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Pemberdayaan Masyarakat dalam Optimalisasi Konsumsi Vitamin D untuk Pencegahan Defisiensi Vitamin D pada Penderita Tuberkulosis Paru di Puskesmas Sakdiah, Siti; Sitanggang, Fardiah Tilawati
Jurnal Pengabdian kepada Masyarakat (ABDIKEMAS) Vol 6 No 2 (2024): Jurnal Pengabdian kepada Masyarakat (ABDIKEMAS)
Publisher : Pusat Penelitian dan Pengabdian kepada Masyarakat, Politeknik Kesehatatan Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/j.abdikemas.v6i2.2497

Permasalahan utama TB adalah malnutrisi yang menyebabkan perubahan keseimbangan respon immun, yang sangat meningkatkan kerentanan individu terhadap infeksi atau perkembangan infeksi menjadi penyakit. Salah satu nutrisi yang berperan penting pada respon immun terhadap Mycobacterium tuberculosis adalah vitamin D. Pemberdayaan masyarakat dalam optimalisasi konsumsi vitamin D untuk pencegahan defisiensi vitamin d pada penderita tuberkolosis paru ini sangat penting dengan sasaran penderita TB, keluarga dan kader.Tujuan Pengabdian kepada masyarakat adalah untuk memberdayakan masyarakat dalam optimalisasi konsumsi vitamin D untuk pencegahan defisiensi vitamin D pada penderita TB paru. Kegiatan yang dilakukan adalah pemberdayaan masyarakat yakni penderita TB paru dan kader kesehatan dalam optimalisasi vitamin D untuk pencegahan defisiensi vitamin D pada pasien TB paru. Dalam kegiatan ini juga terlihat partisipasi dari peserta sangat tinggi dengan dilihat dari jumlah peserta juga keaktifan pada saat diskusi. Dari hasil kegiatan pengabmas dan dari evaluasi didapatkan peningkatan pengetahuan signifikan dari pengetahuan para penderita TB paru, keluarga penderita TB paru dan juga kader kesehatan di wilayah Puskesmas Penyengat Olak, terlihat dari uji statistic terdapat perbedaan serta kenaikan signifikan dari pengetahuan mengenai Vitamin D. Dari kegiatan ini juga masyarakat sudah diberdayakan dalam optimalisasi Vitamin D terutama dalam pemanfaatan sumber daya lokal seperti ikan lambak sebagai sumber vitamin D bagi penderita TB paru sehingga kedepannya konsistensi dari pelaksanaan ini dapat mencegah terjadinya defisiensi Vitamin D bagi penderita TB paru.

Potensi Vitamin D3 pada Minyak Ikan Lambak Pipih untuk Penurunan Sitokin Pro Inflamasi Sakdiah, Siti; Sitanggang, Fardiah Tilawati; Maharani, Eva Ayu; Widhyasih, Retno Martini
Journal of Telenursing (JOTING) Vol 6 No 2 (2024): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v6i2.13012

This study aims to analyze the differences in vitamin D3 levels in fish oil in the body parts of lamb fish. The method used is an experiment with a Factorial Randomized Design with three replications. The results showed that the Vitamin D3 content in lamb fish oil is quite high, ranging from 767.52 IU / g to 787.34 IU / g. The highest vitamin D3 content is in group one, namely the whole fish (scales, head, meat, bones, and innards). The conclusion is that there is a significant difference between the vitamin D3 content in fish oil and whole fish, meat, meat, and waste. Keywords: Inflammation, Fish Oil, Flat Lambak, Vitamin D

CRP/Lymphocyte Ratio and CRP/Albumin Ratio for Prognosis of Hyperglycemia in Patients Tuberculosis with Diabetes Mellitus Sitanggang, Fardiah Tilawati; Sakdiah, Siti; Putra, Egy Sunanda
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): December 2024
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1593

