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All Journal JFIOnline Jurnal Farmasi dan Sains Indonesia (JFSI) Indonesian Journal of Pharmaceutical Education Jurnal Farmasi Kryonaut
Nafi'ah, Rahma
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Formulasi Sediaan Gel Niosom Kafein dan Usaha Peningkatan Absorpsi melalui Kulit Nafi'ah, Rahma; Darijanto, Sasanti Tarini; Mudhakir, Diky
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (389.23 KB) | DOI: 10.35617/jfi.v7i1.157

Abstract

Cellulite is a condition in the skin that changes the topographic of the skin surface. Caffeine can be used as an active compound for its slimming effect. To improve the penetration into the skin and increasing its solubility for cellulite treatment, caffeine was formulated as niosome vesicles. Niosome was made by using thin layer hydration method. Span 60, caffeine and cholesterol dissolved in chloroform and evaporated to produse a thin layer. The dispersion of caffeine and niosome was formulated in the form of gel using 6% of HPMC gel base. To determine the formulation stability, caffeine niosome gel was stored at a room temperature and accelerated condition using climatic chamber at a temperature of 40⁰C, 75% RH for 28 days. The result was then compared with caffeine gel. The diffusion rate of both gels was determined in vitro using flow through method. The results showed that the niosome system improved the solubility of caffeine up to 20,34 mg/ml and also showed that the pH and viscosity of caffeine niosome gel were stable under room temperature and accelerated condition.The diffusion test showed that the flux of caffeine niosome gel is 13.991 μg/cm2Keywords : Caffeine, niosome, cellulite, diffusion test.
Yellow Pumpkin Fruit Extract (Cucurbita moschata D) in Cream Preparation as a Facial Moisturizer Fauzia, Rizki Rahmah; Nafi'ah, Rahma; Widyaningsih, Hanum
Indonesian Journal of Pharmaceutical Education Vol 5, No 1 (2025): January–April 2025
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v5i1.26842

Abstract

Indonesia is a tropical country that has a fairly high exposure to sunlight, but excessive sun exposure can cause skin damage such as dry skin with prevalence of 41,2% to 99,1% in the elderly adult population  . Therefore, it is necessary to make products that function to moisturize the skin. Yellow pumpkin is an alternative ingredient that can be used as a skin moisturizer because it contains flavonoid compounds, tannins, saponins, alkaloids, and triterpenoids. The novelty in this study is that no one has researched yellow pumpkin fruit extract cream as a facial moisturizer, different measurement methods, substitution of ingredients in the formula from VCO to MCT and the addition of preservatives and fragrances. This study aims to determine the effectiveness of facial moisturizers, yellow pumpkin fruit extract creams, and the physical quality of preparations. In this study, the researcher used an experimental method. The extraction process uses a maceration method with a solvent of 96%, then a cream formula is made with a concentration of yellow pumpkin fruit extract of 5%, 10%, and 15%. The evaluation of facial moisturizing cream preparations includes organoleptis tests, homogeneity tests, pH tests, dispersion tests, adhesion tests, viscosity tests, and irritation tests. The tool used to measure skin moisture is Skin Analyzer CR-302 by looking at the percentage of moisture. The results of the effectiveness test of yellow pumpkin extract facial moisturizing cream (Cucurbita moschata D) for 28 days of use had a moisture percentage of 44.00% at an extract concentration of 5%, 48.67% at an extract concentration of 10%, and 55.00% at an extract concentration of 15%. The higher the concentration of the extract, the better the moisture level. The results of the effectiveness test of yellow pumpkin fruit extract cream preparations (Cucurbita moschata D) have effectiveness as a skin moisturizer with a sig value (0.008 0.050). The conclusion showed that the preparation of the moisturizing cream of yellow pumpkin fruit extract (Cucurbita moschata D) with the best concentration at a concentration of 15%. The preparation of the moisturizing cream of yellow pumpkin fruit extract (Cucurbita moschata D) meets the requirements of the evaluation test.
Formulasi Lotion Sari Buah Mangga (Mangifera Indica L.) Sebagai Pelembab Kulit Karphiawati, Aldilla Shalsa; Zuniarto, Ahmad Azrul; Pandanwangi TW, Siti; Karsidin, Bambang; Nafi'ah, Rahma; Zakiah, Fitri; Dewi, Komala
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p28-34

Abstract

Making mango juice lotion (Mangifera indica L.) using various concentration variations is expected to produce mango juice lotion (Mangifera indica L.) which meets the requirements for a good lotion and tests skin moisture against the mango juice lotion formula (Mangifera indica L.). This study aims to determine the best concentration of mango (Mangifera indica L.). In this study, mango juice was obtained by extortion, made in the form of lotion and tested for skin moisture using a Skin Analyzer. Data analysis in the form of SPPS (Statistical Product and Service Solution) tables. The results showed that the addition of the concentration of mango juice (Mangifera indica L.) had an effect on the resulting skin moisture. The selected formula of Mango juice lotion (Mangifera indica L.), namely formula 1 with a concentration of 5%, has a skin moisture value of 70,55%, and Mango fruit juice lotion (Mangifera indica L.).
STUDI IN SILICO SENYAWA DALAM KULIT UBI JALAR UNGU TERHADAP AKTIVITAS PENGHAMBATAN ENZIM ACE SEBAGAI ANTIHIPERTENSI Widyawati, Fanny Febriana; Nurohman, Ikra; Nugraha, Yoga; Nafi'ah, Rahma
Jurnal Farmasi Kryonaut Vol 5 No 1 (2026): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v5i1.182

Abstract

Hipertensi merupakan salah satu masalah kesehatan utama yang memicu penyakit kardiovaskular. Enzim pengonversi angiotensin (ACE) berperan penting dalam regulasi tekanan darah sehingga menjadi target utama pengembangan obat antihipertensi. Kulit ubi jalar ungu (Ipomoea batatas var. Ayamurasaki) diketahui mengandung metabolit sekunder, seperti flavonoid, antosianin, dan asam fenolik, yang berpotensi sebagai inhibitor ACE. Penelitian ini bertujuan memancarkan potensi 10 senyawa aktif kulit ubi jalar ungu sebagai penghambat ACE melalui pendekatan in silico. Metode yang digunakan meliputi penambatan molekul (Gnina), serta prediksi farmakokinetik (SwissADME) dan toksisitas (ProTox-III). Hasil docking menunjukkan bahwa senyawa uji yaitu myricetin (-9,07), quercetin (-10,75), cyanidin (-9,95), pelargonidin (-9,39), peonidin (-9,36), 3CQA (-9,33), apigenin (-9,22), 4CQA (-9,19), dan 5CQA (-8,88) memiliki nilai ikatan bebas rendah dan memiliki afinitas baik, Senyawa berinteraksi melalui hidrogen hidrogen, hidrofobik, dan elektrostatik. Prediksi toksisitas menunjukkan sebagian besar senyawa berada pada tingkat 5 (tidak beracun), kecuali myricetin dan quercetin (Tingkat 3). Seluruh senyawa uji memiliki profil farmakokinetik yang baik, sehingga mendukung potensinya sebagai kandidat antihipertensi alami.
Co-Authors Dewi, Komala Diky Mudhakir Fauzia, Rizki Rahmah Fauziyah, Rizki Rahmah Karphiawati, Aldilla Shalsa Karsidin, Bambang Nugraha, Yoga Nurohman, Ikra Sahputri, Cintya Ayu Sasanti Tarini Darijono Siti Pandanwangi TW Widyaningsih, Hanum Widyawati, Fanny Febriana Yuliantini, Arin Zakiah, Fitri Zuniarto, Ahmad Azrul