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All Journal Jurnal Kesehatan Andalas Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Kesehatan FKUB Jurnal Ilmu Kedokteran dan Kesehatan Majalah Kedokteran Andalas Kieraha Medical Journal Indonesian Journal of Cancer
Trianto, Heru Fajar
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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KORELASI ANTARA STATUS METASTATIK KELENJAR GETAH BENING AKSILA DENGAN EKSPRESI CD44 DAN CXCR4 PADA KARSINOMA PAYUDARA Trianto, Heru Fajar; Joewarini, Endang; Rahniayu, Alphania
Majalah Kesehatan FKUB Vol 6, No 2 (2019): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.673 KB) | DOI: 10.21776/ub.majalahkesehatan.006.02.7

Abstract

Karsinoma payudara merupakan salah satu keganasan terbanyak yang menyerang wanita di dunia.  Salah satu faktor prognosis karsinoma payudara adalah metastasis pada  kelenjar getah bening aksila. CD44 merupakan protein transmembran dan penanda sel punca kanker yang memiliki pengaruh pada pertumbuhan tumor, metastasis, dan rekurensi. CXCR4 merupakan reseptor kemokin yang terekspresi pada beberapa sel tumor salah satunya karsinoma payudara. Penelitian ini bertujuan membuktikan adanya korelasi antara status metastatik kelenjar getah bening aksila dengan ekspresi CD44 dan CXCR4 pada karsinoma payudara. Sebanyak 46 sampel  blok parafin pasien karsinoma payudara diperoleh dari Instalasi Patologi Anatomik RSUD Dr.Soetomo Surabaya periode Januari- Desember 2017. Blok parafin dipotong dan dilakukan pulasan immunohistokimia dengan antibodi monoklonal CD44 dan CXCR4. Ekspresi CD44 dan CXCR4 dinilai menggunakan skor imunoreaktif (Immunoreactive score (IRS)). Hasil menunjukkan ekspresi CD44 dan CXCR lebih kuat pada karsinoma payudara dengan metastasis kelenjar getah bening aksila dibandingkan tanpa metastasis kelenjar getah bening aksila (p = 0,001 dan  p = 0,005). Terdapat korelasi positif yang signifikan antara status metastatik kelenjar getah bening aksila dengan ekspresi CD44 dan CXCR4 (p = 0,001 dan p = 0,004). Kesimpulannya adalah terdapat korelasi yang signifikan antara ekspresi CD44 dan CXCR4 dengan kejadian metastasis kelenjar getah bening pada karsinoma payudara. Hal ini menunjukkan bahwa CD44 dan CXCR4  memiliki peran penting dalam kejadian metastasis kelenjar getah bening pada karsinoma payudara. 
Tinjauan Literatur : PATOGENESIS INFEKSI HUMAN PAPILLOMAVIRUS SEBAGAI DASAR DALAM PENGEMBANGAN PENCEGAHAN DAN TERAPI BARU PADA KANKER PENIS Trianto, Heru Fajar; Rahaju, Anny Setijo
Majalah Kesehatan FKUB Vol 8, No 3 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.03.7

