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All Journal Jurnal Surya Medika JURNAL ANALIS LABORATORIUM MEDIK Jaringan Laboratorium Medis Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Jurnal Laboratorium Khatulistiwa
Sofyanita, Eko Naning
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Perbedaan Hasil Pewarnaan Hematoxylin Eosin (HE) pada Histologi Ginjal Mencit (Mus musculus) Berdasarkan Ketebalan Mikrotom: Differences in Hemtoxylin Eosin Staining Results in Mice Kidney Histology (Mus musculus) Based on Microtome Thickness Sofyanita, Eko Naning; Siwi, Utami Purnama
Jurnal Surya Medika (JSM) Vol. 10 No. 1 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i1.5051

Abstract

Tahap pemotongan (sectioning)  menggunakan mikrotom merupakan tahap pembuatan jaringan yang perlu diperhatikan ukuran ketebalannya. Ukuran ketebalan mikrotom yang dapat digunakan yaitu 3-5 μm. Hewan mencit memiliki banyak keunggulan, sedangkan organ ginjal mencit (Mus musculus) merupakan salah satu organ yang sering digunakan dalam penelitian. pewarnaan jaringan yang sering digunakan secara rutin adalah pewarna yang dapat memulas inti dan sitoplasma serta jaringan penyambungnya yaitu pewarnaan Hematoxylin Eosin (HE). Tujuan dari penelitian ini adalah mengetahui perbedaan hasil pewarnaan HE pada histologi ginjal mencit berdasarkan ketebalan mikrotom 3 μm, 6 μm  dan 9 μm. Penelitian ini menggunakan jenis penelitian Eksperimental dengan desain penelitian true experimental post test only control group design. Inti sel tampak berwarna biru keunguan pada kelompok pemotongan mikrotom 3 μm dengan rata-rata nilai 2,97. Sitoplasma tampak jelas dan berwarna merah muda pada kelompok pemotongan mikrotom 3 μm dengan rata-rata nilai 3. Keseragaman warna pada kelompok pemotongan mikrotom 3 μm dengan intensitas warna yang merata pada seluruh lapang pandang dengan rata-rata nilai 3. Hasil uji Kruskal Wallis dan Man Whitney pada ketebalan pemotongan mikrotom 3 μm, 6 μm dan 9 μm menunjukkan adanya perbedaan hasil kualitas pewarnaan sediaan preparat ginjal mencit dengan signifikan p= 0.000. Kesimpulan penelitian ini yaitu pemotongan menggunakan organ ginjal mencit dapat menggunakan ketebalan 3 μm.
Global Research Trends on the Role of Chlorogenic Acid on Antidiabetic Mechanisms and Reproductive Hormone Regulation (2015-2025): A Bibliometric Analysis Sofyanita, Eko Naning; Suwondo, Ari; Nugroho, Heri; Juniarto, Achmad Zulfa
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 12: DESEMBER 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v8i12.8557

Abstract

Introduction: Chlorogenic acid (CGA) is a natural chemical discovered in a variety of plants that has been associated with numerous health benefits. Recent evidence suggests that CGA impacts reproductive hormone regulation, thus linking metabolic health and endocrine function. Understanding trends and gaps in research at this intersection is crucial. This study characterizes global research patterns, collaboration, and thematic evolution on CGA's antidiabetic activity and its influence on reproductive hormones through bibliometric analysis. Methods: Data were retrieved from the Scopus database using the keywords ("Chlorogenic Acid") AND ("Antidiabetic") AND ("Reproductive Hormone" OR "Testosterone" OR "LH" OR "FSH" OR "Estrogen" OR "Sperm" OR "Fertility") OR ("Reproductive Hormone" OR "Testosterone" OR "LH" OR "FSH" OR "Estrogen" OR "Sperm" OR "Fertility"). Publications from 2015 to 2025 were included. Bibliometric analysis was performed using VOSviewer and Biblioshiny to visualize co-authorship networks, keyword co-occurrence, publication trends, source dynamics, and thematic clusters. Results: A total of 162 relevant publications were identified, with a consistent increase observed from 2015 and a peak in 2024. Egypt, China, South Korea, and Saudi Arabia emerged as leading contributors, concentrating research in Asia and the Middle East. The primary journals were Molecules, Nutrients, and Frontiers in Pharmacology. Keyword mapping identified three principal clusters: phytochemical and antioxidant characterization, metabolic and antidiabetic mechanisms, and hormonal and molecular regulation. Thematic analysis revealed a shift from compound characterization to mechanistic and translational studies integrating metabolism and reproductive endocrinology. Conclusion: Global research increasingly highlights CGA as a bridge between metabolic and hormonal regulation. Our findings show a shift toward interdisciplinary, molecular investigations, but reveal significant gaps in clinical validation and formulation research. Unlocking CGA’s therapeutic potential in metabolic and reproductive health will depend on advanced multiomics, enhanced formulations, and greater global research partnerships.
Co-Authors Achmad Zulfa Juniarto Ari Suwondo Arya Iswara Azahra, Nabila Dina Afrianti1 Djoko Priyatno, Djoko Heri Nugroho Nurul Qomariyah Palupi, Nur Indah Raden Mohamad Herdian Bhakti Rodhi Hartono Roni Afriansya Rosidah, Umi Setyowatiningsih, Lilik Siwi, Utami Purnama Susilawati, Elis WAHYUDI Widiyanto, S.Y. Didik