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All Journal Jurnal Sain Veteriner Indonesia Medicus Veterinus Majalah Kedokteran Bandung Althea Medical Journal Media Kedokteran Hewan The Indonesian Biomedical Journal Jurnal Medik Veteriner JFIOnline The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Rosdianto, Aziiz Mardanarian
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Veterinary

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Profil Hematologis Tikus Putih (Rattus novergicus sp.) Betina Setelah Pemberian Jamu Kesuburan Rosdianto, Aziiz Mardanarian; Manalu, Wasmen; Maheshwari, Hera
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (413.351 KB) | DOI: 10.35617/jfi.v8i1.377

Abstract

ABSTRACT: The use of herbal preparations to improve fertility were empirically beneficial for reproductive health, however its use needs to be supported by scientific evidence. In this study we observed the effects of herbal preparations on haematological parameters, liver function and kidney function of female rats. The estrus cycle of the experimental female rats were previously synchronized by injection with prostaglandin twice in two days interval. The rats were randomly assigned into eight groups i.e., two negative control groups, two positive control groups (injected with pregnant mare serum gonadotropin with effective and double of effective doses), two groups were given herbal preparation A (with effective and double of effective doses), and two groups were given herbal preparation B (with effective and double of effective doses). The treatments were given for 3 consecutive estrous cycles. Parameters measured were hematological parameters (erythrocyte, leukocyte, and hemoglobin), liver functions (SGOT and SGPT concentrations), and renal function (serum ureum concentration). The results showed that the administration of herbal preparation for fertility improved erythrocyte, leukocyte, and hemoglobin parameters, improved liver functions, and optimized renal functions. It was concluded that the administration of herbal preparation for fertility for 3 consecutive estrous cycles did not disturb physiological functions, instead its improved hematological parameters as well as liver and renal functions.Keywords: hematological, herbal, liver function, renal function, female rats  ABSTRAK: Penggunaan jamu kesuburan secara empiris bermanfaat untuk kesehatan reproduksi, namun penggunaannya perlu didukung oleh data ilmiah. Dalam penelitian ini dilakukan pengamatan efek pemberian jamu kesuburan terhadap parameter hematologis, fungsi hati dan fungsi ginjal dari tikus betina. Penelitian ini diawali dengan sikronisasi siklus estrus tikus percobaan dengan penyuntikan prostaglandin dua kali dalam selang waktu dua hari. Tikus-tikus percobaan secara acak dibagi ke dalam delapan kelompok, yaitu dua kelompok kontrol negatif yang hanya diberi pelarut persiapan jamu kesuburan, dua kelompok kontrol positif yang disuntik pregnant mare serum gonadotropin untuk dosis efektif dan 2x dosis efektif, dua kelompok diberi jamu kesuburan A dengan dosis efektif dan 2x dosis efektif, dan dua kelompok yang diberi jamu kesuburan B untuk dosis efektif dan 2x dosis efektif. Perlakuan diberikan selama 3 siklus estrus berturut-turut. Parameter yang diukur adalah status hematologi (eritrosit, hemoglobin, dan leukosit), fungsi hati (kadar SGOT dan SGPT), dan fungsi ginjal (kadar ureum). Hasil penelitian menunjukkan bahwa pemberian jamu kesuburan memperbaiki parameter hematologis, memperbaiki fungsi hati, dan mengoptimalkan fungsi ginjal. Dari hasil penelitian disimpulkan bahwa pemberian jamu kesuburan selama tiga siklus estrus berturut-turut tidak mengganggu fungsi fisiologis tubuh bahkan terbukti memperbaiki parameter hematologis, fungsi hati, dan fungsi ginjal. Kata kunci: Jamu kesuburan, parameter hematologis, fungsi ginjal, fungsi hati, tikus betina 
Correlation Physical Activity, Energy Balance, and Metabolic Syndrome of Physical Fitness in Elderly Age Group Setiawan, Setiawan; Goenawan, Hanna; Lesmana, Ronny; Tarawan, Vita M.; Rosdianto, Aziiz Mardanarian; Purba, Ambrosius
Majalah Kedokteran Bandung Vol 50, No 1 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v50n1.1160