The issue is complicated by the rise in Diabetes Mellitus (DM) cases, a known risk factor for pulmonary TB, with 15% of pulmonary TB patients having a history of DM. DM and chronic hyperglycemia impair immune function, leading to long-term inflammation and worsening TB prognosis. Diagnostic methods include blood culture, AFB examination, chest X-ray, and genotyping, but more accessible tests are needed. Inflammatory markers, particularly lymphocytes, play a crucial role in TB prognosis with DM. Lymphopenia indicates chronic inflammation and a shift to memory lymphocytes. CRP, an inflammatory marker, indicates chronic inflammation, and hypoalbuminemia in DM due to kidney damage further complicates TB prognosis. The ratios of CRP to lymphocytes (CLR) and CRP to albumin (CAR) are gaining attention to better illustrate TB prognosis with DM. This cross-sectional study analyzed CLR and CAR as prognostic indicators in 30 pulmonary TB patients with DM in Jambi City from May to June 2024. CRP was tested at Prodia Jambi Laboratory, while Albumin, Lymphocytes, and blood glucose levels were tested at Labkesda of Jambi Province. The results show a Comparison with each parameter based on treatment status. Both parameters show slightly higher average values in intensive (< 2 months), with an average of 5.55 for CLR and 1.82 for CAR, and there is a significant difference in CLR between intensive and follow-up treatment statuses, and ROC curve shows that CLR parameters have indicated high sensitivity and low false positive rate with AUC 0,692. A significant relationship is found between CLR and blood glucose levels with a p-value of 0.024 and an r-value of 0.411, indicating a moderately strong relationship where an increase in CRP-Lymphocyte ratio corresponds to an increase in blood glucose levels than each parameter.

CRP/Lymphocyte Ratio and CRP/Albumin Ratio for Prognosis of Hyperglycemia in Patients Tuberculosis with Diabetes Mellitus Sitanggang, Fardiah Tilawati; Sakdiah, Siti; Putra, Egy Sunanda
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): Bahasa Inggris
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1593

The issue is complicated by the rise in Diabetes Mellitus (DM) cases, a known risk factor for pulmonary TB, with 15% of pulmonary TB patients having a history of DM. DM and chronic hyperglycemia impair immune function, leading to long-term inflammation and worsening TB prognosis. Diagnostic methods include blood culture, AFB examination, chest X-ray, and genotyping, but more accessible tests are needed. Inflammatory markers, particularly lymphocytes, play a crucial role in TB prognosis with DM. Lymphopenia indicates chronic inflammation and a shift to memory lymphocytes. CRP, an inflammatory marker, indicates chronic inflammation, and hypoalbuminemia in DM due to kidney damage further complicates TB prognosis. The ratios of CRP to lymphocytes (CLR) and CRP to albumin (CAR) are gaining attention to better illustrate TB prognosis with DM. This cross-sectional study analyzed CLR and CAR as prognostic indicators in 30 pulmonary TB patients with DM in Jambi City from May to June 2024. CRP was tested at Prodia Jambi Laboratory, while Albumin, Lymphocytes, and blood glucose levels were tested at Labkesda of Jambi Province. The results show a Comparison with each parameter based on treatment status. Both parameters show slightly higher average values in intensive (< 2 months), with an average of 5.55 for CLR and 1.82 for CAR, and there is a significant difference in CLR between intensive and follow-up treatment statuses, and ROC curve shows that CLR parameters have indicated high sensitivity and low false positive rate with AUC 0,692. A significant relationship is found between CLR and blood glucose levels with a p-value of 0.024 and an r-value of 0.411, indicating a moderately strong relationship where an increase in CRP-Lymphocyte ratio corresponds to an increase in blood glucose levels than each parameter.

Perbandingan Hasil Pemeriksaan Kimia Darah pada Beberapa Tabung Vakum pada Pasien Tuberkulosis Paru Sakdiah, Siti; Sitanggang, Fardiah Tilawati; Simanjuntak, James P
Jurnal Ners Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i1.19922

