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All Journal Pharmacon Walisongo Journal of Chemistry Jurnal Mandala Pharmacon Indonesia Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Buana Farma Pharmacy Reports Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Pharmacy Genius SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT Nanggroe: Journal Of Scholarly Service Journal of Pharmaceutical and Sciences. Journal of Advanced Health Informatics Research Nanggroe: Journal of Scholarly Service Pharmacon: Jurnal Farmasi Indonesia Jurnal Multidisiplin Pengabdian Masyarakat (JMPM)
Samodra, Galih
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Uji Aktivitas Antibakteri Sediaan Gel Facial-Wash Ekstrak Kayu Secang Dan Daun Belimbing Wuluh Terhadap Propionibacterium acnes Hamidah, Ai' Wikri; Samodra, Galih; Prabandari, Rani
Pharmacogenius Journal Vol 3 No 2 (2024): Pharmacy Genius
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/pharmgen.v3i2.336

Abstract

Pendahuluan: Ektrak kayu secang (Caesalpinia sappan L.) dan daun belimbing wuluh (Averrhoa bilimbi L.) memiliki senyawa metabolit sekunder yang berpotensi sebagai agen antibakteri terhadap Propionibacterium acnes. Tujuan: Penelitian ini bertujuan untuk memahami karakteristik fisik dan daya hambat bakteri sediaan gel facial-wash ekstrak kayu secang dan daun belimbing wuluh. Metode: metode penelitian adalah eksperimen. Ekstrak diformulasikan dalam bentuk sediaan gel facial-wash. F1 menggunakan konsentrasi ekstrak kayu secang 5% dan daun belimbing wuluh 10%, F2 menggunakan konsentrasi ekstrak kayu secang 7,5% dan daun belimbing wuluh 7,5%, F3 menggunakan konsentrasi ekstrak kayu secang 10% dan daun belimbing wuluh 5%. Hasil evaluasi sifat fisik mencangkup uji organoleptik, uji pH, uji daya sebar, uji viskositas, uji tinggi busa, dan uji antibakteri menggunakan metode sumuran. Hasil: Hasil pada F1, F2, dan F3 memenuhi persyaratan sediaan gel facial-wash.  Namun, uji pH dan daya sebar pada F3 tidak memenuhi kriteria sediaan gel facial-wash. Hasil uji antibakteri sediaan gel facial-wash esktrak kayu secang dan daun belimbing wuluh metode difusi sumuran, pada kontrol positif 19,07 mm, F1 sebesar 11,53 mm, F2 sebesar 17,07 mm, dan F3 sebesar 20 mm. Kesimpulan: Sediaan gel facial-wash ekstrak kayu secang dan daun belimbing wuluh menghasilkan zona hambat yang kuat terhadap bakteri Propionibacterium acnes.
Pengaruh Ketinggian Tempat Tumbuh Terhadap Kadar Flavonoid Total dan Uji Aktivitas Antioksidan Ekstrak Daun Mahoni (Swietenia Maghoni L.) Aminurita, Agus; Samodra, Galih; Fitriana, Adita Silvia
Pharmacogenius Journal Vol 3 No 2 (2024): Pharmacy Genius
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/pharmgen.v3i2.344

