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All Journal Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Program Kreativitas Mahasiswa - Penelitian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Syntax Literate: Jurnal Ilmiah Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) SANITAS: Jurnal Teknologi dan Seni Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Health Sciences and Medicine JOURNAL SCIENTIFIC OF MANDALIKA (JSM) Journal Sport Science, Healt and Tourism of Mandalika (Jontak) Indonesian Journal of Perinatology Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Journal Pharmaceutical Science and Application (JPSA)

Ketut Widyani Astuti

Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Udayana

Author-ID : 4222729

Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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UJI AKTIVITAS ANTHELMINTIK EKSTRAK ETANOL DAUN PEPAYA PADA CACING GELANG BABI Mahatriny, Ni Nyoman; Sanggra Payani, Ni Putu; Suwanti Devi, Pande Ketut; Yulita, Santri; Astuti, Ketut Widyani; Made Oka, Ida Bagus
Program Kreativitas Mahasiswa - Penelitian PKM-P 2014
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.562 KB)

Papaya leaves ethanol extract was evaluated for anthelmintic activity on pig roundworm by in vitro assay. The aim of this research is to know whether papaya leaves ethanol extract has anthelmintic activity and to determine LC100 and LT100 values of papaya leaves ethanol extract. Anthelmintic activity test was done by using 7 groups with 3 repetition. Group I soaked in CMC-Na 0,5% as control negative; group II soaked in albendazole suspense 0,6% as control positive; groups III-VII soaked in papaya leaves ethanol extract suspense (0,6%; 1,2%; 2,4%; 4,8%; and 9,6% respectively) for 40 hours. Observation was done every 2 hours to know mortality of pig roundworm. Percentage of pig roundworm mortality were analyse by Kruskal-Wallis test along with Mann-Whitney test. LC100 and LT100 value was determine using corrected probit analysis. Papaya leaves ethanol extract at dosage 1,2%; 2,4%; 4,8%; dan 9,6% has a anthelmintic activity because gives a significant value in mortality of pig roundworm if compare with control negative (p<0,05). From corrected probit analysis papaya leaves ethanol extract has LC100 in 8,301% b/v and LT100 in 28,885 hours.Â Â Â Keywords: Â Anthelmintic, Papaya leaves, LC100, LT100.

DIFUSI NATRIUM DIKLOFENAK DALAM GEL METHOCEL 400 PADA BERBAGAI pH Ketut Widyani Astuti; Yeyet C. Sumirtapura; Ni Nyoman Wiwik S.
Jurnal Kimia (Journal of Chemistry) Vol. 6, No. 1 Januari 2012
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.196 KB)

Diffusion of sodium diclofenac in Methocel 400 gel at various pH has been studied. Diffusion test was performed in diffusion cells with artificial membranes of Whatman no.1 filter paper which was immersed in Spangler solution. Measurement of active ingredient concentration that diffuses was performed using UV spectrophotometer at a wavelength of 277 nm.The results showed that highest diffusion of diclofenac sodium occured at pH 7 with a mean percentage of diclofenac sodium diffuses after 240 minutes of 56,88 + 13,70%. The mean percentage of diclofenac sodium which diffuses from the gel Methocel 400 at pH 6 after 240 minutes was 30,39 + 1,08% while that from the Methocel 400 gel at pH 8 was 46,84 + 6,24%.

