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All Journal Journal of Biomedicine and Translational Research Jurnal SOLMA Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Narra J Sanus Medical Journal
Ujianti, Irena
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Journal : Sanus Medical Journal

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Pengaruh Pemberian Diet Restriksi Vitamin B12 Pada Tikus: Kajian Insulin dan Glukosa Plasma Imelda Rosalyn; Dewi Irawati SS; Ujianti, Irena; Patwa Amani
Sanus Medical Journal Vol. 2 No. 1 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5431

Abstract

Background: Deficiency of vitamin B12 remains a health problem in both developed and developing countries. Many journal studies showed an association between deficiency of vitamin B12 and metabolic disorder, one of which is insulin resistance, one of the most significant metabolic diseases. Resistance to insulin may be assessed by changes in plasma glucose and insulin levels. This study explored a possible relationship between vitamin B12 restriction and glucose metabolism. Materials and Methods: This study used an experimental method of 18 male Sprague Dawley rats (Rattus norvegicus, 300-400 gram, age 7-8 months), divided into three groups: control (G1), four weeks treatment group (G2 ) and 12-week treatment group (G3). In the control group, regular feed, the standard diet was given, while the treatment group was assigned vitamin B12, AIN-93M deficiency feed according to the treatment age. Results: Plasma glucose increased in treatment group after 4 weeks (control vs P1= 104.7 ± 5.04 vs 206.8 ± 4.5 p = 0.000) and 12 weeks (control vs P3 = 99.9±6.3 vs 144.7±6.8 p<0.01). Plasma insulin decreased in treatment group after 4 weeks (control vs P1=63.8 ± 1.5 vs 59.9 ± 0.7 p > 0.05) and 12 weeks (control vs P3 = 61.5±0.64 vs 57.4±1 p>0.05). Conclusion: Increased homocysteine deficiency due to dietary vitamin B12 can cause insulin resistance syndrome. As a result, glucose and plasma insulin levels are disrupted Keywords: Homocysteine, vitamin B12 Deficiency, Glucose, Insulin, Insulin Resistance
Analisis Kadar Nrf2 plasma Pada Tikus dengan Defisisensi Vitamin B12 Stujanna, Endin Nokik; Ujianti, Irena; Mustifah, Etty Farida
Sanus Medical Journal Vol. 2 No. 1 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6545

Abstract

Background. Vitamin B12 deficiency is a significant problem, particularly in developing countries. The increasing complexity of the Vitamin B12 molecule, the deficiency condition, causes a complex cell level disorder. The clinical manifestation of vitamin B12 deficiency is anemia, but it is believed that due to the complexity of vitamin B12, there are still other molecular disorders. This study aims to establish the pathway of damage caused by vitamin B12 deficiency in the Nrf2 molecule. Methods. An animal experiment involving 12 male Sprague Dawley rats were randomly divided into control and 16-week treatment. There are two research groups, namely the control group and the treatment group. The control group was given a standard diet, while the treatment group was assigned a vitamin B12 deficiency diet. At the end of treatment, The levels of vitamin B12 in the liver tissue and plasma NRF2 were measured. Statistical Analysis. Nrf2 and vitamin B12 levels were statistically analyzed using the Student's T-test, and the correlation between vitamin B12 and Hb was analyzed using the Spearmen test. Data that cannot use by Independent T-test were tested using the Mann Whitney test. Results/Conclusion. There was no significant difference between the control and treatment groups on plasma Nrf2 levels (4.02 ± 0.59 pg/ml vs 3.34 ± 0.55 pg/ml; p = 0.07) and tissue vitamin B12 (0.0035 ± 0.0016 µg/ml vs 0.0030 ± 0.0006 µg/ml ; p = 0.8). Keywords: Nrf2 Plasma, Defisiensi, Vitamin B12
Gambaran Hematologi pada Defisiensi Vitamin B12 Ujianti, Irena
Sanus Medical Journal Vol. 2 No. 2 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v2i2.7327

Abstract

Background and Aims. Anemia is a condition when the number of red blood cells or hemoglobin is lower than the normal number. The main cause of anemia is a lack of factors for the formation and maturation of red blood cells. Vitamin B12 plays a role in the synthesis and maturation of red blood cells, a lack of this vitamin will cause the formation and maturation of red blood cells to be disrupted. Method. This was an experimental animal study with twelve rats with frederer's family. The rat was fed a Vitamin B12 Deficient Diet for 16 weeks as the treatment group and standard diet as the control group. Vitamin B12 in the liver was analyzed in rats for 16 weeks. Hemoglobin and MCV were analyzed in plasma for 16 weeks. Results are expressed as means of control, and test animals were established by ANOVA using SPSS 20.0 software Results. In the present study, we found that liver vitamin B12 level was decreased in treatments groups compares to the positive control group at sixteen weeks (p<0.01). Hemoglobin was decreased in the treatment group compare positive control group at sixteen weeks (p<0.001). Mean Corpuscular Volume (MCV) was increased in the treatment group's compare positive control group at sixteen weeks (p<0.01) Conclusions. Our findings demonstrate that vitamin B12 deficiency decreased hemoglobin and increased MCV.
The Effect Of Virtual Physical Exercise On Body Mass Index And Waist Circumstances Of Students Faculty Of Medicine Budisusilo, Wawan; Ujianti, Irena; Pangestu , Mulyoto
Sanus Medical Journal Vol. 6 No. 1 (2024)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v6i1.16003