Clinical laboratories are required to produce accurate laboratory examination results so that patient diagnoses are correct. Laboratory examination results are greatly influenced by pre-analytical stages such as the performance of the blood collection tube. Blood collection tubes used in laboratories vary in terms of brand, type and additives in them. Additives in blood collection tubes can affect the accuracy of laboratory test results. To prevent this situation, every laboratory must carry out validation before using blood collection tubes. Almost all clinical laboratories have not carried out collection tube validation activities blood before use. The study aimed to analyze differences in creatinine, GGT, HDL and LDH levels in serum collected in several blood collection tubes used in the laboratory. The research design is analytical descriptive. The sample consisted of 40 healthy adult respondents aged between 18 and 55 years (based on CLSI GP34-A). The parameters studied were creatinine, GGT, HDL and LDH levels from serum collected from blood collection tubes of different types and brands. The research was conducted in the clinical chemistry laboratory, medical laboratory technology department, Health Polytechnic, Ministry of Health, Jambi. in vitro diagnostic technology, namely validation of blood collection tubes. The resulting data from the research was tested using statistical tests.

Edukasi Vitamin D pada pasien asma dalam upaya pencegahan kekambuhan asma di wilayah Puskesmas Olak Kemang Kota Jambi Sitanggang, Fardiah Tilawati; Sakdiah, Siti; Simanjuntak, James P
BINAKES: Jurnal Pengabdian Kesehatan Masyarakat Vol 4 No 01 (2023): Jurnal Binakes
Publisher : Poltekkes Kemenkes Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35910/binakes.v4i01.656

Asthma is a chronic inflammation of the airways characterized by recurrent wheezing, coughing and tightness in the chest, especially at night due to airway obstruction. Asthma increases with air quality and changes in lifestyle. The severity of asthma is influenced by vitamin D, which plays a role in increasing the immune response (immunomodulator) and reducing inflammation in the lungs. Research by Simanjuntak et al in 2022 shows that vitamin D deficiency is strongly correlated with asthma and the severity of asthma. The prevalence of asthma in Jambi City is 1.7% with a recurrence of 62% and is the highest cause of death in Jambi City. Olak Kemang Health Center, Jambi City is one of the health centers that has a high number of asthma patients, namely 95 people with a low level of knowledge regarding vitamin D and asthma. After providing education regarding vitamin D and asthma, there was a significant change, namely an increase in knowledge which was visible from the pre and post tests. The involvement of government officials such as community health center officers and cadres plays a significant role in motivating asthma patients to take part in educational activities.

Hitung Sel Eosinofil dan Imunoglobulin E Sebagai Penanda Biologis Penyakit Paru Obstruktif Kronis (PPOK) Fardiah Tilawati; Sakdiah, Siti; Simanjuntak, James Perdinan; Mustopa, Raden; Yuliandari, Neta
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Peningkatan jumlah penderita Penyakit Paru Obstruktif Kronik (PPOK) sudah menjadi permasalahan kesehatan yang semakin mengkhawatirkan terutama dalam masyarakat di dunia saat ini. Peningkatan terutama terjadi di negara berkembang yang memiliki proporsi risiko utama, perokok, yang masih tinggi. Studi ini mengamati potensi parameter pemeriksaan laboratorium hitung sel eosinofil yang sederhana untuk menilai potensinya sebagai penanda kondisi perkembangan PPOK. Dengan desain case control hasil uji tersebut dianalisis dengan membandingkan antar subjek yang belum pernah didiagnosis menderita PPOK namun memiliki kebiasaan merokok yang merupakan faktor risiko utamanya dengan subjek bukan perokok. Pengujian hitung sel eosinofil terhadap spesimen darah dan saliva adalah parameter yang dapat diterapkan dalam analisis laboratorium klinik untuk diagnosis berbagai kondisi alergi. Namun dalam analisis rutin pengujian tersebut tidak dilakukan terhadap spesimen saliva (air liur. Pengujian dilakukan terhadap parameter hitung sel eosinofil dan keberadaan Imunoglobulin E (IgE), baik pada spesimen darah maupun saliva sebagai bahan yang akan dianalisis. Hasil penelitian mendapatkan jumlah eosinofil dan IgE pada saliva dan darah lebih tinggi pada pasien PPOK dibandingkan dengan kontrol (Non PPOK perokok dan Non PPOK non perokok), sedangkan eosinofil dan IgE pada saliva dan darah juga lebih tinggi pada kelompok kontrol perokok dibandingkan dengan non perokok dengan perbedaan yang signifikan. Selain itu parameter jumlah eosinofil pada saliva serta IgE pada saliva dapat menggambarkan deteksi dini dari perjalanan penyakit PPOK dengan ditunjukkan dengan korelasi yang kuat antar parameter.