Abstract

Fitness becomes an important benchmark for public health in every age group. Activities with poor adverse fitness are at risk of injury. Good fitness is gained from a balance in everyday physical activity with conditions that are free of metabolic syndrome. This study investigated the relationship of physical activity, energy balance, and metabolic syndrome to the fitness of 166 professors of Universitas Padjadjaran who underwent a 1-month fitness checkup at BAPELKES Bandung in the period of 2017. Based on the regression analysis, the results showed a significant relationship between physical activity, energy balance, and metabolic syndrome on the physical fitness of the elderly group (F = 25.9290> F table = 2.427) with normal data distribution (Kolmogorov-Smirnov test). The results also showed a moderate relationship (R = 0.569 and R2 = 0.324). It also partially showed significant influence between physical activity and fitness (t = 8.541> t table = 1.975), significant influence between energy balance and physical fitness (t = 2.248> t table = 1.975), and no significant partial influence between metabolic syndrome and physical fitness of the elderly group (t = -0.029 <t table = 1.975). Hence, there is a relationship between physical activity, energy balance, metabolic syndrome and physical fitness  of Professors in Universitas Padjadjaran.Key words: Energy balance, metabolic syndrome, physical fitness  Hubungan Aktivitas Fisik, Keseimbangan Energi, dan Sindrom Metabolik terhadap Kebugaran Fisik pada Kelompok Usia LanjutKebugaran menjadi tolak ukur penting bagi kesehatan masyarakat pada setiap kelompok usia. Aktivitas dengan kebugaran usia lanjut yang kurang baik berisiko terjadi cedera. Kebugaran yang baik diperoleh dari keseimbangan dalam aktivitas fisik sehari-hari dengan kondisi bebas dari sindrom metabolik. Penelitian ini mempelajari hubungan aktivitas fisik, keseimbangan energi, dan sindrom metabolik dengan kebugaran 166 orang Guru Besar di Universitas Padjadjaran yang dilakukan pemeriksaan kebugaran selama 1 bulan di BAPELKES Bandung periode tahun 2017. Berdasar atas analisis regresi hasil penelitian menunjukkan hubungan yang signifikan antara aktivitas fisik, keseimbangan energi, dan sindrom metabolik dengan kebugaran fisik kelompok usia lanjut (F=25,9290 > Ftable=2,427) dengan distribusi data normal (tes Kolmogorov-Smirnov). Hasil juga menunjukkan hubungan yang moderat (R= 0,569 dan R2= 0,324). Secara parsial juga menunjukkan pengaruh yang signfikan aktivitas fisik dengan kebugaran (t= 8.541> t tabel= 1.975), pengaruh signifikan keseimbangan energi dengan kebugaran fisik (t= 2,248> t tabel= 1,975), dan tidak ada pengaruh signifikan secara parsial terhadap sindrom metabolik dengan kebugaran fisik kelompok usia lanjut (t= -0,029 < t tabel= 1,975). Berdasar atas hasil penelitian dapat disimpulkan hubungan = aktivitas fisik, keseimbangan energi, dan sindrom metabolik dengan kebugaran fisik guru besar Universitas Padjadjaran.Kata kunci: Kebugaran, keseimbangan energi, sindrom metabolik
Kajian Pustaka: Pemanfaatan Herbal Berkhasiat Sebagai Suplemen dalam Penanggulangan Penyakit pada Ikan Budidaya Ariefqi, Muhammad Naufal; Syamsunarno, Mas Rizky Angguna Adipurna; Rosdianto, Aziiz Mardanarian
Indonesia Medicus Veterinus Vol 9 (6) 2020
Publisher : Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/imv.2020.9.6.1000

Abstract

Indonesia sebagai negara maritim berperan penting dalam sektor akuakultur. Kelimpahan hasil sektor ini menjadi daya tarik dunia. Melihat potensinya agar stabil diperlukan pengelolaan protokol kesehatan produk yang terjaga termasuk perikanan air tawar. Ikan menjadi rentan saat hadirnya penyakit. Patogen penyakit seperti akibat kontak dengan parasit, bakteri, virus, dan jamur harus ditangani dengan tepat. Kita ketahui medikasi yang diberikan memanfaatkan bahan kimia sintetis sebagai pengobatan. Selain bahan sintesis, tanaman obat berkhasiat (herbal) Indonesia dapat menjadi alternatif untuk pengobatan. Secara empiris khasiat yang dihasilkan pun sangat kompetitif dan aman dibandingkan kimia sintesis. Seperti pencegah infeksi, penghilang stres, peningkat kekebalan tubuh spesifik maupun nonspesifik, bahkan mengoptimalkan pertumbuhan fisik. Khasiat ini sejalan/linear dengan kandungan fitokimia utama bahan alam ini bermanfaat sebagai penentu dalam mengatasi penyakit. Informasi pemanfaatan herbal-herbal untuk ikan masih sangat jarang dilaporkan. Berdasarkan hal tersebut,pemanfaatan herbal terkini dapat dikaji menuju percepatan suplementasi terstandar sebagai metode penanggulangan penyakit pada ikan.
Kajian Pustaka: Pemanfaatan Herbal Sebagai Alternatif dalam Peningkatan Fungsi Reproduksi Ikan Jatiswara, Ismaya; Rosdianto, Aziiz Mardanarian; Budinuryanto, Dwi Cipto
Indonesia Medicus Veterinus Vol 9 (5) 2020
Publisher : Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/imv.2020.9.5.821

