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All Journal HAYATI Journal of Biosciences INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Teknologi dan Manajemen
sholeh, moch
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Engineering Health Professions Social Sciences

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Increased Anti-Proliferation Performance of NanoChitosan-Moringa Seeds Extract and Co-Treatment with Doxorubicin in Liver Cancer Cells Susanto, Hendra; Sholeh, Moch; Tri Endharti, Agustina; Nik Malek, Nik Ahmad Nizam; Amaliyah Firdaus, Sa’diyatul Rizqie; Yuda Handaya, Adeodatus; Taufiq, Ahmad
HAYATI Journal of Biosciences Vol. 32 No. 2 (2025): March 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.2.414-425

Abstract

Hepatocellular carcinoma (HCC) with high epidemiological report data. Pathogenesis in HCC also involves several signaling pathways. This study aims to evaluate the in vitro activity of Moringa seed NanoChitosan against Hep G2 liver cancer cells and Co-Treatment with Doxorubicin. Initially, nanoparticles were prepared by extracting Moringa seeds, formulating them into nano chitosan, and then characterizing the compounds and particle sizes. The IC50 dose was investigated using the MTT assay. Then, the IC50 dose was confirmed in more detail through immunofluorescence, betatrophin gene, several genes in the Wnt-βcatenin-CyclinD1 proliferation pathway, and the addition of the apoptotic effector Caspase-3 using RT-qPCR analysis. Each treatment used a single dose of NCH-Mosee and co-treatment or combination with 4 μg/ml doxorubicin. The IC50 dose was 994 μg/ml in single treatment and 649 μg/ml in combined treatment with Dox. Hep G2 showed a decrease in the expression level of each parameter measured with increasing single dose and combination treatment (p < 0.050). Histologically, cells shrank, betatrophin expression was inhibited, and luminescence was seen, which decreased with increasing dose. In conclusion, NCH-Mosee with dose-tracking toxicity combined with Dox can suppress the viability of Hep G2 cells.
Betatrophin: A promising biomarker for metabolic syndrome and diabetes mellitus risk screening in teenagers Susanto, Hendra; Aulanni’am, Aulanni’am; Wuragil, Dyah Kinasih; Taufiq, Ahmad; Sunaryono, Sunaryono; Trijoyo Purnomo, Jerry Dwi; Krisnawati, Dyah Ika; Sholeh, Moch
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 1 (2025): Advances in biomarkers, therapeutics, and probiotics: Recent updates in medical l
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i1.6028

Abstract

Metabolic syndrome (MetS) and diabetes mellitus (DM) have become primary concerns worldwide, especially among the younger population. The Indonesian Boarding School model (IBS/Boarding School) is a large education system with a significant number of pupils (teenagers) and has the potential to become a center for metabolic disease, particularly among teenagers, due to their daily intake. This study aimed to provide a baseline screening for MetS and the risk of DM development in Boarding School teenagers. During this observational study, 90 healthy serological samples were obtained from senior and junior high school students. The circulating level of betatrophin was measured using a human betatrophin ELISA kit. Additionally, metabolic syndrome and DM screening data were analyzed using a rapid reverse-flow immunochromatography kit for 65 kDa glutamic acid decarboxylase (GAD65). Among the 90 healthy students, a high prevalence of GAD65 was observed, indicating a potential risk factor for metabolic diseases. Furthermore, higher serum betatrophin levels were observed in the samples. The circulating level of betatrophin was found to have a significant correlation with age, gender, body mass index (BMI), systolic blood pressure (SBP), fasting blood glucose (FBG), sleeping duration, and duration of stay at Boarding School (p < 0.05). Betatrophin emerged as a potential predictor of BMI, SBP, and FBG in students (p < 0.05). Both betatrophin and GAD65 have shown promise as future biomarkers, opening up a new avenue for assessing metabolic syndrome and the risk of DM. This underscores the importance of future programs in Boarding Schools focusing on MetS and DM prevention management, making the audience feel the significance of their work in addressing these pressing health issues.
Pushover Analysis of Harvard Dormitory Thursina International Islamic Boarding School Building with Inter Story Isolated System Modification Rahman, Aulia; Fajarwati, Anisah Nur; Sholeh, Moch; Sugiarto, Agus
Jurnal Teknologi dan Manajemen Vol 6, No 1 (2025): January
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat ITATS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31284/j.jtm.2025.v6i1.6283

Abstract

Recently the demands of additional building functions have varied. These demands tend to affect structure stability because of the effects of additional mass. For example, Harvard Dormitory Thursina International Islamic Boarding School, located in Dau region, Malang city, East Java, Indonesia, a 11 x 8 m2 swimming pool is relocated on 4th floor. A big mass of pool certainly performs bigger lateral force due to seismic behaviour of structure itself. To reduce that, the IIS method is installed on the 3rd floor as it has damper effect along X and Y axis that is provided by LRB spring systems. IIS is widely used mainly in Japanese high-rise structures such as Shiodome Sumitomo building and Umeda Tower. To analyse the IIS modified structure, it is performed pushover analysis as controlled deformation is stated 18 in at rooftop. The results showed that 465 kN shear force and 160 mm story drift occurred on the 3rd floor which is the largest value compared to other stories. It is also obtained 230 mm lateral deflection of rooftop as the first plastic hinges are formed.
Co-Authors Agus Sugiarto Ahmad Taufiq Amaliyah Firdaus, Sa’diyatul Rizqie Anisah Nur Fajarwati Aulanni’am, Aulanni’am Aulia Rahman Hendra Susanto Krisnawati, Dyah Ika Nik Malek, Nik Ahmad Nizam Sunaryono Sunaryono, Sunaryono Tri Endharti, Agustina Trijoyo Purnomo, Jerry Dwi Wuragil, Dyah Kinasih Yuda Handaya, Adeodatus