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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB Ophthalmologica Indonesiana
Vierlia, Wino Vrieda
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Agriculture, Biological Sciences & Forestry Environmental Science Health Professions Medicine & Pharmacology Neuroscience Public Health

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Rho- Kinase Inhibitor Y-27632 Decreases the Thickness of Trabecular Meshwork in Juvenile Rats Mod-el Injected with Sodium Hyaluronate Vierlia, Wino Vrieda; Wulandari, Lely Retno; Sujuti, Hidayat; Effendi, Ma'sum
Journal of Tropical Life Science Vol 8, No 2 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.08.02.13

Abstract

Most glaucoma drugs lower the intraocular pressure (IOP) by decreasing the aqueous humor production and increasing the outflow through uveoscleral pathway. None of these drugs work mainly on increasing outflow through the trabecular pathway. Consequently, the experiment to develop glaucoma drugs directly target at the trabecular outflow pathway is highly required. The purpose of this study is to reveal the effect of rho-kinase inhibitor Y-27632 on the thickness of trabecular meshwork in juvenile rats model injected with sodium hyalu-ronate.  This study was an experimental study with posttest only control group design. Twenty-four rats were included in this study. Each eye of the rat would be considered as one sample. Samples were divided into 6 groups, negative control group, positive control I group with intracameral sodium hyaluronate injection, posi-tive control II group with topical Y-27632 10 mM, and three experimental groups with intracameral injection of sodium hyaluronate and Y-27632 10-1 mM, 1 mM, and 10 mM respectively. After the procedures all rats were sacrificed and enucleated. Trabecular meshwork tissue was stained with Hematoxilene-Eosin and evalu-ated under 400× microscopic magnification. Quantitative measurements were taken using computerized image analysis with dot slide program.  There were significant statistic differences among the positive control I group and the experimental groups (p-value < 0.05) as well as the positive control II group and the experi-mental groups (p-value < 0.05). The highest mean of decreasing trabecular meshwork thickness was noted in the group given by sodium hyaluronate and Y-27632 10 mM with value of 118.42 µm. There was decreasing thickness of trabecular meshwork due to the effect of rho- kinase inhibitor Y-27632 in juvenile rats injected with sodium hyaluronate.
HUBUNGAN KADAR HBA1C DENGAN REACTIVE OXYGEN SPECIES DALAM SERUM DARAH DAN GRADASI KATARAK PADA PASIEN KATARAK DENGAN DIABETES MELITUS Handayani, Nina; Trifena, Pasenggo; Vierlia, Wino Vrieda
Majalah Kesehatan FKUB Vol 7, No 2 (2020): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (380.591 KB) | DOI: 10.21776/ub.majalahkesehatan.2020.07.02.1

Abstract

Katarak merupakan suatu kelainan yang ditandai dengan adanya kekeruhan pada lensa mata. Selain karena penuaan, faktor lain yang terlibat dalam pembentukan katarak adalah diabetes melitus. Kondisi hiperglikemia berasosiasi dengan stres oksidatif yang berperan dalam proses pembentukan katarak. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar HbA1C dengan reactive oxygen species (ROS) dalam serum darah dan gradasi katarak pada pasien katarak dengan diabetes melitus.  Penelitian ini bersifat observasional dengan rancangan cross-sectional dan teknik consecutive sampling dengan subjek sebanyak 44 orang yang terbagi menjadi 4 kelompok berdasarkan kadar HbA1C: (1). HbA1C normal, (2).  HbA1C terkontrol baik (&lt;6,5%), (3). HbA1C terkontrol sedang (6,5-7.9%), dan (4). HbA1C terkontrol buruk (≥8%); dan 3 kelompok berdasarkan gradasi katarak. Hasil uji Kruskal-Wallis menunjukkan perbedaan signifikan (p &lt; 0,05) rerata ROS pada masing-masing kelompok HbA1C. Kemudian dari hasil uji lanjut Mann-Whitney, tidak didapatkan perbedaan signifikan antara kelompok 1 dengan kelompok 2, 3, dan 4; terdapat perbedaan signifikan antara kelompok 2 dengan 3 dan 4; dan tidak didapatkan perbedaan signifikan antara kelompok 3 dan 4. Hasil uji korelasi Spearman menunjukkan terdapat hubungan negatif yang tidak signifikan antara kadar HbA1C dengan ROS pada kelompok 1 (p = 0,958, r = -0,016) dan pada kelompok 4 (p = 0,163, r = -0,477); hubungan negatif yang signifikan pada kelompok 2 (p = 0,04, r = -0,817); dan hubungan positif yang tidak signifikan pada kelompok 3 (p = 0,518, r = 0,232). Hasil uji Kruskal-Wallis menunjukkan perbedaan yang tidak signifikan (p &gt; 0,05) rerata kadar ROS pada kelompok gradasi katarak II, III, dan IV. HbA1C dapat digunakan sebagai salah satu penanda peningkatan ROS pada pasien katarak diabetika, dimana tingginya kadar ROS diperkirakan akan menyebabkan peningkatan progresifitas katarak. 
THE ROLE OF ETHANOL CONSUMPTION IN ALTERING VISUAL OUTCOMES IN METHANOL-INDUCED TOXIC OPTIC NEUROPATHY: A CASE COMPARISON I Nyoman Surya Ari Wahyudi; Vierlia, Wino Vrieda; Prayitnaningsih, Seskoati
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.17