Abstract

Reproduksi merupakan bagian dari sistem fisiologis tubuh yang sangat penting dalam siklus hidup mahluk hidup termasuk ikan. Tujuan utama reproduksi adalah mempertahankan keberadaan dan kelanjutan suatu spesies. Review literatur ini merupakan sebuah ulasan pemanfaatan herbal berkhasiat pada pakan untuk meningkatkan performa reproduksi ikan. Metode penelusuran literatur dilakukan secara elektronik melalui garba digital ilmiah. Jenis data yang digunakan adalah data sekunder. Data yang diperoleh kemudian dikumpulkan, dianalisis, dan disesuaikan berdasarkan kriteria dari manfaat ragam herbal yang memberikan pengaruh pada performa reproduksi ikan. Secara khusus, pada ulasan kali ini penulis mengulas mengenai temuan dari studi terdahulu terkait dengan pemafaatan herbal berkhasiat secara invitro dan invivo. Aspek reproduksi yang dibahas pada ulasan ini adalah peningkatan kualitas gonad, peningkatan kualitas telur, dan peningkatan perilaku reproduksi ikan.
Hematological Profile in Dairy Cattle with Foot and Mouth Diseases in Lembang, West Bandung Majid, Rully Abiyoga; Septiyani, Septiyani; Gradia, Resti; Rosdianto, Aziiz Mardanarian; Hidayatik, Nanik
Jurnal Medik Veteriner Vol. 6 No. 3 (2023): Special Issue: International Conference on Veterinary Medicine and Health Scien
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss3.2023.70-78

Abstract

Foot and mouth disease (FMD) is a widespread infectious disease that significantly affects the dairy farming sector in Indonesia. In reducing the impact caused by FMD, proper treatment performed by veterinarians is necessary. Hematological profile can be used as a data reference to prioritize dairy cattle infected with FMD. This study aimed to describe the hematological profile in dairy cattle with FMD infection. This study was collected data from 15 dairy cattle with FMD infection at Koperasi Peternak Sapi Bandung Utara (KPSBU), Lembang, West Bandung, West Java, Indonesia. Parameters observed in the hematology analyzer were the numbers of erythrocytes, leukocytes, lymphocytes, neutrophils, platelets, hemoglobin, hematocrit, MCV, MCH, MCHC, RDW, and MPV. The results of the examination of hematological profile showed various numbers. It found lymphopenia, neutrophilia, and high MPV values. It was suggested for veterinarians to refer to this study's results to determine an effective and efficient treatment.
Physalis angulata Linn. As a Potential Liver Antifibrotic Agent In Rats. Bestari, Muhammad Begawan; Rohmawaty, Enny; Rosdianto, Aziiz Mardanarian; Usman, Hermin A.; Saragih, Winda A. M.; Zuhrotun, Ade; Hendriani, Rini; Wardhana, Yoga Windhu; Ekawardhani, Savira; Wiraswati, Hesti Lina; Agustanti, Nenny; Dewi, Sumartini; Wijaya, Muhammad Palar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023206