STANDARISASI DAN SKRINING FITOKIMIA EKSTRAK ETANOL 70% DAUN JERUK LIMAU (Citrus amblycarpa (Hassk.) Osche) G. M. D. Putra; D. A. Satriawati; N. K. W. Astuti; A. A. G. R. Yadnya-Putra
Jurnal Kimia (Journal of Chemistry) Vol.12 No.2 Juli 2018
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Jeruk limau (Citrus amblycarpa (Hassk.) Osche) merupakan tanaman endemik Indonesia yang memiliki potensi besar sebagai obat. Pendekatan kemotaksonomi terhadap daun C. amblycarpa dilakukan untuk memprediksi potensinya dalam pengobatan. Sebelum dilakukan pengujian aktivitas farmakologi, serbuk dan ekstrak yang diperoleh dari hasil ekstraksi menggunakan pelarut etanol 70% terlebih dahulu dilakukan studi pendahuluan meliputi perhitungan persentase rendemen ekstrak, pemeriksaan organoleptik dan mikroskopik serbuk, standarisasi serbuk dan ekstrak, dan skrining fitokimia untuk mengetahui kandungan metabolit sekunder dari daun C. amblycarpa. Standarisasi yang dilakukan meliputi penetapan kadar abu total, penetapan kadar abu tidak larut asam, penetapan kadar abu larut air, dan penetapan kadar air dari serbuk simpilisa dan ekstrak. Skrining fitokimia terhadap ekstrak etanol 70% daun C. amblycarpa meliputi pemeriksaan alkaloid, pemeriksaan flavonoid, pemeriksaan polifenol dan tanin, pemeriksaan glikosida, pemeriksaan steroid dan triterpenoid, pemeriksaan saponin, serta pemeriksaan minyak atsiri. Hasil skrining fitokimia menunjukkan bahwa ekstrak etanol 70% daun C. amblycarpa mengandung senyawa golongan flavonoid, polifenol dan tanin, glikosida, serta minyak atsiri. Kata Kunci: Citrus amblycarpa (Hassk.) Osche, jeruk limau, standarisasi, skrining fitokimia

KULIT BUAH JERUK LIMAU (Citrus amblycarpa (Hassk.) Osche) SEBAGAI ANALGESIK R. A. I. K. Maharani; N. K. Cahyaningsih; M. D. Abimanyu; K. W. Astuti
Jurnal Kimia (Journal of Chemistry) Vol.14 No.1 Januari 2020
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the treatment options for relieving pain. However, long-term use can trigger gastrointestinal bleeding. Therefore, alternative analgesics which have the same therapeutic effect with lower side effects are needed. Limau (Citrus amblycarpa) is an empirical drug for tingling and cramping. The aim of the study is to determine the analgesic activity of ethanol extract of C. amblycarpa fruit peel. The method used in testing analgesic activity is the Hot Plate method. The study was conducted by dividing 30 mice into 6 groups. The group given CMC-Na 1% was used as a negative control, the group given suspension of sodium diclofenac dose of 6.5 mg/kg of body weight was used as a positive control, and the group given suspension of ethanol extract of C. amblycarpa fruit peel with dose variations 100, 300 and 600 mg/kg of body weight. The test animals were placed on top of the Hot Plate with a temperature of 70°C at 30 minutes after giving suspension test and the response time of mice to heat was observed every 30 minutes for 3 hours with cut off time 15 second. Based on the test results, it can be concluded that the administration of ethanol extract of C. amblycarpa fruit peel with 100, 300 and 600 mg/kg of body weight gave analgesic activity on mice compared to the negative controls (CMC-Na 1%). Keywords: C. amblycarpa, Fruit Peel, Analgesics, Hot Plate

PROFIL TERAPI OBAT PADA PASIEN RAWAT INAP DENGAN DIARE AKUT PADA ANAK DI RUMAH SAKIT UMUM NEGARA Arifani Siswidiasari; Ketut Widyani Astuti; Sagung Chandra Yowani
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 2 Juli 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

