Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Biology, Medicine, & Natural Product Chemistry
Pratiwi, Cokorda Agung
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
The Effect of Pilocarpine Hydrochloride on The Occurrence of Temporal Lobe Epileptic Seizures in White Mice (Mus musculus L.) BALB/C Strain Audria, Intan Safira; Harkitasari, Saktivi; Diah Witari, Ni Putu; Ningrum, Rima Kusuma; Putra Parwati, Tjok Istri; Sumadewi, Komang Trisna; Wiranatha, I Gede; Pratiwi, Cokorda Agung
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.67-72

Abstract

The objective of this research was to determine the effective dosage of pilocarpine hydrochloride to provoke epileptic seizures in animal models. In this study, a true-experimental method was utilized, employing a post-test only control group design. A total of 32 white mice (Mus musculus Linnaeus UICC 524) BALB/c strains were divided into four different groups for this study. The experimental groups were subjected to varying dosages of pilocarpine hydrochloride: 220 mg/kgBW as group I, 320 mg/kgBW as group II, and 350 mg/kgBW as group III. On the other hand, the control group was administered a saline solution (NaCl 0.9%) at a dosage of 0.16% ml/kgBW. Both pilocarpine hydrochloride and saline solution (NaCl 0.9%) were injected intraperitoneally (i.p) into mice. In group I, none of the mice experienced epileptic seizures, and they all survived. In contrast, in group III, all the mice experienced epileptic seizures, but none of them survived. The Man-Whitney Test showed significant differences in seizure occurrence across doses (p<0.01). The effective dose of pilocarpine hydrochloride for inducing epileptic seizures associated with temporal lobe epilepsy (TLE) in this study appears to be in the range of 320 mg/kgBW to 350 mg/kgBW.
Co-Authors Anom Suardika Arabani, Jessica Jevera Audria, Intan Safira Cokorda Agung Wahyu Purnamasidhi Divasta, I G Mahapraja Dwi Atmaja, Bima Kumara I Made Jawi I Wayan Putu Sutirta Yasa Krisnadewi Rahadi, Putu Nindya Ni Putu Diah Witari, Ni Putu Pradnyani, Ayu Mas Eka Pujawan, I Made Naris Putra Parwati, Tjok Istri Rima Kusuma Ningrum Saktivi Harkitasari, Saktivi Sumadewi, Komang Trisna Suwarya, Dwi Nurcahya Ananda Tirtha Yasa, I Nyoman Wawan Tjandra, David Christopher Wiranatha, I Gede