Abstract

Background: No drug with a liver antifibrotic effect for treating non-alcoholic fatty liver disease (NAFLD) has been approved. Physalis angulata Linn., better known to Indonesian as ciplukan, has natural abilities in various metabolic and inflammatory diseases. This study aims to determine the effect of ethyl acetate fraction of P. angulata in the NAFLD rat model by examining alanine aminotransferase (ALT), cholesterol levels, and liver histopathological features, which are methods to evaluate the course of the disease and the potential antifibrotic effect.Method: This research is an in vivo study on male Wistar rats conducted at the Animal Laboratory, Faculty of Medicine, Universitas Padjadjaran, from September to November 2020. Rats were grouped randomly into seven groups of 5 each. The NAFLD models were created by giving a diet containing 20% margarine for four weeks. The intervention groups were given vitamin E, ethyl acetate fraction of P. angulata, and both combinations. The statistical analysis examined differences in each group based on their histopathological features, ALT, and cholesterol levels.Results: Histopathological results in the group given P. angulata at a dose of 0.32 mg resembled normal liver, and the ALT level was similar to vitamin E. The administration of P. angulata at 0.16 mg dose improved cholesterol levels.Conclusions: P. angulata ethyl acetate fraction at a dose of 0.32 mg improved the histopathological and serum ALT levels in the NAFLD rat model, which could be the basis for the mechanism of P. angulata's antifibrotic ability in NAFLD conditions.
Acute Anti-Inflammatory Study by Oral Administration of Cherry Leaf (Muntingia Calabura L.) Infusion in Inflammation-induced Wistar Strain White Rats (Rattus Norvegicus) Ramadhan, Putra; Rohmawaty, Enny; Rosdianto, Aziiz Mardanarian
Jurnal Sain Veteriner Vol 43, No 2 (2025): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.92910

Abstract

Inflammation is a response of the body’s defense system in preparation for tissue repair. Acute inflammation is characterized by heat, redness, pain, and formation of edema. Acute inflammation involve the realese of inflammatory mediators. Muntingia calabura is a herbal plant commonly used as an anti-inflammatory medicine containing bioactive coumpounds such as flavonoids, triterpenoids, and alkaloids that can inhibit the regulation of inflammatory mediators. This study aims to determine the anti-inflammatory activity and optimal dosage of M. calabura infusion in addressing acute inflammation in rats. The research method is a laboratory experiment using Wistar strain white rats that divided into 7 treatment groups: normal, negative control, positive control (sodium diclofenac and methylprednisolone), and M. calabura infusion at doses of 150, 300, and 600 mg/kg body weight. Each rats model induced with 1% carrageenan at 0.2 ml intraplantar, the formed edema is measured using a plethysmometer every 30 minutes for the first 3 hour and every 60 minutes for the following 3 hour. The result indicate that M. calabura infusion has acute anti-inflammatory effect on white rats model induced with carrageenan, with the most optimal dose being 600 mg/kg body weight, showing a pattern of anti-inflammatory activity similar to methylprednisolone.
Correlation of Various Levels of Body Mass Index to Vascular Endothelial Growth Factor-A Permana, Noah Jefferson; Lesmana, Ronny; Setiawan, Setiawan; Lubis, Leonardo; Rosdianto, Aziiz Mardanarian; Rejeki, Purwo Sri
Althea Medical Journal Vol 12, No 3 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n3.4296

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Background: Obesity, reflected by high body mass index (BMI) value, has become a global health concern. Both obesity and vascular endothelial growth factor-A (VEGF-A) are major risk factors for cardiometabolic diseases. Although many studies have shown that obesity induces angiogenesis through increased VEGF-A, there remains a  gap regarding the correlation between BMI categories and VEGF-A levels. This study aimed to analyze the correlation between various level of BMI and VEGF-A concentrations.Methods: This cross-sectional in vivo study analyzed blood samples from 90 adults enrolled in the Universitas Padjadjaran Wellness Program ( December 2022–June 2023) selected using simple random sampling.VEGF-A concentrations were measured using multiplex ELISA assays. Data normality was assessed using the Kolmogorov-Smirnov test. Differences between BMI groups were analyze with ANOVA, and correlations were evaluated using Pearson’s test. Results: Of the 90 samples, 62 were included, and were grouped as normal weight (29%), overweight (32.2%), obesity class I (30.6%), obesity class II (6.4%), and obesity class III (1.6%). Mean VEGF-A concentrations showed an increasing trend with higher BMI, though differences between groups were not statistically significant (p=0.482). A weak positive correlation was observed between BMI and VEGF-A levels (r=0.267; p=0.036).Conclusion: Higher BMI is associated with higher VEGF-A, indicating obesity-induced inflammation and angiogenic activity. These findings highlight the importance of weight control through balanced diet and physical activity to mitigate long-term risks of cardiometabolic and chronic diseases.
A Case Report: Coccidiosis in Layer Farm, Sumedang Hartady, Tyagita; Darmesti, Daniswara Danindra; Hermawan, Firda Aisyah; Khairani, Shafia; Windria, Sarasati; Wismandanu, Okta; Rosdianto, Aziiz Mardanarian; Satryo, Faisal Amri
Media Kedokteran Hewan Vol. 35 No. 1 (2024): Media Kedokteran Hewan
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mkh.v35i1.2024.36-44

