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All Journal Jurnal Kesehatan Andalas Jurnal Kesehatan Masyarakat (JKM) CENDEKIA UTAMA Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Kesehatan FKUB Jurnal Ilmu Kedokteran dan Kesehatan Majalah Kedokteran Andalas Journal of Public Health Research and Community Health Development (JPH RECODE) Kieraha Medical Journal Indonesian Journal of Cancer Folia Medica Indonesiana
Trianto, Heru Fajar
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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PERBEDAAN KARAKTERISTIK PASIEN KANKER KOLOREKTAL BERDASARKAN LOKASI TUMOR DI RSUD DR. SOEDARSO PONTIANAK TAHUN 2017-2020 Yasri, Rafif Ibtsa; Trianto, Heru Fajar; Lestari, Desriani
JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama Vol 13, No 1 (2025): JKM (Jurnal Kesehatan Masyarakat) Cendekia Utama
Publisher : STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jkm.v13i1.2597

Abstract

Kanker kolorektal merupakan salah satu jenis kanker yang paling sering terjadi dan menduduki peringkat ketiga sebagai kanker dengan jumlah kasus tertinggi di dunia. Kanker kolorektal dapat disebabkan oleh beberapa faktor risiko, baik faktor genetik maupun lingkungan. Secara klinis, kanker kolorektal tumbuh dan berasal dari lokasi yang berbeda-beda. Perbedaan lokasi ini dapat berpengaruh pada manifestasi klinis dan metastasis tumor yang berbeda. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan usia, jenis kelamin, riwayat merokok, status pekerjaan dan Indeks Massa Tubuh (IMT) pasien kanker kolorektal berdasarkan lokasi tumor di RSUD Dr. Soedarso Pontianak periode tahun 2017-2020. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross-sectional. Sampel penelitian ini adalah pasien kanker kolorektal di RSUD Dr. Soedarso Pontianak periode tahun 2017-2020 serta memenuhi kriteria inklusi dan eksklusi dengan teknik total sampling. Analisis statistik dilakukan dengan menggunakan Uji Chi-Square dan Uji Alternatif Fisher’s Exact Terdapat perbedaan yang bermakna dari riwayat merokok (p<0,05) dan IMT (p<0,05) berdasarkan lokasi tumor kanker kolorektal. Tidak terdapat perbedaan yang bermakna dari usia (p>0,05), jenis kelamin (p>0,05) dan status pekerjaan (p>0,05) berdasarkan lokasi tumor kanker kolorektal. Terdapat perbedaan yang bermakna dari riwayat merokok dan IMT berdasarkan lokasi kanker kolorektal
Hubungan antara tumor-infiltrating lymphocytes dengan parameter klinikopatologi pada kanker kolorektal Trianto, Heru Fajar; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Hartono, Henky; Ftrianingrum, Iit; Lestari, Desriani
Majalah Kedokteran Andalas Vol. 46 No. 4 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p949-958.2023

Abstract

Latar Belakang: Kanker kolorektal termasuk dalam keganasan terbanyak di dunia. Berbagai faktor turut mempengaruhi prognosis dari kanker salah satunya sistem imun. Sistem imun di sekitar tumor memiliki pengaruh terhadap progesivitas sel kanker. Salah satu sistem imun yang dapat diamati adalah Tumor-infiltrating lymphocytes (TIL). Tujuan: Penelitian ini bertujuan untuk membuktikan adanya hubungan antara TIL dengan berbagai parameter klinikopatologi pada kanker kolorektal. Metode : Penelitian ini menggunakan desain potong lintang. Subjek penelitian berupa 38 sampel blok parafin dan slide hematoksilin-eosin (HE) serta data klinikopatologi yang berasal dari sediaan operasi kanker kolorektal pada Laboratorium Patologi Anatomi RSUD Dr. Soedarso periode Januari – Desember 2020. Penilaian jumlah TIL dibagi menjadi tiga kelompok yaitu ringan (0-10%), sedang (11-59%), dan berat (60-100%). Hasil: Hasil penelitian menunjukkan bahwa jumlah TIL terbanyak adalah TIL berat yaitu sebanyak 16 kasus (42,1%). Hasil uji korelasi Spearman menunjukkan hubungan antara jumlah TIL dengan derajat diferensiasi, stadium Dukes dan stadium p TNM dengan nilai p<0,005. Tidak terdapat hubungan antara jumlah TIL dengan ukuran tumor, status metastasis kelenjar getah bening, status metastasis jauh, dan lokasi tumor. Kesimpulan: Terdapat hubungan antara jumlah TIL dengan derajat keganasan, stadium Dukes dan stadium pTNM yang merupakan faktor-faktor prognosis pada kanker kolorektal.
Differentiation of Microvessel Density Based on The Breast Cancer Patient Characteristics Including Age, Stage, Tumor Size, and Lymph Node Metastasis Salsabila, Tasya; Pratiwi, Sari Eka; Trianto, Heru Fajar; Ilmiawan, Muhammad In'am; Lestari, Desriani; Fitrianingrum, Iit; Hartono, Henky
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1041

