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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Majalah Obat Tradisional Jurnal Ilmu Kedokteran dan Kesehatan Journal SAGO Gizi dan Kesehatan Journal of Experimental and Clinical Pharmacy (JECP)
Fatmaria, Fatmaria
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Antibacterial Activity of Pasak Bumi Stem (Eurycoma longifolia J.) Extract against Salmonella typhi Sirait, Christine; Hanasia, Hanasia; Martani, Natalia Sri; Ysrafil, Ysrafil; Fatmaria, Fatmaria
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.91168

Abstract

Typhoid fever is caused by consuming food or water contaminated with Salmonella typhi. The disease develops from bacterial infection through the consumption of contaminated sustenance and drink. The bacterium can cause bacteremia, which is bacteria living in the blood, penetrating the mucosal epithelium of the small intestine and entering the lymphatic flow. Therefore, this study aimed to assess the potential inhibitory effect of ethanol extracts derived from stems of Eurycoma longifolia (pasak bumi) on the growth of Salmonella typhi bacteria. Compounds such as alkaloids, saponins, flavonoids, terpenoids, and tannins in pasak bumi stems possessed antibacterial properties. Extracts were made using 96% ethanol at varying concentrations (10%, 20%, 30%, 40%, 50%) with distilled water and chloramphenicol as negative and positive control. The result showed that pasak bumi stem extracts inhibited Salmonella typhi, with increasing efficacy at higher concentrations and statistical analysis reported significant differences between all treatment groups (p<0.001). Average zone diameter was 0 mm and 23.10 mm for negative and positive control, as well as 2.75 mm, 4.10 mm, 5.24 mm, 6.98 mm, and 8.55 mm for 10%, 20%, 30%, 40% and 50% extracts, respectively. This study provided verification of antibacterial effects of pasak bumi stem ethanol extracts against Salmonella typhi.
The Correlation between Protein, Iron, and Vitamin C Intake with Hemoglobin Levels in Pregnant Women Sitorus, Elisabeth Prihana Rotua; Handayani, Septi; Balyas, Abi Bakring; Widayati, Ratna; Fatmaria, Fatmaria; Permatasari, Silvani
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 1 (2024): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i1.17311

Abstract

Hemoglobin is an important component of the human body. It aims to transport oxygen and carbon dioxide. Anemia during pregnancy often occurs in the second trimester. Pregnant women tend to be vulnerable to malnutrition since their nutritional needs will increase to satisfy the needs of both the mother and the fetus. Protein intake plays a crucial role in the transportation of iron in the body. Meanwhile, vitamin C serves as a promoter of iron absorption. This research aims to determine and analyze the correlation between protein, iron, and vitamin C intake and hemoglobin levels in pregnant women at Kayon Public Health Center, Jekan Raya District. This research used an analytic observational method with a cross-sectional approach and a purposive sampling technique. Bivariate analysis was also applied by using the Spearman test. The latter results obtain a p-value of 0.748 between protein intake and hemoglobin level; a p-value of 0.222 between vitamin C intake and hemoglobin level; and a p-value of 0.050 between iron intake and hemoglobin level. There was a correlation between iron intake and hemoglobin level, yet there was no correlation between protein and vitamin C intake with hemoglobin level.
Potential of Ciplukan Leaf Extract (Physalis angulata L.) Against Streptococcus pneumoniae Growth in Vitro Rakhman, Farizky; Widayati, Ratna; Turnip, Oktaviani Naulita; Fatmaria, Fatmaria; Hanasia, Hanasia
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1314

