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All Journal Indonesian Journal of Pharmaceutical Science and Technology Smart Medical Journal Journal of Nutraceuticals and Herbal Medicine Jurnal Farmamedika (Pharmamedica Journal) Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Jurnal Ilmiah Pharmacy Jurnal Farmasi Jurnal Abdimas Kartika Wijayakusuma Jurnal Pengabdian Kesehatan Masyarakat Mulawarman Jurnal Sains dan Kesehatan
Saryanti, Dwi
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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OPTIMASI ASAM STEARAT DAN TEA PADA FORMULA SEDIAAN KRIM EKSTRAK KULIT PISANG KEPOK (Musa paradisiaca L.) Saryanti, Dwi; Setiawan, Iwan; Safitri, Romadona Ayu
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 3 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i3.44

Abstract

Banana kepok peel has flavonoid compounds used as antioxidants. The aim of this research is to get optimum formula of cream by combination of stearic acid and trietanolamin on good physical propertie of cream. Cream was made with stearic acid 15% minimum concentration and maximum concentration 17%, triethanolamine with minimum concentration 2% and maximum concentration 4%. The optimization of the formula was using the simplex lattice design method with parameters are pH, viscosity, spreadability, adhesion and protection. The optimum cream formula on the combination of stearic acid 16.7 grams and triethanolamine 2.3 grams. Verification results of optimal formula cream for pH got 6.1, viscosity 237.47, adhesion 12.32, power spread 18.11, protection 14.98 which showed no significant difference in the test, and has good stability.
OPTIMASI CAMPURAN AVICEL PH 101 DAN LAKTOSA SEBAGAI BAHAN PENGISI PADA TABLET EKSTRAK BUNGA ROSELLA (Hibiscus sabdariffa L.) SECARA GRANULASI BASAH Kokafrinsia, Zila Tjhia; Saryanti, Dwi
Jurnal Riset Kefarmasian Indonesia Vol. 3 No. 2 (2021): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v3i2.124

Abstract

Rosella flower (Hibiscuss sabdariffa L.) in traditional medicine can provide protection against various diseases, such as coronary heart disease, cancer, lowering cholesterol, and liver disorders. This study aims to obtain the optimum formula of tablet of rosella flower extract with a mixture of Avicel PH 101 and lactose as a filler using wet granulation method. Rosella flower extract was obtained by maceration of rosella flower powder using 70% ethanol. The optimization formula for tablets using the Simplex Lattice Design method with Design Expert software version 10. The parameters used in the optimization are weight variation, hardness, friability and disintegration time. Verification of the optimal formula using the SPSS 18 program with the One Sample T-test method with a confidence level of 95%. The results showed that the optimal formula of tablet of rosella flower extract was the Avicel PH 101 97.82%: 2.17% lactose. The optimal formula has weight variation 1.53% ± 0.0073; hardness 5.087 kg ± 0.5135; the friability is 0.3% ± 0.041. The resulting disintegration was 22.99 minutes ± 2.218. The results of the verification of the optimal formula show that there is no significant difference between the predictions of the Simplex Lattice Design method and the results of the tests performed so that it can be said that the method is valid.
OPTIMASI PENGGUNAAN HPMC DAN Na CMC PADA FORMULA TRANSDERMAL PATCH EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DENGAN METODE SIMPLEX LATTICE DESIGN Saryanti, Dwi; Putri Setyadi, Ita Mustika
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.224

Abstract

Transdermal patch is drug delivery system that is pasted through the skin. These preparations can provide a constant drug release, easy to use, reduce the frequency of drug administration, eliminate first-pass metabolism, and reduce side effects such as gastric irritation and improve patient compliance. Blue pea (Clitoria ternatea L.) contains flavonoid compounds that have anti-inflammatory activity. This study aims to obtain the optimal comparison of HPMC and Na CMC as a polymer in the transdermal patch formula of the ethanol extract of the blue pea (Clitoria ternatea L.). Optimization was carried out using the Simplex Lattice Design method with Software Design Expert version 11. The responses used included pH tests, weight tests, thickness tests, folding tests and moisture content tests. The optimal formula obtained from the Simplex Lattice Design method was verified with the SPSS program using the one sample t-test method. The optimal formula of transdermal patch of blue pea ethanol extract was tested for acceptability to determine whether it was acceptable to the respondent or not. The optimal comparison of HPMC and Na CMC as a polymer with transdermal patch preparation of blue pea ethanol extract was 3.5%:1%, with a desirability value of 0.944.
Optimization of Cream Ethanol Extract of Duku Leaves (Lansium domesticum Corr.) as Antibacterial Against Staphylococcus aureus Using the Simplex Lattice Design Method Saryanti, Dwi; Prameswari, Sekar Mayang
Smart Medical Journal Vol 6, No 3 (2023): December
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v6i3.74030

Abstract

Introduction: The secondary metabolites flavonoids and triterpenoids in duku leaves have antimicrobial properties. Cream have some drawbacks, including fragility to erratic stirring, brittleness when dried up, and poor storage stability. Triethanolamine reacts with stearic acid will form triethanolamine stearate which can increase stability of the cream. This research aimed to find the ideal ratio of stearic acid to triethanolamine for making an antibacterial composition.Methods: Optimization of the cream is carried out by Simplex Lattice Design method, made 8 run with the smallest proportion of stearic acid 15g and the highest 17g, and the smallest proportion of triethanolamine 2g and the highest 4g. Responses used in Simplex Lattice Design, namely pH, viscosity, adhesion, and spreadability. T-test was used to verification of the optimal formula and ANOVA was used to analysis of antibacterial data.Results: The optimal formula was 17 grams of stearic acid and 2 grams of triethanolamine make the optimal cream. The test results show that there is no significant difference between the optimal formula and the predictions in the Simplex Lattice Design software, with a pH of 6.33±0.033, a viscosity of 179.67±0.333, an adhesion of 1.377±0.038, and a spreadability of 5.133±0.044. The best formula has moderate antibacterial activity (6.62±0.007 mm inhibition zone) against Staphylococcus aureus.Conclusion: The optimal formula has good physical properties and is efficacious as an antibacterial.
Co-Authors Anggraini, Devina Ingrid Anggraini, Truly Astuti, Nisa Sindi Aulia Nur Rahmawati Ayu Safitri, Winda Devina Ingrid Anggraini Dian Nugraheni Dian Puspitasari Fatmawati, Suci Muslikah Ismawati, Heny Iwan Setiawan Kokafrinsia, Zila Tjhia Kusuma, Eka Wisnu Laksono, Wahid Suryo Nur Rahmawati, Aulia Pertiwi, Natasya Intania Prameswari, Sekar Mayang Pratikno, Argia Lovent Putri Atmaja, Aulia Putri Setyadi, Ita Mustika Putri, Dea Annisa Ramadhan, fitra Isnaini Wulan Safitri, Romadona Ayu Sari, Ananda Alfira Utami , Nastiti Wati, Setia