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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmascience Journal of Nutraceuticals and Herbal Medicine Jurnal Farmamedika (Pharmamedica Journal) Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Jurnal Ilmiah Pharmacy Jurnal Farmasi Jurnal Abdimas Kartika Wijayakusuma Jurnal Pengabdian Kesehatan Masyarakat Mulawarman Jurnal Sains dan Kesehatan
Saryanti, Dwi
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Edukasi dan Workshop “SEDARI HATI” Sediaan Teh Herbal Seledri Atasi Hipertensi di Desa Ngringo Kecamatan Jaten, Kabupaten Karanganyar Anggraini, Truly; Saryanti, Dwi; Devina Ingrid Anggraini
Jurnal Pengabdian Kesehatan Masyarakat Mulawarman Vol. 3 No. 2 (2025): Desember 2025
Publisher : Fakultas Kedokteran, Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Hipertensi sebagai salah satu penyakit tidak menular yang paling umum ditemukan dalam praktek kesehatan. Komplikasi hipertensi dapat mengenai berbagai organ target seperti jantung, otak, ginjal, mata dan arteri perifer. Prevalensi hipertensi di Indonesia berdasarkan diagnosis dokter pada penduduk umur ≥ 18 tahun yaitu 8,4%. Adapun prevalensi hipertensi di Indonesia sebesar 34,11% dan Kabupaten Karanganyar  29,4%. Sedangkan pada tingkat kabupaten, Jaten merupakan kecamatan tertinggi di Kabupaten Karanganyar dimana prevalensinya  13.21%, yang didiagnosis dokter dengan klasifikasi umur 15-24 tahun 5.14%, 25-34 tahun 5.36%, dan 35-44 tahun 13.85%. Salah satu upaya yang dapat dilakukan  dengan menggunakan bahan alami atau herbal yang memiliki beberapa keuntungan yaitu efek samping rendah dan lebih terjangkau karena menggunakan bahan alami yang mudah didapatkan di lingkungan rumah. Salah satu tanaman herbal Indonesia yang mudah ditanam, baik dataran tinggi maupun dataran rendah dan biasa digunakan masyarakat untuk terapi hipertensi adalah seledri (Apium graveolens). Tujuan: untuk meningkatkan pengetahuan masyarakat tentang di Desa Ngringo RT 001/RW 015, Jaten, Karanganyar, peningkatan pengetahuan tentang pemanfaatan bahan alam untuk hipertensi serta pengolahan bahan alam menjadi produk teh herbal untuk pencegahan hipertensi. Hasil: Terdapat peningkatan pengetahuan tentang hipertensi dan pemanfaatan bahan alam untuk hipertensi berdasarkan nilai pre test dan post test yang signifikan. Terdapat produk teh herbal seledri yang dapat dimanfaatkan untuk pencegahan hipertensi.
Optimasi HPMC dan Carbopol sebagai Polimer dalam Sediaan Tablet Floating Sari Buah Jambu Biji Merah (Psidium guajava L.): Optimization of HPMC and Carbopol as Polymers in Floating Tablets of Red Guava Juice (Psidium guajava L.) Laksono, Wahid Suryo; Saryanti, Dwi; Kusuma, Eka Wisnu
Jurnal Sains dan Kesehatan Vol. 8 No. 2 (2026): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v8i2.2586