Abstract

One of the most often utilized measures in calculating body proportion criterion is the BMI. The goal of this study is to see if there is a link between BMI and glucose levels in students who are given virtual physical activity. A high sedentary lifestyle is thought to be linked to the high prevalence of metabolic disorders among students. A rise in BMI or waist circumference levels indicates that a person may be at risk for a variety of metabolic disorders as a result of body mass index. An experimental study was utilized to investigate if there was a difference in the respondents' body mass index and waist circumference before and after the intervention. Before and after the treatment, there were significant variations in waist circumference (76.921.51 vs 74.651.47 cm, p0.001) and BMI (23.540.76 vs 23.050.77 cm, p0.001). Furthermore, with a value of r=0.895 and p0.001, there is a high link between BMI and waist circumference.
Enhancing Reproductive Health and Sexually Transmitted Infection Prevention Awareness through Community Engagement Mustifah, Etty Farida; Ujianti, Irena; Sukarya, Wawang Setiawan; Pangestu, Mulyoto
Sanus Medical Journal Vol. 6 No. 2 (2024)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v6i2.18202

Abstract

ntroduction The Thousand Islands, a popular tourist destination in DKI Jakarta Province, is facing a new challenge, namely the increasing concern about the transmission of Sexually Transmitted Infections (STIs) triggered by the increase in tourism visits. In response to this issue, a community service activity was carried out by the Faculty of Medicine at UHAMKA. Objective The aim of this activity is to raise awareness and knowledge in the community, particularly among educators in the Thousand Islands, about the dangers of and prevention against STIs and the importance of Reproductive Health Education. Method The partners in this community service activity are teachers in the Thousand Islands. A total of 30 teachers were involved in this training. The methods used involve training and counseling that incorporate direct training and open discussions. Data were collected through observations and field notes. Results The results of this activity include an increase in understanding and skills of teachers concerning Reproductive Health Education and STI prevention, which they can apply in educating students. Additionally, it was found that community awareness about the dangers of STIs also increased as a direct result of this activity. Conclusion The conclusion that can be derived from this activity is that appropriate education and training on reproductive health and the prevention of STIs for the community, specifically educators, can be an effective strategy in controlling STI transmission in tourist areas like the Thousand Islands. This activity also helps to strengthen the local health system in dealing with the challenge of STI transmission.
The Relationship Between Iron Deficiency Anemia and Stunting in Children: A Review Ujianti, Irena; Mustifah, Etty F; Indriyati, Leli Hesti
Sanus Medical Journal Vol. 7 No. 2 (2025)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v7i2.15115

Abstract

Background: Iron deficiency anemia and stunting are two serious public health issues affecting millions of children worldwide, especially in developing countries. Both conditions impact the health and development aspects of children, but recent studies indicate a link between the two conditions. Objective: This article aims to study and investigate the relationship between iron deficiency anemia and the occurrence of stunting in children. Moreover, it will identify the main causative factors and propose intervention strategies to address and reduce the prevalence of these two nutritional problems. Methods: This summary is based on a literature review regarding the impact of iron deficiency anemia and stunting in children, as well as the relationship between them. Results: Iron deficiency anemia is associated with a reduced oxygen transport capacity in the blood, affecting the cognitive and physical development of children. Conclusion: The impact of stunting results from chronic undernutrition manifested in disproportionate physical growth, especially shorter stature compared to age standards. Studies show a correlation between iron deficiency and a higher chance of experiencing stunting.
Co-Authors Afifah, Devana A. Al’asyi, Assyu’ara Ardiansah, Fery Arkananta, Kiflan Budisusilo, Wawan Dewi Irawati SS ERLIN LISTIYANINGSIH Faizin, Bimo J. Farhan, Randhiva Ghaisani, Sakinah Imelda Rosalyn Indriyati, Leli Hesti Lakhsmi, Betty Semara Lakshmi, Bety S. Lestari, Dwi Retna Lubis, Raisya ZN. MULYOTO PANGESTU Mustifah, Etty F Mustifah, Etty Farida Nadika, Rara Pangestu , Mulyoto Patwa Amani Rahayu, Leni Sri Rahmadina, Salsabila P. Sanjaya, Arief Indra Sri Suciati Ningsih Stujanna, Endin Nokik Sukarya, Wawang Setiawan Sumardi . Zahirah, Zahirah