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All Journal JURNAL FARMASIMED (JFM) International Journal Of Science, Technology & Management (IJSTM) Jurnal Pengmas Kestra (JPK)
Purba, Novandi
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Phytochemical Screening And Antidiabetic Test Of Ethanol Extract Of Sapodilla Kecik Leaves (Manilkara kauki (L) Dubard) On Decreasing Blood Glucose Of Diabetic Rats Purba, Novandi; Harahap, Urip; Hasibuan, Poppy Anjelisa Z.
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.869

Abstract

The development of traditional medicine needs to be carried out so that Indonesia's natural wealth can be utilized as effectively as possible to improve people's welfare. As with diabetes, some reputable traditional herbal medicines contain antidiabetic properties. Natural antidiabetic drugs derived from compounds isolated from plants can be used as an alternative to traditional medicine for diabetes because they have potential side effects. Diabetes can be treated alternatively by using various substances, especially those containing polyphenols, such as flavonoids. Sapodilla kecik (Manilkara kauki (L.) Dubard) from the Sapotaceae family is a type of plant used in traditional medicine; leaves, roots and bark can be used to treat diarrhoea in children, seeds can be used as a febrifuge, anthelmintic, and as an antileprotic. Secondary metabolites in sapodilla kecik leaves are flavonoids, alkaloids, tannins, triterpenoids and glycosides. This research was carried out by characterizing and screening phytochemicals to determine the content of compounds in Sapodilla kecik (Manilkara kauki (L.) Dubard) and carrying out antidiabetic tests on streptozotocin-nicotinamide-induced diabetic rats. The results showed that sapodilla kecik leaves fulfilled the simplicia characterization requirements. Sapodilla leaves contain secondary metabolites such as alkaloids, flavonoids, tannins, glycosides, saponins and steroids. The ethanol extract of sapodilla kecik leaves at a dose of 500 mg/Kg BW starting from the 4th day of treatment, a dose of 250 mg/Kg BW starting on the 8th day of treatment, and a dose of 125 mg/Kg BW starting on the 12th day was able to reduce the KGD of induced diabetic rats with nicotinamide and streptozotocin.
Formulation of Ethanol Extract Lotion from Snake Fruit (Salacca zalacca) as an Antioxidant Purba, Novandi; Aminah; Intan
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/vy39nj40

Abstract

The skin is the outermost layer of the body that functions as the main protector from environmental exposure, including free radicals that can cause cell damage such as premature aging, dry skin, and various other skin disorders. Efforts to maintain healthy skin can be done through the use of appropriate cosmetic products, one of which is in the form of lotion. Lotion is a topical preparation that is easy to apply and can increase moisture and provide protection to the skin. Snake fruit (Salacca zalacca), a plant native to Indonesia that grows in tropical areas, is known to contain various bioactive compounds such as anthocyanins, flavonoids, flavonols, polyphenols, and β-carotene which have potential as antioxidants. This study aims to formulate and evaluate body lotion preparations based on ethanol extract of snake fruit (Salacca zalacca) as an antioxidant. The research methods include the preparation of simple drugs, extraction with ethanol solvents, body lotion formulations with varying extract concentrations (3%, 6%, and 9%), as well as physical quality evaluations including organoleptic tests, homogeneity, spreadability, pH, and irritation tests on volunteers. Antioxidant activity was tested using the DPPH (2,2- diphenyl-1-picrylhydrazyl) method. The results showed that all body lotion formulations met the physical evaluation requirements, with stable, homogeneous characteristics, good spreadability, and a pH that matched the skin's pH. The  irritation test showed that the preparation was safe to use because it did not cause irritation reactions on the volunteers' skin. Antioxidant activity testing showed that the ethanol extract of snake fruit had relatively strong antioxidant activity, with activity increasing along with increasing extract concentration in the preparation. Based on the results of the study, it can be concluded that the ethanol extract of snake fruit (Salacca zalacca) has the potential to be formulated into a stable, safe, and effective body lotion as an antioxidant to protect the skin from damage caused by free radicals.
Co-Authors Alfrisa, Bagus AMINAH Andriani Harianja, Bulan Br Turnip, Nur Ulina M. Br. Turnip, Nur Ulina M Br. Turnip, Nur Ulina M. Cahayani Zebua, Kristian Cahya, Cucu Arum Dwi Edrianto, Vicky Ginting, Radika Handayani, Diah Tri Hasibuan, Ahmad Syukur intan Karnirius Harefa Karokaro, Tati Murni Khairil Akbar Lubis, Kholilah Putri Poppy Anjelisa Z. Hasibuan Putri, Nabila Sari, Lasma Novita Sinurat, Jhon Patar Situmorang, Novidawati Suci Wulandari Sunariati, Sunariati Urip Harahap