Abstract

Background: Breast cancer is the most common malignant tumor in the world and Indonesia. One well-known prognostic marker is microvessel density (MVD), the numerical value of angiogenesis. In recent years, it has been recognized that tumor growth depends on angiogenesis. Therefore, this study aimed to determine the differentiation of MVD based on the breast cancer patients' characteristics including age, stage, tumor size, and lymph node metastasis in the Anatomical Pathology Laboratory of Soedarso Hospital. Methods: This research was an observational study with a cross-sectional approach. The study was conducted by observing the slides of Hematoxylin-Eosin (HE) in breast cancer patients. Samples were taken using the total sampling technique. The samples were observed by two observers. 51 tissue preparations met the inclusions and exclusions criteria. MVD cut-off points are taken by calculating the median. Research analysis was using the Kruskal-Wallis test in SPSS version 24. Results: All samples of this study were women and had invasive ductal carcinoma. Breast cancer tends to occur in patients aged 48-53 years, has stage III, lymph node metastasis (N2). The patients have a low MVD rate but have a large tumor size (T4). Kruskal Wallis test showed that there was a differentiation of MVD based on age (p = 0.029). While, there was no differentiation of MVD based on stage (p=0.974), tumor size (0.069), and lymph node metastasis (0.571). Conclusions: There was a differentiation of MVD based on the age of breast cancer patients in the Anatomical Pathology Laboratory at Soedarso Hospital.
Necrosis area, Tumor Size, and Lymph Node of Breast Cancer Laili, Kharima; Pratiwi, Sari Eka; Ilmiawan, Muhammad In'am; Trianto, Heru Fajar; Fitrianingrum, Iit
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1121

Abstract

Background: Breast cancer is the leading cause of cancer deaths in women worldwide in 2020. The high mortality rate is often influenced by various reasons, one of which is patients's prognosis. One of the prognostic factors is necrosis area, caused by hypoxic tumor tissue that can affect tumor growth and metastasis. Therefore, this study aims to determine the relationship between necrosis area with tumor size and lymph node metastasis in breast cancer patients. Methods: This study was an observational analytic with a cross-sectional approach. This research was conducted at the Anatomical Pathology Laboratory of Dr Soedarso Pontianak General Hospital and the Microscopy Laboratory of the Faculty of Medicine Tanjungpura University from September until November 2022. The study sample was 55 slides of Formalin-Fixed Paraffin-Embedded (FFPE). The study was conducted by observing the preparations under a microscope and then analyzed using ImageJ and SPSS software. The independent variable in this study was the necrosis area in the tumor microenvironment, and the dependent variables were tumor size and lymph node metastasis in breast tissue. Results: All study samples were female patients with invasive ductal carcinoma. Breast cancer tends to occur in patients aged 48-55 years. The highest percentage of necrosis area was 21% and the most diagnosed breast tumor size and lymph node metastasis were stage T4 and stage N2. Spearman's rho correlation test showed that there was no relationship between necrosis area and tumor size (p = 0.122; r = 0.16) and lymph node metastasis (p = 0.637; r = 0.18). Conclusions: There is no correlation between necrosis area with tumor size and lymph node metastasis of breast cancer patients in the Anatomical Pathology Laboratory at Dr Soedarso Pontianak General Hospital.
TINGKAT PENGETAHUAN MENGENAI KANKER PAYUDARA, SERTA SIKAP DAN PERILAKU PEMERIKSAAN PAYUDARA SENDIRI (SADARI) PADA SANTRIWATI PONDOK PESANTREN USHULUDDIN SINGKAWANG Alkamil, Ahmad Wildan; Pratiwi, Sari Eka; Trianto, Heru Fajar
Kieraha Medical Journal Vol 5, No 2 (2023): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v5i2.6845

