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All Journal Indonesian Journal of Pharmaceutical Science and Technology Science and Technology Indonesia Padjadjaran Journal of Dentistry Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Pengabdian Kepada Masyarakat MEMBANGUN NEGERI JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT
Kurniawan, Muhammad Fariez
Universitas Muhammadiyah Yogyakarta
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Science and Technology Indonesia

 1 
Quercetin in Drug Carriers: Polymer Composite, Physical Characteristics, and In vitro Study Kurniawan, Muhammad Fariez; Setyawan, Dwi; Hariyadi, Dewi Melani
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.380-412

Abstract

Quercetin is a highly prevalent flavonoid commonly found in a wide variety of fruits and vegetables. This compound has various biological actions, indicating great potential in preventing diseases and promoting health but the disadvantages include low solubility and instability. The disadvantages can be overcome by using a polymer composite in the form of microspheres in the formulation. Therefore, this study aimed to review various uses of polymers in delivering quercetin compounds. The results showed that various polymers in microspheres have been formulated with quercetin to minimize the weaknesses. The delivery systems developed and reported from several related studies include microencapsulation, microcapsules, microparticles, microspheres, solid lipid microparticles (SLM), and nanoparticles. Polymers including Gelatine, Maltodextrin and Inulin, Carnauba wax, Poly (lactic-co-glycolic acid (PLGA), Gyceryl behenate, Pectin, Nano-hydroxyapatite, Polycaprolactone, Starch, Chitosan, Eudragit S 100, Sodium Alginate, Ethyl cellulose, and Alumina efficiently improved the properties of quercetin, enabling the utilization as a controlled drug delivery agent. Therefore, developing a quercetin delivery system using composite polymers presents both an opportunity and a challenge for future applications.
Pectin Red Dragon Fruit Peel Pectin-Based Microspheres for Oral Quercetin Delivery: Characterization, Stability Study, Digestion Resistance, and Cytotoxicity Against HeLa Cells Kurniawan, Muhammad Fariez; Setyawan, Dwi; Hariyadi, Dewi Melani
Science and Technology Indonesia Vol. 10 No. 4 (2025): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.4.1049-1073

Abstract

This study aims to evaluate the potential of red dragon fruit skin pectin to be used as a polymer compared with commercial pectin in the quercetin microsphere. Microspheres were made using the ionic gelation technique. Ten formulas were created, utilizing pectin from red dragon skin extracted with oxalic acid (OA75), citric acid (CA75), acetic acid (AA75), and commercial pectin at 1% and 1.5% concentrations. A gel permeation chromatography test (GPC) was performed to evaluate pectin’s molecule weight. Parameters were assessed, including yield, moisture content (MC), Carr’s Index, Hausner ratio, swelling index, Fourier Transform Infrared Spectroscopy (FTIR), particle size, polydispersity index (PDI), drug loading (DL), encapsulation efficiency (EE), Scanning Electron Microscope (SEM), in vitro drug release, accelerated stability test at a temperature of 40±2oC and RH 75±5% for 3 months and thermal stability test in the form of DSC and XRD at the same temperature and humidity for 9 months, digestion resistance with incubation in artificial stomach and intestinal solution for 4 hours continued with cytotoxicity test on HeLa cells with MTT Assays. Results of FTIR indicate a strong interaction between quercetin and pectin in forming a stable microsphere structure; SEM showed the spheres morphologically. The kinetics of quercetin release from microspheres was the Korsmeyer-Peppas model. DL and EE had no significant differences for 3 months and no significant changes in the glass transition in the DSC test during testing until month 9. The FF formulation (1.5% AA75) had the highest cytotoxic activity against HeLa cells and a high Selectivity Index.
Analysis of Hydrolyzed Collagen in Facial Serum for Halal Authentication Using FTIR Spectroscopy and Multivariate Calibration Salamah, Nina; Firdaus, Rizqi Amalia; Guntarti, Any; Ahda, Mustofa; Uddin, Abm Helal; Kurniawan, Muhammad Fariez
Science and Technology Indonesia Vol. 10 No. 4 (2025): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.4.1270-1279

Abstract

Cosmetic trends in Indonesia are on the rise, particularly for facial serum products. However, most of these products lack halal certification, posing an important concern for Muslim consumers due to the potential use of haram substances, such as pork gelatin. This study seeks to identify the source of gelatin in serum products using the Fourier Transform Infrared (FTIR) spectroscopy and chemometric analysis. The samples used in this study include a reference facial serum formulated with pure bovine and porcine gelatin concentrations in the ratios of 1:0, 8:2, 5:5, 2:8, and 0:1, three hydrolyzed collagen serums that are not yet labeled halal and available on Shopee, and one serum that is labeled halal. The method used was FTIR combined with PLS chemometrics and PCA. The isolation of facial serum gelatin was performed using acetone at -20oC, followed by analysis via FTIR at wave numbers ranging from 4000 to 400 cm-1. FTIR results indicated the presence of functional groups in gelatin constituents, including C O, N H, C N, and C H aliphatic. The wavelengths employed for PLS and PCA analysis ranged from 1631 to 1430 cm-1. Calibration results showed R2=0.9936 and RMSEC=3.0445%. Internal validation yielded RMSECV=0.1674% and R2=0.9994 whilst external validation yielded RMSEP=0.9981% and R2=0.9910. Lastly, PCA analysis revealed that one halal-labeled serum sample contained bovine gelatin, whereas the three examined commercial serums were free from both pork and bovine gelatin.
Co-Authors Adienia, Vitrisia Aji Winanta Andewa, Shylvia Muchsin Andrian, Zulkifli Anggraini, Dita Annisa, Amartya Nadhia Any Guntarti Apriliyanti, Suci Baeha, Wahdatul Khairat Dewi Melani Hariyadi Dwi Setyawan Fajarani, Rizky Anita Firdaus, Moch Arriyan Firdaus, Rizqi Amalia Iskak, Rifki Umami Isnan, Ahmad Arif Kemal Asyidiq, Muhammad Maziyah, Nurul Mustofa Ahda Nina Salamah Nining Sugihartini Nisa, Alditta Khoirun Pinasti Utami, Pinasti Pratama, Zikri Fatua Rizki Amalia, Adhitya Anisa Rizqi, Additya Sabeta, Meilidya Vani Septiawan, Darul Supriyono, Devany Vinandhita Tedjo Yuwono Tita Ratya Utari Uddin, ABM Helal Vella Lailli Damarwati Wardany, Herdita Nugraheny Kusuma WIDYASTUTI Zahira, Safna Tiara