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All Journal Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) MITRA: Jurnal Pemberdayaan Masyarakat Jurnal Farmasi Indonesia

Sagala, Reynelda Juliani

Prodi Farmasi, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Katolik Atma Jaya, Jakarta 14440, Indonesia

Author-ID : 1260423

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

Published : 6 Documents Claim Missing Document

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Articles

The Combination of Ethanol Extracts of Phyllanthus niruri Linn, Typhonium flagelliforme and Piper crocatum increase the Macrophage Phagocytosis In Vitro Reynelda Juliani Sagala; Retno Murwanti
Majalah Obat Tradisional Vol 25, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.46705

Research on the activity of Phyllanthus niruri Linn, Typhonium flagelliforme (Lodd.) Blume and Piper crocatum have been conducted and showed various immunomodulatory activity. This study aims to investigate the immunomodulatory activity of the combination of the ethanolic extracts of Phyllanthus niruri Linn, Typhonium flagelliforme (Lodd.) Blume, and Piper crocatum by determining its macrophages phagocytic index and macrophages phagocytic capacity. Therefore, such a combination could be an alternative drug to increase immune response. In this study, the extraction procedure was carried out through maceration by using an ethanolic solvent. Combinations of herbs ethanol extract were varied in four groups of combination, at three different concentrations of 1 μg/ml, 10 μg/ml, and 100 μg/ml for each group. Macrophages were isolated from the peritoneum cavity of male mice (Mus musculus), and its phagocytic activity was quantified through the Leijh method (1986). The phagocytic index and phagocytic capacity of macrophages were determined by using latex beads as a trigger of phagocytosis and compared with negative controls of media, DMSO, and four groups of ethanolic extract combinations in different concentrations. The results indicate that all of combination group ethanol extract with a concentration of 10 μg/ml was significantly (p<0.05) optimum activated phagocytic index. Therefore the combination of Phyllanthus niruri Linn, Piper crocatum, and Thyphonium flagelliforme (Lodd.) Blume ethanolic extract might be prospective to increase nonspecific immune response.

Drug Information Service during Covid-19 Pandemic Sherly Tandi Arrang; Reynelda Juliani Sagala; Dion Notario; Erlia Anggrainy Sianipar; Fonny Cokro
MITRA: Jurnal Pemberdayaan Masyarakat Vol 5 No 1 (2021): MITRA: Jurnal Pemberdayaan Masyarakat
Publisher : Institute for Research and Community Services

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitra.v5i1.1467

Pharmacists and pharmaceutical personnel need to support improving the people’s quality of life during the covid-19 outbreak by providing pharmaceutical services, one of which is the Drug Information Service (PIO). Many regions in Indonesia, including DKI Jakarta, have placed large-scale social restrictions since March 2020. In connection with that, the Department of Pharmacy of Atma Jaya Catholic University of Indonesia (PSFUAJ) organized an online PIO program. This program aimed to provide the service of Covid-19 drug-related information and education to the community. The PIO was carried out from April to July 2020 via whatsapp, email, and telephone. In addition, health education was provided through e-flyers, published on Instagram @pio_farmasi_uaj. Eighty percent of the questions were submitted via whatsapp, while the rest was sent via email. Most of the questions submitted (80%) were categorized into self-edication. Further examination shows that the common questions were related to drug choice (27.78%). These data indicate that most questioners tend to provide self-medication first and that they will only see a doctor if they have not recovered or experienced any improvement. PSFUAJ will continue running this program and disseminating this program to a broader audience.

Review Waktu Larut Mempengaruhi Kualitas Tablet Effervescent Sediaan Herbal Sagala, Reynelda Juliani; Rachmawati, Putriana; Kambira, Pretty F.A
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 13 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The effervescent tablet is an alternative dosage form to deliver the active pharmaceutical ingredients or natural products for therapeutic effects. Moreover, this dosage form is also used in the food industry for nutritional drinks. The tablet is preferred because of its practicality, improve water solubility, refreshing taste, and more easily absorbed than the conventional tablet. Tablet’s water dissolving time in the medium will affect the rate and amount of active ingredients. The disintegrating time of effervescent tablets is affected by the concentration of both acid and base elements, the tablet binder’s concentration (PVP), the interaction between citric acid and tartaric acid, and the concentration of the base element, the water content over the tablet, and the lubricant’s variation. The acid will affect the disintegration time however its imbalance will decrease the freshness. Therefore, an optimal balance of the base and acid element is required to make an effervescent tablet with a good disintegration time and an appropriate refreshing taste.