Abstract

Kanker penis merupakan salah satu keganasan pada pria yang jarang terjadi. Berbagai faktor risiko berperan dalam kejadian kanker penis, salah satunya adalah infeksi Human Papillomavirus (HPV). Infeksi HPV merupakan salah satu penyakit menular seksual yang terjadi pada usia reproduktif. Tinjauan literatur ini bertujuan untuk menjelaskan peran infeksi HPV terhadap kejadian kanker penis,  perkembangan vaksin untuk mengurangi risiko terjadinya kanker penis serta imunoterapi untuk meningkatkan angka kesembuhan dan menurunkan angka kematian akibat kanker penis. Artikel didapatkan melalui penelusuran secara online menggunakan Pubmed, Sage Journals, dan Google Cendekia menggunakan kata kunci human papillomavirus, penile cancer, kanker penis, vaccine, atau targeted therapies. Hasil penelusuran offline melalui hasil penelitian yang tidak dipublikasikan dan buku referensi. Hasil pencarian online mendapatkan 9110 artikel yang terkait dengan kata kunci, namun hanya 31 artikel yang ditelaah. Hasil telaah mejelaskan bahwa patogenesis infeksi HPV pada proses onkogenesis kanker penis melibatkan berbagai jalur molekuler dan sistem imun di sekitar tumor yang dapat digunakan sebagai dasar dalam pengembangan upaya pencegahan dan terapi baru. Salah satu cara pencegahan kanker penis adalah dengan pemberian vaksin HPV menggunakan teknologi Virus-Like Particles (VLP) yang dapat mencegah kejadian lesi genital. Kaitan antara HPV dan sistem imun dikembangkan sebagai terapi target yang baru. Beberapa penelitian mengenai terapi target pada kanker yang berkembang saat ini menunjukan bahwa pemberian immune checkpoint inhibitors dapat meningkatkan sistem imun dalam proses eliminasi sel kanker. Terapi target tersebut dapat meningkatkan angka kesembuhan dari penderita dan mengurangi efek samping dari terapi yang ada saat ini. 
The Difference in Patient Characteristics based on Cervical Cancer Stage at Soedarso Hospital Fatinah, Nabilah Nurul; Pratiwi, Sari Eka; Trianto, Heru Fajar; Wahyudi, Tri; Rahmayanti, Sari
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 23, No 2 (2023): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v23i2.16961

Abstract

Cervical cancer ranks fourth-most in cancer mortality in women worldwide and second in incidence and mortality from cancer in women in Indonesia. Many cervical cancer patients are diagnosed at an advanced stage with a poor prognosis and increased mortality, so it is necessary to identify the characteristics related to the stage. This research aims to determine the differences in patient characteristics based on the cervical cancer stage. This study was analytical with a cross-sectional approach. Samples were taken using consecutive sampling techniques with a total sample of 99 people. The research was conducted at Soedarso Hospital Pontianak by collecting data from medical records and an anatomical pathology laboratory. Most cervical cancer patients in this study were 41-50 years of age (39,4%), were a housewife (78,8%), had graduated from elementary school (44,4%) and had a number parity of more than 5 (31,3%). The data were analyzed using the Kruskal-Wallis. Statistical tests showed a significant difference between age (p 0.000), occupation (p 0.003), and parity (p 0.017) to the cervical cancer stage. It indicated that older ages, more parity, and housewife tended to be diagnosed with an advanced stage of cervical cancer. This study implied that older women, more parity, and housewives should be more aware of cervical cancer risk.
The Role of Tumor-Associated Macrophage Density to Tumor Size and Lymph Node Metastases of Invasive Ductal Carcinoma Patients at Dr. Soedarso General Hospital Pontianak Nugraha, Muhammad Fikri; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Trianto, Heru Fajar; Fitrianingrum, Iit; Hartono, Hengky
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1161

Abstract

Background: Invasive ductal carcinoma is the most common form of breast cancer worldwide and has a high mortality rate. The main component of the innate immune system in the tumor environment is the tumor-associated macrophage (TAM). Certain types of TAM are known to affect tumor size and lymph node metastasis which makes the cancer prognosis worse. Currently, TAM identification is generally identified using immunohistochemical staining techniques that require high costs and special expertise. An easy and inexpensive TAM identification technique is needed in determining breast cancer prognostic factors. This study focused on TAM density and its role in tumor size and lymph node metastases of invasive ductal carcinoma patients.Methods: This research is an observational analytic study using a cross-sectional approach. This study was conducted by observing the Hematoxylin-Eosin (HE) preparation of invasive ductal carcinoma patients. This study used 55 medical record data and histopathology laboratory reports of invasive ductal carcinoma patients at Dr. Soedarso General Hospital Pathological Anatomy Laboratory. TAM density cut-off is measured by calculating the median data of TAM density. Research analysis was performed using Spearman’s rho correlation test in SPSS version 24.Results: The cut-off value for determining TAM density obtained from observations based on the average value was 29. The highest number of tumor size groups was T4, and the highest number of lymph node metastases was N2. TAM density was significantly not correlated to tumor size (p = 0.285, p 0.05) and lymph node metastases (p = 0.479, p 0.05) Conclusions: This study found no significant correlation between TAM density, assessed through a cost-effective method using HE staining, and tumor size or lymph node metastasis in invasive ductal carcinoma patients.
Hubungan Albuminuria dan Laju Filtrasi Glomerulus pada Pasien Diabetes Melitus Tipe 2 yang Tidak Terkontrol Parinding, Vinny Vania; Ilmiawan, Muhammad In'am; Fitrianingrum, Iit; Trianto, Heru Fajar; Mardhia, Mardhia
Jurnal Kesehatan Andalas Vol. 11 No. 2 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.1994