Abstract

Pneumonia is a disease that infects the lungs, and antibiotics such as tetracycline show a high degree of resistance. Therefore, the use of alternative natural materials, such as ciplukan leaves (Physalis angulata L.), which the Dayak people commonly use to treat lung diseases, is necessary. This study aimed to prove that the extract of ciplukan leaves can inhibit Streptococcus pneumoniae by measuring the diameter of the clear zone and determining the Minimum Inhibitory Concentration (MIC). The extract was obtained by maceration using 96% ethanol, and then concentrations of 5%, 10%, 15%, 20%, and 25% were prepared. The positive control was levofloxacin 5 µg, and the negative control was DMSO 1%. The average inhibition zone diameters of the ciplukan leaf extract were 5% (0 mm), 10% (0.17 mm), 15% (0.45 mm), 20% (1.95 mm), 25% (2.67 mm). Antibacterial test using the disk diffusion method. From the Kruskal-Wallis and Mann-Whitney Post Hoc statistical test, a significance value of <0.05 was obtained. Therefore, There is an effect of ciplukan leaf extract on Streptococcus pneumoniae at concentrations of 15%, 20%, and 25%, with the MIC 15%.
Uji Aktivitas Antibakteri Herba Meniran (Phyllanthus niruri Linn) Terhadap Bakteri Propionibacterium acnes dan Staphylococcus epidermidis Saputra, Aldi Aditya; Hanasia, Hanasia; Fatmaria, Fatmaria; Martani, Natalia Sri; Trinovita, Elsa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 6 (2025): Volume 12 Nomor 6
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Jerawat merupakan infeksi kulit yang sering berlangsung terutama pada wajah, dikarenakan bakteri Propionibacterium acnes juga Staphylococcus epidermidis. Jerawat umumnya diobati dengan antibiotik, tetapi resistensi antibiotik mampu mengakibatkan infeksi yang lebih serius dan sulit disembuhkan. Meniran ialah tanaman herbal berpotensi jadi obat karena dapat menghasilkan metabolit sekunder yang bersifat antibakteri. Penelitian ini tujuannya membuktikan bahwa ekstrak herba meniran (Phyllanthus niruri Linn.) dapat menghalangi perkembangan Propionibacterium acnes dan Staphylococcus epidermidis secara in vitrodan mengetahui konsentrasi efektif terhadap Propionibacterium acnes juga Staphylococcus epidermidis. Ekstrak herba meniran di ekstraksi menggunakan Ultrasonic-assisted extraction (UAE) memanfaatkan pelarut etanol 96%. Ekstrak dibuat menjadi beberapa konsentrasi 5%, 25%, 50%, 75%, 100% dengan aquadest jadi kontrol negatif juga doksisiklin jadi kontrol positif. Uji antibakteri dilaksanakan menggunakan metode difusi cakram. Ekstrak herba meniran (Phyllanthus niruri Linn.) menghalangi pertumbuhan bakteri Propionibacterium acnes pada konsentrasi 50%, 75%, dan 100%. Staphylococcus epidermidis pada seluruh konsntrasi. Konsentrasi efektif Propionibacterium acnes pada konsentrasi 50% dan Staphylococcus epidermidis pada konsentrasi 5%.
Pengaruh konsentrasi ekstrak daun pare (momordica charantia l.) terhadap kematian larva aedes aegypti Halim, Rahmawati; Toemon, Agnes Immanuela; Ysrafil, Ysrafil; Fatmaria, Fatmaria; Turnip, Oktaviani Naulita
Jurnal SAGO Gizi dan Kesehatan Vol 6, No 2 (2025): Agustus
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v6i2.2320

Abstract

Background: Dengue Hemorrhagic Fever (DHF) is a health problem in Indonesia, transmitted by the Aedes aegypti mosquito. Bitter melon leaves contain active compounds such as saponins, alkaloids, and flavonoids belived to be effective as larvacides and are expected to serve as a more environmentally friendly alternative for mosquito control in preventing the spread of DHF.Objective: To determine the potential of natural biolarvacide from bitter melon leaf extract (Momordica charantia L.) against Aedes aegypti larvae.Methods: An experimental study was conducted at the Public Health Laboratory of Tanah Bumbu in July 2024. This experimental research used 375 Aedes aegypti larvae with five treatments and three repetitions, observing the number of larvae that died after 24 hours. The data were analyzed using the Shapiro-Wilk test, Levene's test, Kruskal-Wallis test, Mann-Whitney test, and probit analysis.Results: Bitter melon leaf extract at concentrations of 0,3% and 0,6% did not cause larval death, so it was not effective in inhibiting the growth of Aedes aegypti. While at concentrations of 0,9% showed a significant effect in inhibiting larval growth. The results of the Kruskal-Wallis test on the death of larvae treated with bitter melon leaf extract obtained a significance value of 0,008 (p <0,05). The results of the Mann-Whitney test showed that there was a significant difference between the concentration of 0,9% bitter melon leaf extract and the positive control abate, as well as between the negative control aquadest and the concentration of 0,9% bitter melon leaf extract. The results of the probit analysis test obtained an LC50 value of 1,202%.Conclusion: The 0.9% concentration of bitter melon leaf extract can inhibit the growth of Aedes aegypti larvae. However, it is not yet suitable as an alternative bio-larvicide.
Co-Authors Balyas, Abi Bakring Elsa Trinovita Hanasia, Hanasia Handayani, Septi Natalia Sri Martani Permatasari, Silvani Rahmawati Halim Rakhman, Farizky Saputra, Aldi Aditya Sirait, Christine Sitorus, Elisabeth Prihana Rotua Toemon, Agnes Immanuela Turnip, Oktaviani Naulita Widayati, Ratna Ysrafil, Ysrafil