Survey of Inflammatory Biomarkers in Blood and Sputum in Pulmonary Tuberculosis Patients Simanjuntak, James Perdinan; Sakdiah, Siti; Sitanggang, Fardiah Tilawati; Maharani, Eva Ayu
Jurnal Health Sains Vol. 4 No. 10 (2023): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v4i10.1092

Tuberculosis (TB) is still a global health problem that exists today. Various efforts to reduce the number of TB patients have been carried out ranging from detection efforts to treatment and prevention efforts. Many studies have been conducted previously to look at the detection potential of laboratory diagnoses in finding new cases of tuberculosis. Likewise, efforts to detect prognosis in the laboratory to monitor the development of the condition of TB patients. The development of inflammatory conditions in TB patients is important to accelerate the healing process of these patients. Inflammatory marker tests have been widely performed on several types of laboratory test parameters. CRP and LDH are types of testing that have potential as markers of inflammatory development in TB patients. However, proven tests generally use blood specimens, which are commonly used in laboratory analysis for these parameters. Meanwhile, the current research theme has also been directed at the use of other types of specimens that can show inflammatory conditions experienced by a person. Saliva is known to have potential as another alternative specimen that can be used for such purposes. Saliva is easily obtained and does not require invasive techniques such as needle invocation, so it is considered to have more advantages if it can be proven as a laboratory test specimen that can provide information that is as good and accurate as blood or serum. This study aimed to assess the potential of saliva as an alternative specimen for laboratory analysis with the aim of markers in the assessment of prognosis of TB patients. CRP examination and LDH enzyme activity were chosen in this study of serum and saliva specimens of TB subjects and controls. From this study, it is expected to be shown that saliva can be used as an alternative specimen in laboratory analysis for inflammatory marker tests on both parameters. The results obtained showed that the measurement of LDH activity and and CRP levels in saliva observed in this study proved to have good potential in predicting the presence of inflammation and cell damage experienced by TB subjects. LDH test results have a strong relationship between serum and saliva as laboratory test materials, even salivary LDH levels are higher than serum. While CRP, although saliva showed low levels, the correlation test carried out still showed a strong relationship between the results of the two types of specimens.

The Effects of Sungkai Leaf and Cinnamon Bark Extracts on MDA and IL-10 in MSG Induced Chronic Kidney Disease in Wistar Rats Afrianti, Dina; Maulana, Mochamad Rizal; Sakdiah, Siti; Febriyani, Erisa; Wahyudi, Wahyudi; Ali, Irwan
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.661

Monosodium glutamate (MSG) is known to trigger oxidative stress and inflammation, contributing to kidney tissue damage. This study aimed to evaluate the protective effects of sungkai leaf extract (Peronema canescens Jack) and cinnamon bark extract (Cinnamomum burmannii) on kidney histology, as well as malondialdehyde (MDA) and interleukin-10 (IL-10) levels in male Wistar rats induced with excessive MSG. A total of 30 rats were divided into six groups: normal control, positive control (MSG only), and four treatment groups receiving MSG alongside sungkai leaf extract (28 mg or 56 mg) or cinnamon bark extract (4% or 8%) for 10 days. MDA and IL-10 levels were measured using ELISA, and kidney tissue was examined histologically. The results showed that both extracts significantly reduced MDA (P= 0,000) levels and increased IL-10 (P= 0,000) levels compared to the positive control. The most prominent protective effect was observed in the group treated with 56 mg of sungkai leaf extract, followed by the 8% cinnamon bark group. Histopathological analysis revealed notable improvements in kidney structure, approaching normal conditions in treated groups. These findings suggest that sungkai leaf and cinnamon bark extracts, particularly at higher doses, offer protective benefits against MSG-induced kidney damage through antioxidant and anti-inflammatory mechanisms.

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