Abstract

Methanol toxicity can cause a rapid onset of severe bilateral vision loss with prominent optic nerve head edema. This case report provides clinical manifestation of two similar acute cases of methanol induced toxic optic neuropathy with different visual outcome. The patients admitted to emergency room with weakness, headache, nausea, abdominal pain and blurred vision. Both patients drank the same bootleg alcohol 3 days before admission. The first case present worse clinical condition than the second case. Further history taking revealed the patient in second case had ingested ethanol 3 hours prior to the bootleg alcohol. Both patients were treated with hemodialysis, high dose of intravenous steroid and folic acid along with supportive therapies. Funduscopy examination and optic nerve head Ocular Coherence Tomography revealed worse edema in the first patient. On the first month follow-up, the visual acuity (VA) of the first case showed no significant improvement, while the second case revealed normal VA on both eyes. The better visual outcome in second case may caused by history of ethanol consumption which prevented more severe methanol toxicity, but further investigation may still be needed.
OPTIC NEURITIS AND SEIZURES IN A PEDIATRIC PATIENT: IS IT RELATED TO NEUROMYELITIS OPTICA SPECTRUM DISORDER? Wulandari, Lely Retno; Vierlia, Wino Vrieda
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.18

Abstract

Background: Optic neuritis is a significant manifestation of central nervous system (CNS) demyelinating disorders, including Neuromyelitis Optica Spectrum Disorder (NMOSD). Pediatric cases are particularly challenging due to overlapping symptoms with other neurological conditions. Objective: This case report discusses a pediatric patient presenting with bilateral optic neuritis and seizures, raising suspicion of NMOSD. Methods: A 12-year-old male presented with acute bilateral vision loss and seizures. Comprehensive ophthalmological examinations, laboratory tests, and neuroimaging such as magnetic resonance imaging (MRI) and optical coherence tomography (OCT ) were performed. Due to financial constraints, specific NMOSD diagnostics, such as AQP4-IgG antibody testing, were not conducted. The patient was treated with high-dose intravenous methylprednisolone (IVMP) following the Optic Neuritis Treatment Trial (ONTT) protocol and valproic acid for seizure control. Results: Significant improvement in visual acuity was observed within five days of IVMP treatment. The right eye (RE) improved from hand motions to 6/48, and the left eye (LE) from hand motions to 6/144. By day eight, further improvement in visual acuity was noted. Seizures were effectively controlled with valproic acid, and no additional neurological symptoms were reported during follow-up. MRI showed no characteristic lesions, and laboratory results were within normal limits. Conclusion: The success of treatment despite diagnostic limitations suggests that with timely intervention, favorable outcomes are possible even in challenging settings. Future research should focus on developing accessible diagnostic tools and protocols that can be implemented in resource-limited environments. Additionally, awareness and training for healthcare providers in such settings are essential to improve early recognition and treatment of NMOSD.
HUBUNGAN UKURAN PUPIL DENGAN KELAINAN REFRAKSI PADA SINDROM METABOLIK MAUPUN NON SINDROM METABOLIK PADA POPULASI DI DESA KABUPATEN MALANG Aini, Kurrotul; Sulistyowati, Anny; Vierlia, Wino Vrieda
Majalah Oftalmologi Indonesia Vol 49 No S1 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/ha8fm564