Abstract

Coccidiosis is a parasitic disease that causes economic losses on chicken farms. A case was found on a farm in Rancaekek, Bandung Regency, where there was a one-year-old laying hen that stopped producing eggs, experienced decreased pectoral muscle mass, and had mild ataxia. The diagnosis was made by necropsy procedure and fecal examination. There were lesions in the small intestine, these lesions manifested as ballooning filled with orange mucus and the presence of petechial hemorrhages on the luminal wall and decreased pectoral muscle mass was found. A Fecal examination was performed using the floating method and the McMaster calculation. The results of the fecal examination revealed Eimeria sp. oocysts and Trichostongylus tenuis eggs. The diagnosis of this case is coccidiosis infection caused by two species of Eimeria sp., namely Eimeria maxima and Eimeria tenella. This infection has resulted in a nutritional deficiency, manifested by a decrease in pectoral muscle mass.    
Sarcopenic Obesity: The Underlying Molecular Pathophysiology and Prospect Therapies Meiliana, Anna; Dewi, Nurrani Mustika; Defi, Irma Ruslina; Rosdianto, Aziiz Mardanarian; Qiantori, Adziqa Ammara; Wijaya, Andi
The Indonesian Biomedical Journal Vol 16, No 4 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i4.3176

Abstract

BACKGROUND: Age contributes to body composition alteration, rises a common disorder in elderly known as sarcopenic obesity (SO), which is characterized by the combination of obesity (excess fat mass) and sarcopenia (reduced skeletal muscle mass) clinical form and function.CONTENT: The primary cause of SO is insulin resistance. Glucose transporter 4 (GLUT4) dysfunction results in impaired fatty acids oxidation. Decreased muscle mass results in lower mitochondria number and volume. Both will increase oxidative stress. Together with altered myokines in SO, oxidative stress was promoted and lead to higher M1 macrophages and failure in autophagy. The pro-inflammatory condition and dysbiosis links SO to a variety of cardiometabolic conditions, including non-alcoholic fatty liver disease, type 2 diabetes, and cardiovascular disease. The mortality, comorbidities, cardiometabolic diseases, and disability or impairment of SO is higher compare to obesity or sarcopenia alone. Some treatments have been developed for SO including adequate dietary intake, vitamin D and antioxidant supplementation, and exercises.SUMMARY: SO is more prevalent among the elderly and has a significant negative impact on their quality of life. Therefore, maintaining muscle mass and strength as well as preventing obesity should be the key goals of initiatives to support healthy aging.KEYWORDS: aging, body composition, obesity, sarcopenia, skeletal muscle, metabolic syndrome
Co-Authors Ade Zuhrotun Ambrosius Purba ANDI WIJAYA Anna Meiliana Ariefqi, Muhammad Naufal Darmesti, Daniswara Danindra Dewi, Sumartini Dwi Cipto Budinuryanto Enny Rohmawaty Gradia, Resti Hanna Goenawan HERA MAHESHWARI Hermawan, Firda Aisyah Hesti Lina Wiraswati Hidayatik, Nanik Irma Ruslina Defi Jatiswara, Ismaya Khairani, Shafia Leonardo Lubis Majid, Rully Abiyoga Mas Rizky A.A. Syamsunarno Muhammad Begawan Bestari Nenny Agustanti Nurrani Mustika Dewi, Nurrani Mustika Okta Wismandanu Permana, Noah Jefferson Qiantori, Adziqa Ammara Ramadhan, Putra Rejeki, Purwo Sri Rini Hendriani Ronny Lesmana Saragih, Winda A. M. Sarasati Windria Satryo, Faisal Amri Savira Ekawardhani Septiyani Septiyani, Septiyani Setiawan Setiawan Tarawan, Vita M. Tyagita Hartady Usman, Hermin A. Wasmen Manalu Wijaya, Muhammad Palar Yoga Windhu Wardhana