Abstract

Pendahuluan: Mahoni merupakan salah satu tumbuhan tropis dari famili Meliaceae yang berasal dari Hindia Barat. Kandungan senyawa kimia yang ada di dalam mahoni diantaranya senyawa flavonoid, saponin, alkaloid, steroid, dan terpenoid. Beberapa penelitian menyatakan bahwa metabolit sekunder pada tanaman dipengaruhi oleh ketinggian tempat tumbuh. Tujuan: Tujuan dari penelitian ini adalah mengetahui pengaruh ketinggian tempat tumbuh terhadap kadar flavonoid total dan aktivitas antioksidan ekstrak metanol daun Mahoni (Switenia maghoni L). Metode: penelitian ini merupakan penelitian eksperimental yang dilakukan dengan metode kolorimetri untuk mengetahui kadar flavonoid total daun mahoni dan menggunakan metode dpph untuk menetapkan aktivitas antioksidan daun mahoni (Swietenia maghoni L). Hasil: Hasil analisis statistik one way ANOVA nilai signifikansinya dari analisis flavonoid total sebesar 0,000 < 0,05. Aktivitas antioksidan esktrak metanol daun Mahoni berpengaruh secara signifikan terhadap ketinggian lokasi tumbuh. Hal ini ditunjukkan oleh nilai signifikasi (P<0,05). Kesimpulan: Dalam penelitian ini, dapat disimpulkan bahwa ketinggian lokasi tumbuh berpengaruh terhadap kadar total flavonoid dan aktivitas antioksidan daun Mahoni (Swietenia mahagoni (L.)
Molecular mechanism of glucocorticoid-induced hyperglycemia Sari, Destika Ambar; Samodra, Galih; Kusuma, Ikhwan Yuda
Pharmacy Reports Vol. 1 No. 1 (2021): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (175.572 KB) | DOI: 10.51511/pr.1

Abstract

Glucocorticoids are widely used as strong anti-inflammatory and immunosuppressive drugs to treat various diseases. However, the use of glucocorticoids can cause several side effects, such as hyperglycemia. This review aims to discuss the effect of glucocorticoids on increasing glucose in molecular levels based on literature studies. A literature searching was carried out on the PubMed, Science Direct, and Google Scholar databases published in 2010-2020. Glucocorticoids can cause an increase in blood glucose levels by several mechanisms. In the liver, glucocorticoids increase endogenous plasma glucose and stimulate gluconeogenesis. Glucocorticoids increase the production of non-esterified fatty acids which affect the signal transduction of insulin receptor substrate-1 in skeletal muscle. In adipose, glucocorticoids increase lipolysis and visceral adiposity through increased transcription and expression of protein adipose triglyceride lipase and hormone-sensitive lipase. In pancreatic beta cells, glucocorticoids directly inhibit the beta cell response to glucose through the role of protein kinase B and protein kinase C. At the molecular level, glucocorticoids can cause hyperglycemia through mechanisms in the liver, skeletal muscle tissue, adipose tissue, and pancreatic beta cells.
Effectiveness of Cream Preparations Combination of Bay Leaf Extract (Syzygium polyanthum Wight) and Papaya Leaf (Carica Papaya L) as Anti-Inflammation Samodra, Galih; Kusuma, Ikhwan Yudha; Melani, Reina
Journal of Advanced Health Informatics Research Vol. 1 No. 2 (2023)
Publisher : Peneliti Teknologi Teknik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59247/jahir.v1i2.37

Abstract

Bay leaves (Sygyzium polyanthum Wight) and papaya leaves (Carica papaya L) are plants that have anti-inflammatory activity due to their flavonoid compounds. The purpose of this study was to determine the formulation of bay leaf and papaya leaf extracts into cream preparations. The treatment group consisted of 4 groups. The first group is the positive control (voltarene), the second group is the negative control (1% carrageenan). The third group was the group that was given the combination cream treatment of bay leaf and papaya leaf extract formula 2 and the fourth group was the group that was given the cream treatment combination of bay leaf and papaya leaf extract formula 3. The anti-inflammatory test was carried out based on observations for six hours by looking at edema volume and edema percentage. LSD test results showed that the cream formula 2 treatment (anionic) and the cream formula 3 treatment (nonionic) showed a significant difference with the negative control with a significance value of 0.000 (p <0.05). This shows that formula 2 cream treatment (anionic) and formula 3 cream treatment (nonionic) can potentially reduce edema volume and can inhibit edema on the soles of rats induced with carrageenin
FORMULASI DAN UJI STABILITAS FISIK SEDIAAN FACIAL WASH EKSTRAK ETANOL DAUN MATOA (Pometia Pinnata J.R & G. Forst.) Dzakiyyatunnisa, Hanifah; Nawangsari, Desy; Samodra, Galih
Jurnal Buana Farma Vol. 4 No. 4 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i4.1185

