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All Journal CHEMISTRY PROGRESS Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal BIO-EDU: Jurnal Pendidikan Biologi Jurnal Pengabdian Ibnu Sina
Rostina Melpin
Universitas Prisma
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Social Sciences

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PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT BATANG PAKOBA (Syzygium sp.) TERHADAP GAMBARAN HISTOPALOGI GINJAL TIKUS PUTIH YANG DIINDUKSI ETILEN GLIKOL Walean, Mario; Rumondor, Rolef; Mailangkay, Hendra; Melpin, Rostina
CHEMISTRY PROGRESS Vol 11, No 1 (2018)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.11.1.2018.27911

Abstract

ABSTRAK Pakoba sebagai tanaman endemik Sulawesi Utara yang mempunyai manfaat secara etnomedikal dalam mengobati batu ginjal. Tujuan dari penelitian ini untuk mengetahui gambaran histopatologi ginjal yang diiduksi etilen glikol dengan pemberian ekstrak etanol kulit batang pakoba. Tikus putih jantan dewasa (n= 20) dengan berat rata-rata 150-200 gram dibagi menjadi 4 kelompok perlakuan. Kelompok pertama sebagai kontrol normal dengan pemberian aquadest, kelompok kedua diberikan etilen glikol 0,75%, kelompok ketiga dan keempat diberi etilen glikol 0,75 % dan ekstrak etanol kulit batang pakoba 150 mg/kg BB dan 300mg/kg BB. Hasil penelitian menunjukkan gambaran histopalogi ginjal dengan pemberian ekstrak etanol kulit batang pakoba 150 mg/kg BB dan 300 mg/kg BB dapat memperbaiki ginjal tikus yang mengalami kerusakan akibat pemberian etilen glikol. Dosis 300 mg/kg BB lebih baik dalam memperbaiki ginjal dibandingkan dengan dosis 150 mg/kg BB.  ABSTRACT Pakoba as a North Sulawesi endemic plant that has ethnomedical benefits in treating kidney stones. The purpose of this research was to investigate the histopathology of  kidney rats induced ethylene glycol by administration of bark ethanol extract of pakoba. Adult male rats (n = 20) with an average weight of 150-200 grams divided into 4 treatment groups. The first group as normal control with aqueous, the second group was given 0.75% ethylene glycol, the third and fourth groups were given 0,75% ethylene glycol and 150 mg/kg BW and 300 mg/kg BW bark ethanol extract of bark. The results showed renal histopatogy  with the ethanol extract of pakoba steam bark 150 mg/kg BW and 300 mg/kg BW can repair the renal kidney damaged due to ethylene glycol induced. Dose 300 mg/kg BW better in repairing kidney compared with dose 150 mg/kg BB. 
UJI TOKSISITAS IN VITRO METODE BSLT DAN TOKSISITAS AKUT ORAL EKSTRAK ETANOL KULIT BATANG PAKOBA (Syzygium luzonense (Merr.) Merr.) Walean, Mario; Melpin, Rostina; Rondonuwu, Mervina; Pinontoan, Kinzie Feliciano
BIO-EDU: Jurnal Pendidikan Biologi Vol 6 No 3 (2021): Jurnal BIO-EDU Volume 6 Nomor 3 Tahun 2021
Publisher : Jurusan Pendidikan Biologi, Fakultas Ilmu Pendidikan, Universitas Timor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32938/jbe.v6i3.1249

