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All Journal Biologi Edukasi : Jurnal Ilmiah Pendidikan Biologi Ilmu dan Budaya JURNAL AKADEMI KEPERAWATAN HUSADA KARYA JAYA JFIOnline Jurnal Sehat Mandiri Majalah Farmasetika Jurnal Menara Medika Journal of Tropical Biodiversity Jurnal Keperawatan dan Kebidanan Nasional Jurnal Akademika Baiturrahim Jambi Journal for Quality in Women's Health
Suprihatin Suprihatin
Universitas Nasional
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Journal of Tropical Biodiversity

 1 
Acute and Subchronic Toxicity Of Temu Tis (Curcuma purpurascens) Rhizome in White Rat(Rattus norvegicus) Suprihatin Suprihatin; Carles Tambunan; Ernawati Sinaga
Journal of Tropical Biodiversity Vol 1 No 1 (2020): December 2020
Publisher : Universitas Nasional Jakarta

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Abstract

Temu tis (Curcuma purpurascens BI) is a species of Curcuma that has not been widely studied. Although it is not very well known, temu tis is also used as a traditional medicine to treat coughs, stomach aches, and skin infections. The results of several studies proved that temu tis rhizome extract has bioactivity as an antioxidant and anti-cancer. Temu tis is also proven to contain flavonoids, terpenoids, triterpenoids, steroids, and essential oils. Because it contains bioactive substances, it is estimated that temu tis rhizome extract has the potential to be used as a medicine, therefore its safety needs to be tested. In this study, an acute and subchronic toxicity test was conducted for the ethanol extract of temu tis rhizome which was given orally to white mouse (Rattus norvegicus) using various increased doses to see the toxic effects, both qualitative and quantitative, and subchronic effects in an increase of serum level measurements for both serum glutamic pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT). From the results, there was no visible toxic effect and mortality of mouse in the doses tested, namely between 1250-5000 mg/Kg body weight with the administration for 14 days. From the calculation results, the LD50 value of temu tis rhizome extract is greater than 5000 mg/Kg body weight, so it is classified into category 5 or non-toxic according to the Globally Harmonized System of Classification (GHS). Subchronic toxicity test results also showed that the administration of temu tis extract for 28 days in a dose range of 1,250-5,000 mg /Kg body weight did not significantly affect the activity of the SGOT and SGPT enzymes in the experimental mouse.
Phytochemical, Antibacterial and Antioxidant Activities Test of Three Macro-Algae Phaeophyceae Extracts from Pulau Tidung Coastal Kepulauan Seribu Sri Handayani; Suprihatin Suprihatin; Retno Widowati; Nyoman Yudi; Indra Rahayu
Journal of Tropical Biodiversity Vol 1 No 1 (2020): December 2020
Publisher : Universitas Nasional Jakarta

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Abstract

Macro-algae is a Thallophyta plant that has been known to have potential as a food and medicine ingredient, one of that is in the Kepulauan Seribu, particularly on Pulau Tidung coastal. Therefore this study aimed to explore the potential of three types of macro-algae: Hormophysa triquerta, Padina austraslis, and Sargassum binderi (Phaeophyceae) on the Pu;au Tidung coastal by revealing the phytochemical content, antibacterial, and antioxidant activity. The design used in this study was completelyrandomized factorial designs. The phytochemicals tested were flavonoid, alkaloid, tannin, saponin, quinon, steroid, and terpenoid. Antibacterial were tested by diffusion wel method on Muller Hinton agar in a petri dishes with a size of 100 mm and a thickness of 10 mm. The three tested macro-algae were extracted using methanol solvent and divided into four concentrations: 5%, 10%, 15%, and 20%. The test bacteria used were Staphylococcus aureus ATCC 6539 and Escherichia coli ATCC 8739. Observation of the antibacterial test was carried out 24 hours after incubation at 370C. Antioxidant activity at concentrations of 100, 200, 300, 500, 700 ppm was carried out by the DPPH (1,1-diphenil-2-pikrylhidrazyl) method. The results of phytochemical tests showed that flavonoids and steroids were found in the three macro-algae tested, while saponins were only found in S. binderi. The results of the inhibition zone showed that the three macroalgae extract tested did not inhibit E. coli bacteria. The largest inhibition zone was shown at a concentration of 20% against S. aureus bacteria, namely, H. triquerta = 10.09 ± 0.89, P. austraslis = 11, 46 ± 1.09, and S. binderi 8.00 ± 1.29. The regression results of the tested macro -algae antioxidant activity showed that the IC50 values were 13,290 ppm (H. triquerta), 3,800 ppm (P. australis), and 4,053 ppm (S. binderi).
Co-Authors Adrien Jems Akiles Unitly Ami Damayanti Anni Suciawati Bunga Tiara Carolin Carles Tambunan Dianovianti Dianovianti Ernawati Sinaga Fitri Istiqomah Gita Usi Prastika Ida Wiryanti Ika Mahartiningsih Indirasari Indirasari Indra Rahayu Maria Antonia Nesi Munirang Wahab Nyoman Yudi Putri Azzahroh Retno Widowati Rini Kundayanti Risza Choirunissa Safrida Safrida Shinta Novelia Sri Handayani Wahab, Munirang Yenny Aulya Yeti Ida Sumarni