Abstract

Kulit wajah adalah bagian tubuh yang selalu terpapar debu, polusi, sinar ultraviolet, radikal bebas bahkan seringkali sisa sisa riasan jika tidak dibersihkan dengan baik. Oleh karena itu, kulit wajah harus mendapat perhatian ekstra agar tetap terjaga dengan baik. Perawatan wajah awal bisa dilakukan secara rutin dengan menggunakan pembersih wajah. Namun banyak pembersih wajah yang mengandung bahan kimia sintetis seperti triclosan yang dapat menyebabkan disfungsi tiroid. Untuk mengatasinya, Anda bisa menggunakan bahan alami seperti daun matoa. Ekstrak etanol daun matoa mempunyai efek antibakteri terhadap bakteri staphylococcus aureus. Tujuan penelitian ini untuk mengetahui formula facial wash ekstrak etanol daun matoa dengan uji sifat fisik dan stabilitas sediaan, untuk mengetahui respon iritasi sediaan dan untuk mengetahui kesukaan responden. Metode penelitian ini yaitu eksperimental laboratorium. Hasil pengujian organoleptik dan homogenitas didapatkan hasil yaitu tidak ada perbedaan pada formula kecuali warna pada F3 lebih coklat tua. Pengujian pH didapatkan hasil tidak memenuhi standar pH. Berdasarkan pengujian statistik diketahui bahwa viskositas mendapatkan nilai p value <0,05 yang berarti terdapat perbedaan yang signifikan dengan penggunaan konsentrasi ekstrak etanol daun matoa. Pada hasil uji stabilitas, nilai pH pada ketiga formula tidak mempunyai pengaruh yang signifikan, nilai daya sebar F3 mempunyai pengaruh yang signifikan, nilai daya busa pada F1 mempunyai pengaruh yang signifikan, nilai viskositas pada ketiga formula mempunyai pengaruh yang signifikan. Hasil uji hedonik menunjukkan F1 mendapatkan rangking kesukaan pertama dengan persentase 33,90 %.
The Effect of Temperature and Fermentation Duration on pH Level and Vitamin C Content of Butterfly Pea Flower (Clitoria ternatea L.) Kombucha Setyaji, Andy Anggoro; Fitriana, Adita Silvia; Samodra, Galih
Walisongo Journal of Chemistry Vol. 7 No. 2 (2024): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v7i2.19519

Abstract

Kombucha is produced through the fermentation of a tea and sugar mixture with a symbiotic culture of bacteria and yeast (SCOBY). It contains various compounds beneficial to health, including vitamin C. The pH level and vitamin C content of kombucha are affected by fermentation temperature and time. Correspondingly, this study aimed to determine the effects of temperature and fermentation duration on the pH level and vitamin C content of butterfly pea kombucha. The research was conducted employing laboratory experimental methods, including a UV-Vis spectrophotometer to measure vitamin C content and a digital pH meter to measure pH levels. The limit of detection (LoD) and the limit of quantification (LoQ) values for the UV-Vis spectrophotometer were 0.115 ppm and 3.77 ppm, respectively. The results indicated that fermentation temperature did not affect the pH or vitamin C content. However, the pH level was affected by fermentation time, while vitamin C content was not statistically affected. The highest pH value (5.11) was observed on day 0 of fermentation, and the highest vitamin C content (2.94%) was recorded on day 6 at a temperature of 30°C.
UJI AKTIVITAS ANTIINFLAMASI KOMBINASI EKSTRAK DAUN SALAM (Syzygium polyanthum (Wight) Walp) dan EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP UDEMA KAKI TIKUS PUTIH JANTAN YANG DIINDUKSI KARAGENIN Syahputra, Dhika Adhil; Samodra, Galih; Prabandari, Rani
Jurnal Farmasi & Sains Indonesia Vol 5 No 2 (2022)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol5no2p1-6

