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All Journal Biology, Medicine, & Natural Product Chemistry RADIAL: JuRnal PerADaban SaIns RekAyasan dan TeknoLogi RADIAL: Jurnal Peradaban Sains, Rekayasa dan Teknologi
Wiranatha, I Gede
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Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Electrical & Electronics Engineering Engineering Environmental Science Mechanical Engineering Medicine & Pharmacology Public Health

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The Effect of Pilocarpine Hydrochloride on The Occurrence of Temporal Lobe Epileptic Seizures in White Mice (Mus musculus L.) BALB/C Strain Audria, Intan Safira; Harkitasari, Saktivi; Diah Witari, Ni Putu; Ningrum, Rima Kusuma; Putra Parwati, Tjok Istri; Sumadewi, Komang Trisna; Wiranatha, I Gede; Pratiwi, Cokorda Agung
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.67-72

Abstract

The objective of this research was to determine the effective dosage of pilocarpine hydrochloride to provoke epileptic seizures in animal models. In this study, a true-experimental method was utilized, employing a post-test only control group design. A total of 32 white mice (Mus musculus Linnaeus UICC 524) BALB/c strains were divided into four different groups for this study. The experimental groups were subjected to varying dosages of pilocarpine hydrochloride: 220 mg/kgBW as group I, 320 mg/kgBW as group II, and 350 mg/kgBW as group III. On the other hand, the control group was administered a saline solution (NaCl 0.9%) at a dosage of 0.16% ml/kgBW. Both pilocarpine hydrochloride and saline solution (NaCl 0.9%) were injected intraperitoneally (i.p) into mice. In group I, none of the mice experienced epileptic seizures, and they all survived. In contrast, in group III, all the mice experienced epileptic seizures, but none of them survived. The Man-Whitney Test showed significant differences in seizure occurrence across doses (p<0.01). The effective dose of pilocarpine hydrochloride for inducing epileptic seizures associated with temporal lobe epilepsy (TLE) in this study appears to be in the range of 320 mg/kgBW to 350 mg/kgBW.
PENATAAN KAWASAN WISATA BENDUNGAN PAGUYAMAN DI KECAMATAN WONOSARI DENGAN PENDEKATAN ARSITEKTUR EKOLOGI Djailani, Zuhriati A.; Wiranatha, I Gede
RADIAL : Jurnal Peradaban Sains, Rekayasa dan Teknologi Vol. 12 No. 2 (2024): RADIAL: JuRnal PerADaban SaIns RekAyasan dan TeknoLogi
Publisher : Universitas Bina Taruna Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37971/radial.v12i2.459

Abstract

Tourism is a development sector that has become the focus of the Indonesian government because it plays a crucial role in the country’s progress, especially as a foreign exchange contributor. As one of the important economic sectors, tourism not only drives the economy but also serves as an effective means to reduce unemployment rates. One of the potential tourist attractions in Gorontalo is the Paguyaman Dam. This dam offers beautiful natural scenery, often utilized by the community for recreation and tourism. However, using the Paguyaman Dam as a tourist attraction has not gotten serious attention from the local government,necessitating improvements in various aspects such as area development, facility provision, and enhancement of supporting infrastructure. Applying the ecological architecture approach, the design concept adapts to the climate and surrounding environment, optimizes low energy use,and utilizes existing resources. The focus of developing the Paguyaman Dam tourism area aims to provide facilities that support tourism and recreational activities there. This research employs a descriptive qualitative method, with primary and secondary data, involving direct observation,interviews, literature studies, book references, journals, and online sources. The collected data are analyzed to produce a design concept that adheres to applicable regulations. The results of this report are a design concept that can serve as a guide for continuing the development of the Paguyaman Dam tourism area.
PENATAAN KAWASAN WISATA BENDUNGAN PAGUYAMAN DI KECAMATAN WONOSARI DENGAN PENDEKATAN ARSITEKTUR EKOLOGI Djailani, Zuhriati A.; Wiranatha, I Gede
RADIAL : Jurnal Peradaban Sains, Rekayasa dan Teknologi Vol. 12 No. 2 (2024): RADIAL: JuRnal PerADaban SaIns RekAyasan dan TeknoLogi
Publisher : Universitas Bina Taruna Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37971/radial.v12i2.459

Abstract

Tourism is a development sector that has become the focus of the Indonesian government because it plays a crucial role in the country’s progress, especially as a foreign exchange contributor. As one of the important economic sectors, tourism not only drives the economy but also serves as an effective means to reduce unemployment rates. One of the potential tourist attractions in Gorontalo is the Paguyaman Dam. This dam offers beautiful natural scenery, often utilized by the community for recreation and tourism. However, using the Paguyaman Dam as a tourist attraction has not gotten serious attention from the local government,necessitating improvements in various aspects such as area development, facility provision, and enhancement of supporting infrastructure. Applying the ecological architecture approach, the design concept adapts to the climate and surrounding environment, optimizes low energy use,and utilizes existing resources. The focus of developing the Paguyaman Dam tourism area aims to provide facilities that support tourism and recreational activities there. This research employs a descriptive qualitative method, with primary and secondary data, involving direct observation,interviews, literature studies, book references, journals, and online sources. The collected data are analyzed to produce a design concept that adheres to applicable regulations. The results of this report are a design concept that can serve as a guide for continuing the development of the Paguyaman Dam tourism area.
Co-Authors Audria, Intan Safira Djailani, Zuhriati A. Ni Putu Diah Witari, Ni Putu Pratiwi, Cokorda Agung Putra Parwati, Tjok Istri Rima Kusuma Ningrum Saktivi Harkitasari, Saktivi Sumadewi, Komang Trisna