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. Patients with diabetes mellitus require optimal glycemic control. Poorly controlled diabetes mellitus is at risk for complications, such as diabetic nephropathy. Diabetic nephropathy is characterized by albuminuria and can lead to decreased Glomerular Filtration Rate (GFR). Objectives: To determined the relationship between albuminuria and GFR in a patient with poorly controlled type 2 diabetes mellitus. Methods: This research was conducted at the Pontianak Branch of Prodia Health Clinic Laboratory in March 2021, using secondary data of laboratory examination results from DM patients in the 2020 period. This research was observational analytics with a cross-sectional approach. The number of samples that comply with the research criteria was 273 people. Bivariate analysis using Spearman’s correlation test. Results: Spearman's correlation test results showed significance (p=0.001) and correlation coefficient (r=0.209). Conclusion: Albuminuria and GFR in a patient with poorly controlled type 2 diabetes mellitus are significantly and positively correlated.Keywords:  albuminuria, poorly controlled type 2 diabetes mellitus, glomerular filtration rate
Relationship Between Tumor Infiltrating Lymphocytes (TIL) With Histopathological Grading, Tumor Size, and Axillary Lymph Node Metastases in Breast Cancer at the Anatomical Pathology Laboratory of Soedarso Hospital Pontianak Damayanti, Renita; Trianto, Heru Fajar; Pratiwi, Sari Eka; Suhardiman, Eko Rustianto; Fitrianingrum, Iit
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1164

Abstract

Background: Breast cancer has a high prevalence rate, with diagnosis often occurring at an advanced stage (stage III-IV), particularly in developing countries. Tumor-infiltrating lymphocytes (TILs) are a prognostic factor that can be assessed based on histopathological features in relation to response to therapy. Furthermore, histopathological grading, tumor size, and lymph node metastasis are predictive factors for breast cancer prognosis. This study aimed to investigate the relationship between TIL and other predictive factors, histopathological grading, tumor size, and axillary lymph node metastasis.Methods: This research is an observational analytic study with a cross-sectional approach. This research was approached by observing the 55 tissue slides of hematoxylin-eosin (HE) in breast cancer patients that met the inclusion and exclusion criteria. The inclusion criteria included breast cancer patients who underwent histopathological examination at the Anatomical Pathology Laboratory of Dr. Soedarso Hospital Pontianak in the period January until December 2021 with invasive carcinoma of no special type and had undergone Modified Radical Mastectomy (MRM) surgery. The exclusion criteria were patients with breast cancer recurrence and double primary cancer cases, and no data on tumor size was obtained on the results of histopathological examination. The data collected was then statistically analyzed with the Spearman test. Results: Breast cancer in this study was mostly diagnosed as grade III, T4, and N2. The results of the Spearman's rho correlation test showed that there was no correlation between TIL and the histopathological grading (p = 0.231; r = 0.164 ), tumor size (p = 0.507; r = -0.091), and axillary lymph node metastases (p = 0.842; r = -0.028).Conclusions: There is no statistically significant correlation between TIL and the grade, tumor size, and axillary lymph node metastases in breast cancer at the anatomical pathology laboratory of Soedarso Hospital Pontianak.
Hubungan Gangguan Kognitif Dan Kemandirian Fisik Dengan Mental Emosional Pada Lansia Di Puskesmas Sebangkau Kalimantan Barat Yi, Sin; T.T., Agustina Arundina; Trianto, Heru Fajar
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 3 (2025): Volume 12 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i3.18751