Abstract

Red guava (Psidium guajava L.) is a plant rich in bioactive compounds such as flavonoids and vitamin C, which possess antioxidant activity and potential as a therapy for gastric ulcers. One of the innovative dosage forms to enhance therapeutic effectiveness is the floating tablet. This study aimed to develop and optimize a floating tablet formulation from red guava juice using a combination of hydroxypropyl methylcellulose (HPMC) and carbopol as matrix polymers for controlled drug release. Optimization was carried out using the Simplex Lattice Design (SLD) method, with evaluations including granule physical properties (compressibility) and tablet quality tests (weight uniformity, hardness, friability, floating lag time, and total floating duration). Verification of the optimum formula was performed using a one-sample t-test. The optimization results showed the optimum formula with HPMC 49,72 mg and Carbopol 10,27 mg, with a desirability value of 0,598. The physical properties test results showed a floating-lag time of 1,66±0,24 seconds, total floating duration of 9,69±0,00 hours, weight uniformity (CV) of 2,22±0,270 %, tablet hardness of 4,18±0,41 kg, and friability of 0,39±0,19%. Verification results indicated no significant difference between predicted and actual values, confirming the validity of the optimization model. It can be concluded that the combination of HPMC and Carbopol as polymers in the formulation of floating tablets of red guava juice shows potential to be further developed as an oral dosage form with a modified release system. Keywords:          Psidium guajava L., floating tablet, HPMC, Carbopol, optimization   Abstrak Jambu biji merah (Psidium guajava L.) adalah tumbuhan kaya akan senyawa bioaktif seperti flavonoid dan vitamin C yang memiliki aktivitas antioksidan dan berpotensi digunakan sebagai terapi tukak lambung. Salah satu bentuk inovasi sediaan untuk meningkatkan efektivitas terapi adalah tablet floating. Penelitian ini bertujuan untuk mengembangkan dan mengoptimalkan formula tablet floating dari sari buah jambu biji merah dengan kombinasi polimer Hydroxypropyl Methylcellulose (HPMC) dan Carbopol sebagai matriks pengontrol pelepasan obat. Proses optimasi dilakukan menggunakan metode Simplex Lattice Design (SLD), dan evaluasi meliputi uji sifat fisik granul (kompresibilitas) serta uji mutu tablet (kekerasan, total waktu mengapung kerapuhan, keseragaman bobot, dan floating lag time). Verifikasi formula optimum dengan menggunakan uji one sample t-test. Hasil optimasi menunjukkan bahwa formula optimum dengan perbandingan HPMC 49,72mg dan Carbopol 10,27mg dengan nilai desirability 0,598. Hasil uji sifat fisik  tablet dengan floating lag time 1,66±0,24 detik, total waktu floating 9,69±0,00 jam, keseragaman bobot (CV) 2,22±0,270%, kekerasan tablet 4,18±0,41 kg, dan kerapuhan 0,39±0,19%. Hasil verifikasi menunjukkan tidak terdapat perbedaan signifikan antara nilai prediksi dan aktual, menandakan model optimasi valid. Dapat disimpulkan bahwa kombinasi HPMC dan Carbopol sebagai polimer dalam formulasi tablet floating sari buah jambu biji merah, serta berpotensi dikembangkan lebih lanjut sebagai sediaan oral dengan sistem pelepasan termodifikasi. Kata Kunci:         Psidium guajava L., tablet floating, HPMC, Carbopol, optimasi
Effect of Tween 80 Concentration on the Physicochemical Characteristics of Strawberry (Fragaria × ananassa) Fruit Extract Nanoemulsion Saryanti, Dwi; Suharyanto; Melati Andini Putri, Livi
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.920

Abstract

Strawberries (Fragaria x ananassa Duch.) contain non-polar flavonoids and function as antioxidants. Nanotechnology can increase drug bioavailability, has a kinetically stable system, has the ability to penetrate deeper into the skin, lowers viscosity, and delivers the active substance to the skin surface to form a thin layer. The purpose of this study was to observe the effect of Tween 80 as a surfactant on the fruit extract nanoemulsion formulation. Nanoemulsion is made from Tween 80 surfactant, PEG 400 cosurfactant, and virgin coconut oil oil phase. The concentration of Tween 80 used by F1, F2, and F3 was 20%, 30%, and 40%. The preparations were tested for organoleptic properties, pH, viscosity, transmittance and droplet size on the formula with the smallest droplet size. The organoleptic of the resulting nanoemulsion is in the form of a clearer brown colour, a characteristicic odour, and a, and a liquid form,form, and there is no separation phase. The effect of varying the concentration of Tween 80 in the nanoemulsion formulation of strawberry fruit extract: the higher the concentration of Tween 80, the higher the pH value, % transmittance and viscosity of the preparation. The droplet sizes on F1, F2, and F3 were 5722.77 ± 1.53 nm, 3328.5 ± 0.00 nm, and 25.97 ± 0.90 nm with a polydispersity index of 16.312 ± 4.32, 9.927 ± 0.00, and 1.060 ± 0.11. Nanoemulsions of strawberry fruit extract with a concentration of 40% can produce good preparations. The antioxidant testing findings utilising the ABTS method revealed that the strawberry extract nanoparticle formulation exhibited an IC50 value of under 50, signifying exceptionally potent antioxidant activity.
OPTIMASI ASAM STEARAT DAN TEA PADA FORMULA SEDIAAN KRIM EKSTRAK KULIT PISANG KEPOK (Musa paradisiaca L.) Saryanti, Dwi; Setiawan, Iwan; Safitri, Romadona Ayu
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 3 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i3.44

