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All Journal Journal of Indonesian Tourism and Development Studies Veterinary Biomedical and Clinical Journal Jurnal Pengabdian, Pendidikan dan Teknologi Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Wuragil, Dyah Kinasih
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Social Sciences Veterinary Other

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The Potency of Pluchea indica Less as Preventive Effort to Lead (Pb) Pertubation on Rats (Rattus norvegicus) Organs Aulanni'am, Aulanni'am; Julianto, Andri; Dewi, Made Artari; Dirgahariyawan, Tri Cahyo; Mahdi, Chanif; Wuragil, Dyah Kinasih; Herawati, Herawati
Veterinary Biomedical and Clinical Journal Vol. 1 No. 1 (2019): Vol. 1 No. 1 2019
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (450.161 KB) | DOI: 10.21776/ub.VetBioClinJ.2021.001.01.1

Abstract

Lead (Pb) is one of the heavy m metals polluting the environment which is harmful to t the organism. Pb accumulation triggers free radic cals and disrupts the body's metabolism. Pluche indic ca leaf extract is reported contain flavonoids whiich act as antioxidants and can counteract free radiccal attacks. The purpose of this study was to de etermine the role of Pluchea indica leaf extract preve entive therapy in counteracting free radicals due too exposure to Pb in rats (Rattus norvegicus). Wistar mmale rats aged of 8-10 weeks with a body weight of about 200-250 grams. Rats were divided into 5 tr reatment groups, were group A as negative contr rol, group B as positive control induced by lead (Pb)) 10 mg/rat/day, groups C,D,E given with ethano olic extract of Pluche indica leavesof 200 mg/kgBW, , 400 mg/kgBW, and 600 mg/kgBW and lead (Pb b) exposure of 10mg/ rat/day. Kidney, liver and jejunaal histopathology using HE staining was observed microscopically. The results showed that the administtration of Pluche indica leaves extract could preve ent tissue damage to the kidney, liver and jejunum in rats exposured to Pb. Dose of 600 mg/kgBW show wed histopathological improvement in kidney, liver annd jejunum. The greater the dose, the better prev ention of tissue damage as indicated by tissue condition resembling those of control rats. The conclusion of this study, the Pluchea indica leaf extract has the potential to prevent organ damaged exposed to lead.
Management of Avian Influenza H9N2 Vaccination in Broiler Chickens at JAPFA COMFEED Myanmar Pte Ltd. Verian, Bagas Ridjalu; Prasetyo, Dodik; Adrenalin, Sruti Listra; Wuragil, Dyah Kinasih; Cahyo, Budi Nur
Veterinary Biomedical and Clinical Journal Vol. 6 No. 1 (2024): Vol. 6 No. 1 2024
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.VetBioClinJ.2024.006.01.3

Abstract

Avian influenza virus subtype H9N2 (AIV-H9N2) has been a concern for poultry health in the last 20 years. The virus emerged in domestic poultry in the mid-1990s and has been reported in several Asian countries, including Myanmar. AI subtype H9N2 caused huge economic losses to the poultry industry in the form of respiratory distress and 25% weight loss in broiler chickens. This study discusses the administration of Avian Influenza (AI) H9N2 strain inactivated vaccine to commercial broiler chickens at JAPFA COMFEED Myanmar Pte Ltd. The vaccination process was carried out through subcutaneous injection in the neck and intramuscular injection in the pectoralis musculus in the chest area of chickens at 11 days of age, with a dose of 0.5 ml per chicken. The vaccine used was VAKSIMUNE® AI H9 which uses oil as the emulsion material. Results from the HI serology test showed that 6 cages from Myothar and Wah Net Chaung farms showed protective antibody titers against Avian Influenza H9N2 virus at 30-40 days of age, with normal titer values or ≥24. This indicates that the AI subtype H9N2vaccine used is an effective antigen, capable of stimulating the broiler immune system, and has implications for increasing antibodies every week. This study contributes to the understanding of AI H9N2 vaccination management in commercial broilers at JAPFA COMFEED Myanmar Pte Ltd. With positive results in the serology test, it can be concluded that vaccination using VAKSIMUNE® AI H9 is effective in protecting broilers from Avian Influenza H9N2 infection, providing strong support to the sustainability of production and animal health in a commercial farm environment.
PKM PENERAPAN RECIRCULATING AQUACULTURE SYSTEM UNTUK PENGELOLAAN AIR DAN KESEHATAN IKAN BERKELANJUTAN DI POKDAKAN ROI LELE KABUPATEN MALANG Yanuhar, Uun; Wuragil, Dyah Kinasih; Suryanto, Heru; Mufidah, Rhobithotus; Fauliza, Tifa; Wardani, Nezya Pramudya; Pahlefi, Reval; Adhitya, Dewa Sukma Trinanda; Caesar, Nico Rahman
Jurnal Pengabdian Pendidikan dan Teknologi (JP2T) Vol 3, No 2 (2022)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um080v3i22022p159-165