Abstract

Latar Belakang: Kanker payudara adalah kanker dengan kasus baru tertinggi dan penyebab utama kematian akibat kanker pada wanita. Diagnosis dan pemahaman mengenai upaya pencegahan kanker payudara memegang peranan penting dalam meningkatkan prognosis selain faktor klinis lainnya. Oleh karena itu, penelitian ini difokuskan untuk menggambarkan tingkat pengetahuan tentang kanker payudara, sikap dan perilaku pemeriksaan payudara sendiri (SADARI). Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran tingkat pengetahuan tentang kanker payudara, sikap dan perilaku pemeriksaan payudara sendiri (SADARI) pada santriwati Pondok Pesantren Ushuluddin Singkawang. Metode: Penelitian ini merupakan penelitian deskriptif yang menggambarkan tingkat pengetahuan tentang kanker payudara pada santriwati di Pondok Pesantren Ushuluddin Singkawang, sikap dan perilaku SADARI. Sebanyak 88 santriwati dipilih melalui teknik stratified random sampling. Variabel diukur dengan menggunakan kuesioner pengetahuan, sikap dan perilaku SADARI. Hasil: Sebagian besar responden memiliki tingkat pengetahuan tentang kanker payudara yang sedang yaitu sebesar 46%; Responden memiliki sikap SADARI yang positif sebanyak 85%; Responden memiliki perilaku SADARI yang baik sebanyak 86% Kesimpulan: Tingkat pengetahuan santriwati Pondok Pesantren Ushuluddin Singkawang tentang kanker payudara sebagian besar adalah sedang; Sikap santriwati Pondok Pesantren Ushuluddin Singkawang terhadap SADARI sebagian besar adalah positif; Perilaku santri Pondok Pesantren Ushuluddin Singkawang terhadap BSE sebagian besar baik.
Expression of Melanoma Antigen Genes A11 and A12 in Non-Small Cell Lung Cancer Mastutik, Gondo; Rahniayu, Alphania; , Isnin Anang Marhana; Amin, Mochamad; Trianto, Heru Fajar; I'tishom, Reny
Folia Medica Indonesiana Vol. 59, No. 4
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Highlights: 1. In this study, new primers designed using the semi-nested polymerase chain reaction (PCR) method were utilized to identify MAGE-A11 and MAGE-A12 expressions in specimens collected from core biopsy, forcep biopsy, and bronchoalveolar lavage. 2. The histopathological analysis revealed positive expressions of MAGE-A11 and MAGE-A12 in specimens diagnosed with non-small cell lung cancer (NSCLC) as well as in specimens with no malignant cells. 3. This study provides evidence indicating that the detection of messenger ribonucleic acid (mRNA) of MAGE-A11 and MAGE-A12 by nested reverse transcription PCR can improve the accuracy of lung cancer diagnosis. Abstract The melanoma antigen gene (MAGE) belongs to the group of cancer-testis antigens that are exclusively expressed in germ cells but may be re-expressed in cancer cells. The highly expressed MAGE-A subfamily in lung cancer may potentially be a diagnostic and prognostic biomarker. This study aimed to identify MAGE-A11 and MAGE-A12 expressions in lung tumors obtained from core biopsy, forceps biopsy, and bronchoalveolar lavage specimens. A cross-sectional observational study was conducted on 90 patients clinically diagnosed with lung tumors. These patients received core biopsy, forceps biopsy, and bronchoalveolar lavage interventions after ethical approval was obtained. The complementary deoxyribonucleic acid (cDNA) quality was assessed by the polymerase chain reaction (PCR) of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The assessment was performed to ascertain if all specimens exhibited positive PCR amplification of the GAPDH gene. MAGE-A11 and MAGE-A12 were identified through a semi-nested reverse transcription PCR. The positive results were detected by measuring the PCR products, with MAGE-A11 and MAGE-A12 at base pairs (bp) of 858 and 496 in the first and second rounds, respectively. The expressions of MAGE-A11 and MAGE-A12 were observed in 3 (3.33%) and 40 (44.44%) out of 90 specimens, respectively. The prevalence rate of non-small cell lung cancer (NSCLC) was 31.11% (28/90). Among these cases, 3.57% (1/28) showed the expression of MAGE-A11, while 32.14% (9/28) exhibited the expression of MAGE-A12. Sixty-two (68.89%) out of 90 patients were diagnosed with no tumor cell malignancy. Out of 62 cases, 2 (3.23%) exhibited the expression of MAGE-A11, while 31 (50%) demonstrated the expression of MAGE-A12. MAGE-A11 and MAGE-A12 were detected in NSCLC and certain specimens with a pathological diagnosis that indicated the absence of malignant cells. In conclusion, MAGE A11 and MAGE A12 have potential markers to improve the pathological diagnosis of lung cancer. Further investigation is necessary to explore the expression of MAGE-A in correlation with lung cancer progression.
LIFESTYLE EDUCATION TO PREVENT CHRONIC DISEASES AMONG INDONESIAN MIGRANT WORKERS IN MALAYSIA: A COMMUNITY EMPOWERMENT Asmarawati, Tri Pudy; Effendy, Lyndia; Jonny; Suidah, Hartin; Thamrin, Husin; Lestari, Kusuma Scorpia; Kunsah, Baterun; Irnandi, Dicky Faizal; Trianto, Heru Fajar
Journal of Public Health Research and Community Health Development Vol. 9 No. 2 (2026): March
Publisher : Fakultas Ilmu Kesehatan, Kedokteran dan Ilmu Alam (FIKKIA), Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jphrecode.v9i2.68666

