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All Journal Microbiology Indonesia Sari Pediatri The Indonesian Journal of Infectious Diseases AL-HAYAT: Journal of Biology and Applied Biology Jurnal Respirologi Indonesia Journal of Clinical Microbiology and Infectious Diseases Neurona Jurnal Kefarmasian Indonesia JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Dimas Seto Prasetyo
Departemen Mikrobiologi Fakultas Kedokteran Universitas Indonesia/KSM Mikrobiologi Klinik RSUPN Dr Cipto Mangunkusumo, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Galactomannan Test in Suspected Invasive Pulmonary Aspergillosis Patients: An Evidence-Based Case Report Rahmiati, Lina; Mubarokah , Mubarokah; Prasetyo, Dimas Seto
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.954

Abstract

Background: Invasive pulmonary aspergillosis is a severe fungal infection with a high mortality rate. However, because the clinical and radiological images are non-specific, and culture results take a long time and yield unsatisfactory results, rapid, high-accuracy tests are needed. Consequently, the diagnosis of invasive pulmonary aspergillosis remains difficult. The objective of this study was to assess the galactomannan (GM) test as a diagnostic tool for patients with suspected invasive pulmonary aspergillosis. Methods: Articles were searched through three databases (PubMed, Embase, and Cochrane) using keywords based on PICO components related to suspected invasive pulmonary aspergillosis and the GM test. Titles and abstracts were screened, duplicates were removed, and articles were filtered according to inclusion and exclusion criteria. The critical appraisal was performed using methods recommended by the Center for Evidence-Based Medicine at the University of Oxford. Results: Three studies reported serum GM test sensitivities ranging from 71% to 88%, suggesting that this assay may be suitable as a screening tool due to its adequate true positive detection rate. The specificity values in these studies ranged from 89% to 98%, indicating good accuracy in correctly identifying true negative cases. However, considerable heterogeneity was observed across the studies. Conclusion: The GM test is a promising rapid diagnostic tool for suspected invasive pulmonary aspergillosis, enabling earlier and more accurate antifungal treatment. However, further studies are needed to standardize its cut-off values and interpretation to ensure consistent clinical application.
Co-Authors Abdelrazig, Omnia Amir Osman Angky Budianti Anis Karuniawati Ardiana Kusumaningrum Badriul Hegar Budiman Bela Cliff Clarence Haliman Conny R Tjampakasari Fadilah Fadilah, Fadilah Febi Arfini Fera Ibrahim Gortap Sihotang Hana Paraswati Putri Herna Herna Herna, Herna Hindra Irawan Satari Iin Maemunah Janice Tandraeline Lestari, Resti Hardianti Margono, Djiwa Maria Astika Dewi Martin Hartiningsih Mubarokah , Mubarokah Mursinah Mursinah Mursinah Mursinah Nadia Maretti Nathan, Johan Rahmiati, Lina Riamin Sitorus Rika Febriana Pinem Santya Fatma Dewi Sari Wiraswasty T Mirawati Sudiro Wibawa, Bagus Wira Yulia Rosa Saharman Yulianti Ningtias, Pranudiah Zaenab Azzahra