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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Majalah Obstetri dan Ginekologi Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Perinatology
Kesty, Cindy
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Health Professions Medicine & Pharmacology Nursing Public Health

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Pulmonary hypertension in pregnancy Bernolian, Nuswil; Kesty, Cindy; Mirani, Putri; Lestari, Peby Maulina; Martadiansyah, Abarham; Agustria, Rizky
Indonesian Journal of Perinatology Vol. 5 No. 1 (2024): Available online: 1 June 2024
Publisher : The Indonesian Society of Perinatology, South Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/inajperinatol.v5i1.36

Abstract

Pulmonary hypertension (PH) is a persistent increase in mean pulmonary arterial pressure (mPAP) of at least 20–25 mm Hg during right cardiac catheterization. For every million patients, there were 97 PH cases. Women are more likely than men (1.7:1) to receive a diagnosis, with a mean age of 37 years. The classification, pathophysiology, mechanism, and management of postpartum hemorrhage (PH) are the main aims of this review study. Pulmonary artery hypertension (PAH), pulmonary hypertension (PH) associated with left heart disease, pulmonary hypoxia and/or lung illnesses, chronic thromboembolic PH, and PH with unknown multifactorial processes are the five categories into which PH is divided. Women, particularly those of reproductive age, make up about 80% of individuals with idiopathic PAH. Pregnancy-related PH is one of the long-standing heart conditions with a significant morbidity and mortality rate. Its estimated death rate ranges from 30.56%. Pregnancy is therefore not advised in PH patients. Treating people with PH requires early diagnosis and effective treatment. These patients have optimism because of the impending PH medications (phosphodiesterase type 5 inhibitors, nitric oxide, endothelin receptor antagonists, and calcium channel blockers) as well as the advancements in hemodynamic monitoring and intensive care in PH specialty facilities. Pregnant women with PH should be treated with a multidisciplinary approach, such as obstetricians, cardiologists, intensivists, and neonatologists.
The role of stem cells in obstetrics and gynecology: A systematic review Mirani, Putri; Legiran; Kesty, Cindy; Andrina, Hana
Majalah Obstetri & Ginekologi Vol. 31 No. 3 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I32023.129-138

Abstract

HIGHLIGHTS Stem cell technology has various roles in the field of obstetrics and gynecology, including fertility study as well as tissue damage repair. Safety profile of stem cells technology use in human still need to be assessed.   ABSTRACT Objective: This study aimed to review the role of stem cells in obstetrics and gynecology. Materials and Methods: This review used several databases, the PubMed, Wiley Online Library, and ScienceDirect to search open access original and review articles in English related to stem cells, obstetrics, and gynecology in the last 10 years. The results were analyzed qualitatively. Results: Out of 1,016 records identified through database searching, fifteen articles were eligible for review. Several articles reported the role of stem cells in endometrium repair. Stem cell can also increase endometrial thickness and increase the likelihood of pregnancy. In the field of gynecology, stem cells can be used as potential treatment for stress urinary incontinence and anal incontinence. Despite of all those abilities, stem cells might have errors, such as chromosomal abnormalities, epigenetic and genetic defect, which could potentially turn the stem cells into tumor initiating cells (TICs), thus can contribute to ectopic growth of endometrium (endometriosis), leiomyoma, leiomyosarcomas, and adeno-myosis. Conclusion: Stem cell technology has various roles in the field of obstetrics and gynecology, including fertility study as well as tissue damage repair. However, in-depth research to ensure the safety profile of stem cells technology use in human is necessary.
CXC Motif Chemokine Receptor 2: Glimpses into the Molecular Pathogenesis of Placenta Accreta Spectrum Disorder Mirani, Putri; Lestari, Peby Maulina; Murti, Krisna; Liberty, Iche Andriyani; Kesty, Cindy; Andrina, Hana; Stevanny, Bella
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.481