The Diarrhea in children is the highest cause of morbidity and mortality in the world, especially in the developing countries. The purposes of this research are to describe about patient profile, the use of medicines profile and the treatment period in the RSU Negara. The research method used was a descriptive retrospective by taking medical records of childhood diarrhea patients in The Public Hospital RSU Negara from July to December 2012. The diarrhea type studied was acute diarrhea in children in age range of 0-14 years. The results showed that the drugs which were used for the acute diarrhea treatment in the Public Hospital of RSU Negara were: male (69.57%), female (30.43%), with age range: 0 - <1 year old (60.87%), 1 - <5 years old (34.78%), and 5 - <14 years old (4.35%). The highest classification of acute diarrhea were acute diarrhea with mild dehydration (63.04%) and without dehydration (36.96%). The use of antibiotics (89.13%), without antibiotics (10.87%), the use of ringer's lactate (93.48%), dextrose (13.04%), zinc (65.22%), antiemetic (58.69%), antipyretic (54.35 %), antacids (2.17%), H2 blocker (23.91%), probiotics (21.74%), synbiotics (34.78%), ORS (10.87%), dexamethasone (4.35%), dygestive enzymes (2.17%), nystatin (2.17%). The condition of diarrhea patient when they were released from the hospital were cured (67.39%), begins to be cured (32.61%), with various of treatment duration from 3 days (69.57%) , 4 days (23.91%), and 5 days (6.52%).

PEMBERDAYAAN IBU-IBU, BIDAN DAN KADER POSYANDU MELALUI PENYULUHAN TENTANG PEMBERIAN MAKANAN SEHAT UNTUK MENINGKATKAN GIZI DAN DAYA TAHAN TUBUH BAYI DAN ANAK DI DESA PENGOTAN KABUPATEN BANGLI Rini Noviyani; N. P. Ariantari; Rasmaya Niruri; K. Widyani Astuti; S. Chandra Yowani
Buletin Udayana Mengabdi Vol 13 No 2 (2014): Vol 13, No. 2 (2014)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

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The Community Services was held in Bangli Utara Public Health Facility, Pengotan district, Bangli. The purpose of this activity is to give information about balanced nutition and massage for babies to participants which are housewives, midwifery and posyandu staff in Bangli Utara Public Health Facility, Pengotan. They were expected to have better understanding about balanced nutrition compared to imbalanced nutrition and how to massage their babies. The methods used in this activity were deliver information about balanced nutrition and invited discussion also the baby massage practice trained to them. The result showed that participants were very interested in our program. It could be proved by their activity in discussion.Keywords: information, balanced nutrition, baby massage practice

Optimasi Waktu Maserasi untuk Manggis (Garcinia mangostana L.) Rind Menggunakan Pelarut Etil Asetat Ni Putu Ayu Dewi Wijayanti; Dewi LPMK; Astuti KW; Fitri NPE
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Background: Maceration is a non-heating extraction method the result of which is affected by the type of solvent and the maceration time. Objective: To get the higher alpha-mangostin concentration (Garcinia mangostana L.) rind that was macerated using ethyl acetate solvent and to determine the optimum maceration time needed to produce high concentration of alpha-mangostin. Methods: the mangosteen rind was macerated using ethyl acetate with the variation of the maceration time of 6, 12, 24 and 48 hours. The extract was then dried using the freeze drying method. The optimum maceration time was determined by looking at the highest concentration of alpha-mangostin from each extraction time using TLC-densitometry method with a silica gel stationary phase of GF254 and a mobile phase of chloroform”methanol (10:0.1, v/v). Results: The results showed that the difference in the maceration time can affect the concentration of alpha-mangostin compound contained in the extract. Conclusions: It was found out that the 24-hour maceration time produced the highest concentration of alpha-mangostin that is 3031.34 ng.

ACETOSAL, BUAH MENGKUDU (MORINDA CITRIFOLIA L.) DAN WAKTU PERDARAHAN I Wayan Putu Sutirta Yasa; Ketut Widyani Astuti; I Gusti Made Aman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 2 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i2.1007

