Article Per Year (5 Year)
p-Index From 2021 - 2026
0.659
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Indian Journal of Forensic Medicine & Toxicology
Sulistyo Mulyo Agustini
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Evaluation of the 90-Day Administration of Cyperus rotundus Tubers on Nrf2, SOD, and MDA Profiles by Flow Cytometry Setiawan, Meddy; Lestari, Noviana Dwi; Agustini, Sulistyo Mulyo
HAYATI Journal of Biosciences Vol. 32 No. 4 (2025): July 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.4.1025-1032

Abstract

Nuclear factor erythroid 2-related factor 2 (Nrf2), superoxide dismutase (SOD), and malondialdehyde (MDA) are components involved in the antioxidant system and the body's response to oxidative stress. The bioactive compounds of Cyperus rotundus tuber (CRT) have pharmacological effects as antioxidants and anti-inflammatory. This study aimed to evaluate the impact of CRT administration for 90 days on the profiles of Nrf2, SOD, and MDA. 24 male Wistar rats were used in this study and divided into 4 treatment groups: Control, dose 1 (300 mg/kg BW), dose 2 (600 mg/kg BW), and dose 3 (900 mg/kg BW). Oral administration of CRT was carried out for 90 days. On day 91, liver isolation was performed to determine the profiles of Nrf2, SOD, and MDA using Flow Cytometry. Statistical analysis using One-Way ANOVA with P<0.05 was conducted using SPSS. The administration of CRT to Wistar rats for 90 days did not induce toxic or harmful effects. The Nrf2 and MDA profiles did not show excessive activation with CRT administration. The SOD profile increased with D1 administration compared to the control and other doses. The administration of CRT for 90 days has the potential to be used as a natural alternative to address diseases related to oxidative stress.
Co-Authors Aji Masbintoro Anita Fitri Puspasari Annisa’ Hasanah Anung Putri Illahika Asih, Sekar Bragastio Sidharta David S. Perdanakusuma Fadil, Muchamad Faiz Zulkifli Hani, Handini Risma Hasanah, Annisa’ Henydhar Bramastivira Mahdani Lestari, Noviana Dwi Masbintoro, Aji Meddy Setiawan Muchamad Fadil Puspasari, Anita Fitri Retno Handajani Ruby Riana Asparini Susanto, Nadila Apriola Sutrisno, AL-Bidarri Tsamira Annafila Thontowi Djauhari Uswatun Hasanah Zulkifli, Faiz