Abstract

Malaysia is a prominent destination for Indonesian migrant workers in Southeast Asia. Despite their economic importance, migrant workers are susceptible to chronic diseases, particularly hypertension and diabetes, due to constrained access to healthcare, unhealthy behaviors, and demanding working environments. The objective of this community service initiative included the assessment of the health status of Indonesian migrant workers and the promotion of awareness through screening and educational activities. This community service program was conducted in May 2024 at Sekolah Indonesia Kuala Lumpur, in collaboration with the NGO Sharing Organization and the Indonesian Embassy. A total of 113 migrant workers participated in the event. Screening included blood pressure measurement, random blood sugar testing, eye, and reproductive health examinations. Doctoral medical students delivered a mini seminar on chronic disease prevention and management. The majority of participants were women (57%) and within the productive age group (25-55 years). Hypertension was highly prevalent (54%). The mean random blood sugar was 138 ±62.5 mg/dL). Domestic work was the most common occupation. The participants demonstrated a strong interest in health education, and feedback indicated that regular health programs would be welcomed. Indonesian migrant workers in Malaysia show a high burden of hypertension and diabetes but limited disease awareness. Routine health screening, culturally appropriate education, and stronger collaboration between employers, health providers, and the Indonesian Embassy are essential to improve chronic disease prevention and sustain worker productivity.
Co-Authors , Isnin Anang Marhana Aisha, Ayunda Alkamil, Ahmad Wildan Alphania Rahniayu Anny Setijo Rahaju, Anny Setijo Asmarawati, Tri Pudy Baterun Kunsah Damayanti, Renita Dicky Faizal Irnandi Endang Joewarini Fatinah, Nabilah Nurul Fattarini, Winni Ftrianingrum, Iit Gondo Mastutik Hartin Suidah Hartono, Henky Hengky Hartono I'tishom, Reny Ilmiawan, Muhammad In'am Jonny Kusuma Scorpia Lestari, Kusuma Scorpia Laili, Kharima Lestari, Desriani Lyndia Effendy Mardhia, Mardhia Mawarni, Irsa MOCHAMAD AMIN Nugraha, Muhammad Fikri Parinding, Vinny Vania Salsabila, Tasya Sari Eka Pratiwi Sari Rahmayanti Suhardiman, Eko Rustianto T.T., Agustina Arundina Tejoyuyono, Agustina Arundina Triharja Thamrin, Husin Tri Wahyudi Yasri, Rafif Ibtsa Yi, Sin