Abstract

Investigation into the mechanism underlying excessive trophoblast invasion yields further strategies and insights for the diagnosis and treatment of placenta accreta spectrum disorder (PASD). We conducted a comprehensive literature review to analyze the relationship between CXCR2 expression and PASD, as well as the possibility of CXCR2 being used as a therapeutic and diagnostic biomarker for PASD. Chemokines are well-known mediators in the immune system, particularly for cell recruitment, angiogenesis, and tumor infiltration. CXCR2 is an important component of the immune system, particularly in neutrophils. One of the CXCR2 ligands, IL-8, has also been found to be expressed in the decidua and trophoblasts of humans and to promote autocrine or paracrine trophoblast migration and invasion. The potential role of CXCR2 in trophoblast invasion in PASD provides researchers with a glimpse into the molecular pathogenesis of PASD.CXC Motif Chemokine Receptor 2: Sekilas tentang Patogenesis Molekuler Gangguan Spektrum Plasenta AkretaAbstrakInvestigasi mekanisme invasi berlebihan trofoblas pada gangguan Spektrum Plasenta Akreta (SPA) akan memberikan lebih banyak strategi dan ide untuk diagnosis dan pengobatan. Kami melakukan tinjauan literatur yang komprehensif untuk menganalisis hubungan antara ekspresi CXCR2 dan SPA serta potensi CXCR2 sebagai penanda terapeutik dan diagnostik untuk SPA. Kemokin berperan sebagai mediator dalam sistem imun karena perannya dalam perekrutan sel, angiogenesis, dan infiltrasi tumor. CXCR2 mempengaruhi sistem imun, terutama pada neutrofil. Salah satu ligan CXCR2, IL-8, juga telah ditemukan diekspresikan dalam desidua dan trofoblas manusia serta untuk mempromosikan migrasi dan invasi trofoblas autokrin atau parakrin. Peran CXCR2 dalam invasi trofoblas pada SPA memungkinkan para peneliti untuk melihat sekilas patogenesis molekuler SPA.Kata kunci: penanda; CXCR2; plasenta akreta
Pencegahan Abortus pada Awal Kehamilan Bernolian, Nuswil; Pangemanan, Wim T.; Syamsuri, Ahmad Kurdi; Ansyori, M. Hatta; Mirani, Putri; Lestari, Peby Maulina; Martadiansyah, Abarham; Kesty, Cindy
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.403

Abstract

Abortus merupakan suatu kejadian terminasi kehamilan dengan usia kehamilan <20 minggu dan berat janin <500 g. Angka kejadian abortus disebutkan sekitar 15% dari seluruh kehamilan. Terdapat beberapa faktor risiko abortus yaitu faktor risiko yang dapat dimodifikasi dan tidak dapat dimodifikasi. Beberapa faktor risiko yang dapat dimodifikasi yaitu faktor nutrisi, konsumsi kafein, alkohol, kebiasaan merokok, infeksi, paparan radiasi, beban kerja, dan pengaruh obat-obatan. Beberapa faktor risiko yang tidak dapat dimodifikasi, yaitu genetik, kelainan kongenital, dan lain-lain. Dengan mengetahui faktor risiko tersebut, dokter dapat melakukan pencegahan dan intervensi yang sesuai dengan kondisi masing-masing pasien yang mengalami abortus. Metode yang digunakan adalah tinjauan pustaka dengan menggunakan beberapa database seperti Pubmed, Wiley Online Library, dan ScienceDirect dari 10 tahun terakhir.Prevention of Miscarriage in Early PregnancyAbstractMiscarriage is an event of termination of pregnancy with < 20 weeks of gestation and fetal weight < 500 grams. The incidence of miscarriage is around 15% of all pregnancies. There are several risk factors for miscarriage, namely modifiable and non-modifiable risk factors. Some modifiable risk factors are nutritional factors, consumption of caffeine, alcohol, smoking habit, infection, radiation exposure, workload, and the influence of drugs. Several risk factors that can not be modified, namely genetics, congenital abnormalities, and others. By knowing these risk factors, doctors can carry out prevention and intervention according to the conditions of each patient who undergoes miscarriage. The method used is a literature review using several databases such as Pubmed, Wiley Online Library, and ScienceDirect from the last 10 years.Key words: miscarriage, prevention, risk factors, pregnancy.
Correlation of Vitamin D and Antimullerian Hormone Level in Infertile Women with Polycystic Ovary Syndrome and Obesity Usman, Fatimah; Saleh, Irsan; Effendi, Kms. Yusuf; Putra, Hadrians Kesuma; Abadi, Adnan; Siahaan, Salmon Charles Pardomuan Tua; Kesty, Cindy; Rizda, Dian Permata; Stevanny, Bella; Lestari, Peby Maulina
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.723

