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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication The Indonesian Biomedical Journal Universa Medicina Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation eProceedings of Engineering Jurnal Material dan Energi Indonesia
Irma Ruslina Defi
Departemen Ilmu Kedokteran Fisik Dan Rehabilitasi Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung
Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : The Indonesian Biomedical Journal

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Irisin, A Fascinating and Multifunctional Protein: Implication for Health Defi, Irma Ruslina; Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2996

Abstract

BACKGROUND: Fibronectin type III domain-containing protein 5 (FNDC5), or also known as irisin, has been identified for two decades but almost completely disregarded for 10 years. It is present in skeletal muscle, heart, and brain, and in reaction to exercise can transform white adipose tissue into brown. Since then, irisin has gained a lot of attention for its potencies in treating metabolic disorders. In this review article, the potential future of irisin especially on metabolism and aging process will be discussed.CONTENT: Sedentary lifestyle is acknowledged as risk factor for type 2 diabetes mellitus, obesity, immune system issues, asthma, and neurological or heart illness. Irisin is secreted by muscle cells when exercising, produced after the proteolytic cleavage of FNDC5 protein. Irisin has positive impacts on maintaining physiological balance including reducing inflammation, keeping the bone homeostasis, as well as influencing metabolic processes and the neurological system function. Due to these many and advantageous characteristics, irisin could be a possible choice for preventing and managing disorders associated with modern society, and finding the agents to increase irisin can be beneficial.SUMMARY: Irisin offers a fresh potential basis for kinesitherapy and shows promise as a therapeutic target due to its various biological activities. Irisin pathway can be activated through dietary changes, the use of natural substances and drugs and can interact with this signalling pathway which involved peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and uncoupling protein mRNA 1 (UCP1) to resolve obesity and its metabolic comorbidities.KEYWORDS: irisin, FNDC5, exercise, inflammation, obesity, nervous system
Sarcopenic Obesity: The Underlying Molecular Pathophysiology and Prospect Therapies Meiliana, Anna; Dewi, Nurrani Mustika; Defi, Irma Ruslina; Rosdianto, Aziiz Mardanarian; Qiantori, Adziqa Ammara; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3176

Abstract

BACKGROUND: Age contributes to body composition alteration, rises a common disorder in elderly known as sarcopenic obesity (SO), which is characterized by the combination of obesity (excess fat mass) and sarcopenia (reduced skeletal muscle mass) clinical form and function.CONTENT: The primary cause of SO is insulin resistance. Glucose transporter 4 (GLUT4) dysfunction results in impaired fatty acids oxidation. Decreased muscle mass results in lower mitochondria number and volume. Both will increase oxidative stress. Together with altered myokines in SO, oxidative stress was promoted and lead to higher M1 macrophages and failure in autophagy. The pro-inflammatory condition and dysbiosis links SO to a variety of cardiometabolic conditions, including non-alcoholic fatty liver disease, type 2 diabetes, and cardiovascular disease. The mortality, comorbidities, cardiometabolic diseases, and disability or impairment of SO is higher compare to obesity or sarcopenia alone. Some treatments have been developed for SO including adequate dietary intake, vitamin D and antioxidant supplementation, and exercises.SUMMARY: SO is more prevalent among the elderly and has a significant negative impact on their quality of life. Therefore, maintaining muscle mass and strength as well as preventing obesity should be the key goals of initiatives to support healthy aging.KEYWORDS: aging, body composition, obesity, sarcopenia, skeletal muscle, metabolic syndrome
Co-Authors ADIKUSUMA, FAJAR WIRA Al Barqi, Nuzula Chafidh Ambrosius Purba Andi Basuki ANDI WIJAYA Andika Nugroho Putra Anguda, Ricky Anna Meiliana Badai B Tiksnadi Budi Setiabudiawan Cahyandari Nurlaelatiningsih Chandrawati Gultom Christopher Rinaldi Damayanti, Yuke Derry Suselo Deta Tanuwidjadja Dian Marta Sari Dila Larasati Dini Fitriani Elizabeth Elizabeth Ellyana Sungkar Farida Arisanti Gaga Irawan Nugraha Hanna Goenawan Henny Anggraini Sadeli Irsan Agung Ramdhani Jennie Jennie Jennie Jennie Kastella, Faysal Ku Shi Yun Ku Shi Yun, Ku Shi Lazuardhi Dwipa Marina Annette Moeliono Mohamad, Intan Sabrina NATAZIA, AMARA DWI Novaria Puspita Novita, Dessy NURJANAH, FARIDA A Nurrani Mustika Dewi, Nurrani Mustika Panji Fortuna Hadisoemarto Puspita, Novaria Putri Dyah Utami Ryadi Qiantori, Adziqa Ammara Qiantori, Andri Rachmat Gunadi Wachjudi Rachmat Zulkarnain Goesasi Rahdiyanti, Putri Teesa Ricky Anguda Ronny Lesmana Rosdianto, Aziiz Mardanarian Rudolf Andean Sari Sekarsari Satria Mandala Setiawan Setiawan Setiawan Setiawan SETIAWAN, M. BAYU Sitti Nurun Nikmah Sunaryo B Sastradimaja Sunaryo Barki Sastradimaja Sunaryo Sastradimaja Barki Sastradimaja Tertianto Prabowo Tertianto Prabowo Tertianto Prabowo Theresia Chandra Tania Novy Tresnasari, Cice Vina Megitasari Vita Murniati Tarawan Vitriana Vitriana Vitriana Vitriana Widjaja Laksmi Kusumaningsih