Abstract

Meningkatnya angka harapan hidup pada lansia memicu pergeseran jenis penyakit menjadi penyakit degeneratif yang berkaitan dengan proses penuaan. Penurunan kemandirian fisik dan fungsi kognitif akibat penuaan dapat memengaruhi kesehatan mental lansia. Maka dari itu, fokus penelitian ini ada pada hubungan antara gangguan kognitif dan kemandirian fisik dengan kondisi mental emosional lansia, yang masih jarang diteliti di Indonesia. Tujuan penelitian ini adalah untuk menganalisis hubungan antara gangguan kognitif dan kemandirian fisik terhadap mental emosional lansia di Puskesmas Sebangkau tahun 2020. Pendekatan yang digunakan dalam penelitian ini adalah cross-sectional. Serta menggunakan teknik consecutive sampling yang menghasilkan 93% sampel. Data variabel diperoleh dari Register Kohort Lansia di Puskesmas Sebangkau. Uji chi-square dilakukan untuk menganalisis Bivariat. Dari penelitian menggunakan SPSS 25.0 didapatkan signifikansi sebesar 0,039 (P<0,05) untuk hubungan gangguan kognitif dengan mental emosional, dan 0,000 (P<0,05) untuk hubungan kemandirian fisik dengan mental emosional. Dengan demikian, terdapat hubungan signifikan antara gangguan kognitif dan kemandirian fisik dengan kondisi mental emosional lansia di Puskesmas Sebangkau tahun 2020.
Clinical and Pathological Characteristics of Breast Cancer Patients at Soedarso Hospital Pontianak Aisha, Ayunda; Pratiwi, Sari Eka; Trianto, Heru Fajar; Suhardiman, Eko Rustianto; Fitrianingrum, Iit
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1163

Abstract

Background: Breast cancer has been identified as the most commonly diagnosed cancer in Indonesia, contributing to the highest incidence rate in 2020. The clinical characteristics of cancer patients in Indonesia may vary depending on the region, and social and cultural factors can also play a role in these differences. West Kalimantan, a province in Indonesia, is known for its diverse population comprising three significant ethnic groups: Malay, Dayak, and Chinese. This study aims to describe the characteristics of breast cancer patients in West Kalimantan.Method: This study is a descriptive study conducted on patients from 2019 to 2022. The study included 143 breast cancer patients who met the inclusion and exclusion criteria. All medical records were reviewed and analyzed to obtain the variable data; they were age, gender, origin, ethnicity, education, clinical manifestation, stage of breast cancer, tumor size, lymph node metastasis, distant metastases, lymphangioinvasion, histopathology type, and grading.Results: Breast cancer patients for the 2019 to 2022 period totaled 341 patients. Breast cancer has the highest number of cases in 2022, 148 patients. In this study, 143 patients from 2019 to 2022 met the inclusion criteria. Breast cancer was found from age 30 with a peak at the age of 44-50 years, and all patients were women. The highest percentage of patients had completed primary education (28%). Most patients came from Pontianak city (37.1%), with the most ethnic groups being Malays (73.5%). The most common clinical symptom was a painless lump (97.9). Most patients came at stage IIIb (29.4%). Pathological characteristics are tumor size T4 (42%), N1 lymph node metastasis (30.1%), 86.4% of patients had no distant metastasis. A total of 77.6% of patients had negative lymphangioinvasion. Based on histopathology, the type of invasive ductal carcinoma ranks the highest (79%) and had grade 3 breast cancer (47.6%).Conclusion: Breast cancer cases in Soedarso Hospital have increased every year. The majority of breast cancer patients at Soedarso Hospital from 2019 to 2022 were in advanced stages and the type of invasive ductal carcinoma with grade 3.
HUBUNGAN STATUS GIZI, JENIS KELAMIN, USIA, PEKERJAAN DAN RIWAYAT PENYAKIT PENYERTA DENGAN KADAR GULA DARAH PUASA PADA PASIEN RAWAT INAP DIABETES MELITUS TIPE II DI RSUD DR. SOEDARSO PONTIANAK PERIODE JANUARI - DESEMBER 2021 Mawarni, Irsa; Tejoyuyono, Agustina Arundina Triharja; Trianto, Heru Fajar
Kieraha Medical Journal Vol 7, No 1 (2025): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v7i1.9818