Research regardless the effect of noni fruit for increasing bleeding time have already been carried out widely. The similar activity ofnoni fruit extract and acetosal can be concerned that the fruit extract has a potential activity for prolonged bleeding time. This study aimsto know the present of prolonged of bleeding time as a results of intake of combination of noni fruit extract with acetosal on mice. Thisresearch was carried out at Unit Binatang Percobaan, Departemen Farmakologi Universitas Udayana. This is an experimental study withpre and post-test control group design. Subject was compromised of 3 groups of mice and each group contain of 7 mice. The first groupwas treated with a dose of 40 mg/kg bw acetosal, the second group treated with a dose of 100 mg/kg bw ethanol noni fruit extract, andthe third group treated with combination of 40 mg/kg bw acetosal and 100 mg/kg bw ethanol extract of noni fruit. All groups werefed once per day for a week. Bleeding time was determined on the basis of tail bleeding method. This study results that the first groupexperience bleeding time increased from 61.42±9.43 second to 160.71±19.77 second. Increase bleeding time of the second group is from59.14±7.12 to 138.14±59.91 second. For the third group, the bleeding time increases from 65.00±7.91 to 213.00±20.92 second.One Way ANOVA analysis indicates that there is a significant different among these three groups after treatment p = 0.006 (p<0.05).Bleeding time of the third group which was treated with combination of noni fruit and acetosal results in the highest increase compareto the other two groups. In conclusions, combination of noni fruit and acetosal treatment results in increase of bleeding time on mice.

Validation of Method for Determining Alpha- Mangostin Level of Ethyl Acetate Extract of Mangosteen Rind Using TLCSpectrodensitometry N. P. A. D. Wijayanti; L.P.M.K. Dewi; K.W. Astuti
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

Abstract Objective: Mangosteen rind (Garcinia mangostana L.) contains secondary metabolites, namely alpha-mangostin which has antioxidant activity, as well as antibacterial and anti-aging properties. In order to obtain a maximum amount of alpha-mangostin compounds, the maceration method using ethyl acetate was used. To ensure the effectiveness of the mangosteen rind extraction process, all of the processes and methods in preparing the extract should be properly controlled, particularly the analytical method used in determining the alpha-mangostin level of the extract. The method used should be able to determine the alphamangosteen level accurately. This study aimed to test the validation of the analytical method used. Method: The parameters for the validation of the analytical method tested in this study include accuracy, precision, range and linearity, limit of detection (LOD), limit of quantitation (LOQ) and specificity. In this study, the level of alpha-mangostin in the extract was determined using TLC-Spectrodensitometry with the stationary phase of the silica gel plate GF 254 and the mobile phase of chloroform and methanol (10:0.1 v/v). Result: The results of the study showed that this method has met the acceptance criteria for validation with the accuracy value in the range of percent recovery, from 93.85 % to 111.16%; precision with KV <2%; specification with spectrum correlation >0.99; linearity with r =0,99372; limit of detection (LOD) of 5.33 ng and limit of quantitation (LOQ) of 11.43 ng.

DEVELOPMENT OF GEL DOSAGE FORM OF ETHYL ACETATE EXTRACT OF MANGOSTEEN RIND Ketut Widyani Astuti; Ni Putu Ayu Dewi Wijayanti; I Gusti Ngurah Jemmy Anton Prasetia
Journal of Health Sciences and Medicine Vol 1 No 1 (2017): JHSM (Febuary 2017)
Publisher : Institute for Research and Community Services Udayana University

Abstract Alpha-mangostin is a xanthonoid compound contained in mangosteen rind (Garcinia mangostana L.) and has an antibacterial effect against Staphylococcus aureus, the bacterium that causes acne. In this study, mangosteen rind extract is formulated in a gel dosage form. This study aimed to determine the optimum formula, the physical and chemical properties as well as the optimum formula release profile of the gel dosage form of mangosteen rind extract. The mangosteen rind extract gel formula consists of viscolam, propylene glycol, glycerin, microcare®, ethyl acetate extract of mangosteen rind, and distilled water. The formula was optimized by varying the concentrations of viscolam (2% and 5%), propylene glycol (5% and 20%) and glycerin (2% and 15%) using a factorial experimental design program called Design Expert 7.0.0. The 8 formulas were developed into gel dosage form and the physical and chemical properties were then evaluated. The evaluation tests include viscosity, dispersive power, and pH tests. The evaluation results were processed using the Design Expert 7.0.0 program to determine the optimum formula. The results of the analysis showed the optimum formula of gel dosage form of mangosteen rind extract with viscolam percentage of 4.97%, propylene glycol of 9.91%, glycerin of 12.23%, microcare® of 0.3%, TEA (q.s), ethyl acetate extract of mangosteen rind of 1%, and distilled water of 45%. The evaluation results of the physical and chemical properties of the gel optimum formula revealed the viscosity of 2,345 cps, dispersive power of 6.59 cm, and pH of 6.74. Alpha-mangostin release test on the optimum formula revealed a flux value of 41.327 ?g/cm2/t1/2. From these results, it is concluded that the optimum formula has met the physical and chemical characteristics of a good gel.