Abstract

Inflammation or inflammation is the body's normal response to tissue damage caused by physical trauma, chemical and microbial damage. Plants that are thought to have anti-inflammatory properties are bay leaves (Syzygium polyanthum (Wight) Walp). Which acts as an anti-inflammatory in bay leaves and papaya leaves are flavonoids. Bay leaf and papaya leaf extracts were extracted using 70% ethanol by maceration method. The test animals were divided into 7 groups, namely a negative control group (Na CMC), a positive group (Diclofenac Sodium 50 mg), a single dose group of 100 mg/kgBW bay leaf extract, a single dose group of 100 mg/kgBW papaya leaf extract, and a combination group of leaf extracts. salam and papaya leaf extract 50mg/kgBB: 50mg/kgBB, 150mg/kgBB: 100mg/kgBB, 250mg/kgBB: 200mg/kgBB. Treatment 1 hour after the hind legs of rats was induced by subplantar carrageenin. The results showed that the combination of bay leaf and papaya leaf extracts had anti-inflammatory activity. The results of the calculation of the inflammatory power in the combination group showed inflammatory activity.
The Effect of Temperature and Fermentation Duration on pH Level and Vitamin C Content of Butterfly Pea Flower (Clitoria ternatea L.) Kombucha Setyaji, Andy Anggoro; Fitriana, Adita Silvia; Samodra, Galih
Walisongo Journal of Chemistry Vol. 7 No. 2 (2024): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology UIN Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/wjc.v7i2.19519

Abstract

Kombucha is produced through the fermentation of a tea and sugar mixture with a symbiotic culture of bacteria and yeast (SCOBY). It contains various compounds beneficial to health, including vitamin C. The pH level and vitamin C content of kombucha are affected by fermentation temperature and time. Correspondingly, this study aimed to determine the effects of temperature and fermentation duration on the pH level and vitamin C content of butterfly pea kombucha. The research was conducted employing laboratory experimental methods, including a UV-Vis spectrophotometer to measure vitamin C content and a digital pH meter to measure pH levels. The limit of detection (LoD) and the limit of quantification (LoQ) values for the UV-Vis spectrophotometer were 0.115 ppm and 3.77 ppm, respectively. The results indicated that fermentation temperature did not affect the pH or vitamin C content. However, the pH level was affected by fermentation time, while vitamin C content was not statistically affected. The highest pH value (5.11) was observed on day 0 of fermentation, and the highest vitamin C content (2.94%) was recorded on day 6 at a temperature of 30°C.
Penyuluhan dan Edukasi Pengendalian Hipertensi Melalui Pola Hidup Sehat bagi Masyarakat Desa Penembangan Kecamatan Cilongok Kabupaten Banyumas Samodra, Galih; Santoso, Cahyo Budi; Fitriani, Artika Wina; Swandari, Mika Tri Kumala
Nanggroe: Jurnal Pengabdian Cendikia Vol 4, No 1 (2025): April
Publisher : Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.15275140

Abstract

This Community Service Activity (PKM) aims to increase the knowledge and awareness of the Penembangan Village community, Cilongok District, Banyumas Regency regarding the importance of controlling hypertension through a healthy lifestyle. Hypertension is a non-communicable disease that is often ignored but has a serious impact on health. Through structured counseling and education, this activity provides information on risk factors, impacts, and strategies for preventing and managing hypertension. The methods used include lectures, interactive discussions, and direct practice related to the implementation of a healthy lifestyle such as a balanced diet, physical activity, and stress management. The results of this activity showed a significant increase in participants' knowledge and awareness of the importance of a healthy lifestyle in controlling hypertension. In addition, participants also showed a higher commitment to implementing a healthy lifestyle in their daily lives. It is hoped that this activity can be sustainable and become a model for similar programs in other areas, so that it can contribute to reducing the prevalence of hypertension and improving the quality of life of the community.
Pelatihan Pemanfaatan Limbah Minyak Jelantah Menjadi Lilin Aromaterapi Di Desa Windujaya Kurniasih, Khamdiyah Indah; Samodra, Galih; Setianingsih, Siti; Nurkholis, Fiqih; Hakim, Lukman
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 4, No 1 (2025)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v4i1.31247