Abstract

Latar Belakang. Diabetes melitus (DM) merupakan salah satu dari empat prioritas penyakit tidak menular. Tes glukosa darah puasa menggunakan darah vena merupakan penentuan baku emas untuk diagnosis diabetes mellitus tipe 2 dan sering digunakan di rumah sakit. Beberapa faktor yang diduga memengaruhi pengendalian kadar gula darah adalah status gizi, jenis kelamin, usia, pekerjaan dan riwayat penyakit penyerta. Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan antara status gizi, jenis kelamin, usia, pekerjaan dan riwayat penyakit penyerta dengan kadar gula darah puasa pada pasien rawat inap DMT2 di RSUD Dr Soedarso Pontianak. Metode. Penelitian ini merupakan studi analitik korelasi dengan pendekatan potong lintang. Sebanyak 70 pasien terpilih melalui teknik total sampling menggunakan data rekam medis. Analisis bivariat menggunakan uji kruskal wallis dan chi square. Hasil. Hasil uji kruskal wallis dan chi square menunjukkan terdapat hubungan yang signifikan antara status gizi dengan kadar gula darah puasa (p = 0,020),  jenis kelamin dengan kadar gula darah puasa (p = 0,011),  usia dengan kadar gula darah puasa (p = 0,002), jenis pekerjaan dengan kadar gula darah puasa (p = 0,003), serta riwayat penyakit penyerta dengan kadar gula darah puasa (p = 0,001). Kesimpulan: Terdapat hubungan signifikan antara status gizi, jenis kelamin, usia, pekerjaan dan riwayat penyakit penyerta dengan kadar gula darah puasa pada pasien rawat inap DMT2 di RSUD Dr Soedarso Pontianak.
HUBUNGAN ANTARA USIA DAN JENIS KELAMIN DENGAN DERAJAT DIFERENSIASI KANKER KOLOREKTAL PADA LABORATORIUM PATOLOGI ANATOMI RSUD DR. SOEDARSO Fattarini, Winni; Trianto, Heru Fajar; Pratiwi, Sari Eka
JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama Vol 13, No 1 (2025): JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jkm.v13i1.2603

Abstract

Menurut pemeringkatan secara global di dunia, kanker kolorektal paling sering dijumpai pada laki-laki di urutan keempat dan pada wanita di urutan ketiga. Beberapa faktor klinikopatologik diketahui berperan sebagai indikator prognosis kanker ini, di antaranya usia, jenis kelamin, dan derajat diferensiasi histologis. Penelitian ini mengevaluasi hubungan antara usia dan jenis kelamin dengan derajat diferensiasi kanker kolorektal berdasarkan data dari Laboratorium Patologi Anatomi RSUD Dr. Soedarso. Desain penelitian menggunakan pendekatan observasional analitik dengan metode potong lintang. Data diperoleh dari 207 pasien yang dipilih melalui teknik total sampling dan analisis dengan uji Chi Square. Hasil penelitian menunjukkan nilai p untuk hubungan usia dengan derajat diferensiasi sebesar 0,124 dan hubungan jenis kelamin dengan derajat diferensiasi sebesar 0,366. Dengan demikian, tidak terdapat hubungan bermakna antara usia maupun jenis kelamin dengan derajat diferensiasi kanker kolorektal pada laboratorium tersebut.
Co-Authors Aisha, Ayunda Alkamil, Ahmad Wildan Alphania Rahniayu Anny Setijo Rahaju, Anny Setijo Damayanti, Renita Endang Joewarini Fatinah, Nabilah Nurul Fattarini, Winni Ftrianingrum, Iit Hartono, Henky Hengky Hartono Ilmiawan, Muhammad In'am Laili, Kharima Lestari, Desriani Mardhia, Mardhia Mawarni, Irsa Nugraha, Muhammad Fikri Parinding, Vinny Vania Pratiwi, Sari Eka Salsabila, Tasya Sari Rahmayanti Suhardiman, Eko Rustianto T.T., Agustina Arundina Tejoyuyono, Agustina Arundina Triharja Tri Wahyudi Yasri, Rafif Ibtsa Yi, Sin