Co-Authors Anak Agung Gede Rai Yadnya Putra Anak Agung Wahyu Putri Agustini Anak Agung Wahyu Putri Agustini Anak Agung Wahyu Putri Agustini Arifani Siswidiasari Aryadnyani, Ni Putu Aryani, Kadek Indra Cokorda Istri Mirayani Pemayun Cokorda Istri Mirayani Pemayun Cokorda Istri Mirayani Pemayun D. A. Satriawati Damayanti, Dewa Ayu Trisna Dewa Ayu Satriawati Dewi Inderiati Dewi LPMK Dewi, Ni Pande Kadek Sinta Firsta Sesarina Mintariani Firsta Sesarina Mintariani Firsta Sesarina Mintariani Fitri NPE G. M. D. Putra I Gde Pande Aninditha Putra Wicaksana I Gusti Made Aman I Gusti Ngurah Agung Dewantara Putra I Gusti Ngurah Jemmy Anton Prasetia I Made Agus Gelgel Wirasuta I Nyoman Hariyasa Sanjaya I Nyoman Hariyasa Sanjaya I Wayan Martadi Santika I Wayan Putu Sutirta Yasa I. N. K. Widjaja Ida Bagus Made Oka L.P.M.K. Dewi Lestari, Ni Wayan Febriari Liyani, Kadek Yunita Luh Putu Febryana L Luh Putu Febryana Larasanty Luh Putu Febryana Larasanty M. D. Abimanyu M. R Sutharini Made Diah Vendita Sakuntari Made Diah Vendita Sakuntari Made Diah Vendita Sakuntari Made Krisna Adi Jaya N. K. Cahyaningsih N. K. M. Ariani, N. L. P. V. Paramita N. P. A. D. Wijayanti N. P. A. D. Wijayanti N. W. M Lina N.M.P. Susanti Ni Komang Anik Pirgantari Ni Komang Anik Pirgantari Ni Komang Anik Pirgantari Ni Komang Cahyaningsih Ni Luh Gede Lisniawati Ni Luh Made Diah Mas Cahyani Putri Ni Luh Made Diah Mas Cahyani Putri Ni Luh Made Diah Mas Cahyani Putri Ni Luh Md Dwi Laxmi Satriani Ni Luh Md Dwi Laxmi Satriani Ni Luh Md Dwi Laxmi Satriani Ni Nyoman Fabby Sukarmini Ni Nyoman Mahatriny, Ni Nyoman Ni Nyoman Wiwik S Ni Nyoman Wiwik S. Ni Putu Ariantari Ni Putu Ayu Dewi Wijayanti Ni Putu Linda Laksmiani Ni Putu Nining Gianni Ni Putu Nining Gianni Ni Putu Nining Gianni Ni Putu Sanggra Payani, Ni Putu Ni Wayan Dewi Purwanti Ni Wayan Dewi Purwanti Ni Wayan Dewi Purwanti Nirmalayanthi, Putu Ayuning Dinda Pande Ketut Suwanti Devi, Pande Ketut Putu Ita Purnama Dewi R. A. I. K. Maharani Rasmaya Niruri Rini Noviyani Sagun Chandra Yowani Santri Yulita Santri Yulita, Santri Siwananda, I Dewa Made T. Maharani Warditianin, Ni Kadek Widhyasih, Retno Martini Wiwik S, Ni Nyoman Yeyet C. Sumirtapura Yeyet C. Sumirtapura Yeyet C. Sumirtapura

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