Abstract

Minyak jelantah adalah minyak yang telah digunakan secara berulang-ulang hingga 3-4 kali penggorengan. Dampak negative dari minyak goreng bekas jika dibuang begitu sajatanpapengolahanakanmenjadilimbahdanakanmerusaklingkungansekitar.Salahsatubentuk  produk hasil pengolahan minyak goreng bekas adalah lilin aromaterapi. Sasaranmitra  pengabdian ini adalah masyarakat ekonomi non produktif di desaWindujaya yang bekerja bekerja sebagai Ibu Rumah Tangga dan tidak memiliki penghasilan. UrgensiPemberdayaan Masyarakat Pemula ini meningkatkan keterampilan Kelompok Kader DesaWindujaya dalam Pelatihan Pembuatan lilin aromaterapi yang berbahan dasar limbah minyak jelantah. Tujuan kegiatan ini yaitu, meminimalisasipembuangan minyak jelantah, berubahnya pola hidup masyarakat untuk mengolah limbahminyak jelantah berbasis zero waste industry, berkurangnya pembuangan minyak jelantahdisembarang tempat dapat mengurangi resiko pencemaran air tanah, dan erciptanya produklilinaromaterapidansabunbernilaiekonomis. Kegiatan ini telah terlaksana pada tanggal 18 agustus 2024 dengan peserta ibu rumah tangga yang ada di Desa Winduajaya, Banyumas. Metode Kegiatan ini menggunakan metode difusi ilmu pengetahuan dan teknologi (ipteks) dengan tahapan berupa tahapan persiapan dan koordinasi terkait dengan pengetahuan Masyarakat terhadap lombah minyak jelantah ,Pemberdayaan Masyarakat, monitoring dan evaluasi serta sasaran pelatihan.  Hasil pengabdian didapat bahwa terdapat peningkatan pengetahuan terkait pemanfaatan limbah minyak jelantah dalam bentuk lilin aromaterapi.
Co-Authors Adita Adita Silvia Fitriana Agung Pangestu Al-Hakim, Rosyid Aminurita, Agus Ardianto, Rian Artika Wina Fitriani Bambang Sumantri, R Bagus Cahyani, Intan Nur Cahyo Budi Santoso Dzakiyyatunnisa, Hanifah Fauziah , Fani Nur Fauziah Fauziah Hamidah, Ai' Wikri Hidayah, Ainayatul Ikhwan Yuda Kusuma Jayusman, Hadi Kaaffah , Silma Khoirun Nisa Kurniasih, Khamdiyah Indah Kusuma, Ikhwan Yudha Kusuma, Khamdiah Indah Lukman Hakim Melani, Reina Mika Tri Kumala Swandari, Mika Tri Kumala Muttaqin, Cecep Darwis Nawangsari, Desy Nofiyanti, Laela Suci Nur Rahmawati Nurkholis, Fiqih Pamungkas, Ajeng Sukma Pardigantara, Awang Prabandari, Rani Pratama, Anugrah Gusti Rachmawati, Ira Sari, Destika Ambar Sebayang, Septian Setiawan, Retno Agus Setiyoputro, Aji Setyaji, Andy Anggoro Siti Setianingsih Sunarti Suryani, Riska Syahputra, Dhika Adhil Wahyuningrum, Aldina Yuliani, Anis Fitria