboratorium penanda tumor seperti CEA dan CA 19-9 sebagai pilihan pertama untuk skrining awal. Penelitian ini bertujuan untuk mengetahui gambaran kadar CEA dan CA 19-9 pada suspek kanker pankreas di Rumah Sakit X Jakarta Utara periode Januari – Desember 2021. Penelitian ini menggunakan metode deskriptif analitik dengan data sekunder dari pemeriksaan kadar CEA dan CA 19-9 pada 100 pasien suspek kanker pankreas. Kanker pankreas pada umumnya diderita laki-laki dan usia lanjut dan pada penelitian ini didapatkan laki-laki 66% dan lansia sebanyak 35%. Hasil pemeriksaan CEA dan CA 19-9 yang dilakukan bersamaan didapatkan hasil CEA abnormal dan CA 19-9 abnormal sebanyak 40%. Kombinasi serum CA 19-9 dan CEA dapat meningkatkan spesifisitas. Pada penelitian ini, kenaikan CEA didapatkan pada 41% kasus suspek kanker pankreas. Penanda tumor CA 19-9 dianggap yang paling baik untuk diagnosis kanker pankreas, karena mempunyai sensitivitas dan spesitivitas tinggi dan pada penelitian ini didapatkan 68% didapatkan kadar abnormal. Kadar CA 19-9 dan CEA serum yang abnormal berkorelasi erat dengan prognosis pasien kanker pankreas. Selain itu, dibandingkan dengan pasien dengan kadar CA 19- 9 dan CEA yang normal, pasien dengan peningkatan kadar CA 19-9 atau CEA seringkali memiliki prognosis yang lebih buruk yang menunjukkan bahwa tumor sudah dalam stadium lanjut.. Simpulan, Pemeriksaan CEA dan CA 19-9 dapat digunakan sebagai penanda tumor yang sensitive dan spesifik sebagai pemeriksaan skrining kanker pankreas, namun tetap perlu dilakukan penunjang diagnostik seperti pencitraan untuk mengetahui stadium kanker pankreasKata kunci : CEA, CA 19-9, Skrining Kanker Pankreas
Gambaran Hasil Pemeriksaan Anti–HIV dan HBsAg Metode Immunochromatography Tes Pada Ibu Hamil Di RSAB Harapan Kita Jakarta Widhyasih, Retno Martini; Nengsih, Maharani Kurnia; Zuraida, Zuraida
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 9 No. 2 (2023): Anakes: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v9i2.1856

Abstract

Isu kesehatan ibu dan anak tetap menjadi fokus perhatian berbagai pihak di tingkat global, regional dan Indonesia. Dalam upaya menurunkan kematian ibu serta melahirkan generasi yang sehat dan berkualitas yang merupakan tujuan pelayanan kesehatan ibu sebagaimana diamanatkan dalam UU Kesehatan, maka pelayanan antenatal yang berkualitas merupakan bagian yang sangat penting dan akan memberikan kontribusi yang sangat besar dalam mencapai tujuan tersebut, Salah satu penyakit yang harus dideteksi selama kehamilan adalah infeksi HIV dan Hepatitis B pada ibu hamil. Lebih dari 90% bayi terinfeksi HIV tertular dari ibu HIV selama kehamilan, saat persalinan dan menyusui. Tujuan penelitian adalah mengetahui gambaran hasil pemeriksaan Anti-HIV dan HBsAg pada ibu hamil di RSAB Harapan Kita. Metode penelitian ini adalah deskriptif menggunakan data sekunder berdasarkan Rekam Medis RSAB Harapan Kita periode Januari – Juni 2022 dengan responden sebanyak 495 pasien ibu hamil yang melakukan pemeriksaan Anti-HIV dan HBsAg. Simpulan hasil penelitian ini menunjukkan gambaran hasil pemeriksaan Anti-HIV pada ibu hamil dengan hasil Reaktif sebanyak 1 orang (0,2 %) dan HBsAg Reaktif sebanyak 8 orang (1,6 %). Ibu hamil hendaknya agar lebih meningkatkan kewaspadaan dan menghindari faktor-faktor risiko yang bisa menyebabkan penularan penyakit HIV dan Hepatitis B untuk mencegah terjadinya penularan secara kongenital kepada janinnya.Kata kunci : HIV, Hepatitis B, Ibu hamil
Gambaran Hasil Pemeriksaan Hepatitis C Virus Viral Load Di RSPAD Gatot Soebroto Jakarta Al Yasin, Fatin; Zuraida, Zuraida; Widhyasih, Retno Martini
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 10 No. 1 (2024): ANAKES: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v10i1.2027

