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All Journal The Journal of Experimental Life Sciences (JELS) Pendas : Jurnah Ilmiah Pendidikan Dasar JPBIO (Jurnal Pendidikan Biologi) Journal Of Human And Education (JAHE) Electronic Journal of Education, Social Economics and Technology LoroNG Alamtana Bioconsortium : Biological Research and Education
Mutiati, Enni
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The effects of combined black pepper extract and yogurt on histology of mice digestive organs Mutiati, Enni; Inayah, Nurul; Putri, Kanza Nabila
JPBIO (Jurnal Pendidikan Biologi) Vol 11, No 1 (2026): April 2026
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v11i1.5881

Abstract

Black pepper contains piperine, which can irritate the digestive organs. Therefore, this study combined black pepper with yogurt containing probiotic bacteria, which are known to play a role in maintaining the balance of microbiota and digestive tract health. The objective of this study was to analyze the histopathology and histomorphometry of the digestive organs, particularly the stomach and small intestine, of mice (Mus musculus) after administration of a combination of black pepper extract and yogurt. The present study was conceptualized as an experimental study, employing a completely randomized design (CRD), encompassing five distinct treatments (distilled water, yogurt, a black pepper extract at a dose of 25, 50, 75 mg/kg BB, and yogurt. The results demonstrated that the thickness of the stomach wall in all treatment groups remained within the normal range. Treatment P2 demonstrated optimal outcomes, exhibiting a thickness of each layer of the stomach wall that ranged between the minimum and maximum values. In the small intestine, all histomorphometric parameters exhibited values that remained within the normal range. The conclusion of this research is combination did not result in an increase in gastric acid secretion and did not induce irritation to the gastric and small intestinal mucosa of mice.
Co-Authors Akhmad Ferdiansyah, Akhmad Al-Farisi, Bayuda Luqman Artatik Gatot Ciptadi Hidayatullah, Mohammad Nurul Nasich, Moch. Nurul Inayah Putri, Kanza Nabila Rukmana, Siti Sa'diyah, Halimatus Sa’diyah, Halimatus Siti Rukmana SRI RAHAYU