A A LITERATURE REVIEW OF HERBAL SUNSCREEN’S DOSAGE FORM AND SPF VALUE CLAIM Rachmawati, Putriana; Sagala, Reynelda Juliani; Kambira, Pretty Falena Atmanda
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 13 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

The Indonesian government recommended sunbathing for 15 to 30 minutes in the morning to deal with the Covid-19 pandemic. Exposure to sunlight will activate the formation of vitamin D, which the body needs for defense against Covid-19 infection. However, excessive sun exposure will cause skin problems, including psoriasis, sarcoidosis, sunburn to skin cancer. One of the protections against sun exposure is the use of sunscreen. Sunscreen protects the skin from UV exposure by two mechanisms, namely, absorbing UV rays or reflecting UV rays. Currently, many sunscreens are developed with active substances derived from nature in various dosage forms. Sunscreen protection is stated using a photoprotector claim in the form of an SPF value or other supporting claims. This SPF value can be claimed using in vivo test, which previously could be predicted by on paper and in vitro approaches. Sunscreen safety is carried out by ensuring that the raw materials used comply with the requirements and penetration tests.

Review: Metode Peningkatan Kecepatan Disolusi Dikombinasi Dengan Penambahan Surfaktan: Review: The Different Methods of Enhancing Dissolution Rate by the Present of Surfactant Sagala, Reynelda Juliani
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 5 No. 1 (2019): (March 2019)
Publisher : Universitas Tadulako

Dissolution and solubility rates are very important parameters in designing a pharmaceutical dosage form, especially for oral drug administration. Oral drugs that have low dissolution rates often require high doses loading to improve the absorption and effectiveness in order to achieve therapeutic concentration. The increasing of drug dose is a less safe alternative solution, therefore researchers have developed physics, chemistry, and other modification in order to increase dissolution rate. These methods such as salt formation, prodrug formation, particle size reduction (micro-crystallization), co-grinding, crystal modification, micellar solubilization and complex formation, solid dispersion and self emulsifying. This review paper will focus on different methods that will be compared with the present of surfactant in these methods. The present of surfactants was able to overcome the limitation of each methods with a mechanism for reducing surface tension, micellar formation, reducing contact angle and increasing of wetting behaviour. Therefore, the present of surfactant in modification of drug dosage form could be considered to increase dissolution rate in order to achieve therapeutic effect.

Development of Gingerol-Loaded Nanostructured Lipid Carriers Using a Two-Step Method Sagala, Reynelda Juliani; Iswandana, Raditya; Louisa, Melva; Surini, Silvia
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 2026: IN PRESS ISSUE (JUST ACCEPTED MANUSCRIPT)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar

Ginger (Zingiber officinale) is well known for its beneficial effects on health, and it use as a culinary spice, mainly due to the presence of bioactive compounds such as 6-,8-, and 10-gingerol. Although 6-gingerol exhibits remarkable therapeutic potential, its clinical application is constrained by poor bioavailability and rapid metabolic degradation. Nanotechnology-based drug delivery systems have been widely explored to overcome these limitations by improving the stability, solubility, and bioavailability of bioactive compounds. Among these systems, nanostructured lipid carriers (NLCs) have attracted considerable to facilitate high drug-loading, enhanced stability, and controlled drug release. To address these issues, this study focused on formulating and characterizing gingerol using nanostructured lipid carriers. Gingerol-loaded NLCs were produced using a two-step process of high-shear homogenization followed by ultrasonication. Different total lipid contents were tested, specifically 5%, 8%, 10%, and 15%. Characterization of the resulting NLCs included particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, in vitro release of gingerol, and stability over 30 days. The findings revealed that the NLC formulation with a total lipid content of 5% yielded the smallest average particle size of 208.32 ± 3.20 nm, alongside the lowest PDI of 0.231 ± 0.014, and the zeta potential measured at -25.90 ± 1.38 mV. The entrapment efficiency for this optimal total lipid was noted to be 70.65 ± 0.75%. Furthermore, stability testing conducted over a designated period demonstrated that the gingerol-loaded NLC formulation with a 5% lipid content maintained its integrity, exhibiting no significant degradation or alteration in properties. The results of this study highlight the critical role of the total lipid content in influencing the characteristics of NLC formulations achieved at 5% total lipid content, which not only improved the properties of gingerol delivery but also presented a potential approach for improving the delivery of compounds with low water solubility such as gingerol.

Co-Authors Arrang, Sherly Tandi Cokro, Fonny Dion Notario Erlia Anggrainy Sianipar Kambira, Pretty F.A Kambira, Pretty Falena Atmanda Melva Louisa rachmawati, Putriana Raditya Iswandana Retno Murwanti Silvia Surini

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