Abstract

Pemeliharaan ikan lele yang dilakukan pembudidaya di Pokdakan ROI Lele sebagian besar tidak melakukan upaya pengelolaan kualitas air seperti, filtrasi, sirkulasi maupun penggantian air (water exchange). Hal ini menyebabkan penurunan mutu air sebagai akibat dari penumpukan sisa pakan maupun feses ikan serta sisa hasil metabolisme lainnya. Lingkungan perairan merupakan suatu hal yang sangat berperan penting dalam pertumbuhan ikan lele (Clarias sp.). Oleh karena itu, perlu adanya manajemen lingkungan dan kesehatan pada pemeliharaan ikan lele (Clarias sp.). Keberhasilan suatu usaha budidaya sangat erat kaitannya dengan kondisi lingkungan yang optimum untuk kelangsungan hidup dan pertumbuhan ikan yang dipelihara. Setelah Tim PKM Mengidentifikasi pemecahan masalah yang ada, maka kegiatan pemecahan atau pengembangan yang dilakukan harus sesuai dengan kebutuhan yakni dengan menerapkan teknologi Recirculating Aquaculture System (RAS) pada kolam budidaya ikan di Pokdakan ROI Lele.  Dalam penerapan sistem RAS, penggunaan filtrasi air sangat menentukan keberhasilan sirkulasi air. Pada progam PKM ini akan menggunakan Filtrasi air terdiri dari filter mekanis, filter biologi dan filter kimia. Hasil dari kegiatan pengabdian masyarakat PKM terhadap mitra adalah Pengetahuannya meningkat, keterampilannya meningkat, kapasitas produksi meningkat dan keuntungannya meningkat.
Principles of Rural Tourism Development in Krisik Village, East Java: The Perspectives of Local Community Aulanni'am, Aulanni'am; Hariati, Anik Martinah; Sawitri, Manik Eirry; Padaga, Masdiana Chendrakasih; Wuragil, Dyah Kinasih; Hakim, Luchman
Journal of Indonesian Tourism and Development Studies Vol. 9 No. 2 (2021)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitode.2021.009.02.05

Abstract

The research aimed to identify the local community perception in Krisik Village in Blitar Regency as a fundamental aspect of rural tourism planning and development. Three points were accepted as basic principles in rural tourism development, namely acceptance of rural tourism as an alternative to rural economic machine growth, promoting indigenous knowledge as a philosophy and value of rural tourism program implementation, and strengthening community-based tourism implementation in rural tourism programs Krisik Villages. Community involvement was a crucial issue in rural tourism planning and development.  In the limitation of human resources, the assistance of the university to support and increase human resources capacity in rural tourism development was important.Keywords: Ecotourism, community perception, tourism planning, tourism development
Oxyhydrogen nanobubbles modulate β-catenin and CD8⁺ in a rat model of hepatocarcinoma Zahrah, Natasya Adiba; Agustin, Netti Astriana; Satyawati, Rendhita Ardilla Putri; Wuragil, Dyah Kinasih; Riawan, Wibi; Indrajani, Olly; Lubab, Ahmad; Hernowo, Aditya Tri; Sumitro, Sutiman Bambang; Widyarti, Sri; Aulanni'am, Aulanni'am
Edubiotik : Jurnal Pendidikan, Biologi dan Terapan Vol. 11 No. 02 (2026): November
Publisher : Biology Education Department, Universitas Insan Budi Utomo, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33503/ebio.v11i02.3439

Abstract

Hepatocellular carcinoma (HCC) continues to be a significant contributor to cancer-associated fatalities, highlighting the worldwide necessity for efficacious treatment approaches. This research assessed the impact of oxyhydrogen nanobubbles (HHOnbs) on β-catenin expression and CD8⁺ T-cell infiltration in a rat model of HCC caused by diethylnitrosamine (DEN) and carbon tetrachloride (CCl₄), while also contrasting their dose-dependent effects with Lenvatinib. Male Wistar rats were divided into six categories: negative control, positive control, HHOnbs given 12 or 24 times, and Lenvatinib provided 3 or 5 times. We evaluated β-catenin expression and the infiltration of CD8⁺ T-cells by immunohistochemical methods. HCC induction elevated β-catenin expression and augmented CD8⁺ T-cell infiltration. HHOnb treatment dose-dependently reduced β-catenin expression by 59.98% and 89.87% and increased CD8⁺ T-cell infiltration by 49.23% and 129.23% following 12 and 24 administrations, respectively. HHOnbs showed stronger β-catenin suppression, whereas Lenvatinib elicited greater CD8⁺ T-cell infiltration. These findings indicate that HHOnbs can suppress oncogenic signaling and enhance antitumor immune responses in experimental HCC. Future studies should assess their long-term efficacy and safety profiles and investigate combination therapies, as the present study did not evaluate these parameters.
Co-Authors Adhitya, Dewa Sukma Trinanda Adrenalin, Sruti Listra Agustin, Netti Astriana Ahmad Lubab, Ahmad Aulanni'am, Aulanni'am Cahyo, Budi Nur Chanif Mahdi Dewi, Made Artari Dirgahariyawan, Tri Cahyo Dodik Prasetyo Fauliza, Tifa Hariati, Anik Martinah Herawati Herawati Hernowo, Aditya Tri Heru Suryanto Indrajani, Olly Julianto, Andri Luchman Hakim Manik Eirry Sawitri Mufidah, Rhobithotus Nico Rahman Caesar Padaga, Masdiana Chendrakasih Pahlefi, Reval Satyawati, Rendhita Ardilla Putri Sri Widyarti Sutiman B. Sumitro Verian, Bagas Ridjalu Wardani, Nezya Pramudya Wibi Riawan Yanuhar, Uun Zahrah, Natasya Adiba