Abstract

The Hepatitis C virus (Hepatitis C virus, HCV), which belongs to the Ribonucleic Acid (RNA) virus, belongs to the Flaviviridae family and the Hepacivirus genus. The entry of this virus will produce antibodies against HCV which can be measured through serological examination which indicates a history of infection. This study aims to determine the results of the HCV Viral load examination in Hepatitis C patients at Gatot Soebroto Army Hospital, Jakarta. This research was conducted descriptively using secondary data obtained from Medical Records and Clinical Pathology on the results of Viral load examinations on 225 patient data who underwent Viral load examinations. The results showed that 121 (53.8%) were detected and 104 (46.2%) were not detected. Based on the age category, high detectable Viral load results were found in the 36-45 year old age category (Lateadults) with a detected number of 27 (12%) patients, 46-55 years (Early elderly) detected 33 (14.7%) patients and age 65> (Elderly) was detected in 31 (13.8%) patients. However, in this study it was not known for sure the cause of HCV. The conclusion of this research is that Hepatitis C viral load examination is an indicator of treatment success Keyword : Hepatitis C, Age category, Gender, Viral load Libraries  
Gambaran Hasil Pemeriksaan Penderita Demam Tifoid dengan Metode Widal di Laboratorium Kesehatan Daerah Kota Sukabumi Zaranggi, Ahmad; Fauziah, Prima Nanda; Widhyasih, Retno Martini
Jurnal Ilmiah Kesehatan Vol 16 No 2 (2024): Jurnal Ilmiah Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/jik.v16i2.2240

Abstract

Typhoid fever is a systemic disease that becomes a world health problem. Typhoid fever occurs in both tropical and sub-tropical countries, especially in developing countries. To determine the exact diagnosis of this disease required examination Widal test. typhoid characterized by prolonged heat followedby bacteremia and bacterial invasion of Salmonella sp. The study aims to determine whether the diagnosis of Typhoid Fever Suspect isappropriate with the Widal Serology Test. The type of this research is descriptive research. Population of this research is outpatient in Sukabumi city health laboratory patients with typhoid fever in august 2020 – april 2021. The sample in this study were as many as 30 respondents. The results showed that the percentage of Widal Serology Test on positive Typhoid Fever was 18 people and 12 people with negative Widal Serology Test results. Positive results for Salmonella typhi O = 9 samples, Salmonella typhi H = 8 samples, Salmonella paratyphi AO as many as 9 samples, with positive results for Salmonella paratyphi BO as many as 11 samples, with positive results for Salmonella paratyphi CO as many as 13 samples, with positive results for Salmonella paratyphi AH as many as 7 samples, with a positive result of Salmonella paratyphi BH as many as 8 samples, with a positive result of Salmonella paratyphi CH as many as 7 samples. The conclusion of this study for the Widal Serology Test in positive Typhoid Fever was around 60%.The conclusion of the writing of this is more a hepatitis b patients (100%) men than women with age 30 - 65 years, decline and a rise in the number of platelets and SGPT and SGOT levels .
Relationship between Procalcitonin Levels (PCT) and Disease Severity in Hospitalized Patients Confirmed Positive for COVID-19 Fajrunni'mah, Rizana; Rada, Fransiska; Widhyasih, Retno Martini
JURNAL INFO KESEHATAN Vol 20 No 1 (2022): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol20.Iss1.638

Abstract

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This disease attacks the respiratory tract and spreads rapidly almost throughout the world, hence, WHO has declared COVID-19 as a global pandemic. The presence of inflammation and bacterial co-infection in COVID-19 hospitalized patients can increase procalcitonin (PCT) levels as a biomarker of inflammation. Elevated PCT levels are also associated with disease severity. The objective of this study is to determine the relationship between PCT levels and disease severity in hospitalized patients who are confirmed positive for COVID-19. This research method is analytic observational with cross sectional design. The sample is in the form of medical record data for 180 COVID-19 patients who are hospitalized at Bhayangkara Tk. I Raden Said Sukanto Hospital, Jakarta for the period July-December 2020. The relationship between PCT levels and disease severity was statistically analyzed using the Chi Square test. The results of this study were 109 (60.6%) men and 71 (39.4%) women with the highest age group being 46-59 years. The average PCT level was 10.38 ng/mL with the lowest level of 0.01 ng/mL and the highest level of 282.00 ng/mL. PCT levels <0.5 ng/mL were discovered in 111 patients (61.7%) and PCT levels 0.5 ng/mL in 69 patients (38.3%). The severity of disease in mild-moderate illness was 87 patients (48.4%), severe was 35 patients (19.4%), and critical was 58 patients (32.2%). The Chi Square test showed that there was a relationship between PCT levels and disease severity in COVID-19 patients (p = 0.000). The higher the PCT level, the higher the severity of the disease, thus, PCT can be used as an indicator to see the severity of the disease.
Co-Authors Al Yasin, Fatin Aryadnyani, Ni Putu Ashari, Sigit Burhannudin Burhannudin Choirunisa, Churiyyah Eka Dewi Inderiati Diah Lestari, Diah Fardiah Tilawati Sitanggang Hakim, Aisyah Iriyanti, Dewi Bintang Ketut Widyani Astuti Maharani, Eva Ayu Mukti, Septiana Widya Nengsih, Maharani Kurnia Nurdiani, Catu Umirestu Permana, Atna Prima Nanda Fauziah PUJI LESTARI Rada, Fransiska Rizana Fajrunni’mah Sakdiah, Siti Siridian, Prima Indah Siridian2 Indah Suminar, Nunu Warditianin, Ni Kadek Zaranggi, Ahmad Zuraida Zuraida