Abstract

Purpose: This study aims to assess the relationships between pupil size and refractive errors in both metabolic syndrome and non-metabolic syndrome populations residing in rural areas of Malang. Methods: A descriptive study was carried out in 2019 across three villages in Malang districts. All attending participants underwent a comprehensive ocular examination, including pupil size assessment. Pupil abnormalities were defined as deviations from the normal diameter of 2-4 mm in bright light. Clinically relevant refractive errors included hyperopia (SphEq value ? 0.25 D), myopia (SphEq value ? -0.25 D), and astigmatism (cylinder ? 0.25 D). Blood samples gauged serum fasting glucose, high-density lipoprotein cholesterol, and triglyceride levels. Waist circumference, systolic, and diastolic blood pressure were measured. Metabolic Syndrome diagnosis followed the 2006 International Diabetes Foundation criteria. Participants were categorized into metabolic syndrome and non-metabolic syndrome groups. Results: The examination involved 953 participants, encompassing 944 right eyes and 942 left eyes. For the right eye, 434 eyes showed emmetropia, 252 exhibited myopia, 141 had hyperopia, and 117 presented astigmatism. Pupillary abnormalities were linked to astigmatism, but lacked significance (p = 0.893). The left eye results indicated 444 eyes with emmetropia, 244 with myopia, 138 with hyperopia, and 116 with astigmatism. Correlation with pupillary abnormalities yielded a non-significant p-value of 0.864. Pupil size outcomes in metabolic syndrome (499 eyes) and non-metabolic syndrome (454 eyes) were not significant (p = 0.649). Conclusion: Refractive error does not correlate with pupil size in metabolic syndrome and nonmetabolic syndrome.
RELATIONSHIP OF PUPIL SIZE WITH REFRACTIVE ERROR IN METABOLIC SYNDROME AND NON METABOLIC SYNDROME: AMONG RURAL POPULATION IN MALANG AINI, KURROTUL; Sulistyowati, Anny; Vierlia, Wino Vrieda; Holipah
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/n3rj1394

Abstract

Introduction & ObjectivesNearly one in four Indonesians has metabolic syndrome (MS). One of the microvascular side effectsin Metabolic Syndrome affects the eyes. The aim of this study to evaluate the relationship of pupilsize with refractive error in MS and non-MS groups among rural populations in Malang. MethodsA descriptive study was carried out in 2019 in three villages in Malang districts. A detailed ocularexamination was conducted on all participants who attended a research facility. We definedpupillary abnormalities and clinically important refractive errors. Blood samples were obtained todetermine the parameter of the metabolic syndrome by IDF 2006 criteria. Subjects were classifiedinto 2 groups: Metabolic Syndrome status and non metabolic syndrome. Results953 participants completed the examination which consists of 944 right eyes and 942 left eyes. Theresults of visual acuity on the right eye: emmetropia in 434 eyes, myopia with 252 eyes, hyperopiawith 141 eyes, and astigmatism with 17 eyes where if it is not significant if associated with pupillaryabnormalities (P-value 0.893). On the left eye, the emmetropia results were 444 eyes, while formyopia were 244 eyes, hyperopia as many as 138, and astigmatism in 116 eyes and if associatedwith pupillary abnormalities, the result also not significant (P-value 0.864). The result of pupil sizewith metabolic syndrome 499 eye and non syndrome metabolic 454 eye are not significant (p-value0.649). ConclusionRefractive error didn’t relate pupil size in metabolic syndrome and non metabolic syndrome.
Co-Authors Aini, Kurrotul Effendi, Ma'sum Hidayat Sujuti Holipah I Nyoman Surya Ari Wahyudi Lely Retno W Nina Handayani Seskoati Prayitnaningsih Sulistyowati, Anny Trifena, Pasenggo