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All Journal Majalah Obat Tradisional Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) MITRA: Jurnal Pemberdayaan Masyarakat Jurnal Farmasi Indonesia

Sagala, Reynelda Juliani

Prodi Farmasi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Katolik Atma Jaya, Jakarta 14440, Indonesia

Author-ID : 1260423

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Articles

The Combination of Ethanol Extracts of Phyllanthus niruri Linn, Typhonium flagelliforme and Piper crocatum increase the Macrophage Phagocytosis In Vitro Reynelda Juliani Sagala; Retno Murwanti
Majalah Obat Tradisional Vol 25, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.46705

Research on the activity of Phyllanthus niruri Linn, Typhonium flagelliforme (Lodd.) Blume and Piper crocatum have been conducted and showed various immunomodulatory activity. This study aims to investigate the immunomodulatory activity of the combination of the ethanolic extracts of Phyllanthus niruri Linn, Typhonium flagelliforme (Lodd.) Blume, and Piper crocatum by determining its macrophages phagocytic index and macrophages phagocytic capacity. Therefore, such a combination could be an alternative drug to increase immune response. In this study, the extraction procedure was carried out through maceration by using an ethanolic solvent. Combinations of herbs ethanol extract were varied in four groups of combination, at three different concentrations of 1 μg/ml, 10 μg/ml, and 100 μg/ml for each group. Macrophages were isolated from the peritoneum cavity of male mice (Mus musculus), and its phagocytic activity was quantified through the Leijh method (1986). The phagocytic index and phagocytic capacity of macrophages were determined by using latex beads as a trigger of phagocytosis and compared with negative controls of media, DMSO, and four groups of ethanolic extract combinations in different concentrations. The results indicate that all of combination group ethanol extract with a concentration of 10 μg/ml was significantly (p<0.05) optimum activated phagocytic index. Therefore the combination of Phyllanthus niruri Linn, Piper crocatum, and Thyphonium flagelliforme (Lodd.) Blume ethanolic extract might be prospective to increase nonspecific immune response.

Drug Information Service during Covid-19 Pandemic Sherly Tandi Arrang; Reynelda Juliani Sagala; Dion Notario; Erlia Anggrainy Sianipar; Fonny Cokro
MITRA: Jurnal Pemberdayaan Masyarakat Vol 5 No 1 (2021): MITRA: Jurnal Pemberdayaan Masyarakat
Publisher : Institute for Research and Community Services

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitra.v5i1.1467

Pharmacists and pharmaceutical personnel need to support improving the people’s quality of life during the covid-19 outbreak by providing pharmaceutical services, one of which is the Drug Information Service (PIO). Many regions in Indonesia, including DKI Jakarta, have placed large-scale social restrictions since March 2020. In connection with that, the Department of Pharmacy of Atma Jaya Catholic University of Indonesia (PSFUAJ) organized an online PIO program. This program aimed to provide the service of Covid-19 drug-related information and education to the community. The PIO was carried out from April to July 2020 via whatsapp, email, and telephone. In addition, health education was provided through e-flyers, published on Instagram @pio_farmasi_uaj. Eighty percent of the questions were submitted via whatsapp, while the rest was sent via email. Most of the questions submitted (80%) were categorized into self-edication. Further examination shows that the common questions were related to drug choice (27.78%). These data indicate that most questioners tend to provide self-medication first and that they will only see a doctor if they have not recovered or experienced any improvement. PSFUAJ will continue running this program and disseminating this program to a broader audience.

Review Waktu Larut Mempengaruhi Kualitas Tablet Effervescent Sediaan Herbal Sagala, Reynelda Juliani; Rachmawati, Putriana; Kambira, Pretty F.A
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Sediaan tablet effervescent menjadi alternatif pilihan untuk menghantarkan bahan aktif obat baik sintesis maupun yang berasal dari bahan alam agar memberikan efek terapi farmasetika maupun minuman bernutrisi di bidang pangan. Bentuk sediaan ini lebih disukai karena praktis, cepat larut dalam air dan rasa menyegarkan sehingga lebih mudah diabsorbsi dibandingkan dengan bentuk sediaan tablet konvensional. Kecepatan dan jumlah bahan aktif yang dapat diabsorbsi dipengaruhi oleh waktu larut tablet dalam medianya. Waktu larut tablet effervescent dipengaruhi oleh konsentrasi keseimbangan sumber basa dan asam, konsentrasi bahan pengikat (PVP), interaksi antara asam sitrat dan asam tartrat, konsentrasi sumber basa, kondisi kadar air di sekitar tablet, variasi bahan pelicin. Konsentrasi sumber asam mempengaruhi waktu larut tetapi ketidakseimbangan konsentrasi sumber asam dapat mengurangi efek kesegaran. Sehingga perlu optimalisasi sumber asam dan basa agar menghasilkan sediaan tablet effervescent dengan waktu larut yang baik dan memberikan rasa menyegarkan yang sesuai. Kata kunci: Tablet effervescent; waktu larut; rasa menyegarkan

A A LITERATURE REVIEW OF HERBAL SUNSCREEN’S DOSAGE FORM AND SPF VALUE CLAIM Rachmawati, Putriana; Sagala, Reynelda Juliani; Kambira, Pretty Falena Atmanda
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The Indonesian government recommended sunbathing for 15 to 30 minutes in the morning to deal with the Covid-19 pandemic. Exposure to sunlight will activate the formation of vitamin D, which the body needs for defense against Covid-19 infection. However, excessive sun exposure will cause skin problems, including psoriasis, sarcoidosis, sunburn to skin cancer. One of the protections against sun exposure is the use of sunscreen. Sunscreen protects the skin from UV exposure by two mechanisms, namely, absorbing UV rays or reflecting UV rays. Sunscreen has various dosage forms that are tailored to the needs of consumers. Several dosage forms are preferred because they are easy to use and can be used in groups of children. Sunscreen protection is stated using a photoprotector claim in the form of an SPF value or other claims that support the function of sunscreen. Although SPF has been used worldwide, there are several standard claims for the effectiveness of sunscreens in several countries, such as the broad spectrum and UVA-PA (PA+ to PA++++) claims.

Review: Metode Peningkatan Kecepatan Disolusi Dikombinasi Dengan Penambahan Surfaktan: Review: The Different Methods of Enhancing Dissolution Rate by the Present of Surfactant Sagala, Reynelda Juliani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Dissolution and solubility rates are very important parameters in designing a pharmaceutical dosage form, especially for oral drug administration. Oral drugs that have low dissolution rates often require high doses loading to improve the absorption and effectiveness in order to achieve therapeutic concentration. The increasing of drug dose is a less safe alternative solution, therefore researchers have developed physics, chemistry, and other modification in order to increase dissolution rate. These methods such as salt formation, prodrug formation, particle size reduction (micro-crystallization), co-grinding, crystal modification, micellar solubilization and complex formation, solid dispersion and self emulsifying. This review paper will focus on different methods that will be compared with the present of surfactant in these methods. The present of surfactants was able to overcome the limitation of each methods with a mechanism for reducing surface tension, micellar formation, reducing contact angle and increasing of wetting behaviour. Therefore, the present of surfactant in modification of drug dosage form could be considered to increase dissolution rate in order to achieve therapeutic effect.

Co-Authors Arrang, Sherly Tandi Cokro, Fonny Dion Notario Erlia Anggrainy Sianipar Kambira, Pretty F.A Kambira, Pretty Falena Atmanda rachmawati, Putriana Retno Murwanti

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