Abstract

Introduction: Increasing amount of research indicates that women with PCOS are more likely to have a shortage in vitamin D with abnormally high anti-Müllerian hormone (AMH) levels. This study aims to assess the correlation between vitamin D and Anti-Mullerian Hormone (AMH) levels in infertile women with polycystic ovarian syndrome (PCOS) and obesity. Method: This observational cross-sectional study examined all obese women with PCOS who sought infertility treatment at Dr. Mohammad Hoesin Hospital Palembang from August 2021 to November 2021. PCOS diagnosis was determined using the Rotterdam criteria. All research subjects underwent a physical examination and transvaginal ultrasound to evaluate body mass index (BMI) and polycystic ovary morphology. Blood samples were collected to evaluate their testosterone, AMH, and vitamin D levels. Statistical analysis was performed using the Spearman correlation test with IBM® SPSS Statistics version 24. Results: Thirty infertile women with PCOS and obesity were included in the study, with average age of 31.17±4.48 years and average BMI of 33.45±2.67 kg/m2. The majority of the subjects had polycystic ovary morphology (86.7%) and oligomenorrhea (76.7%). No correlation between BMI and vitamin D as well as AMH levels was found in infertile women with PCOS and obesity. The Spearman test showed moderate negative correlation (p = 0.011. r = -0.458) between vitamin D and AMH levels in infertile women with PCOS and obesity. Conclusion: There is a moderate negative correlation between vitamin D and AMH levels among infertile women with PCOS and obesity. Further research is required to comprehend the role of vitamin D in female fertility.Korelasi Vitamin D dan Kadar Hormon Anti-Müllerian pada Wanita Infertil dengan Sindrom Ovarium Polikistik dan ObesitasAbstrakPendahuluan: Semakin banyak penelitian melaporkan bahwa wanita dengan PCOS cenderung mengalami defisiensi vitamin D dengan penignkatan kadar hormon anti-Müllerian (AMH). Penelitian ini bertujuan untuk mengkaji hubungan vitamin D dan kadar AMH pada wanita infertil dengan sindrom ovarium polikistik (SOPK) dan obesitas.Metode: Penelitian ini merupakan studi observasional potong lintang terhadap seluruh wanita infertil dengan SPOK dan obesitas yang di RSUP Dr. Mohammad Hoesin Palembang pada bulan Agustus 2021 hingga November 2021. Diagnosis SOPK ditegakkan berdasarkan kriteria Rotterdam. Seluruh subjek penelitian menjalani pemeriksaan fisik dan ultrasonografi transvaginal untuk menilai indeks massa tubuh (IMT) dan morfologi ovarium polikistik. Sampel darah dikumpulkan dari semua wanita untuk mengukur kadar testosteron, AMH, dan vitamin D. Analisis statistik dilakukan dengan menggunakan uji korelasi Spearman menggunakan IBM® SPSS Statistics versi 24.Hasil: Tiga puluh wanita infertil dengan SOPK dan obesitas dilibatkan dalam penelitian ini dengan usia rata-rata 31,17±4,48 tahun dan rata-rata IMT 33,45±2,67 kg/m2. Mayoritas subjek memiliki morfologi ovarium polikistik (86,7%) dan oligomenore (76,7%). Tidak ada korelasi antara IMT dan vitamin D maupun kadar AMH pada wanita infertil dengan SOPK dan obesitas. Uji Spearman menunjukkan korelasi negatif sedang (p=0.011.r=-0.458) antara kadar vitamin D dan AMH pada wanita infertil dengan SOPK dan obesitas. Kesimpulan: Kadar vitamin D berkorelasi negatif dengan kadar AMH pada wanita infertil dengan SOPK dan obesitas. Penelitian lebih lanjut diperlukan untuk memahami peran vitamin D pada kesuburan wanita.Kata kunci: Anti-Müllerian Hormone, Indeks Massa Tubuh, Obesitas, Sindrom Ovarium Polikistik, Vitamin D
Ultrasound Assessment of Fetal Biometry at Raden Mattaher Hospital herlambang, Herlambang; Firmansyah, Frimansyah; Kesty, Cindy; Aryani, Puspa Muthia; Divanna, Diora Asha
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 13 No. 2 (2025): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v13i2.47814

Abstract

Background: Fetal biometry is the cornerstone of modern prenatal care. This study aims to assess fetal size (fetal biometry at a given time point compared to normal charts) and estimate fetal weight (EFW) using the Hadlock formula. Methods: A descriptive retrospective study in order to establish fetal biometry in the third trimester of pregnancy and incorporated into Hadlock's formula to estimate fetal weight. Four fetal biometry measurements (BPD, HC, AC and FL) were collected from ultrasonography examination results in Raden Mattaher General Hospital. Data were documented using case report form and being tabulated using Microsoft Excel 2011 Version 14.7.0 (161029). All data were analyzed using SPSS 25.0. Results: There were 100 data of pregnant women who underwent fetal biometry ultrasound examinations from February 2021 to April 2023, 100 data samples were obtained that met the criteria for inclusion in the study. The data was distributed based on gestational age from 9 weeks to 41 weeks of gestation. Data on four biometric parameters were collected and calculated using Hadlock formula to obtain an estimate of fetal weight. In the study, it was estimated the weight of the fetus at the 33rd week of pregnancy was 1800 grams, which was in the 10-50 percentile on Hadlock curve. Conclusion: Assessment of fetal biometry is one of the main components of modern prenatal care. Accurate pregnancy dating is essential for further interpretation of both fetal size and growth. Measuring biometrics parameters, including Head Circumference (HC), Biparietal Diameter (BPD), Abdominal Circumference (AC), and Femur Length (FL), and combining them into an estimated fetal weight should be part of the routine ultrasound exam.
Co-Authors Adnan Abadi, Adnan Agustria, Rizky Anang Ansyori Andrina, Hana Aryani, Puspa Muthia Divanna, Diora Asha Effendi, Kms. Yusuf Firmansyah, Frimansyah Herlambang Iche Andriyani Liberty, Iche Andriyani Krisna Murti Legiran Legiran Martadiansyah, Abarham Muhammad Irsan Saleh Nuswil Bernolian Peby Maulina Lestari, Peby Maulina Putra, Hadrians Kesuma Putri Mirani Rizda, Dian Permata Salmon Charles Pardomuan Tua Siahaan Stevanny, Bella Syamsuri, Ahmad Kurdi Usman, Fatimah Wim T. Pangemanan