Abstract

Pakoba merupakan tanaman endemik Sulawesi Utara yang dimanfaat secara etnomedikal untuk mengobati pengobatan diabetes, ramuan obat setelah melahirkan, obat sakit ginjal dan sakit perut. Tujuan dari penelitian ini untuk mengetahui tingkat toksisitas akut oral menggunakan tikus putih dan toksisitas secara in vitro metode Brine Shrimp Lethality Test (BSLT) ekstrak etanol kulit batang pakoba (EEKBP). Hasil dari pengujian toksisitas metode BLST, EEKBP memiliki nilai LC50 = 380.19 ppm dan hasil uji toksisitas akut EEKBP dengan dosis 1.000, 5.000, 10.000, dan 15.000 ppm tidak menimbulkan gejala toksik dan kematian pada hewan uji. Perlu ada penelitian lanjut mengenai Fraksinasi EEKBP dilanjutkan dengan pengujian toksisitas metode BSLT dan aktivitas biologis dari masing-masing hasil fraksinasi.
Perbaikan Histopatologi Pankreas Tikus Hiperglikemia setelah Pemberian Ekstrak Etanol Kulit Batang Pakoba (Syzygium luzonense (Merr.) Merr.) Mario Walean; Rostina Melpin; Mervina Rondonuwu; Kinzie Feliciano Pinontoan
Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 37, No 1 (2020)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mib.2020.37.1.1210

Abstract

Pakoba as an endemic plant in North Sulawesi has ethnomedical benefits in treating diabetes. The purpose of this study was to determine the histopathological of pancreatic hyperglycemic rats induced by alloxan by the administration of pakoba stem bark ethanol extract (PSBEE). Rats with an average weight of 150-200 gr were divided into 5 treatment groups. Group I as a normal control without alloxan administration then group II alloxan control, group III were treated with glibenclamide 5 mg/kgbw, groups IV and V were treated with PSBEE 150 and 300 mg/kgbw oral gavage. Phytochemical screening results of PSBEE contain a lot of alkaloids, flavonoids, and tannins. A dose of 300 mg/kgbw PSBEE is better in repair pancreatic cells in hyperglycemia rats compared with a dose of 150 mg/kgbw. There needs further research to know the antioxidant activity, the mechanism of the active compound content of the pakoba stem bark as an antihyperglycemic.
TEKNIK PENGOLAHAN SELAI TOMAT SEBAGAI MEDIA BELAJAR DAN DUKUNGAN BAGI UMKM PANGAN LOKAL DI SMA KRISTEN PONTAK, MINAHASA SELATAN Melpin, Rostina; Dusun, Citra; Mandang, Filan O; Lomo, Christine P; Aida, Yuannita
Jurnal Pengabdian Ibnu Sina Vol. 5 No. 1 (2026): Januari 2026
Publisher : LPPM Universitas Ibnu Sina

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36352/j-pis.v5i1.1310

Abstract

The Community Service Program (CSP) on tomato jam processing techniques at SMA Kristen Pontak, South Minahasa, was implemented as a solution to the abundant tomato harvests that are often not absorbed by the market, reducing farmers’ economic value. The main problems faced by partners include limited knowledge of product diversification, food hygiene standards, and basic marketing strategies. The objective of this program is to improve the skills of students, teachers, and local MSMEs in processing tomatoes into hygienic, durable, and marketable jam products, while strengthening collaboration between schools and communities in local economic empowerment. The method applied was a participatory approach through five stages: preparation, socialization, training and demonstration, mentoring implementation, and evaluation and dissemination. Evaluation was conducted using pre-test and post-test to measure improvements in participants’ knowledge and skills. Results showed significant progress, with the average pre-test score of 57 increasing to 82 in the post-test, reflecting a 44% improvement. The highest increase was observed in simple marketing strategies, rising from 50 to 78 (a 56% gain), followed by food hygiene from 55 to 80, and processing techniques from 58 to 83. The program successfully produced trial tomato jam products with simple yet marketable packaging and established collaborative networks between schools and MSMEs. Overall, this initiative provided positive impacts in education through practice-based learning and strengthened the capacity of local food MSMEs, serving as a replicable model for entrepreneurship development based on local resources.
Co-Authors Dusun, Citra Kinzie Feliciano Pinontoan Lomo, Christine P Mailangkay, Hendra Mandang, Filan O Mario Walean Mervina Rondonuwu Rolef Rumondor Yuannita Aida