Abstract

Banana kepok peel has flavonoid compounds used as antioxidants. The aim of this research is to get optimum formula of cream by combination of stearic acid and trietanolamin on good physical propertie of cream. Cream was made with stearic acid 15% minimum concentration and maximum concentration 17%, triethanolamine with minimum concentration 2% and maximum concentration 4%. The optimization of the formula was using the simplex lattice design method with parameters are pH, viscosity, spreadability, adhesion and protection. The optimum cream formula on the combination of stearic acid 16.7 grams and triethanolamine 2.3 grams. Verification results of optimal formula cream for pH got 6.1, viscosity 237.47, adhesion 12.32, power spread 18.11, protection 14.98 which showed no significant difference in the test, and has good stability.
OPTIMASI CAMPURAN AVICEL PH 101 DAN LAKTOSA SEBAGAI BAHAN PENGISI PADA TABLET EKSTRAK BUNGA ROSELLA (Hibiscus sabdariffa L.) SECARA GRANULASI BASAH Kokafrinsia, Zila Tjhia; Saryanti, Dwi
Jurnal Riset Kefarmasian Indonesia Vol. 3 No. 2 (2021): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v3i2.124

Abstract

Rosella flower (Hibiscuss sabdariffa L.) in traditional medicine can provide protection against various diseases, such as coronary heart disease, cancer, lowering cholesterol, and liver disorders. This study aims to obtain the optimum formula of tablet of rosella flower extract with a mixture of Avicel PH 101 and lactose as a filler using wet granulation method. Rosella flower extract was obtained by maceration of rosella flower powder using 70% ethanol. The optimization formula for tablets using the Simplex Lattice Design method with Design Expert software version 10. The parameters used in the optimization are weight variation, hardness, friability and disintegration time. Verification of the optimal formula using the SPSS 18 program with the One Sample T-test method with a confidence level of 95%. The results showed that the optimal formula of tablet of rosella flower extract was the Avicel PH 101 97.82%: 2.17% lactose. The optimal formula has weight variation 1.53% ± 0.0073; hardness 5.087 kg ± 0.5135; the friability is 0.3% ± 0.041. The resulting disintegration was 22.99 minutes ± 2.218. The results of the verification of the optimal formula show that there is no significant difference between the predictions of the Simplex Lattice Design method and the results of the tests performed so that it can be said that the method is valid.
OPTIMASI PENGGUNAAN HPMC DAN Na CMC PADA FORMULA TRANSDERMAL PATCH EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DENGAN METODE SIMPLEX LATTICE DESIGN Saryanti, Dwi; Putri Setyadi, Ita Mustika
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.224

Abstract

Transdermal patch is drug delivery system that is pasted through the skin. These preparations can provide a constant drug release, easy to use, reduce the frequency of drug administration, eliminate first-pass metabolism, and reduce side effects such as gastric irritation and improve patient compliance. Blue pea (Clitoria ternatea L.) contains flavonoid compounds that have anti-inflammatory activity. This study aims to obtain the optimal comparison of HPMC and Na CMC as a polymer in the transdermal patch formula of the ethanol extract of the blue pea (Clitoria ternatea L.). Optimization was carried out using the Simplex Lattice Design method with Software Design Expert version 11. The responses used included pH tests, weight tests, thickness tests, folding tests and moisture content tests. The optimal formula obtained from the Simplex Lattice Design method was verified with the SPSS program using the one sample t-test method. The optimal formula of transdermal patch of blue pea ethanol extract was tested for acceptability to determine whether it was acceptable to the respondent or not. The optimal comparison of HPMC and Na CMC as a polymer with transdermal patch preparation of blue pea ethanol extract was 3.5%:1%, with a desirability value of 0.944.
Co-Authors Anggraini, Devina Ingrid Anggraini, Truly Apriliana, Weny Halfina Astuti, Nisa Sindi Aulia Nur Rahmawati Ayu Safitri, Winda Devina Ingrid Anggraini Dian Nugraheni Dian Puspitasari Effendi, Aliza Nurul Rizkia Fatmawati, Suci Muslikah Hidaya, Anggi Fajriatu Ismawati, Heny Iwan Setiawan Kokafrinsia, Zila Tjhia Kumalasari, Lavira Silvi Kusuma, Eka Wisnu Laksono, Wahid Suryo Melati Andini Putri, Livi Nur Rahmawati, Aulia Pertiwi, Natasya Intania Pratikno, Argia Lovent Priyanto, Fitri Amanda Putri Atmaja, Aulia Putri Setyadi, Ita Mustika Putri, Dea Annisa Ramadhan, fitra Isnaini Wulan Safitri, Romadona Ayu Sari, Ananda Alfira Suharyanto Tri Yulianti, Tri Utami , Nastiti Wati, Setia