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All Journal Molucca Medica Journal of Neurointervention and Stroke (JNeViS)
Halim, Wijoyo
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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EFEK MEDIATOR VASCULAR CELL ADHESION MOLECULE-1 (VCAM-1) TERHADAP SEVERITAS DAN OUTCOME PASIEN STROKE ISKEMIK AKUT Assa, Christantina Pradescha; Bahar, Ashari; Akbar, Muhammad; Bintang, Andi Kurnia; Tammasse, Jumraini; Soraya, Gita Vita; Halim, Wijoyo
Molucca Medica Vol 17 No 1 (2024): VOLUME 17, NOMOR 1, APRIL 2024
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/10.30598/molmed.2024.v17.i1.16

Abstract

Introduction: Atherosclerosis is currently recognized as part of the inflammatory disease. In the acute phase, inflammation causes brain edema and expansion of ischaemic area. Vascular cell adhesion molecule 1 (VCAM-1) plays a crucial role in the inflammation mechanism immediately after cerebral damage in stroke, facilitating the migration of leukocytes across the endhothelial cells. Objective: This study aimed to establish the correlation between VCAM-1 serum levels and severity and outcomes in stroke patients. Research Methodology: It was a cross-sectional study conducted from September to November 2023 on 51 patients with acute ischemic stroke at RSUP Wahidin Sudirohusodo Makassar and other affiliated hospitals. VCAM-1 serum levels were examined using the ELISA principle. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) upon admission, and clinical outcomes were evaluated using the modified Rankin Scale (mRS) on the 30th day of onset. Results: Mann- Whitney test results showed no difference in serum VCAM-1 levels between severity groups (mild and moderate) and clinical outcome groups (good and poor). Spearman correlation test results indicated a correlation between serum VCAM-1 levels and severity (p=0.635, r=-0.068) and clinical outcomes (p=0.459, r=-0.106). Conclusion: There is no association between serum VCAM-1 levels and the severity and clinical outcomes of acute ischemic stroke patients. Recommendation: Further research is needed to explore the relationship between serum VCAM-1 levels and severity and clinical outcomes in acute ischemic stroke patients at various centers in Indonesia.
PERBANDINGAN PENGARUH TERAPI ADJUVANT CONSTRAINT INDUCED MOVEMENT THERAPY DENGAN REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION TERHADAP FUNGSI MOTORIK EKSTREMITAS ATAS PADA PASIEN STROKE ISKEMIK Tarigan, Ngalasantaru Janstar; Umbas, David Gunawan; Bintang, Andi Kurnia; Tammasse, Jumraini; Amran, Muhammad Yunus; Bahar, Ashari; Zainuddin, Andi Alfian; Halim, Wijoyo
Molucca Medica Vol 17 No 1 (2024): VOLUME 17, NOMOR 1, APRIL 2024
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/10.30598/molmed.2024.v17.i1.26

Abstract

Introduction Stroke is an acute disorder of cerebral perfusion or vascularization. Stroke patients commonly encounter numerous functional disorders, such as motor, psychological or behavioral disorders, where the most typical symptom is hemiparesis which greatly affects their ability to carry out daily life activities. Repetitive Transcranial Magnetic Stimulation (rTMS) is one of the interventions proposed to improve stroke recovery. Constraint-Induced Movement Therapy (CIMT) is a neurological rehabilitation treatment designed to improve upper extremity motor function after stroke Objective: This study aims to compare the effectiveness of rTMS with CIMT in improving upper extremity motor function in ischemic stroke patients. Research Methodology: This is an experimental clinical trial study with a randomized pre-test post-test control group design on 30 ischemic stroke patients at Wahidin Sudirohusodo General Hospital Makassar and other network hospitals. Repetitive Transcranial Magnetic Stimulation was carried out for 10 stimulations, CIMT was carried out for 30 days. Motor improvement was evaluated by measuring the Fugl Mayer Assessment Upper Extremity (FMA-UE) score Results: The Friedmann test showed that rTMS and CIMT provided significant changes in FMA-UE scores (p: 0.000). Mann Whitney test showed there was a significant difference in FMA-UE scores in the rTMS group compared to CIMT (p: 0.000) Conclusion: There was a significant difference in the FMA-UE score in the rTMS group compared to CIMT. Recommendation: Further research is needed with longer observation and stimulation time and looks at the effectiveness of these two therapeutic modalities through a biomarker so that more objective results can be obtained.
Comparison of Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio as a Predictor of Clinical Outcome in Acute Ischemic Stroke Gunawan, Anthony; Bahar, Ashari; Hawari, Irbab; Halim, Wijoyo
Journal of Neurointervention and Stroke Vol. 1 No. 1: MAY 2025
Publisher : Neurointervention Working Group of Indonesian Neurological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63937/jnevis-2025.11.8

Abstract

Highlight: NLR and PLR are associated with stroke outcomes They may influence outcomes via thromboinflammatory pathways ABSTRACT Introduction: Stroke is a clinical syndrome characterized by neurological deficits lasting more than 24 hours or resulting in death, caused exclusively by cerebrovascular disease. Stroke is a leading cause of mortality, responsible for 7.8 million deaths worldwide each year and accounting for 13% of all deaths. Several studies have revealed the role of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting stroke. However, no study has directly compared NLR and PLR levels with the clinical outcomes of acute ischemic stroke (AIS). Objective: This study aims to compare the predictive value of the NLR and PLR with the clinical outcome of AIS based on the Modified Rankin Scale (mRS) and with the incidence of early neurological deterioration (END) based on NIHSS. Method: This was a prospective observational study. NLR and PLR values were obtained from routine blood examinations, and stroke outcome were assessed using the mRS. Result: A total of 125 ischemic stroke patients met the inclusion criteria. Chi-square test showed that NLR was associated with mRS outcomes, with an odds ratio (OR) of 6.1, while PLR was associated with mRS with an OR of 5.6. Fisher's exact test revealed a statistically significant association between NLR and the incidence of END (OR 19.26; p<0.001), as well as between PLR and END (OR 5.9; p=0.003). Conclusion: NLR and PLR have predictive value for both clinical outcome and the incidence of END in patients with acute ischemic stroke.
Co-Authors Amran, Muhammad Yunus Andi Alfian Zainuddin Andi Kurnia Bintang, Andi Kurnia Anthony Gunawan, Anthony Assa, Christantina Pradescha Bahar, Ashari David Gunawan Umbas Hawari, Irbab Muhammad Akbar Soraya, Gita Vita Tammasse, Jumraini Tarigan, Ngalasantaru Janstar